1. Brain Tumors
3. Glial Tumors
2. Immunophenotypic Characterization of Infiltrating Poly- and Mononuclear Cells in Childhood Brain Tumors
2. The Significance of Immunohistochemistry
3. Original Immunohistochemical Observations
4. Intermediate filaments (IFs)
5. Expression of Homeobox B3, B4, and C6 Gene Products
6. Cell proliferation
7. Epidermal growth factor (EGF) and its receptor (EGFR)
8. p53, the guardian of the integrity of the genome
9. Apoptosis in Brain Tumors
11. Tumor-related Neoangiogenesis in Childhood Brain Tumors
12. Presence of Matrix Metalloproteinases (MMPs)
13. The MAGE gene family
II. ANTI-NEOPLASTIC BIOLOGICAL THERAPIES
3. Experimental Therapies in Brain Tumors
4. Biologic Anti-Neoplastic Therapies
2. Active nonspecific immunomodulation of natural immunity
3. Thymic hormones
4. Interferons: basic and preclinical studies
5. Tumor Necrosis Factors
6. The discovery of interleukin-2: basic principles
5. The lymphokine activated killer (LAK) cell phenomenon
1. Administration of rIL-2 and LAK cells: preclinical trials
6. Angiogenesis Inhibition in Anti-Neoplastic Therapy
7. Antigen Presentation by Dendritic Cells and Their Significance in Anti-Neoplastic Immunotherapy
1. Active antigen specific immunotherapy (tumor vaccines)
2. Antigen Presentation within Childhood Brain Tumors
3. Immunosuppression within the Cellular Microenvironment of Childhood Brain Tumors
4. The Dendritic Cell Network
5. Antigen Presentation by DCs
6. The Significance of DCs in Anti-Neoplastic Immunotherapy
8. Genetically Engineered Antibodies for Direct Anti-Neoplastic Treatment and Systematic Delivery of Various Therapeutic Agents to Cancer Cells
2. Human Cancer Cell Related Antigens
3. Oncogenes and Growth Factors in Neoplastic Cells
4. Antibodies and Neoplastic Cells
5. Anti-neoplastic Immunotherapeutical Regiments Influenced by Immunohistochemistry
6. Human Antibodies
7. Anti-Idiotypic Antibodies
8. Bispecific Antibodies
9. Radiolabeled Antibodies
10. Construction of Immunotoxins
11. Monoclonal Antibodies: Carriers of Drugs, Toxins and Cytotoxic Cells
12. Clinical Trials with Monoclonal Antibodies and their Minimal Toxicity
9. Cancer-Testis Antigens: Promising Targets for Antigen Directed Anti-neoplastic Immunotherapy
2. Cancer/Testis Antigens
3. Detection of Cancer/Testis Antigens in Various Malignant Neoplasms and their Therapeutic Significance
10. Materials and Methods
1. Tissues and Tissue Handling
2. Libraries of Antibodies
3. Antigen Retrieval Technique
4. Immunoalkaline Phosphatase Antigen Detection Technique
5. Immunoperoxidase Antigen Detection Technique
6. Controls in Immunocytochemistry
7. Evaluation of the Immunoreactivity (immunostaining)
8. Tissue Processing for Tissue Culture Experiments
9. Preparation of Thymic, Peripheral Blood and Bone Marrow Cell Suspensions
10. Isolation of Cortical Thymocytes
11. Isolation of Thymic Nurse Cells (TNCs)
12. Thymic Stromal Cell (RE & DC) Cultures
13. Proliferation Assay (PA) for Thymocytes and Peripheral Blood Hematopoietic Cells
14. Transmission Electronmicroscopy (TEM) of Cultured Thymic Medullary Cells (RE, DC, including LC, & IDC) and Macrophages
15. Scanning Electronmicroscopic (SEM) Procedure for Tissue Samples
Just two months before the September 11 terrorist attacks, Dr. Judy Melinek began her training as a New York City forensic pathologist. While her husband and their toddler held down the home front, Judy threw herself into the fascinating world of death investigation—performing autopsies, investigating death scenes, counseling grieving relatives. Working Stiff chronicles Judy’s two years of training, taking readers behind the police tape of some of the most harrowing deaths in the Big Apple, including a firsthand account of the events of September 11, the subsequent anthrax bio-terrorism attack, and the disastrous crash of American Airlines Flight 587.
