This stunningly presented collection of maps, illustrations and commentary offers an authoritative overview of the global distribution of major epidemic diseases on a variety of spatial scales from the local to the global. The Atlas is arranged in an historical sequence, beginning with classic plagues such as the 'Black Death' and cholera and moving on through smallpox and measles to 'modern' diseases such as AIDS and Legionnaires' disease. Over 400 figures are incorporated, including 150 specially drawn maps supported by micrographs of the causative agents, photographs of the disease vectors, historical prints and graphs of changing incidence. The text for each disease includes discussion of its nature and epidemiological features, its origin (where known) and historical impacts, and its global status at the start of the twenty-first century. The book concludes with an informed look towards the future, assessing the probable impacts of major medical advances on life expectancy and the chances of success of programmes for the global eradication of diseases such as polio and measles.
The World Atlas of Epidemic Diseases makes a major new contribution to our knowledge of the global burden of disease and is an informative and fascinating reference on the changing distributions of disease. It will be an invaluable resource for anyone interested in the spread, control and eradication of epidemic disease.
Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years.
The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist.
From the Persian Queen Atossa, whose Greek slave may have cut off her diseased breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease.
Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
A New York Times Notable Book
A Washington Post and Seattle Times Best Book of the Year
From the Pulitzer Prize-winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle).
“Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.
“Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome.
“A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).
You may not know that you have Lyme. It can mimic every disease process including Chronic Fatigue Syndrome, Fibromyalgia, autoimmune conditions like MS, psychiatric conditions like depression and anxiety, and cause significant memory and concentration problems, mimicking early dementia. It is called the "Great Imitator," and inaccurate testing-combined with a fierce, ongoing debate that questions chronic infection-makes it difficult for sufferers to find effective care.
When Dr. Richard Horowitz moved to the Hudson Valley over two decades ago to start his own medical practice, he had no idea that he was jumping into a hotbed of Lyme disease. He would soon realize that many of the chronic disease diagnoses people were receiving were also the result of Lyme-and he would discover how once-treatable infections, in the absence of timely intervention, could cause disabling conditions. In a field where the number of cases is growing exponentially around the world and answers remain elusive, Dr. Horowitz has treated over 12,000 patients and made extraordinary progress. His plan represents a crucial paradigm shift, without which the suffering will continue.
In this book, Dr. Horowitz:
- Breaks new ground with a 16 Point Differential Diagnostic Map, the basis for his revolutionary Lyme treatment plan, and an overarching approach to treating all chronic illness.
- Introduces MSIDS, or Multiple Systemic Infectious Disease Syndrome, a new lens on chronic illness that may prove to be an important missing link.
- Covers in detail Lyme's leading symptoms and co-infections, including immune dysfunction, sleep disorders, chronic pain and neurodegenerative disorders - providing a unique functional and integrative health care model, based on the most up-to-date scientific research, for physicians and health care providers to effectively treat Lyme and other chronic illnesses.
Cutting through the frustration, misinformation and endless questions, Dr. Horowitz's enlightening story of medical discovery, science and politics is an all-in-one source for patients of chronic illness to identify their own symptoms and work with their doctors for the best possible treatment outcome.
Over the past fifty years, more than three hundred infectious diseases have either newly emerged or reemerged, appearing in territories where they’ve never been seen before. Ninety percent of epidemiologists expect that one of them will cause a deadly pandemic sometime in the next two generations. It could be Ebola, avian flu, a drug-resistant superbug, or something completely new. While we can’t know which pathogen will cause the next pandemic, by unraveling the story of how pathogens have caused pandemics in the past, we can make predictions about the future. In Pandemic: Tracking Contagions, from Cholera to Ebola and Beyond, the prizewinning journalist Sonia Shah—whose book on malaria, The Fever, was called a “tour-de-force history” (The New York Times) and “revelatory” (The New Republic)—interweaves history, original reportage, and personal narrative to explore the origins of contagions, drawing parallels between cholera, one of history’s most deadly and disruptive pandemic-causing pathogens, and the new diseases that stalk humankind today.
