The book begins with the four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field.
New topics in this edition include:
The importance of dose–response
The humane use and care of animals
The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.
Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology.
Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.
A fascinating Jazz Age tale of chemistry and detection, poison and murder, The Poisoner's Handbook is a page-turning account of a forgotten era. In early twentieth-century New York, poisons offered an easy path to the perfect crime. Science had no place in the Tammany Hall-controlled coroner's office, and corruption ran rampant. However, with the appointment of chief medical examiner Charles Norris in 1918, the poison game changed forever. Together with toxicologist Alexander Gettler, the duo set the justice system on fire with their trailblazing scientific detective work, triumphing over seemingly unbeatable odds to become the pioneers of forensic chemistry and the gatekeepers of justice.
In 2014, PBS's AMERICAN EXPERIENCE released a film based on The Poisoner's Handbook.
Includes DVD with image bank
A Doody's Core Title ESSENTIAL PURCHASE for 2011!
4 STAR DOODY'S REVIEW!
"This 12th edition of the most authoritative book in pharmacology is the best both in content and physical appearance....This edition of Goodman & Gilman's continues to be the most authoritative and widely used resource bridging the discipline of pharmacology with therapeutics. Moreover, readers will find this edition to be substantially improved from past editions in both content and physical appearance."--Doody's Review Service
The most universally respected and read medical text in all of pharmacology, Goodman & Gilman’s The Pharmacological Basis of Therapeutics represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease.
Enriched by a new full-color presentation and updated to reflect all critical new developments in drug action and drug-disease interaction, the twelfth edition includes more than 440 color illustrations depicting key principles and actions of specific pathways and therapeutic agents. The companion DVD includes all the images and tables in the text along with narrated animations.
Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12e is divided into nine sections, covering:
More than a textbook, Goodman & Gilman's is a working template for the effective and rational prescribing of drugs in daily practice.
A Doody's Core Title for 2017!
For decades, one name has been synonymous with the most respected, rigorous perspectives on medical toxicology and the treatment of poisoned and overdosed patients: Goldfrank's Toxicologic Emergencies. Presented in full color, Goldfrank’s delivers essential, patientcenteredcoverage of every aspect of poison management. The editors and authors are recognized as preeminent scholars in their specialties and provide unmatched coverage of all aspects of toxicologic emergencies, from pharmacology and clinical presentation to cutting-edge treatment strategies.
Goldfrank's Toxicologic Emergencies, Tenth Edition begins with an examination of medical toxicology principles and techniques. It then reviews the biochemical, molecular, and pathophysiologic basis of toxicology, followed by an intense focus on toxicologic principles related to special patient populations.
FeaturesCase studies enhance your understanding of the clinical application of the text material Practical focus on the pathophysiologic basis of medical toxicology The Antidotes in Depth sections delivers the expertise of toxicologists across the world as they present treatments for critically ill poisoned and overdosed patients and allow you to easily identify key issues relating to the use of complex and often unfamiliar therapies The principles of risk management, medicolegal decision making, patient safety, post mortem toxicology and the assessment of ethanol induced impairment described in chapters and Special Considerations emphasize the interface between medical toxicology, the law, and quality care
A few years ago, journalism professor McKay Jenkins went in for a routine medical exam. What doctors found was not routine at all: a tumor, the size of a navel orange, was lurking in his abdomen. When Jenkins returned to the hospital to have the tumor removed, he was visited by a couple of researchers with clipboards. They had some questions for him. Odd questions. How much exposure had he had to toxic chemicals and other contaminants? Asbestos dust? Vinyl chlorine? Pesticides? A million questions, all about seemingly obscure chemicals. Jenkins, an exercise nut and an enviro-conscious, organic-garden kind of guy, suddenly realized he’d spent his life marinating in toxic stuff, from his wall-to-wall carpeting, to his dryer sheets, to his drinking water. And from the moment he left the hospital, he resolved to discover the truth about chemicals and the “healthy” levels of exposure we encounter each day as Americans.
