A Summer Reading Pick for President Barack Obama, Bill Gates, and Mark Zuckerberg
From a renowned historian comes a groundbreaking narrative of humanity’s creation and evolution—a #1 international bestseller—that explores the ways in which biology and history have defined us and enhanced our understanding of what it means to be “human.”
One hundred thousand years ago, at least six different species of humans inhabited Earth. Yet today there is only one—homo sapiens. What happened to the others? And what may happen to us?
Most books about the history of humanity pursue either a historical or a biological approach, but Dr. Yuval Noah Harari breaks the mold with this highly original book that begins about 70,000 years ago with the appearance of modern cognition. From examining the role evolving humans have played in the global ecosystem to charting the rise of empires, Sapiens integrates history and science to reconsider accepted narratives, connect past developments with contemporary concerns, and examine specific events within the context of larger ideas.
Dr. Harari also compels us to look ahead, because over the last few decades humans have begun to bend laws of natural selection that have governed life for the past four billion years. We are acquiring the ability to design not only the world around us, but also ourselves. Where is this leading us, and what do we want to become?
Featuring 27 photographs, 6 maps, and 25 illustrations/diagrams, this provocative and insightful work is sure to spark debate and is essential reading for aficionados of Jared Diamond, James Gleick, Matt Ridley, Robert Wright, and Sharon Moalem.
You're already living it.
Was diabetes evolution's response to the last Ice Age? Did a deadly genetic disease help our ancestors survive the bubonic plagues of Europe? Will a visit to the tanning salon help lower your cholesterol? Why do we age? Why are some people immune to HIV? Can your genes be turned on -- or off?
Joining the ranks of modern myth busters, Dr. Sharon Moalem turns our current understanding of illness on its head and challenges us to fundamentally change the way we think about our bodies, our health, and our relationship to just about every other living thing on earth, from plants and animals to insects and bacteria.
Through a fresh and engaging examination of our evolutionary history, Dr. Moalem reveals how many of the conditions that are diseases today actually gave our ancestors a leg up in the survival sweepstakes. When the option is a long life with a disease or a short one without it, evolution opts for disease almost every time.
Everything from the climate our ancestors lived in to the crops they planted and ate to their beverage of choice can be seen in our genetic inheritance. But Survival of the Sickest doesn't stop there. It goes on to demonstrate just how little modern medicine really understands about human health, and offers a new way of thinking that can help all of us live longer, healthier lives.
Survival of the Sickest is filled with fascinating insights and cutting-edge research, presented in a way that is both accessible and utterly absorbing. This is a book about the interconnectedness of all life on earth -- and, especially, what that means for us.
Recent advances in evolutionary and ecosystem theory applied to economic structure and process may permit construction of both new economic theory and new tools for data analysis that can help in the design of more robust economic institutions. This may result in less frequent and less disruptive transitions, and enable the design of culturally-specific systems less affected by those that do occur.
This unique and innovative book applies cutting-edge methods from cognitive science and evolutionary theory to the problem of the necessary stabilization of economic processes. At the core of this book is the establishment of a statistics-like toolbox for the study of empirical data that is consistent with generalized evolutionary approaches. This toolbox enables the construction of both new economic theories and methods of data analysis that can help in the design of more robust economic institutions. This in turn will result in less frequent and less disruptive Black Swans, and enable as well the design of culturally-specific systems less affected by those that do occur.
The New York Times bestselling author of The Hormone Cure and The Hormone Reset Diet shows every woman how to create a lifestyle that will help her look great, feel energized, and slow down the effects of aging.
Feel destined for cellulite, saddle bags, and belly fat? Does your family come from a long line of Alzheimer's, cancer, or heart disease? Will nothing help your aging skin or declining libido or flagging energy? This book is for you.
The body is magnificent but it doesn't come with a lifetime warranty, or an operating manual. You're the result of millions of years of evolution, but many of the adaptations that helped your ancestors survive are now working overtime to accelerate the aging process. The assumption here is that we are our genes and therefore trapped by the past. The good news is that your genetic code—the DNA sequence that is the biochemical basis of heredity—can play a minor role in the way you age.