An unvarnished portrait of the daily life of medical examiners—complete with grisly anecdotes, chilling crime scenes, and a welcome dose of gallows humor—Working Stiff offers a glimpse into the daily life of one of America’s most arduous professions, and the unexpected challenges of shuttling between the domains of the living and the dead. The body never lies—and through the murders, accidents, and suicides that land on her table, Dr. Melinek lays bare the truth behind the glamorized depictions of autopsy work on television to reveal the secret story of the real morgue. “Haunting and illuminating...the stories from her average workdays…transfix the reader with their demonstration that medical science can diagnose and console long after the heartbeat stops” (The New York Times).
Grasp the connections between basic science and clinical medicine with clinicopathologic correlations throughout.Learn core concepts quickly and efficiently with a highly templated design that highlights pathogenesis and morphology.
Artwork revised and updated for a more modern look and more three-dimensional feel
Targeted Therapy boxes – provides clinical information on appropriate therapy related to the disease under discussion
All photomicrographs and gross photos reviewed and improved to ensure excellent quality
Efficiently review a wide spectrum of topicswith page references and a parallel organization to both Robbins and Cotran Pathologic Basis of Disease and Robbins Basic Pathology, making additional information easy to locate.
Reinforce your understanding of key contentwith answers and detailed explanations for every question at the end of each chapter.
Enhance your understanding of pathophysiology and integrate pathologywith other medical disciplines by examining correlative laboratory, radiologic, and physical diagnostic data.
Visualize key pathologic concepts and conditionsand test your diagnostic skills with over 1,100 full-color images. Features new questions that reflect today’s hot topics in pathology, keeping you up to date. Includes many new illustrations to enhance visual guidance. Uses a new chapter arrangement to conform to the new Table of Contents in Robbins and Cotran Pathologic Basis of Disease, 8th Edition, for easier cross referencing.
This eBook experience allows you to search all of the text, figures, references, and animations, designed to produce a more rounded learning experience.
When someone you love is depressed . . .
. . . you feel lost, afraid, confused.
. . . you long for the person who was.
. . . you don’t recognize who he or she has become.
. . . you feel shut out.
. . . you feel angry and frustrated.
. . . you feel drained.
. . . you are desperate for a way to connect.
. . . you feel guilty and alone.
. . . you will do anything to help.
“What motivates me now is to share with you what I've learned about how to cope when someone you love is depressed. What I have discovered from years of training and from having counseled hundreds of families who have shared their sorrows and their joys is that there are ways you can help someone you love who is depressed. And in that process, you will grow closer.”—from What to Do When Someone You Love is Depressed
?? Covers all must know topics in a very simple language and lucid style
?? Helps in rapid revision and self-assessment before examination
?? Enlists contrasting features of clinically and morphologically similar conditions in a tabular format for further clarification of concepts
?? Extensively revised, updated, and strengthened to keep up with the latest changes in the standard reference textbooks of pathology
?? Chapter on haematology has been thoroughly reorganized and the most contemporary concepts have been inserted in the chapters on immunity, genetics and neoplasia as well as systemic pathology
?? Provides an integrated approach to the study of pathology
?? Emphasizes understanding of evolution of disease and the use of laboratory tests to interpret the stage of evolution
?? Provides clinical correlation in all major subject areas to enable understanding of clinical situations and development of clinical decision making ability
Forensic Science Under Siege is the first book to integrate and explain these problematic trends in forensic science. The issues are timely, and are approached from an investigatory, yet scholarly and research-driven, perspective. Leading experts are consulted and interviewed, including directors of highly visible forensic laboratories, as well as medical examiners and coroners who are commandeering the discussions related to these issues. Interviewees include Henry Lee, Richard Saferstein, Cyril Wecht, and many others.
