Thoreau was caught at a critical turn in the history of science, between the ebb of Romanticism and the rising tide of positivism. He responded to the challenges posed by the new ideal of objectivity not by rejecting the scientific worldview, but by humanizing it for himself. Tauber portrays Thoreau as a man whose moral vision guided his life's work. Each of Thoreau's projects reflected a self-proclaimed "metaphysical ethics," an articulated program of self-discovery and self-knowing. By writing, by combining precision with poetry in his naturalist pursuits and simplicity with mystical fervor in his daily activity, Thoreau sought to live a life of virtue—one he would characterize as marked by deliberate choice. This unique vision of human agency and responsibility will still seem fresh and contemporary to readers at the start of the twenty-first century.
The official book behind the Academy Award-winning film The Imitation Game, starring Benedict Cumberbatch and Keira Knightley
It is only a slight exaggeration to say that the British mathematician Alan Turing (1912-1954) saved the Allies from the Nazis, invented the computer and artificial intelligence, and anticipated gay liberation by decades--all before his suicide at age forty-one. This New York Times–bestselling biography of the founder of computer science, with a new preface by the author that addresses Turing's royal pardon in 2013, is the definitive account of an extraordinary mind and life.
Capturing both the inner and outer drama of Turing’s life, Andrew Hodges tells how Turing’s revolutionary idea of 1936--the concept of a universal machine--laid the foundation for the modern computer and how Turing brought the idea to practical realization in 1945 with his electronic design. The book also tells how this work was directly related to Turing’s leading role in breaking the German Enigma ciphers during World War II, a scientific triumph that was critical to Allied victory in the Atlantic. At the same time, this is the tragic account of a man who, despite his wartime service, was eventually arrested, stripped of his security clearance, and forced to undergo a humiliating treatment program--all for trying to live honestly in a society that defined homosexuality as a crime.
The inspiration for a major motion picture starring Benedict Cumberbatch and Keira Knightley, Alan Turing: The Enigma is a gripping story of mathematics, computers, cryptography, and homosexual persecution.
The math we learn in school can seem like a dull set of rules, laid down by the ancients and not to be questioned. In How Not to Be Wrong, Jordan Ellenberg shows us how terribly limiting this view is: Math isn’t confined to abstract incidents that never occur in real life, but rather touches everything we do—the whole world is shot through with it.
Math allows us to see the hidden structures underneath the messy and chaotic surface of our world. It’s a science of not being wrong, hammered out by centuries of hard work and argument. Armed with the tools of mathematics, we can see through to the true meaning of information we take for granted: How early should you get to the airport? What does “public opinion” really represent? Why do tall parents have shorter children? Who really won Florida in 2000? And how likely are you, really, to develop cancer?
How Not to Be Wrong presents the surprising revelations behind all of these questions and many more, using the mathematician’s method of analyzing life and exposing the hard-won insights of the academic community to the layman—minus the jargon. Ellenberg chases mathematical threads through a vast range of time and space, from the everyday to the cosmic, encountering, among other things, baseball, Reaganomics, daring lottery schemes, Voltaire, the replicability crisis in psychology, Italian Renaissance painting, artificial languages, the development of non-Euclidean geometry, the coming obesity apocalypse, Antonin Scalia’s views on crime and punishment, the psychology of slime molds, what Facebook can and can’t figure out about you, and the existence of God.
Ellenberg pulls from history as well as from the latest theoretical developments to provide those not trained in math with the knowledge they need. Math, as Ellenberg says, is “an atomic-powered prosthesis that you attach to your common sense, vastly multiplying its reach and strength.” With the tools of mathematics in hand, you can understand the world in a deeper, more meaningful way. How Not to Be Wrong will show you how.
This story is at the same time a historical novel and an accessible explication of some of the biggest ideas of mathematics and modern philosophy. With rich characterizations and expressive, atmospheric artwork, the book spins the pursuit of these ideas into a highly satisfying tale.
Probing and ingeniously layered, the book throws light on Russell's inner struggles while setting them in the context of the timeless questions he spent his life trying to answer. At its heart, Logicomix is a story about the conflict between an ideal rationality and the unchanging, flawed fabric of reality.