Jenkins spent the next two years digging, exploring five frontiers of toxic exposure—the body, the home, the drinking water, the lawn, and the local box store—and asking how we allowed ourselves to get to this point. He soon learned that the giants of the chemical industry operate virtually unchecked, and a parent has almost no way of finding out what the toy her child is putting in his or her mouth is made of. Most important, though, Jenkins wanted to know what we can do to turn things around. Though toxins may be present in products we all use every day—from ant spray, perfume, and grass seed to shower curtains and, yes, baby shampoo—there are ways to lessen our exposure. ContamiNation is an eye-opening report from the front lines of consumer advocacy.
154 full-color flashcards teach you to recognize and treat drug overdoses and poisoningsThe most fun, engaging, and effective way to learn clinical toxicology Each card takes an illustrated approach to a particular syndrome or toxin reminding you of all you have to know On the back of each card, succinct text describes the typical presentation, signs and symptoms, mechanisms of action, treatment, and clinical pearls. Covers all major drug overdoses and poisons A great way to study on the go, quiz yourself, or brush up just before an exam
This is the first book that offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors, biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, prophylactic, therapeutic and countermeasures, and the role of homeland security.Presents a comprehensive look at all aspects of chemical warfare toxicology in one reference work. This saves researchers time in quickly accessing the very latest definitive details on toxicity of specific agents used in chemical warfare as opposed to searching through thousands of journal articles. Will include the most agent-specific information on the marketIncludes detailed coverage of the most exhaustive list of agents possibly used as chemical warfare agents in one source. Section 4: Agents That Can Be Used as Weapons of Mass Destruction ? 25 chapters long. Other books on the market only include a sample selection of specific agents. Offering all possible agents detailed under one cover makes this appealing to a wider audience and saves researchers timeThe Forward will be written by Dr. Tetsuo Satoh, Chiba University, Japan. He is one of the most respected, recognizable authorities on chemical warfare agents which will set the authoritative tone for the bookCovers risk to humans, animals and the environment equally. Researchers involved in assessing the risks involved with a possible chemical warfare attack and those who are developing response plans to such attacks must look at not only the risks to human health but to our wildlife and environment as well. The holistic approach taken in this book ensures that the researchers have ready access to the details no matter which aspect of the effects of CWA's they might be concerned with
Volume Four discusses:
The extent to which postnatal metal exposure through breastfeeding can impair an infant's health
Selenium bioavailability and metabolism, effects of selenium exposure, and mechanisms of selenium toxicity
The fate of toxic and nontoxic arsenic compounds in the human body upon ingestion
The biological role of sulfur, sulfur metabolism, deficiencies, and toxicity
The effects on fluoride on teeth, bones, kidneys, arteries, hormones, the brain, and the reproductive system
Food-borne disease outbreaks, microbial quality and risk assessment of food-borne microorganisms in ready to eat foods
Effect of T-2 toxin on DNA and chromosomes, circulatory system, skin, reproductive system, liver and spleen, gastrointestinal tract, brain and neurotransmitters, and more
Investigation of the interference of AFB1 with molecular components of cell cycle checkpoints
Analyzes cycad consumption and its effects on the neurological systems and its manifestations; describes bio-chemical changes and morphological or pathological outcomes through time in detail
Lectins in the human diet, toxicity and biological effects, immunomodulatory effects, modulation of immune function by dietary lectins in disease
This is a valuable resource for anyone involved in the food industry or academics researching food science and food technology.
This volume summarizes and evaluates the literature in the area of metal effects on fertility and reproduction in humans, laboratory animals, and wildlife. International experts have contributed chapters that explore how the ovary, testes, uterine system, and neuroendocrine system, among others, respond to metal exposure. Reviewing both current knowledge and cutting edge data, the chapters focus on either a particular metal or a particular population.