To reveal how a new pandemic might develop, Sonia Shah tracks each stage of cholera’s dramatic journey, from its emergence in the South Asian hinterlands as a harmless microbe to its rapid dispersal across the nineteenth-century world, all the way to its latest beachhead in Haiti. Along the way she reports on the pathogens now following in cholera’s footsteps, from the MRSA bacterium that besieges her own family to the never-before-seen killers coming out of China’s wet markets, the surgical wards of New Delhi, and the suburban backyards of the East Coast.
By delving into the convoluted science, strange politics, and checkered history of one of the world’s deadliest diseases, Pandemic reveals what the next global contagion might look like— and what we can do to prevent it.
· Downloadable data sets
· Library of computer programs in SAS, SPSS, Stata, HLM, MLwiN, and more
· Additional material for data analysis
Following introductory chapters on the nature, structure and function of bacteria, diagnostic methods and antibiotic use, the principles are then applied to each organ system. Here relevant aspects of epidemiology, pathogenesis, diagnosis, treatment and public health are covered. There are chapters on infection is a modern society, including the immuncompromised patient, and infection control in the hospital and community.
In the context of new problem-based curricula, this book will be welcomed especially by medical students, trainee physicians and microbiologists, laboratory biomedical scientists and nurses working in infection control.
What causes mental illness? We've long blamed stress, trauma, and brain-chemistry imbalances. But a new theory is quietly achieving critical mass. In INFECTIOUS MADNESS, award-winning science writer Harriet Washington reveals that schizophrenia, obsessive-compulsive disorder, Alzheimer's, and anorexia also may be caused by bacteria, parasites, or viruses. Weaving together cutting-edge research and case studies, INFECTIOUS MADNESS shows how strep throat can trigger rapid-onset OCD in a formerly healthy teen and how contact with cat litter elevates the risk of schizophrenia. Featuring a new afterword by the author, and rich in science, medical mysteries, cultural nuance, and evidence-based recommendations, INFECTIOUS MADNESS pulls back the curtain on a new paradigm with profound implications for us all.
Complete and up-to-date, this book describes safer sex practices, testing protocols, and symptoms, and details commonly known treatments as well as significant recent medical advances—including new testing for the herpes virus, the vaccine against the human papilloma virus (HPV), and new discoveries about the effectiveness of spermicides and condoms. For each disease, Dr. Marr offers the latest Sexually Transmitted Disease Treatment Guidelines from the Centers for Disease Control and Prevention.
Forthright, compassionate, and practical, this guide is a trusted source of advice for anyone who is sexually active.
Damaged Goods adds to our knowledge of how women are affected by living with chronic STDs and reveals the stages of their sexual- self transformation. From the anxiety of being diagnosed with an STD to issues of blame and shame, Nack-herself diagnosed with a cervical HPV infection-shows why these women feeling that they are "damaged goods," question future relationships, marriage, and their ability to have healthy children.
When Pamela Weintraub, a science journalist, learned that her oldest son tested positive for Lyme disease, she thought she had found an answer to the symptoms that had been plaguing her family for years—but her nightmare had just begun. Almost everything about Lyme disease turned out to be deeply controversial, from the microbe causing the infection, to the length and type of treatment and the kind of practitioner needed.
On one side of the fight, the scientists who first studied Lyme describe a disease transmitted by a deer tick that is hard to catch but easy to cure no matter how advanced the case. On the other side, rebel doctors insist that Lyme and a soup of "co-infections" cause a complicated spectrum of illness often dramatically different – and far more difficult to treat – than the original researchers claim. Instead of just swollen knees and a rash, patients can experience exhaustion, disabling pain, and a "Lyme fog" that leaves them dazed and confused. As patients struggle for answers, once-treatable infections become chronic.
In this nuanced picture of the intense controversy and crippling uncertainty surrounding Lyme disease, Pamela Weintraub sheds light on one of the angriest medical disputes raging today. The most comprehensive book ever written about the past, present and future of Lyme disease, Cure Unknown exposes the ticking clock of a raging epidemic and the vulnerability we all share.
Grasp and retain vital concepts easilythanks to a user-friendly color-coded format, succinct text, key concept boxes, and dynamic illustrations.
Effectively review for problem-based courseswith the help of chapter introductions and "Lessons in Microbiology" text boxes that highlight the clinical relevance of the material, offer easy access to key concepts, and provide valuable review tools.
Approach microbiology by body system or by pathogenthrough an extensively cross-referenced "Pathogen Review" section.