The scientific reality is that 90 percent of the signs of aging and disease are caused by lifestyle choices, not your genes. In other words, you have the capability to overcome and transform your genetic history and tendencies. Harvard/MIT—trained physician Sara Gottfried, M.D. has created a revolutionary 7-week program that empowers us to make the critical choices necessary to not just look young, but also feel young.
Dr. Gottfried identifies and builds this book around the five-key factors that lead to accelerated aging -the muscle factor, the brain factor, the hormone factor, the gut factor, and the toxic fat factor. The 7-week program addresses these factors and treats them in an accessible and highly practical protocol and is as follows:Feed—Week 1Sleep—Week 2Move—Week 3Release—Week 4Expose—Week 5Soothe—Week 6Think—Week 7
Younger increases not only your lifespan, but also your healthspan. Dr. Gottfried's program makes it possible to change the way you age, stay younger longer, and remain healthy and vibrant for all of your days.
News stories report almost daily on the remarkable progress scientists are making in unraveling the genetic basis of disease and behavior. Meanwhile, new technologies are rapidly reducing the cost of reading someone's personal DNA (all six billion letters of it). Within the next ten years, hospitals may present parents with their newborn's complete DNA code along with her footprints and APGAR score. In Genetic Twists of Fate, distinguished geneticists Stanley Fields and Mark Johnston help us make sense of the genetic revolution that is upon us.
Fields and Johnston tell real life stories that hinge on the inheritance of one tiny change rather than another in an individual's DNA: a mother wrongly accused of poisoning her young son when the true killer was a genetic disorder; the screen siren who could no longer remember her lines because of Alzheimer's disease; and the president who was treated with rat poison to prevent another heart attack. In an engaging and accessible style, Fields and Johnston explain what our personal DNA code is, how a few differences in its long list of DNA letters makes each of us unique, and how that code influences our appearance, our behavior, and our risk for such common diseases as diabetes or cancer.
This book takes a more formal 'groupoid' perspective and generalizes the results of that book to processes of 'distributed cognition' characteristic of large institutions that can entertain several, sometimes many, simultaneous 'global workspaces' which must compete for resources while communicating and cooperating.
Equivalence classes of 'states' produce a network of language-analogs characterizing interacting cognitive modules which entertain multiple workspaces. Equivalence classes of these language-analogs produce dynamical manifolds describing temporal processes carried out by multiple-workspace institutions.
New York Times science reporter Gina Kolata follows a family through genetic illness and one courageous daughter who decides her fate shall no longer be decided by a genetic flaw.
The phone rings. The doctor from California is on the line. “Are you ready Amanda?” The two people Amanda Baxley loves the most had begged her not to be tested—at least, not now. But she had to find out.
If your family carried a mutated gene that foretold a brutal illness and you were offered the chance to find out if you’d inherited it, would you do it? Would you walk toward the problem, bravely accepting whatever answer came your way? Or would you avoid the potential bad news as long as possible?
In Mercies in Disguise, acclaimed New York Times science reporter and bestselling author Gina Kolata tells the story of the Baxleys, an almost archetypal family in a small town in South Carolina. A proud and determined clan, many of them doctors, they are struck one by one with an inscrutable illness. They finally discover the cause of the disease after a remarkable sequence of events that many saw as providential. Meanwhile, science, progressing for a half a century along a parallel track, had handed the Baxleys a resolution—not a cure, but a blood test that would reveal who had the gene for the disease and who did not. And science would offer another dilemma—fertility specialists had created a way to spare the children through an expensive process.
A work of narrative nonfiction, Mercies in Disguise is the story of a family that took matters into its own hands when the medical world abandoned them. It’s a story of a family that had to deal with unspeakable tragedy and yet did not allow it to tear them apart. And it is the story of a young woman—Amanda Baxley—who faced the future head on, determined to find a way to disrupt her family’s destiny.