A massive amount of data on this subject has been generated, summarized, and reviewed over the years. While there are many books available on metals toxicity and on reproductive toxicity, no current book explores both in the same volume. Culling information from throughout the literature, Metals, Fertility, and Reproductive Toxicity supplies an in-depth look at the role of metals in endocrine disruption and the spectrum of mechanisms involving metals that can influence reproduction.
Emergency Response Planning is designed to help corporate and municipal managers quickly understand their roles in proactive and reactive emergency management. Author Paul Erickson shows how to develop partnerships with federal, state, and local government agencies, as well as community groups in order to prevent, prepare for, and respond to natural disasters and manmade emergencies.
Emergency Response Planning provides essential information to help you comply with government regulations, design an emergency response plan, train personnel, use the proper safety equipment, safeguard information systems, and resume normal operations after an emergency as quickly as possible. It will also help consultants design emergency response plans for their clients, and provide practical information for students studying business continuity and emergency issues.
Is an important resource for:Corporate and municipal managers involved in emergency managementOrganizational safety committee membersIndustrial health and safety consultants and their clientsGraduate and undergraduate students studying emergency response issuesOutlines both proactive and reactive strategies to reduce risk to human life, health, and propertyDescribes how to form effective partnerships with government agencies and community support resourcesDefines the roles of corporate and municipal managers, planning team members, and response personnelExplains regulations and guidelines from key agencies including OSHA, EPA, FEMA, CDC, US Fire Administration, and moreMakes information easy to understand with dozens of tables, illustrations, and appendices
The first part considers the general principles of acids and bases and methods of end-point determination. This part also covers the fundamentals, advantages, and limitations of titration instruments, such as potentiometers, burets, titration vessels, and electrodes. The classification of titration solvents according to their functions as color indicators and titrant solutions is provided in this part. The remaining parts describe the analytical procedures for acidity and basicity of nonaqueous solvents. These parts also provide a tabulated data on the acidic and basic strengths, stability, and dissociation constants of various titration solvents.
Analytical chemists, and analytical chemistry teachers and students will find this book invaluable.
This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to illustrate these effects.
Applied Dermatotoxicology: Clinical Aspects is an essential reference for toxicologists in industry, and for those medical professionals who encounter cases of dermal exposure to toxic agents.A concise, yet inclusive review of effects of chemical exposureIncludes background on basic skin biologyProvides vital clinical reference for toxicologists in non-clinical settings
A history of the CRO industry, audit checklists, and overviews of both the pharmaceutical and medical device development processes create a comprehensive overview of how to successfully select and manage a CRO for your project. The book also discusses:
Guidance for selection, protocol and contract development, project management and monitoring of work
Common pitfalls and problems - how to avoid them, and how to solve them if they do occur
How to integrate efforts between groups to achieve the greatest cost effectiveness while maintaining quality and timely production
Prototype forms and templates for increasing coordination between multiple working groups
A series of appendices covering hundreds of prominent service providers worldwide, including contact information
Operative regulations and laws
In addition to providing fundamental guidance on how to select and manage a CRO in the product development process, this reference also includes a set of eight databases that contain contact information for prominent service providers in North America, Europe, and Japan, and overviews of services they offer. It is a complete resource for professionals in biotechnology, and pharmaceutical and medical device development.
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1. Introduction of Toxicology
2. Factors modifying drug action and dosage
3. Drug interactions
6. Drugs acting on cardiovascular system
7. Drugs acting on Gastrointestinal Tract
8. Antiviral drugs
9. Antimalarial drugs
10. Drugs for Tuberculosis
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Today, 20 years after the worst nuclear power plant accident in history, intrepid journalist Mary Mycio dons dosimeter and camouflage protective gear to explore the world's most infamous radioactive wilderness. As she tours the Zone to report on the disaster's long-term effects on its human, faunal, and floral inhabitants, she meets pockets of defiant local residents who have remained behind to survive and make a life in the Zone. And she is shocked to discover that the area surrounding Chernobyl has become Europe's largest wildlife sanctuary, a flourishing - at times unearthly - wilderness teeming with large animals and a variety of birds, many of them members of rare and endangered species. Like the forests, fields, and swamps of their unexpectedly inviting habitat, both the people and the animals are all radioactive. Cesium-137 is packed in their muscles and strontium-90 in their bones. But quite astonishingly, they are also thriving.