Access the complete contents online at studentconsult.com, along with downloadable illustrations...150 multiple choice review questions... "Pathogen Parade"...and many other features to enhance learning and retention. Enhance your learning and absorb complex information in an interactive, dynamic way with Pathogen Parade a quickly searchable online glossary of viruses, bacteria, and fungi.
Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventive medicine.A completely re-written chapter on this topic keeps abreast of the very latest findings.
Several themes explored in the book illustrate ways in which non-medical factors influence our views of a disease and our reaction to it. One of these themes is the tendency to focus blame for the spread of a disease on a particular group (e.g., women, blacks, sinners). The balance between protecting the rights of individuals and protecting the public health, in issues such as whether to quarantine the infected and whether to require mandatory testing for the disease, is another theme. A third theme is the persistent reluctance of many Americans to discuss venereal disease openly because it involves sex, a subject that we are often not comfortable talking about.
Treating these topics together takes advantage of all they have in common. The authors point out the many-shared elements in the methods they present for selecting, estimating, checking, and interpreting each of these models. They also show that these regression methods deal with confounding, mediation, and interaction of causal effects in essentially the same way.
The examples, analyzed using Stata, are drawn from the biomedical context but generalize to other areas of application. While a first course in statistics is assumed, a chapter reviewing basic statistical methods is included. Some advanced topics are covered but the presentation remains intuitive. A brief introduction to regression analysis of complex surveys and notes for further reading are provided. For many students and researchers learning to use these methods, this one book may be all they need to conduct and interpret multipredictor regression analyses.
The authors are on the faculty in the Division of Biostatistics, Department of Epidemiology and Biostatistics, University of California, San Francisco, and are authors or co-authors of more than 200 methodological as well as applied papers in the biological and biomedical sciences. The senior author, Charles E. McCulloch, is head of the Division and author of Generalized Linear Mixed Models (2003), Generalized, Linear, and Mixed Models (2000), and Variance Components (1992).
From the reviews:
"This book provides a unified introduction to the regression methods listed in the title...The methods are well illustrated by data drawn from medical studies...A real strength of this book is the careful discussion of issues common to all of the multipredictor methods covered." Journal of Biopharmaceutical Statistics, 2005
"This book is not just for biostatisticians. It is, in fact, a very good, and relatively nonmathematical, overview of multipredictor regression models. Although the examples are biologically oriented, they are generally easy to understand and follow...I heartily recommend the book" Technometrics, February 2006
"Overall, the text provides an overview of regression methods that is particularly strong in its breadth of coverage and emphasis on insight in place of mathematical detail. As intended, this well-unified approach should appeal to students who learn conceptually and verbally." Journal of the American Statistical Association, March 2006
Since its original publication in 2008, CURE UNKNOWN has become known as a nuanced, groundbreaking picture of the intense controversy and crippling uncertainty surrounding Lyme disease, and the only book of its kind. Award-winning journalist Pamela Weintraub reveals her personal struggle with Lyme after she and her family became seriously ill with the disease, and sheds light on one of the angriest medical disputes raging today.
In recent years, there have been many crucial updates (political, medical and scientific) to the Lyme story; the intense controversy has continued, new information has come out, and paradigm-shifting decisions made at the highest levels of government. In this brand-new final chapter of CURE UNKNOWN, originally published in the May 2013 revised edition, Pamela offers her unique, riveting take on the disease as it stands today, further exposing the ticking clock of a raging epidemic and offering sufferers new hope.
The real story of AIDS—how it originated with a virus in a chimpanzee, jumped to one human, and then infected more than 60 million people—is very different from what most of us think we know. Recent research has revealed dark surprises and yielded a radically new scenario of how AIDS began and spread. Excerpted and adapted from the book Spillover, with a new introduction by the author, Quammen's hair-raising investigation tracks the virus from chimp populations in the jungles of southeastern Cameroon to laboratories across the globe, as he unravels the mysteries of when, where, and under what circumstances such a consequential "spillover" can happen. An audacious search for answers amid more than a century of data, The Chimp and the River tells the haunting tale of one of the most devastating pandemics of our time.