Conventional wisdom dictates that our genetic destiny is fixed at conception. But Dr. Moalem's groundbreaking book shows us that the human genome is far more fluid and fascinating than your ninth grade biology teacher ever imagined. By bringing us to the bedside of his unique and complex patients, he masterfully demonstrates what rare genetic conditions can teach us all about our own health and well-being.
In the brave new world we're rapidly rocketing into, genetic knowledge has become absolutely crucial. INHERITANCE provides an indispensable roadmap for this journey by teaching you:
-Why you may have recovered from the psychological trauma caused by childhood bullying-but your genes may remain scarred for life.
-How fructose is the sugar that makes fruits sweet-but if you have certain genes, consuming it can buy you a one-way trip to the coroner's office.
-Why ingesting common painkillers is like dosing yourself repeatedly with morphine-if you have a certain set of genes.
-How insurance companies legally use your genetic data to predict the risk of disability for you and your children-and how that impacts the coverage decisions they make for your family.
-How to have the single most important conversation with your doctor-one that can save your life.
-Why people with rare genetic conditions hold the keys to medical problems affecting millions.
In this trailblazing book, Dr. Moalem employs his wide-ranging and entertaining interdisciplinary approach to science and medicine-- explaining how art, history, superheroes, sex workers, and sports stars all help us understand the impact of our lives on our genes, and our genes on our lives. INHERITANCE will profoundly alter how you view your genes, your health--and your life.
RTW states have higher poverty rates, lower median household incomes, and lower educational attainment on average and median than non-RTW states. RTW states on average and median have lower life expectancy, higher obesity prevalence, and higher rates of all-cause mortality, early mortality from chronic conditions, child mortality, and risk behaviors than non-RTW states. The higher mortality rates result in startlingly higher annual numbers of years of life lost before age 75. Stroke mortality at age 55-64 in RTW states results in nearly 10,000 years annually lost in excess of what it would be if the mortality rate were that of non-RTW states.
A review of respected publications describes the physiological mechanisms and epidemiology of accelerated aging due to socioeconomic stress. Unions challenge hierarchy directly at work-sites and indirectly through encouraging college education, social mobility, and community and political engagement.
How startling that feudal hierarchy lives in 21st century America, shaping vast differences between states in macro- and micro-economics, educational attainment, innovation, life expectancy, obesity prevalence, chronic disease mortality, infant and child mortality, risk behaviors, and other public health markers! Readers will gain insight about the coming clash between feudal individualism and adaptive collectivism, and, in the last chapter, on ways to win the clash by “missionary” work for collectivism.
When Joselin Linder was in her twenties her legs suddenly started to swell. After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. Delving further into the past, she discovered that her great-grandmother had displayed symptoms similar to hers before her death. Clearly, this was more than a fluke.
Setting out to build a more complete picture of the illness that haunted her family, Joselin approached Dr. Christine Seidman, the head of a group of world-class genetic researchers at Harvard Medical School, for help. Dr. Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation. Here, Joselin tells the story of their gene: the lives it claimed and the future of genomic medicine with the potential to save those that remain.
Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write a gripping and unforgettable exploration of family, history, and love. A compelling chronicle of survival and perseverance, The Family Gene is an important story of a young woman reckoning with her father’s death, her own mortality, and her ethical obligations to herself and those closest to her.
The seventh edition, Trauma reaffirms its status as the leading comprehensive textbook in the field. With a new full-color design and a rich atlas of anatomic drawings and surgical approaches, Trauma, 7e takes you through the full range of injuries the trauma surgeon is likely to encounter. The book also features timely coverage that explains how to care for war victims who may require acute interventions such as amputation.
Supported by numerous x-rays, CT scans, plus informative tables throughout, this trusted reference begins with an informative look at kinematics and the mechanisms of trauma injury. Subsequent chapters provide useful background information on the epidemiology of trauma; injury prevention; the basics of trauma systems, triage, and transport; and much more. The next section meticulously reviews generalized approaches to the trauma patient, from pre-hospital care and managing shock, to emergency department thoracotomy and the management of infections. Trauma then delivers a clear organ-by-organ survey of treatment protocols designed to help you respond to any critical care situation with confidence, no matter what body system is involved. The remaining sections of the book will help you successfully handle specific challenges in trauma—including alcohol and drug abuse, and combat-related wounds—in addition to post-traumatic complications such as multiple organ failure.
