A refugee seeking sanctuary from the horrors of Kristallnacht, Oskar arrives by ship in New York City with only a photograph and an address for an aunt he has never met. It is both the seventh day of Hanukkah and Christmas Eve, 1938. As Oskar walks the length of Manhattan, from the Battery to his new home in the north of the city, he passes experiences the city's many holiday sights, and encounters it various residents. Each offers Oskar a small act of kindness, welcoming him to the city and helping him on his way to a new life in the new world. This is a heartwarming, timeless picture book.
The foundation of modern clinical trials was laid many years before modern developments in biotechnology and genomics. Drug development in many diseases is now shifting to molecularly targeted treatment. Confronted with such a major break in the evolution toward personalized or predictive medicine, the methodologies for design and analysis of clinical trials is now evolving.
This book is one of the first attempts to contribute to this evolution by laying a foundation for the use of appropriate statistical designs and methods in future clinical trials for predictive medicine. It is a useful resource for clinical biostatisticians, researchers focusing on predictive medicine, clinical investigators, translational scientists, and graduate biostatistics students.