In the first book of its kind, journalist Donna Jackson Nakazawa examines nearly 100 debilitating autoimmune diseases—such as multiple sclerosis, lupus, Crohn’s disease, type 1 diabetes, and rheumatoid arthritis—that cause the body to destroy itself, mistakenly attacking healthy cells as the immune system fights off bacteria, viruses, and other invaders. As Nakazawa share the vivid, heartbreaking stories, including her own, of people living with these mysterious, chronic, and often hard-to-diagnose illnesses, she explores the alarming and unexpected connection between this deadly crisis and the countless environmental triggers we’re exposed to every day: heavy metals, toxins, pesticides, viruses, chemicals in the foods we eat, and more.
With the help of leading experts, Nakazawa explores revolutionary preventions, treatments, and cures emerging around the world and offers practical advice for protecting your immune system and reducing your risk of autoimmune disease in the future.
In fifteen easy-to-read chapters, featuring the humorous style and engaging analogies developed by Dr. Sompayrac, How the Immune System Works explains how the immune system players work together to protect us from disease – and, most importantly, why they do it this way.
Rigorously updated for this fifth edition, How the Immune System Works includes the latest information on subjects such as vaccines, the immunology of AIDS, and cancer. A highlight of this edition is a new chapter on the intestinal immune system – currently one of the hottest topics in immunology.
Whether you are completely new to immunology, or require a refresher, How the Immune System Works will provide you with a clear and engaging overview of this fascinating subject. But don’t take our word for it! Read what students have been saying about this classic book:
"What an exceptional book! It's clear you are in the hands of an expert."
"Possibly the Best Small Text of All Time!"
"This is a FUN book, and Lauren Sompayrac does a fantastic job of explaining the immune system using words that normal people can understand."
"Hands down the best immunology book I have read... a very enjoyable read."
"This is simply one of the best medical textbooks that I have ever read. Clear diagrams coupled with highly readable text make this whole subject easily understandable and engaging."
Now with a brand new website at www.wiley.com/go/sompayrac featuring Powerpoint files of the images from the book
Develop a thorough, clinically relevant understanding of immunologythrough a clear overview of immunology with a distinct focus on the management of human disease.
Visualize immunologic processes more effectively.Meticulously developed and updated illustrations, 3-dimensional art, and all-new animations provide a detailed, visual description of the key immunologic and molecular processes.
Grasp the details of experimental observationsthat form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions.
Find information more quickly and easilythrough an organized chapter structure and a more logical flow of material.
Glean all essential, up-to-date, need-to-know information about immunology and molecular biology through extensive updates that cover cytokines, innate immunity, leukocyte-endothelial interactions, signaling, costimulation, and more.
Benefit from numerous new figures and tablesthat facilitate easier retention of the material; quick summaries of each chapter; and nearly 400 illustrations that clarify key concepts.
A New York Times Notable Book.
The Babylonians invented it, the Greeks banned it, the Hindus worshiped it, and the Church used it to fend off heretics. Now it threatens the foundations of modern physics. For centuries the power of zero savored of the demonic; once harnessed, it became the most important tool in mathematics. For zero, infinity's twin, is not like other numbers. It is both nothing and everything.
In Zero, Science Journalist Charles Seife follows this innocent-looking number from its birth as an Eastern philosophical concept to its struggle for acceptance in Europe, its rise and transcendence in the West, and its ever-present threat to modern physics. Here are the legendary thinkers—from Pythagoras to Newton to Heisenberg, from the Kabalists to today's astrophysicists—who have tried to understand it and whose clashes shook the foundations of philosophy, science, mathematics, and religion. Zero has pitted East against West and faith against reason, and its intransigence persists in the dark core of a black hole and the brilliant flash of the Big Bang. Today, zero lies at the heart of one of the biggest scientific controversies of all time: the quest for a theory of everything.
Grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions.Stay abreast of the latest advances in immunology and molecular biology through extensive updates that cover cytokines, innate immunity, leukocyte-endothelial interactions, signaling, costimulation, and more.