FEATURESNEW! Trauma Atlas contains precise, concept-clarifying anatomical illustrations and proven surgical techniques that make common procedures more accessible than ever before High-yield section on specific approaches to the trauma patient prepares you for the wide spectrum of cases in trauma/critical surgery care, including: Disaster and mass casualty; Rural trauma; Management of shock; Post-injury hemotherapy and hemostasis; Emergency department thoracotomy; Diagnostic and interventional radiology; Surgeon-performed ultrasound; Anesthesia and pain management; Infection; A-to-Z overview of the management of specific traumatic injuries; Detailed discussion of the management of complications
Genetically modified organisms (GMOs) including plants and the foods made from them, are a hot topic of debate today, but soon related technology could go much further and literally change what it means to be human. Scientists are on the verge of being able to create people who are GMOs.
Should they do it? Could we become a healthier and ''better'' species or might eugenics go viral leading to a real, new world of genetic dystopia? GMO Sapiens tackles such questions by taking a fresh look at the cutting-edge biotech discoveries that have made genetically modified people possible.
Bioengineering, genomics, synthetic biology, and stem cells are changing sci-fi into reality before our eyes. This book will capture your imagination with its clear, approachable writing style. It will draw you into the fascinating discussion of the life-changing science of human genetic modification.Contents:An Introduction to Playing GodThe Birth and Explosive Growth of GMOsHuman CloningBuild-a-Baby Better via GeneticsDIY Guide to Creating GMO SapiensEugenics and TranshumanismCultural Views on Human Genetic ModificationGMO Sapiens Today and Tomorrow
Readership: Undergraduate biology majors, graduate biology majors, non-experts interested in GMOs, biologists and teenagers interested in cloning and human genetic modification.
Key Features:Books on this hot new topic of creating GMO people are rare, tend to be out-of-date, or have narrow topic rangesThe goal of this book is to educate and entertain an educated lay audience about human genetic modificationKeywords:GMO;Genetically Modified Organism;GMO Sapien;Cloning;Genomics;Designer Babies;Mitochondrial Transfer;Stem Cells;Infertility
"What I find troubling, exciting but scary, is that I find myself agreeing with an undertone, I do not support human germline genetic modification but with all the new information and perspectives available to me I have found myself questioning my own views and will be watching any developments with a fascinated interest I would rather not admit to."The NODE
By a combination of stochastic modeling and economic geography, this book proposes two key causes together explain the explosive spread of the worst of the vector-borne outbreaks.
Ecosystems in which such pathogens are largely controlled by environmental stochasticity are being drastically streamlined by both agribusiness-led deforestation and deficits in public health and environmental sanitation.
As infectious diseases in an age of nation states and global health programs cannot, as much of the present modeling literature presumes, be described by interacting populations of host, vector, and pathogen alone, a series of control theory models is also introduced here. These models, useful to researchers and health officials alike, explicitly address interactions between government ministries and the pathogens they aim to control.
Divided into three restructured sections to make the book easier to use for a variety of readers: Scientific Basis of Human Genetics; Genetics in Medicine and Genomic Medicine; Clinical Genetics, Counselling and Ethics
•Interactive self-assessment questions
•Online hyperlinks to important genetics websites and clinical databases.
•Update of clinical figures to include more full-colour images
•An extensive glossary of terms
•Full colour art to visualise the appearance of genetic disorders and assist with the understanding of complex genetic structures
•Explore the social, ethical and counselling issues surrounding the study and treatment of genetic disorders.
•Elements boxes at the end of each chapter summarizing the basics at a glance.
Breakthroughs in genetic research are changing modern medicine and pharmaceuticals. But what are these changes and how do they affect our individual care? Genomic Messages examines these groundbreaking changes and the questions they raise: What kind of specific medical innovation do we have to look forward to now and tomorrow? How will this “flood” of genetic messages change our lives, our interaction with our physicians and our healthcare system?