Christine Murphy has compiled a book that presents the vaccination dilemma from multiple perspectives. It clearly describes the immune system and its workings--and what science does and does not know about them. It offers suggestions and resources for parents whose children are sick, whether from a common childhood illness or from a vaccination reaction. And it makes a case for an alternate view of disease--as a teacher that allows us to develop physically and spiritually, and as a necessary test of strength that we have chosen out of our destiny.
This book will help educate parents about the vaccination dilemma and prepare them to make, in consultation with one or more health professionals, educated vaccination decisions for their children.
“This book will serve to greatly complement the growing number of texts dealing with mixed models, and I highly recommend including it in one’s personal library.”
—Journal of the American Statistical Association
Mixed modeling is a crucial area of statistics, enabling the analysis of clustered and longitudinal data. Mixed Models: Theory and Applications with R, Second Edition fills a gap in existing literature between mathematical and applied statistical books by presenting a powerful examination of mixed model theory and application with special attention given to the implementation in R.
The new edition provides in-depth mathematical coverage of mixed models’ statistical properties and numerical algorithms, as well as nontraditional applications, such as regrowth curves, shapes, and images. The book features the latest topics in statistics including modeling of complex clustered or longitudinal data, modeling data with multiple sources of variation, modeling biological variety and heterogeneity, Healthy Akaike Information Criterion (HAIC), parameter multidimensionality, and statistics of image processing.
Mixed Models: Theory and Applications with R, Second Edition features unique applications of mixed model methodology, as well as:Comprehensive theoretical discussions illustrated by examples and figures Over 300 exercises, end-of-section problems, updated data sets, and R subroutines Problems and extended projects requiring simulations in R intended to reinforce material Summaries of major results and general points of discussion at the end of each chapter Open problems in mixed modeling methodology, which can be used as the basis for research or PhD dissertations
Ideal for graduate-level courses in mixed statistical modeling, the book is also an excellent reference for professionals in a range of fields, including cancer research, computer science, and engineering.
Visualize the most recent topics in cutaneous pathology such as sporothrix and cutaneous t-cell lymphoma as well as classic problems like alopecia and neurofibromatosis, informed by the latest developments in molecular biology and histologic imaging.
See current dermatologic concepts captured in the visually rich Netter artistic tradition via major new contributions from Netter disciple Carlos Machado, MD - making complex concepts easy to understand and remember through the precision, clarity, detail, and realism for which Netter’s work has always been known.
Get complete, integrated visual guidance on the skin, hair, and nails in a single source, from basic sciences and normal anatomy and function through pathologic conditions.
Adeptly navigate current controversies and timely topics in clinical medicine with guidance from the Editor and informed by an experienced international advisory board.
This volume provides formulas and procedures for determination of sample size required not only for testing equality, but also for testing non-inferiority/superiority, and equivalence (similarity) based on both untransformed (raw) data and log-transformed data under a parallel-group design or a crossover design with equal or unequal ratio of treatment allocations. It contains a comprehensive and unified presentation of statistical procedures for sample size calculation that are commonly employed at various phases of clinical development. Each chapter includes, whenever possible, real examples of clinical studies from therapeutic areas such as cardiovascular, central nervous system, anti-infective, oncology, and women's health to demonstrate the clinical and statistical concepts, interpretations, and their relationships and interactions.
The book highlights statistical procedures for sample size calculation and justification that are commonly employed in clinical research and development. It provides clear, illustrated explanations of how the derived formulas and/or statistical procedures can be used.
Vaccinated is not a biography; Hilleman's experience forms the basis for a rich and lively narrative of two hundred years of medical history, ranging across the globe and throughout time to take in a cast of hundreds, all caught up, intentionally or otherwise, in the story of vaccines. It is an inspiring and triumphant tale, but one with a cautionary aspect, as vaccines come under assault from people blaming vaccines for autism and worse. Paul Offit clearly and compellingly rebuts those arguments, and, by demonstrating how much the work of Hilleman and others has gained for humanity, shows us how much we have to lose.
Witches, Midwives, and Nurses, first published by the Feminist Press in 1973, is an essential book about the corruption of the medical establishment and its historic roots in witch hunters. In this new edition, Barbara Ehrenreich and Deirdre English have written an entirely new chapter that delves into the current fascination with and controversies about witches, exposing our fears and fantasies. They build on their classic exposé on the demonization of women healers and the political and economic monopolization of medicine. This quick history brings us up-to-date, exploring today's changing attitudes toward childbirth, alternative medicine, and modern-day witches.