The ultimate consequences of all these pressures, as well as the future of forensic science, has yet to be determined. This book examines these challenges, while also exploring possible solutions (such as the formation of a forensic science consortium to address specific legislative issues). It is a must-read for all forensic scientists.Provides insight on the current state of forensic science, demands, and future direction as provided by leading experts in the fieldConsolidates the current state of standards and best-practices of labs across disciplinesDiscusses a controversial topic that must be addressed for political support and financial funding of forensic science to improve
Thoroughly revised and up-dated edition of the standard reference work in histotechnology that successfully integrates both theory and practice.Provides a single comprehensive resource on the tried and tested investigative techniques as well as coverage of the latest technical developments.
Over 30 international expert contributors all of whom are involved in teaching, research and practice.Provides authoritative guidance on principles and practice of fixation and staining.
Extensive use of summary tables, charts and boxes.Information is well set out and easy to retrieve.
Six useful appendices included (SI units, solution preparation, specimen mounting, solubility). Provides practical information on measurements, preparation solutions that are used in daily laboratory practice.
Color photomicrographs used extensively throughout. Better replicates the actual appearance of the specimen under the microscope.
Brand new co-editors.
New material on immunohistochemical and molecular diagnostic techniques.Enables user to keep abreast of latest advances in the field.
The second edition has important new material on such topics as observed differences between polarized and non-polarized dermoscopy, newly recognized structures and patterns, refined and revised suggestions for pattern analysis, dermoscopy of the hair and nails, and how to integrate dermoscopy into general clinical practice. It also covers dermoscopically equivocal, false negative, and false positive lesions; discusses further indications for dermoscopy beyond skin cancer; and details common checklists of criteria and algorithms used to diagnose skin lesions.
This third edition is thoroughly revised and expanded with new chapters in different fields. Topics covered address automotive, aviation, military and other environments. Field data collection; injury coding/scaling; injury epidemiology; mechanisms of injury; human tolerance to injury; simulations using experimental, complex computational models (finite element modeling) and statistical processes; anthropomorphic test device design, development and validation for crashworthiness applications in topics cited above; and current regulations are covered. Risk functions and injury criteria for various body regions are included. Adult and pediatric populations are addressed. The exhaustive list of references in many areas along with the latest developments is valuable to all those involved or intend to pursue this important topic on human injury biomechanics and prevention.
The expanded edition will interest a variety of scholars and professionals including physicians, biomedical researchers in many disciplines, basic scientists, attorneys and jurists involved in accidental injury cases and governmental bodies. It is hoped that this book will foster multidisciplinary collaborations by medical and engineering researchers and academicians and practicing physicians for injury assessment and prevention and stimulate more applied research, education and training in the field of accidental-injury causation and prevention.
Bulleted summary boxesprovide quick access to key information and easy review of key concepts.
Highlights pathogenesis, morphology, and pathophysiologic content throughout. Includes increased and updated clinical topics.
New artwork and more schematic diagrams summarize key pathologic processes.
This much praised and widely used reference manual on has been extensively revised and expanded to cover the entire field of anatomic pathology. The Third Edition features the incorporation of full-color images in the text with updates of new diagnostic and prognostic information. New classifications and numerous new entities and histologic variants are fully explored. Useful immunostaining biomarkers and emerging molecular targets and relevant molecular findings that have emerged from recent genomic studies are incorporated in each chapter.
Written by internationally recognized authorities, the comprehensive, evidence-based practice information is presented in an outline format that is clear and easy to follow. Up-to-date and richly detailed, Essentials of Anatomic Pathology, Third Edition offers both the pathologist-in-training and the practicing pathologist a concise summary of all the critical information needed to recognize, understand and interpret anatomic pathology.
The AJCC Cancer Staging Atlas, 2nd Edition, is an official publication of the American Joint Committee on Cancer, the recognized international leader in state-of-the-art information on cancer staging. This Atlas has been created as a companion to the updated 7th Edition of the AJCC Cancer Staging Manual, which continues to disseminate the importance of anatomical and pathological staging in the management of cancer. This state-of-the-art, invaluable 2nd Edition includes a CD containing PowerPoint slides of all illustrations, additional color, and a user-friendly, easy-to-read layout. The AJCC Cancer Staging Atlas, 2nd Edition will serve as an indispensable reference for clinicians, registrars, students, trainees, and patients.