If fears of the Apocalypse and a lifeless, barren radioactive future have been constant companions of the nuclear age, Chernobyl now shows us a different view of the future. A vivid blend of reportage, popular science, and illuminating encounters that explode the myths of Chernobyl with facts that are at once beautiful and horrible, Wormwood Forest brings a remarkable land - and its people and animals - to life to tell a unique story of science, surprise and suspense.
Dr. Hightower’s quest for answers led her to mercury, a poison that has been plaguing victims for centuries and is now showing up in seafood. But this “explanation” opened a Pandora’s Box of thornier questions. Why did some fish from supermarkets and restaurants contain such high levels of a powerful poison? Why did the FDA base its recommendations for “safe” mercury consumption on data supplied by Saddam Hussein’s Ba’athist extremists? And why wasn’t the government warning its citizens?
In Diagnosis: Mercury, Dr. Hightower retraces her investigation into the modern prevalence of mercury poisoning, revealing how political calculations, dubious studies, and industry lobbyists endanger our health. While mercury is a naturally occurring element, she learns there’s much that is unnatural about this poison’s prevalence in our seafood. Mercury is pumped into the air by coal-fired power plants and settles in our rivers and oceans, and has been dumped into our waterways by industry. It accumulates in the fish we eat, and ultimately in our own bodies. Yet government agencies and lawmakers have been slow to regulate pollution or even alert consumers.
Why? The trail of evidence leads to Canada, Japan, Iraq, and various U.S. institutions, and as Dr. Hightower puts the pieces together, she discovers questionable connections between ostensibly objective researchers and industries that fear regulation and bad press. Her tenacious inquiry sheds light on a system in which, too often, money trumps good science and responsible government. Exposing a threat that few recognize but that touches many, Diagnosis: Mercury should be required reading for everyone who cares about their health.
From cyanide to strychnine, from Botox to ricin and Sarin gas—have you ever wondered about their sources? Where do they come from? How do you detect something that can kill you in a matter of seconds? Macinnis methodically analyzes the science of these killing agents and their uses in medicine, cosmetics, war, and terrorism. With wit and precision, he weighs these questions and many more: Was Lincoln’s volatility caused by mercury poisoning? Was Jack the Ripper an arsenic eater? Can wallpaper kill? For anyone who has ever wondered and been afraid to ask, here is a rich miscellany for your secret questions about toxins.
—From the Foreword, Donald H. Pfister, Harvard University and Harvard University Herbaria, Cambridge, Massachusetts
The CRC World Dictionary of Medicinal and Poisonous Plants: Common Names, Scientific Names, Eponyms, Synonyms, and Etymology provides the starting point for better access to data on plants used around the world in medicine, food, and cultural practices. The material found in the five volumes has been painstakingly gathered from papers of general interest, reports and records, taxonomic revisions, field studies, herbaria and herbarium collections, notes, monographs, pamphlets, botanical literature, and literature tout court. It includes sources available at various natural history libraries, floras and standard flora works, local floras and local histories, nomenclatural histories, and the International Code of Botanical Nomenclature.
Much more than a dictionary, the book provides the names of thousands of genera and species of economically important plants, concise summaries of plant properties, and appropriate observations about medicinal uses. Drawing from a tremendous range of primary and secondary sources, it is an indispensable time-saving guide for all those involved with botany, herbal medicine, pharmacognosy, toxicology, medicinal and natural product chemistry, and agriculture.