Visualize immunologic processes more effectively through a completely revised art program with redrawn figures, a brighter color palette, and more 3-dimensional art.
Find information more quickly and easily through a reorganized chapter structure and a more logical flow of material.
There is a cure for all disease.
It is 100% Natural and costs only a few dollars each month.
Your body heals you by giving it what it needs and making sure you avoid the poisons that cause all disease.
Water is the very Essence of Life.
Without water there would no Life on this planet.
This is why I believe the quality of your health is equal to the quality of your water.
There are no cures with doctors and the medical profession.
They turned their backs on all cures and all real medicine once drug corporations began manufacturing synthetic man-made chemical "medicines” starting in 1939.
Cures ended with Dr. Jonas Salk's polio vaccine which he gave to mankind for free in 1954.
Poisons cause all disease. Without poisons, even germs and viruses could not make you sick.
All disease requires an acidic body to exist in. Your body becomes acidic by habitual consumption of poisons in your food, drinks and water; such as white flour, white sugar, high fructose corn syrup, red meats and the chlorine and fluoride in your water.
This book teaches you how to reverse the acidity of your body, correct your diet deficiencies and to value Water, the very Essence of Life.
There are also some quick cures for some major diseases like migraines, kidney stones, heartburn and others. These cures may seem like "miracle cures”, but they are just science that has been around since man began living on this Earth.
The thing that the Author adds to those centuries of proven healing science is how to recognize and avoid the saturation of poisons that have inundated our food, drinks and water supplies, as well as personal hygiene items.
The Author teaches you how to clean up your current diet and also gives you details on other things you can do to improve your health and speed you on to freedom from disease.
This book was written by a man who cured himself of 10 diseases doctors REFUSE to cure. And did so after doctors said he would be on dialysis or dead by 2009.
Before then, the Author did not know that doctors cure no one.
YOU must decide whether to remain without hope as you have with all doctors - OR...
Learn how to use Natural Science to restore your Natural body to health to rid it of all disease.
For those who choose Life and freedom from sickness, this book was written for YOU!
...A short and to the point book to get you cured of all disease as quickly as possible -
The Cure For All Disease
Visually grasp and retain difficult concepts easilythanks to a user-friendly color-coded format, key concept boxes, explanatory diagrams, and over 190 photos to help you visualize tissues and diseases.
Put concepts into practice. "Critical Thinking Boxes" and 25 online cases encourage you to "think immunologically" while anchoring your understanding of immunology through clinical application.
Gauge your mastery of the materialand build confidence with high-yield style chapter-opening summaries and case-based and USMLE-style questions that provide effective chapter review and quick practice for your exams.
Access the full contents online at www.studentconsult.comwhere you'll find the complete text and illustrations, USMLE-style questions, clinical cases, and much more! Get the depth of coverage you need in a smaller, more manageably sized book. Through meticulous editing and reorganization, primary material remains in the book while more specialized and clinical material has been moved online.
Master the most cutting-edge concepts in immunology.Thorough updates throughout provide the timely knowledge you need ace your exams.
Grasp and retain vital concepts easilythanks to a user-friendly color-coded format, succinct text, key concept boxes, and dynamic illustrations.
Effectively review for problem-based courseswith the help of chapter introductions and "Lessons in Microbiology" text boxes that highlight the clinical relevance of the material, offer easy access to key concepts, and provide valuable review tools.
Approach microbiology by body system or by pathogenthrough an extensively cross-referenced "Pathogen Review" section.
Access the complete contents online at studentconsult.com, along with downloadable illustrations...150 multiple choice review questions... "Pathogen Parade"...and many other features to enhance learning and retention. Enhance your learning and absorb complex information in an interactive, dynamic way with Pathogen Parade – a quickly searchable online glossary of viruses, bacteria, and fungi.
Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventive medicine.A completely re-written chapter on this topic keeps abreast of the very latest findings.