Dr. Stoller maintains that the best evidence in medical research is not incorporated into clinical practice unless the medical cartel has the potential to make large amounts of money promoting the results of the research. Stoller takes his provocative argument a step further, maintaining that if specific research conflicts with a powerful entity’s financial interests, the likely result will be an effort to suppress or distort the results. Stoller cites numerous examples, including corporate influence on GMO labeling and public health.
Stoller also explores how “revolving-door-employment” between the Centers for Disease Control and large pharmaceutical companies can affect research results—as well as our health. Written in an accessible style that is thoroughly appropriate for a lay audience, Incurable Me is a must-read for anyone interested in the state of modern medicine.
Presents information in a concise, at-a-glance format.
Fits into your pocket, for a convenient reference any time.
Offers abundant page references to the parent text, making additional information easy to find.Completely updated to reflect the latest knowledge and techniques across all areas of pathology.
In providing a broad overview of pathology practice management, each chapter employs a didactic framework, including one or more scenarios to illustrate challenges encountered by the writers. This case-based approach facilitates interactive learning and will thus be particularly useful to pathology training programs.
Whatever your stage in the field—from resident to senior pathologist, including those in leadership roles—Pathology Practice Management: A Case-Based Guide is essential reading.
High-quality, carefully annotated color images(50% new!) provide clinically and diagnostically important information on more than 315 new and evolving entities of the head and neck and endocrine organs
State-of-the-art coverageof tumors, tumor development, and tumor genetics as well as normal histology, genetic testing, and new immunohistochemistry studies
Fully integrated, searchable, and linked contentbetween differential diagnostic categories is perfectly suited for residents, while updated genetic testing algorithms, new images, and outstanding graphics make this text ideal for both residents and practitioners
Supporting studies are placed into clinical context, with tables and molecular flow charts that assist with management decisions and prognostic outcome predictions
Time-saving reference featuresinclude bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index
Comparative Osteology is a photographic atlas of common North American animal bones designed for use as a laboratory and field guide by the forensic scientist or archaeologist. The intent of the guide is not to be inclusive of all animals, but rather to present some of the most common species which also have the highest likelihood of being potentially confused with human remains.An affordably priced, compact laboratory/field manual, comparing human and nonhuman bonesContains almost 600 high-quality black and white images and diagrams, including inch and centimeter scales with each photographWritten by the foremost forensic scientists with decades of experience in the laboratory and as expert witnessesAn additional Companion Web site hosts images from the volume the reader can magnify and zoom into to see specific landmarks and features on bones http://booksite.academicpress.com/9780123884374
Updated throughout, it offers a superb complement to more comprehensive textbooks and presentations of pathology, including course syllabi. It can also be used as an adjunct for study of gross and microscopic pathology specimens in laboratory exercises, and makes a great review resource for students, medical residents, physicians and other healthcare professionals.
Grasp and retain key pathologic concepts and conditions. Beginning with a concise summary of the various pathological processes and diseases, each chapter consists of illustrations of pathological processes and diseases accompanied by concise text aimed at clarifying and expanding the information presented in the illustrations.Gain a superb visual understanding through more than 380 classic Netter and new Netter-style images, gross and microscopic photographs and tables.
Reference information effortlessly with numerous tables throughout including 452 figures and 255 slides.
Co-written by a former radiation oncology residency program director and a team of radiation oncology residents, the book is organized in concise sections and is amply illustrated to highlight key points and help the reader understand and retain major concepts. Treatment approaches consistent with published clinical trial protocols that define control/standard of care/consensus radiation treatment are included. In addition to serving as a primary introduction to the field, the book also offers a short review of fundamental concepts for the senior resident prior to written or oral examinations, and is a useful resource for the radiation oncology educator to develop teaching plans and quizzes. Chapter organization is based on the International Atomic Energy Agency Syllabus for the Education and Training of Radiation Oncologists, the syllabus endorsed by both the American Society for Radiation Oncology and the European Society for Therapeutic Radiology and Oncology.