Features:Addresses standards from all international regulatory agencies Presents the steps in risk assessment, including hazard identification, exposure assessment, and risk characterization Covers the assessment of multiple chemical exposures or chemical mixtures Contains data from both human and animal studies Explains the linearized multi-stage mathematical model widely used by the US EPA for characterizing
Intended for just that purpose, International Poisonous Plant Checklist: An Evidence-Based Reference successfully addresses the deficiencies and gaps in the current literature. Using accepted botanic names, the book defines the known set of toxic vascular plants. The use of botanic names satisfies the need for an international standard of identity to support worldwide communication and commerce. Also, taxonomy based on common ancestry and genetic connections provides a rational basis for studying and using plant relationships.
The author supports toxicity information with references to the primary literature. Each entry includes referenced citations supporting the toxicity of the plant, symptoms and circumstances of toxic exposure, dosage and potency, chemical analysis, botany, pharmacology, mechanism and metabolism, and control.
Finally, the book cross-references selected synonyms and common names. The checklist is organized alphabetically with two types of entries. The main entry documents the toxic plants themselves and a secondary entry lists selected synonyms and common names cross-referenced to the main entries.
Including virtually all common animal feed plants, human food plants, and many plants that are sources of herbal products and dietary supplements, tonics, and therapeutic agents, this timely checklist compiles and verifies the known data on toxic vascular plants from around the world.
This comprehensive, time-saving tool is ideal for toxicologists, pharmacologists, drug companies, testing labs, libraries, poison control centers, physicians, legal and regulatory professionals, and chemists.Serves as an all-in-one resource for toxicology informationNew edition includes information on publishers, grants and other funding opportunities, physical hazards, patent literature, and technical reportsUpdated to include the latest internet and electronic sources, e-mail addresses, etc.Provides valuable data about the new fields that have emerged within toxicological research; namely, the biochemical, cellular, molecular, and genetic aspects
From one of the world's top CO experts, Carbon Monoxide Toxicity examines the latest basic science and clinical research from around the world. It addresses the gamut of health-related CO issues, from the history of CO studies to the hidden threat of chronic low-level exposure. The broad themes center on clinical management of various forms of CO poisoning and education of the public on the constant dangers of CO.
Thanks to the success of CO environmental health regulations in the U.S., society is much more aware of the threat of CO poisoning. Increasing numbers of people use CO detectors in public buildings, homes, pleasure boats, and aircraft. Carbon Monoxide Toxicity meets the need for current research on the clinical management of CO poisoning.
Visit the author's Web site at www.coheadquarters.com
Individual articles are preceded by a topical outline and discuss the origin, prevalence, mechanisms of toxicity and damaging effects of each hazardous material.
Comprehensive coverage of individual toxic elements, including
Coverage of hazardous material groups, such as
More general articles, such as
Evaluation and testing of carcinogens
Transport of pollutants
The hemopoietic cells of man and the rhesus monkey display an intimate homogeneity. Their functional activities are close and at times identical. The cynomolgus monkey was enlisted in biomedical studies at a time when rhesus monkeys were not available in sufficient quantities. It has gained increased use in the Far East and in the Western world. It is, for example, employed in the current development of a vaccine against the deadly Ebola virus.
The authors of the book discuss the erythropoietic profiles of normal and abnormal macaques of both sexes and of all age groups as investigated with contemporary electronic methodologies. They cover the role of stress as it is perceived by the monkey and how it impacts erythrocellular values, and how to train the monkey to be a cooperative, unperturbed subject for hematologic study. Additional topics include the role of medication in deriving normal physiologic erythrocellular data, the development of the precursors of the erythrocyte (normoblasts), the morphologic analysis of the megaloblastic series of abnormal erythroid cells, the analysis of erythropoiesis in bone marrow, the relationship of the simian immunodeficiency virus and erythropoiesis, erythrocyte life span, and parasitic invasion of the red cell.