Groundbreaking and provocative, Genomic Messages fuses the often conflicting worlds of medicine and law to provide information and insight that will impact the health choices of every one of us, from how medicine is practiced to concepts of privacy, confidentiality, and informed consent. Ultimately, it reveals how genetic information is changing how we think about ourselves, our health, and our future.
The first four decades after Darwin were dominated by studies in comparative anatomy, embryology, systematics, zoogeography, phytogeography, and paleontology, all intended to discover and examine the evidences of evolution. But the phylogenies of the animal and plant kingdoms, that is, the history of the linkages of animal and plant organisms as they change through time, were less well documented. In particular, the phylogeny of humans is still not completely known.
The period following World War Two saw acceleration of activity in fi elds in and bordering on behavioral genetics. Research in neuroendocrinology showed that higher cortical centers could infl uence and be infl uenced by the hypothalamus, pituitary, thyroid, adrenals, and gonads. Genetic diversity in the function of these organs had obvious consequences for social and cultural behavior. Th e failure of some early and long-reinforced attempts at conditioning by students of comparative animal behavior showed species-specifi c innate behavior could not be ignored in any theory that attempts to combine psychology and anthropology. Th is classic volume summarizes the development of evolutionary thinking, and describes how what we know about genetic diversity links up with research on human behavior.
J. N. Spuhler was known for his pioneering work in the department of anthropological genetics. He taught in many universities including Ohio State University, the University of Michigan, and the University of Mexico. He received the National Academy of Science award for scientific reviewing and his work has appeared in scholarly journals including: Journal of Anthropological Research, Annual Review of Anthropology, and American Journal of Physical Anthropology.
Devising a molecular clock from a certain area of DNA, scientists were able to determine that all humans descend from one common female ancestor, dubbed "Mitochondrial Eve," who lived around 150,000 years ago. From molecules recovered from grinding stones and potsherds, they reconstructed ancient diets and posited when such practices as dairying and boiling water for cooking began. They have reconstituted the beer left in the burial chamber of pharaohs and know what the Iceman, the 5,000-year-old hunter found in the Alps in the early nineties, ate before his last journey. Conveying both the excitement of innovative research and the sometimes bruising rough-and-tumble of scientific debate, Jones has written a work of profound importance. Unlocking the Past is science at its most engaging.
If you are concerned that the cancer in your family is hereditary, you face difficult choices. Should you have a blood test that may reveal whether you have a high likelihood of disease? Do you preemptively treat a disease that may never develop? How do you make decisions now that will affect the rest of your life? This helpful, informative guide answers your questions as you confront hereditary breast and ovarian cancer.
Developed by Facing Our Risk of Cancer Empowered (FORCE), the nation’s only nonprofit organization dedicated to supporting families affected by hereditary breast and ovarian cancer, this book stands alone among breast and ovarian cancer resources. Equal parts health guide and memoir, it defines complex issues facing previvors and survivors and provides solutions with a fresh, authoritative voice.
Written by three passionate advocates for the hereditary cancer community who are themselves breast cancer survivors, Confronting Hereditary Breast and Ovarian Cancer dispels myths and misinformation and presents practical risk-reducing alternatives and decision-making tools. Including information about genetic counseling and testing, preventive surgery, and fertility and family planning, as well as explanations of health insurance coverage and laws protecting genetic privacy, this resource tackles head-on the challenges of living in a high-risk body.
Confronting hereditary cancer is a complex, confusing, and highly individual journey. With its unique combination of the latest research, expert advice, and compelling personal stories, this book gives previvors, survivors, and their family members the guidance they need to face the unique challenges of hereditary cancer.
Used by thousands of medical students each year to succeed on USMLE Step 1, Kaplan's official lecture notes are packed with full-color diagrams and clear review.
The Best Review
Organized in outline format with high-yield summary boxes for efficient study.Clinical correlations and bridges between disciplines highlighted throughout.Full-color diagrams and charts for better comprehension and retention.Updated annually by Kaplan's all-star expert faculty
Looking for more prep? Our USMLE Step 1 Lecture Notes 2018: 7-Book Set has this book, plus the rest of the 7-book series.