This new edition of Immunology: A Short Course:
• Has been fully revised and updated, with a brand new art program to help reinforce learning
• Includes a new chapter on Innate Immunity to reflect the growth in knowledge in this area
• Highlights important therapeutic successes resulting from targeted antibody therapies
• Includes end of chapter summaries and review questions, a companion website at www.wileyimmunology.com/coico featuring interactive flashcards, USMLE-style interactive MCQs, figures as PowerPoint slides, and case-based material to help understand clinical applications
New to this Edition: • Features expanded coverage of the evolution of parasitism and an extensive update to immunology of parasite–host interactions • Offers an enhanced art program featuring life-cycle illustrations and additional SEM and TEM micrographs • New Host Immune Response section for each organismPresents various parasites and examines how they interact with their hosts and respond to new treatmentsEasy to read with photographs, diagrams, and clinical case pictures throughout
Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoringprovides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring.
The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity.
This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful.Focuses on the personalized management of immunosuppression therapy in individual transplant patientsPresents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathologyProvides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patientsReviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy
Men of Mathematics provides a rich account of major mathematical milestones, from the geometry of the Greeks through Newton’s calculus, and on to the laws of probability, symbolic logic, and the fourth dimension. Bell breaks down this majestic history of ideas into a series of engrossing biographies of the great mathematicians who made progress possible—and who also led intriguing, complicated, and often surprisingly entertaining lives.
Never pedantic or dense, Bell writes with clarity and simplicity to distill great mathematical concepts into their most understandable forms for the curious everyday reader. Anyone with an interest in math may learn from these rich lessons, an advanced degree or extensive research is never necessary.
The Magic of Math is the math book you wish you had in school. Using a delightful assortment of examples—from ice cream scoops and poker hands to measuring mountains and making magic squares—this book empowers you to see the beauty, simplicity, and truly magical properties behind those formulas and equations that once left your head spinning. You'll learn the key ideas of classic areas of mathematics like arithmetic, algebra, geometry, trigonometry, and calculus, but you'll also have fun fooling around with Fibonacci numbers, investigating infinity, and marveling over mathematical magic tricks that will make you look like a math genius!
A mathematician who is known throughout the world as the “mathemagician,” Arthur Benjamin mixes mathematics and magic to make the subject fun, attractive, and easy to understand. In The Magic of Math, Benjamin does more than just teach skills: with a tip of his magic hat, he takes you on as his apprentice to teach you how to appreciate math the way he does. He motivates you to learn something new about how to solve for x, because there is real pleasure to be found in the solution to a challenging problem or in using numbers to do something useful. But what he really wants you to do is be able to figure out why, for that's where you'll find the real beauty, power, and magic of math.
If you are already someone who likes math, this book will dazzle and amuse you. If you never particularly liked or understood math, Benjamin will enlighten you and—with a wave of his magic wand—turn you into a math lover.
Beginning with the ancient Near East, the author traces the ideas and techniques developed in Egypt, Babylonia, China, and Arabia, looking into such manuscripts as the Egyptian Papyrus Rhind, the Ten Classics of China, and the Siddhantas of India. He considers Greek and Roman developments from their beginnings in Ionian rationalism to the fall of Constantinople; covers medieval European ideas and Renaissance trends; analyzes 17th- and 18th-century contributions; and offers an illuminating exposition of 19th century concepts. Every important figure in mathematical history is dealt with — Euclid, Archimedes, Diophantus, Omar Khayyam, Boethius, Fermat, Pascal, Newton, Leibniz, Fourier, Gauss, Riemann, Cantor, and many others. For this latest edition, Dr. Struik has both revised and updated the existing text, and also added a new chapter on the mathematics of the first half of the 20th century. Concise coverage is given to set theory, the influence of relativity and quantum theory, tensor calculus, the Lebesgue integral, the calculus of variations, and other important ideas and concepts. The book concludes with the beginnings of the computer era and the seminal work of von Neumann, Turing, Wiener, and others.
"The author's ability as a first-class historian as well as an able mathematician has enabled him to produce a work which is unquestionably one of the best." — Nature Magazine.