The book answers one of the key problems in pesticide analysis: the diversity of chemical functional groups, with varying polarity and physicochemical properties. Pesticides and their metabolites have received particular attention during the last few years in environmental trace-organic analysis. For instance, in the case of groundwater, the use of pesticides has become a cause for concern. Under the right conditions, pesticides, such as fertilizer nitrogen, can move through the soil into groundwater, a phenomenon once thought improbable. The movement of agrochemicals in surface water flow can be, in some instances, a major problem, specially in the case of water soluble pesticides that are generally transported to estuarine and coastal waters. Estuarine waters feature gradients of both pollutant concentrations and physicochemical characteristics such as salinity, turbidity and pH, and all these parameters must be carefully considered when developing methods of analysis for trace organics in estuarine waters.
One of the key parameters in analytical determination is the environmental sampling. Different protocols and devices are needed for sampling sea-water samples - usually using large sample volumes of more than 50 litres either with LLE or SPE, with the problems encountered due to dissolved and particulate matter - which is different from drinking water and well water sampling. The representativeness of the sampling is also of concern.
The sample preparation of organic compounds from water matrices has been recognized to be a bottleneck and it has been traditionally neglected in the literature. We should comment following R.W. Frie's ideas - that the most sophisticated hardware is useless if the chemistry in the protocol does not work. During the last few years new adsorbents have appeared - carbon type, polymeric sorbents with high capacity and immunosorbents - which can more efficiently trap the more polar compounds.
The development of advanced automation methods based, usually on solid phase extraction techniques - PROSPEKT, OSP-2 and ASPEC XL - are examples of commercially available equipment that are of growing importance. These systems are generally coupled to LC and GC techniques.
Sampling and sample handling can not be regarded as separate techniques in the analytical process and both should be integrated into the whole analytical determination. For this reason, validation and confirmation methods, such as mass spectrometry, either GC-MS and/or LC-MS, are needed. These serve to check the quality assurance of the developed method. The discussion between multiscreening versus specific methods of analysis and the influence of the matrix (ground-, surface- and estuarine-water), is also a point of concern due to the diversity of chemical classes within the compounds of study.
In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides.Describes everything you need to know about Organophosphates and CarbamatesExtensively covers pesticides, nerve agents, therapeutic drugs, and flame retardantsDescribes epidemiology of the world's major disasters involving Organophosphates and CarbamatesCovers animal, human, aquatic, and wildlife toxicity of AnticholinesterasesInsights into in-depth cholinergic and noncholinergic mechanisms of toxicityDescribes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesisProvides in vitro and in vivo models for neurotoxicity testingIntegrates knowledge of studies in lab animals and humansOffers risk/safety assessment and national/international guidelines for permissible levels of pesticide residuesDescribes management of Anticholinesterase poisoning in humans
With more than 1150 entries, this second edition has been expanded in length, breadth and depth, and provides an extensive overview of the many facets of toxicology.
Also available online via ScienceDirect – featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com.
*Second edition has been expanded to 4 volumes
*Encyclopedic A-Z arrangement of chemicals and all core areas of the science of toxicology
*Covers related areas such as organizations, toxic accidents, historical and social issues, and laws
*New topics covered include computational toxicology, cancer potency factors, chemical accidents, non-lethal chemical weapons, drugs of abuse, and consumer products and many more!
A Doody's Core Title for 2017!General Principles of Toxicology Disposition of Toxicants Nonorgan-directed Toxicity Target Organ Toxicity Toxic Agents Environmental Toxicology Applications of Toxicology
Casarett & Doull’s Essentials of Toxicology is an easy-to-absorb distillation of the major principles and concepts that were presented in depth in Casarett & Doull’s Toxicology: The Basic Science of Poisons, Eighth Edition, the field’s gold-standard text.
Presented in full color, the book concisely describes the science of toxicology, and includes important concepts from anatomy, physiology, and biochemistry to facilitate the understanding of the principles and mechanisms of toxicant action on specific organ systems. A summary of key points at the beginning and review questions at the end of each chapter help you study, understand, and memorize the material.