Edited by Lynnette R. Ferguson, a well-known and internationally respected researcher, the book covers a wide range of issues, from the purely scientific to ethical, consumer-driven, and public health aspects. It takes a close look at gene–diet interactions and explores the ways in which studies on nutrigenomics and nutrigenetics can help modulate disease risk in cardiovascular disease, obesity, diabetes, and inflammatory bowel disease. Topics include regulatory challenges, genetic testing for consumers, data mining, transcriptomic analysis, and the role of science and health professionals in the commercialization of nutrigenomics and nutrigenetics. The book also examines industry–academia partnerships as a nexus between the science and its commercialization by the food industry. These partnerships will be an important determinant of what value the technologies bring, not only to the market but to the wider health and well-being of society.
Exploring how nutrigenomics and nutrigenetics can help modulate disease risk, this timely book brings together stimulating, well-thought-out perspectives from established and emerging researchers. It provides valuable information on a subject that is becoming increasingly important for nutritionists, dieticians, and clinical professionals, as well as for the food industry and research community.
Ideal for both researchers and healthcare providers
Understanding Clinical Research addresses both the operational challenges of clinical trials and the needs of clinicians to comprehend the nuances of research methods to accurately analyze study results. This timely resource covers all aspects of clinical trials--from study design and statistics to regulatory oversight--and it delivers a detailed yet streamlined overview of must-know research topics.
The text features an accessible three-part organization that traces the evolution of clinical research and explains the bedrock principles and unique challenges of clinical experimentation and observational research. Reinforcing this content are real-life case examples--drawn from the authors' broad experience--that put chapter concepts into action and contribute to a working knowledge of integral research techniques.
FEATURES:The most definitive guide to promoting excellence in clinical research, designed to empower healthcare providers to assess a study's strengths and weaknesses with confidence and apply this knowledge to optimize patient outcomes In-depth coverage of fundamental research methods and protocols from preeminent authorities provides readers with an instructive primer and a springboard for ongoing clinical research education Clear, comprehensive three-part organization: Section One: Evolution of Clinical Research offers a succinct history of clinical trials, drug regulations, and the role of the FDA while covering the impact of information technology and academic research organizations Section Two: Principles of Clinical Experimentation takes you through the typical phases of clinical trials in the development of medical products, from initial human subject research to postapproval surveillance studies Section Three: Observational Research highlights the underlying principles, pitfalls, and methods for case-control studies, cohort studies, registries, and subgroup analyses within randomized trials
Understanding Patient Safety, 2e is the essential text for anyone wishing to learn the key clinical, organizational, and systems issues in patient safety. The book is filled with valuable cases and analyses, as well as up-to-date tables, graphics, references, and tools -- all designed to introduce the patient safety field to medical trainees, and be the go-to book for experienced clinicians and non-clinicians alike.
FeaturesNEW chapter on the critically important role of checklists in medical practice NEW case examples throughout Expanded coverage of the role of computers in patient safety and outcomes Expanded coverage of new patient initiatives from the Joint Commission
The 8th edition of Tintinalli’s Emergency Medicine provides the depth and breadth of coverage that reflects the complexity and expertise needed to practice emergency medicine successfully in today’s fast–paced environments. It is an important contemporary clinical emergency care resource for physicians, NPs, and PAs who practice emergency medicine and for emergency medicine and pediatric emergency medicine fellows. It remains the preferred study guide for in-training and board examinations and recertification.