Benoit Mandelbrot, the creator of fractal geometry, has significantly improved our understanding of, among other things, financial variability and erratic physical phenomena. In The Fractalist, Mandelbrot recounts the high points of his life with exuberance and an eloquent fluency, deepening our understanding of the evolution of his extraordinary mind. We begin with his early years: born in Warsaw in 1924 to a Lithuanian Jewish family, Mandelbrot moved with his family to Paris in the 1930s, where he was mentored by an eminent mathematician uncle. During World War II, as he stayed barely one step ahead of the Nazis until France was liberated, he studied geometry on his own and dreamed of using it to solve fresh, real-world problems. We observe his unusually broad education in Europe, and later at Caltech, Princeton, and MIT. We learn about his thirty-five-year affiliation with IBM’s Thomas J. Watson Research Center and his association with Harvard and Yale. An outsider to mainstream scientific research, he managed to do what others had thought impossible: develop a new geometry that combines revelatory beauty with a radical way of unfolding formerly hidden laws governing utter roughness, turbulence, and chaos.
Here is a remarkable story of both the man’s life and his unparalleled contributions to science, mathematics, and the arts.
This book is written in the same engaging conversational style as the published reference book The Immune Response: Basic and Clinical Principles and conveys the same fascinating appeal of immunology. The authors bring clarity, readability and continuity of voice to an audience that requires only a brief survey of the most fundamental concepts in basic and clinical immunology. Primer to The Immune Response is beautifully illustrated with over 200 superb figures and 36 full-color plates, and further enhanced by the inclusion of 60 tables and 6 Appendices. Included with purchase of the book is website access to a captivating “Immunomovie" that truly brings the immune response to pathogens to life. This new and unique immunology textbook compactly but elegantly covers both basic and clinical principles.Over 200 elegant 2-4 color illustrations36 full-color plates of basic and clinical items of interestTake-home message and “Did You Get It? self-test quiz at the end of each chapter6 Appendices that provide topic enrichment60-minute "Immunomovie" illustrating the immune response to bacterial, viral and parasitic infections
The Golden Ratio is a captivating journey through art and architecture, botany and biology, physics and mathematics. It tells the human story of numerous phi-fixated individuals, including the followers of Pythagoras who believed that this proportion revealed the hand of God; astronomer Johannes Kepler, who saw phi as the greatest treasure of geometry; such Renaissance thinkers as mathematician Leonardo Fibonacci of Pisa; and such masters of the modern world as Goethe, Cezanne, Bartok, and physicist Roger Penrose. Wherever his quest for the meaning of phi takes him, Mario Livio reveals the world as a place where order, beauty, and eternal mystery will always coexist.
The immune system has incredible power to protect us from the ravages of infection by killing disease-causing microbes or eliminating them from the body. Boosted by vaccines, it can protect us individually and as a "herd" from diseases such as measles. As Dr. Paul explains, however, the power of the immune system is a double-edged sword: an overactive immune system can wreak havoc, destroying normal tissue and causing diseases such as type I diabetes, rheumatoid arthritis, and multiple sclerosis. The consequences of an impaired immune system, on the other hand, are all too evident in the clinical agonies of AIDS and other immunodeficiency diseases.
Packed with illustrations, stories from Dr. Paul’s distinguished career, and compelling narratives of scientific discovery, Immunity presents the three laws of the human immune system—universality, tolerance, and appropriateness—and explains how the system protects and harms us. From the tale of how smallpox was overcome to the lessons of the Ebola epidemic to the utility of vaccines and the hope that the immune system can be used to treat or prevent cancer, Dr. Paul argues that we must position ourselves to take advantage of cutting-edge technologies and promising new tools in immunological research, including big data and the microbiome.-- Daniel M. Davis, University of Manchester, author of The Compatibility Gene: How Our Bodies Fight Disease, Attract Others, and Define Our Selves
Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitroCovers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodiesColor illustrations enhance explanations of the immune system
The infection, known as Zika fever, often causes no or only mild symptoms, similar to a very mild form of dengue fever. It is treated by rest. Since the 1950s, it has been known to occur within a narrow equatorial belt from Africa to Asia. The virus spread eastward across the Pacific Ocean 2013–2014 Zika virus outbreaks in Oceania to French Polynesia, New Caledonia, the Cook Islands, and Easter Island, and in 2015 to Mexico, Central America, the Caribbean, and South America, where the Zika outbreak has reached pandemic levels. As of 2016, the illness cannot be prevented by medications or vaccines. Zika may spread from a pregnant woman to the baby. This may result in microcephaly and other severe brain problems. Zika infections in adults can, rarely, result in Guillain-Barré syndrome.