Reflecting the expertise of more than sixty renowned contributors, Casarett & Doull’s Essentials of Toxicology is logically divided into seven sections:
Succinct and comprehensive, there is no better text for gaining an understanding of essential principles, toxicokinetics, how toxic effects are passed on to succeeding generations, how each body system responds to poisons, and the specific effects of a wide range of toxic agents than Casarett & Doull’s Essentials of Toxicology.
In this gripping exploration, Nancy Langston shows how these chemicals have penetrated into every aspect of our bodies and ecosystems, yet the U.S. government has largely failed to regulate them and has skillfully manipulated scientific uncertainty to delay regulation. Personally affected by endocrine disruptors, Langston argues that the FDA needs to institute proper regulation of these commonly produced synthetic chemicals.
Volume I covers “General Considerations and Volume II is devoted to “Specific Metals. A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals.Contains 61 peer reviewed chapters dealing with the effects of metallic elements and their compounds on biological systemsIncludes information on sources, transport and transformation of metals in the environment and on certain aspects of the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human healthCovers the toxicology of metallic nanomaterials in a new comprehensive chapterMetal toxicology in developing countries is dealt with in another new chapter emphasizing the adverse effects on human health by the inadequate handling of "ewaste Other new chapters in the 4th edition include: Toxic metals in food; Toxicity of metals released from medical devices; Gene-environment interactions; Neurotoxicology of metals; Cardiovascular disease; Renal effects of exposure to metals; Gold and gold mining; Iridium; Lanthanum; Lithium and Rhodium
The world's leading and most authoritative textbook on poisons has more to offer students,toxicologists, and pharmacologists than ever before. Now in full color, and thoroughly revised, the eighth edition of Casarett & Doull's TOXICOLOGY: The Basic Science of Poisons not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date, revealing, and in-depth look at the systemic responses of toxic substance available anywhere.
Combined with the latest thinking by the field's foremost scholars plus solid coverage of general principles, modes of action, and chemical-specific toxicity, this landmark text continues to set the standard for toxicology references.
NEW to the Eighth EditionFULL-COLOR design to allow for a clearer interpretation of the basic components of toxicology featured throughout the text EXPANDED tables, illustrations, and other visuals are updated with state-of-the-art standards that makes this edition even more current and relevant DVD with image bank features all tables and illustrations from the text in presentation-ready format NEW CHAPTERS include "Toxic Effects of Calories" and "Toxic Effects of Nanoparticles"
Cleaning parts and surfaces with solvents is simple, effective and low-cost. Although health and safety and environmental concerns come into play with the use of solvents, this book explores how safe and compliant solvent-based cleaning techniques can be implemented. A key to this is the selection of the right solvent. The author also examines a range of newer "green" solvent cleaning options.
This book supplies scientific fundamentals and practical guidance supported by real-world examples. Durkee explains the three principal methods of solvent selection: matching of solubility parameters, reduction of potential for smog formation, and matching of physical properties. He also provides guidance on the safe use of aerosols, wipe-cleaning techniques, solvent stabilization, economics, and many other topics.
A compendium of blend rules is included, covering the physical, chemical, and environmental properties of solvents.Three methods explained in detail for substitution of suitable solvents for those unsuitable for any reason: toxic solvents don't have to be tolerated; this volume explains how to do betterEnables users to make informed judgments about their selection of cleaning solvents for specific applications, including solvent replacement decisionsExplains how to plan and implement solvent cleaning systems that are effective, economical and compliant with regulations
By incorporating the latest research in this area and featuring practical scenarios, this reference is a complete and actionable guide to all aspects of preclinical drug testing.Chapters written by world-renowned contributors who are experts in their fieldsIncludes the latest research in preclinical drug testing and international guidelinesCovers preclinical toxicology in small molecules and biologics in one single source
Part I presents the history and nature of immune response, and it describes the general features of the innate and adaptive immune responses. This part also explores the components of the immune system such as the cells and tissues. It also illustrates the intracellular communication through signal induction, intercellular communication through cytokines, and the cellular movement in the immune system. Furthermore, this part discusses proteins and genes, the development, activation and effector functions of both B cells and T cells.