NEW to this edition:
• Full-color design with more tables than ever to succinctly present key information
• Extensive updates to all sections, incorporating the latest guidelines, evidence-based protocols, and relevant research
• Expanded pediatric section, with complete clinical information for general and pediatric emergency physicians
• Expanded coverage of common emergency department procedures, with improved illustrations
• Online access to more than 30 videos, covering a wide range of procedural and diagnostic topics and focusing on the latest ultrasound-guided techniques
From the reviews of the seventh edition:
"Collectively, they have once again produced an excellent text that manages to cover the broad scope of emergency medicine while remaining an easily readable and practical resource....Last, for the inevitable comparison of this current edition of Tintinalli's Emergency Medicine with other available emergency medicine textbooks available: in my opinion, Tintinalli’s still comes out on top. It is more concise and easier to read than some, yet it covers the breadth of emergency medicine practice more comprehensively than others....Just as previous editions did, the seventh presents all of the most pertinent and up-to-date information in a well-organized format that is comprehensive yet easy to read. That and many of the attractive new features in this current edition will ensure its place on my bookshelf for years to come."—JAMA
Infectious Diseases: A Clinical Short COURSE is a concise overview of this important field designed to help the busy physician, medical student, nurse practitioner, and physician assistant to understand, diagnose, and treat common infectious diseases. This unique self-instruction book is organized by system/region as opposed to pathogens—simulating how common pathogens and disorders would be encountered in rounds or in practice.
By indicating the number of days that should be allotted to the study of each chapter, the author has created a schedule for completion of each lesson. A wide array of tables that summarize the methods of clinical assessment, anti-infective agent doses, and drug toxicities--facts that do not require memorization, but do need to be referred to when caring for patients--facilitate this condensed learning schedule. There is no better resource for learning to associate pathogens with the corresponding impact on patients than Infectious Diseases.
FEATURESKey Points summarize the most important facts when managing each infection and facilitate board review Guiding Questions begin each chapter An estimate of the potential severity of each disease gives you a sense of how quickly you should initiate treatment Numerous case examples highlight real-world clinical application of the content Dozens of color plates depict major pathogens All chapters have been updated to reflect the most current treatment and diagnostic guidelines from the Infectious Diseases Society of America NEW! Antibiograms for each major antibiotic class provide a visual depiction of the spectrum of each individual antibiotic; a table listing the most commonly used outpatient antibiotics and their dosing; and much more
This book is also focused on the challenges of diagnostic interpretation of NGS results in a clinical setting. Its final sections are devoted to the emerging regulatory issues that will govern clinical use of NGS, and reimbursement paradigms that will affect the way in which laboratory professionals get paid for the testing.Simplifies complexities of NGS technologies for rapid education of clinical genomicists and genomic pathologists towards genomic medicine paradigmTried and tested practice-based analysis for precision diagnosis and treatment plansSpecific pipelines and meta-analysis for full range of clinically important variants
The third edition of this trusted quick-reference guide has everything you need to keep pace with this fast-moving field—presented in the acclaimed CURRENT format. A practical reference for primary care providers, the book simplifies the treatment of difficult-to-manage rheumatologic diseases and disorders, such as arthritis, lupus, and sarcoidosis.
FeaturesNEW full-color photographs NEW chapters on clinical genetics, drug-induced syndromes, and metabolic myopathies Straightforward, expert coverage of the entire range of rheumatology disorders Full explanations of common and major disorders in clinical immunology Concise chapters geared to the needs of trainees and clinicians First section that addresses common but difficult-to-diagnose rheumatologic complaints—and delivers key “approach to the patient” strategies
Gauge your mastery of the material and build confidence with both case-based andUSMLE-style questions that provide effective chapter review and quick practice for your exams.
This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included.Grasp and retain vital concepts more easily thanks to a color-coded format, succinct text, key concept boxes, tables, and dynamic illustrations that facilitate learning in a highly visual approach.
Effectively review for problem-based courses with the help of text boxes that help you clearly see the clinical relevance of the material.
Much more than a text describing how to perform a history and physical examination, DeGowin's Diagnostic Examination is unmatched in its ability to help you logically assess symptoms and physical signs to facilitate development of reasonable, testable diagnostic hypotheses.
Part physical examination primer, part differential diagnosis guide, DeGowin's:Describes how to obtain a complete history and perform a thorough physical examination Links symptoms and signs with the pathophysiology of disease Presents a symptom, sign, anatomy, and physiology-based approach to differential diagnosis Facilitates efficient cost-effective diagnostic testing using focused differential diagnoses
Organized as a practical bedside guide to assist diagnosis, DeGowin's is valuable as a quick reference at the point-of-care or as a text to study the principles and practice of history taking and physical examination.