When a deadly diphtheria epidemic swept through Nome, Alaska, in 1925, the local doctor knew that without a fresh batch of antitoxin, his patients would die. The lifesaving serum was a thousand miles away, the port was icebound, and planes couldn't fly in blizzard conditions—only the dogs could make it. The heroic dash of dog teams across the Alaskan wilderness to Nome inspired the annual Iditarod Trail Sled Dog Race and immortalized Balto, the lead dog of the last team whose bronze statue still stands in New York City's Central Park. This is the greatest dog story, never fully told until now.
This highly acclaimed book has been extensively revised and updated throughout to ensure all drug and dosage recommendations are accurate and in agreement with current guidelines. A new chapter on infections caused by Pneumocystis jirovecii has been added. The book has been designed to enable rapid information retrieval and to help clinicians make informed decisions about diagnosis and patient management. Each chapter concludes with a list of recent key publications which have been carefully selected to facilitate efficient access to further information on specific aspects of fungal infections.
Clinical microbiologists, infectious disease specialists, as well as dermatologists, hematologists and oncologists, can depend on this contemporary text for authoritative information and the background necessary to understand fungal infections.
This book is written in the same engaging conversational style as the published reference book The Immune Response: Basic and Clinical Principles and conveys the same fascinating appeal of immunology. The authors bring clarity, readability and continuity of voice to an audience that requires only a brief survey of the most fundamental concepts in basic and clinical immunology. Primer to The Immune Response is beautifully illustrated with over 200 superb figures and 36 full-color plates, and further enhanced by the inclusion of 60 tables and 6 Appendices. Included with purchase of the book is website access to a captivating “Immunomovie" that truly brings the immune response to pathogens to life. This new and unique immunology textbook compactly but elegantly covers both basic and clinical principles.Over 200 elegant 2-4 color illustrations36 full-color plates of basic and clinical items of interestTake-home message and “Did You Get It? self-test quiz at the end of each chapter6 Appendices that provide topic enrichment60-minute "Immunomovie" illustrating the immune response to bacterial, viral and parasitic infections
According to veterinarian and journalist Mark Walters, we are contributing to—if not overtly causing—some of the scariest epidemics of our time. Through human stories and cutting-edge science, Walters explores the origins of seven diseases: mad cow disease, HIV/AIDS, Salmonella DT104, Lyme disease, hantavirus, West Nile, and new strains of flu. He shows that they originate from manipulation of the environment, from emitting carbon and clear-cutting forests to feeding naturally herbivorous cows “recycled animal protein.”
Since Walters first drew attention to these “ecodemics” in 2003 with the publication of Six Modern Plagues, much has been learned about how they developed. In this new, fully updated edition, the author presents research that precisely pinpoints the origins of HIV, confirms the link between forest fragmentation and increased risk of Lyme disease, and expands knowledge of the ecology of West Nile virus.
He also explores developments in emerging diseases, including a new chapter on flu, examining the first influenza pandemic since the Hong Kong flu of 1968; a new tick-borne infection in the Mid-West; a second novel bird flu in China; and yet a new SARS-like virus in the Middle East.
Readers will not only learn how these diseases emerged but the conditions that make future pandemics more likely. This knowledge is critical in order to prevent the next modern plague.
Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.Completely updated, the 2e presents recent advances driven by new information on the genetics and genomics of the pathogenProvides the latest information concerning the epidemiology, diagnosis, treatment and prevention of toxoplasmosisOffers a single-source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians, and food scientists
Since the third edition, there have been many developments in statistical techniques. The fourth edition provides the medical statistician with an accessible guide to these techniques and to reflect the extent of their usage in medical research.
The new edition takes a much more comprehensive approach to its subject. There has been a radical reorganization of the text to improve the continuity and cohesion of the presentation and to extend the scope by covering many new ideas now being introduced into the analysis of medical research data. The authors have tried to maintain the modest level of mathematical exposition that characterized the earlier editions, essentially confining the mathematics to the statement of algebraic formulae rather than pursuing mathematical proofs.
Received the Highly Commended Certificate in the Public Health Category of the 2002 BMA Books Competition.