Part II focuses on clinical immunology and covers immunity to infection caused by extracellular and intracellular bacteria, viruses, parasites and fungi. This part also describes different kinds of diseases, such as the Acquired Immunodeficiency Syndrome caused by the Human Immunodeficiency virus, tumors, autoimmune diseases, and hematopoietic cancers. This part also includes discussions on vaccination, transplantation, and different types of immune hypersensitivity.Color illustrations enhance key topics and concepts
This third edition caters for this need in a clear and easy-to-read style, featuring:
* Up-to-the-minute information
* Relevant toxicological examples that reinforce principles
* End-of-chapter essay questions
* New and redrawn illustrations
* Glossary of terms
* Extensively revised bibliography
The fundamental principles of absorption, distribution, metabolism and excretion are described in the introductory chapters, as are the types of exposure and response. In subsequent chapters these are clarified with the use of carefully chosen examples. Among the topics considered are the potential adverse effects of drugs, pesticides, food additives and industrial chemicals.
Apply the latest knowledgewith updated diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses. Put the latest knowledge to work in your practice with new or completely revised chapters on Influenza (new pandemic strains); New Middle East Respiratory Syndrome (MERS) Virus; Probiotics; Antibiotics for resistant bacteria; Antifungal drugs; New Antivirals for hepatitis B and C; Clostridium difficile treatment; Sepsis; Advances in HIV prevention and treatment; Viral gastroenteritis; Lyme Disease; Helicobacter pylori; Malaria; Infections in immunocompromised hosts; Immunization (new vaccines and new recommendations); and Microbiome.
Benefit from fresh perspectives and expanded global insightsfrom an expanded team of American and International contributors. Martin Blaser, MD, a leading expert and Muriel G. and George W. Singer Professional of Translational Medicine at New York University School of Medicine, joins veteran PPID editors John E. Bennett, MD, and Raphael Dolin, MD to continue a legacy of excellence.
Find and grasp the information you need easily and rapidlywith newly added chapter summaries.
Manage any challenge in ocular toxicologywith extensive coverage of principles of therapy; ocular drug delivery; methods to evaluate drug-induced visual side effects; and the role of electrophysiology and psychophysics.
Benefit from the masterful guidance and global perspectiveof world authorities in the field who provide need-to-know information on all aspects of ocular toxicology—all in one concise reference.
Confer with the WHO classification systemto determine whether a particular side effect is certain, probable, or likely to occur.
Zero in on the key information you need to knowwith highly templated, concise chapters. Apply the latest knowledge and treatments for newly recognized Adverse Drug Reactions (ADR). Identify which ADR’s are clinically relevant and what to do about them.
Experience clinical scenarioswith vivid clarity through a wealth of new and updated clinical photographs that provide unmatched, visual diagnostic guidance.
Recognize and avoid drug-induced ocular side effectswith data from the National Registry of Drug Induced Ocular Side-Effects (Casey Eye Institute, Portland, OR) and the World Health Organization (Uppsala, Sweden).
Stay up to date and provide state-of-the-art carewith the latest information on approved medications.
Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoringprovides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring.
The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity.
This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful.Focuses on the personalized management of immunosuppression therapy in individual transplant patientsPresents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathologyProvides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patientsReviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy
This informative revised edition presents the chemistry, environmental pollution problems, animal toxicology and information about structure-activity relationships. A brief overview is given of worker exposure and occupational illness.
The book is divided into three parts: chemistry and environmental contamination; experimental toxicology; and human exposure and effects.
Because of the great deal of interest in these compounds much new research work has been conducted since the first edition of this book was published.
This revised edition has retained the effectiveness and clarity of the first edition, while being supplemented with new information, condensed old information, and examples of recent incidents.