Features of Radiation Oncology Primer and Review:
Integrates basic science, clinical science and technical concepts to provide the trainee with a complete introduction to the field of radiation oncologyIs consistent with accepted training syllabus for radiation oncology professionalsOffers a concise presentation with illustrations highlighting key poiintsProvides key points for study and reviewsIncludes treatment approaches consistent with published clinical trial protocols that define control/standard of care/consensus radiation treatmentIs a valuable review resource for board review
Access the full text and more online at expertconsult.com, including 26 virtual lectures by Dr. Elston, clinical and dermatopathology image atlases, and a virtual slide library.
Easily focus on the most important "takeaways" and "must-knows"for each topic through the use of color key points, differential diagnosis, and pearls.
Learn directly from the experts themselvesby "attending" lectures online in a virtual lecture room. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should online access to the web site be discontinued.
Designed to complement Robbins and Cotran Pathologic Basis of Disease, 8th Edition and Robbins Basic Pathology, 8th Edition, this full-color atlas offers more than 1,500 outstanding full-color illustrations that vividly depict the diseases you need to know for pathology courses and USMLE exams. A quick visual reference or review of material for students and professionals alike.Includes gross, microscopic, and radiologic images correlated with examples of normal organs and tissues for comparison.Extensive legends summarize the key information you need to know.Correlates pathology with clinical history, physical exam findings, and clinical laboratory tests.A perfect study complement to Robbins and Cotran Review of Pathology. Includes many new and improved images.
The book adds evolutionary, pathological, and developmental information in a way that reduces the difficulty and total time spent learning gross anatomy by making learning more logical and systematic. It also synthesizes data that would normally be available for students only by consulting several books at a time.
Anatomical illustrations are carefully selected to follow the style of those seen in human anatomical atlases but are simpler in their overall configuration, making them easier to understand without overwhelming students with visual information. The book’s organization is also more versatile than most human anatomy texts so that students can refer to different sections according to their own learning styles.
Because it is relatively short in length and easily transportable, students can take this invaluable book anywhere and use it to understand most of the structures they need to learn for any gross anatomy course.
Since the majority of deaths are due to natural causes, the book emphasizes these situations, yet also examines unnatural circumstances. It begins by providing a general overview of death investigation before delving into a chronological point-by-point analysis of the death scene. Topics discussed include how to assess the body at the scene, and how to investigate natural and unnatural deaths.
Explores Various Causes
Next, the text demonstrates how death manifests in various parts of the body. A section on traumatic injuries examines and demonstrates with color photographs blunt force, sharp force, and a host of other injuries that the death examiner is likely to confront.
The book addresses identification methods and explores how to determine signs of resuscitation and previous surgeries. It concludes with a discussion of the purpose and performance of the autopsy and provides a survey of the different forensic experts that may become useful to the death investigator.
Enhanced by numerous color photos, this volume is a direct, succinct handbook that is invaluable to those that confront the reality of death on a day-to-day basis. Its convenient format makes it the perfect guide to take along to the scene.
Laboratory Management addresses common issues and errors seen in the laboratory management process. The goal is to enable the laboratory manager to avoid or correct such errors by both individual effort and a systems approach in the laboratory. The book addresses potential issues in accreditation and regulatory compliance, laboratory and patient safety, quality management, financial management, human resources management, specimen processing logistics, performance standards, selection and management of commercial laboratories and much more. Each of these can have an adverse impact on the laboratory performance if a management error occurs. Potential management errors are described and discussed in a clinical case-based learning format to effectively illustrate the conditions that contribute to these errors and enable the laboratory manager to recognize and avoid them in daily practice.
Laboratory Management Features:
Descriptions of potential errors in regulatory compliance, operational processes, and patient safety in the laboratory Descriptions of potential errors in financial, human, and test utilization management in the laboratory Descriptions of potential errors in selecting automation and information systems in the laboratory Clinical case discussions provide "real world" illustrations of potential errors and how to anticipate and avoid them in practice Pocket-sized for Portability"