In January 2016, the United States Centers for Disease Control and Prevention (CDC) issued travel guidance on affected countries, including the use of enhanced precautions, and guidelines for pregnant women including considering postponing travel. Other governments or health agencies also issued similar travel warnings, while Colombia, the Dominican Republic, Ecuador, El Salvador, and Jamaica advised women to postpone getting pregnant until more is known about the risks. This book will introduce the virus and also describe steps to tackle this problem.
Immunotherapy of Cancerprovides information on cancer research related to inflammation and immunity, containing outstanding reviews by experts in the field. It is suitable for researchers and students who have an interest in cancer immunobiology.Provides information on cancer research, including outstanding and original reviewsCovers the current progress and emerging concepts in cancer inflammation, immunology, and immunotherapy Suitable for researchers and students studying, and interested in, the field of immunotherapy for cancerIdeal for those studying cancer inflammation, tumor immunology, cancer immunotherapy, dendritic cell, antigen presentation, immune checkpoint, myeloid-derived suppressor cells, macrophages, and tumor environments
Understand the care and treatment of pediatric patients thanks to clinical pearls discussing the best approaches.
Easily refer to appendices that list common food allergies and autoantibodies in autoimmune diseases.Apply the newest diagnostic tests available—for asthma, upper respiratory allergy, and more—and know their benefits and contraindications.
Treat the allergy at its source rather than the resulting reactions through an understanding of the immune mechanisms underlying allergic diseases.
Get coverage of new research that affects methods of patient treatment and discusses potential reasons for increased allergies in some individuals.
Better manage potential anaphylaxis cases through analysis of contributing facts and progression of allergic disease.
Effectively control asthma and monitor its progression using the new step-by-step approach.
Eliminate difficulty in prescribing antibiotics thanks to coverage of drug allergies and cross-reactivity.
Visually Enhances Definitions in the Language of Immunology
Now with more than 1300 illustrations, Atlas of Immunology, Third Edition is the most thorough and up-to-date treatment of essentially all concepts needed to comprehend the complex science of immunology.
Completely revised and expanded, this third edition features:
Hundreds of new illustrations Two new chapters – Immunophenotyping of Hematopoietic Malignances and Immunomodulators An expanded chapter on the history of immunology Additional human CD markers
Written in a highly readable, two-column format, this complete reference covers a wide array of subjects, with content ranging from photographs of field pioneers to illustrations of molecular structures of recently characterized cell receptors, chemokines, and cytokines. The atlas also addresses the major histocompatability complex molecules, immunoglobulins, hematopoietic cells in leukemia, and molecules of related interest to immunologists. You won’t find another publication anywhere that matches the breadth or detail of illustrated immunological concepts.
Allogeneic HSCT is a medical procedure in which a patient receives blood-forming stem cells from a genetically similar but not identical donor. This procedure is commonly performed for people with diseases of the blood, bone marrow, or certain cancers, but it remains risky with many possible complications. As such, experimental practice is reserved for preclinical animal models including the mouse and dog.
These animal models have been essential in developing transplant protocols, including preclinical testing of conditioning regimens, treatment of GVHD, and understanding the pathology of GVHD as well as the immunological mechanisms of GVHD and GVL effect. However, recent research has revealed significant species differences between humans and animal models that must be considered when relating animal model studies to clinical allogeneic HSCT scenarios.Brings together perspectives leading laboratories and clinical research groups to highlight advances from bench to the bedsideGuides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic HSCT scenariosCategorizes the published advances in various aspects of immune biology of allegeneic HSCT to illustrate opportunities for clinical applications