James A. Shapiro proposes an important new paradigm for understanding biological evolution, the core organizing principle of biology. Shapiro introduces crucial new molecular evidence that tests the conventional scientific view of evolution based on the neo-Darwinian synthesis, shows why this view is inadequate to today's evidence, and presents a compelling alternative view of the evolutionary process that reflects the shift in life sciences towards a more information- and systems-based approach in Evolution: A View from the 21st Century.
Shapiro integrates advances in symbiogenesis, epigenetics, and saltationism into a unified approach that views evolutionary change as an active cell process, regulated epigenetically and capable of making rapid large changes by horizontal DNA transfer, inter-specific hybridization, whole genome doubling, symbiogenesis, or massive genome restructuring.
Evolution marshals extensive evidence in support of a fundamental reinterpretation of evolutionary processes, including more than 1,100 references to the scientific literature. Shapiro's work will generate extensive discussion throughout the biological community, and may significantly change your own thinking about how life has evolved. It also has major implications for evolutionary computation, information science, and the growing synthesis of the physical and biological sciences.
Regulatory Aspects of Gene Therapy and Cell Therapy Products: A Global Perspective is part of the American Society of Gene and Cell Therapy sub-series of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students, clinicians, and researchers interested in gene and cell therapy and the regulation of pharmaceuticals.
The key topics covered are association studies, genomic prediction, estimation of population genetic parameters and diversity, gene expression analysis, functional annotation of results using publically available databases and how to work efficiently in R with large genomic datasets. Important principles are demonstrated and illustrated through engaging examples which invite the reader to work with the provided datasets. Some methods that are discussed in this volume include: signatures of selection, population parameters (LD, FST, FIS, etc); use of a genomic relationship matrix for population diversity studies; use of SNP data for parentage testing; snpBLUP and gBLUP for genomic prediction. Step-by-step, all the R code required for a genome-wide association study is shown: starting from raw SNP data, how to build databases to handle and manage the data, quality control and filtering measures, association testing and evaluation of results, through to identification and functional annotation of candidate genes. Similarly, gene expression analyses are shown using microarray and RNAseq data.
At a time when genomic data is decidedly big, the skills from this book are critical. In recent years R has become the de facto tool for analysis of gene expression data, in addition to its prominent role in analysis of genomic data. Benefits to using R include the integrated development environment for analysis, flexibility and control of the analytic workflow. Included topics are core components of advanced undergraduate and graduate classes in bioinformatics, genomics and statistical genetics. This book is also designed to be used by students in computer science and statistics who want to learn the practical aspects of genomic analysis without delving into algorithmic details. The datasets used throughout the book may be downloaded from the publisher’s website.
More than 230 photographs, illustrations, and tables, along with patient/family vignettes clarify difficult concepts and demonstrate clinical significance.
Clinical Commentary Boxeshelp demonstrate how the hard science of genetics has real applications to everyday patient problems and prepare you for problem-based integrated courses.
Self-assessment study questionsaid in retention and review of key material. The latest knowledge and research on gene identification, cancer genetics, gene testing and gene therapy, common disorders, ethical and social issues, and much more so you can keep up with current developments in genetics.
The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia.
Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.
companies promise us everlasting youth, but the effects of
aging are caused by complex biological processes that have only
been brought to light through gerontology research over the past
two decades.<p>Dr. Björn Schumacher is one of the world’s foremost researchers
investigating the molecular mechanisms of aging. He shows how
new insights into biology are transforming our understanding of
the causes of aging and the diseases that affect us when we
grow old.<p>This book explains the genes and the cumulative damage that
drive human aging and disease, gives insights into current and
future therapies for healthy aging, and provides an outlook on
the future of the aging society. This engaging book breaks down
the science for everyday readers and shows what exciting breakthroughs
scientists are working on and what they’ve learned so
far. The author discusses what we can do to take care of ourselves,
and he looks at why we are so keen to deny that we are aging,
when indeed aging is a part of life — for everything from bacteria