Joining the ranks of popular science classics like The Botany of Desire and The Selfish Gene, a groundbreaking, wondrously informative, and vastly entertaining examination of the most significant revolution in biology since Darwin—a “microbe’s-eye view” of the world that reveals a marvelous, radically reconceived picture of life on earth.

Every animal, whether human, squid, or wasp, is home to millions of bacteria and other microbes. Ed Yong, whose humor is as evident as his erudition, prompts us to look at ourselves and our animal companions in a new light—less as individuals and more as the interconnected, interdependent multitudes we assuredly are.

The microbes in our bodies are part of our immune systems and protect us from disease. In the deep oceans, mysterious creatures without mouths or guts depend on microbes for all their energy. Bacteria provide squid with invisibility cloaks, help beetles to bring down forests, and allow worms to cause diseases that afflict millions of people.

Many people think of microbes as germs to be eradicated, but those that live with us—the microbiome—build our bodies, protect our health, shape our identities, and grant us incredible abilities. In this astonishing book, Ed Yong takes us on a grand tour through our microbial partners, and introduces us to the scientists on the front lines of discovery. It will change both our view of nature and our sense of where we belong in it.

"[Mr. Quammen] is not just among our best science writers but among our best writers, period." —Dwight Garner, New York Times

The next big human pandemic—the next disease cataclysm, perhaps on the scale of AIDS or the 1918 influenza—is likely to be caused by a new virus coming to humans from wildlife. Experts call such an event “spillover” and they warn us to brace ourselves. David Quammen has tracked this subject from the jungles of Central Africa, the rooftops of Bangladesh, and the caves of southern China to the laboratories where researchers work in space suits to study lethal viruses. He illuminates the dynamics of Ebola, SARS, bird flu, Lyme disease, and other emerging threats and tells the story of AIDS and its origins as it has never before been told. Spillover reads like a mystery tale, full of mayhem and clues and questions. When the Next Big One arrives, what will it look like? From which innocent host animal will it emerge? Will we be ready?

The 1964 murder of a nationally known cancer researcher sets the stage for this gripping exposé of medical professionals enmeshed in covert government operations over the course of three decades. Following a trail of police records, FBI files, cancer statistics, and medical journals, this revealing book presents evidence of a web of medical secret-keeping that began with the handling of evidence in the JFK assassination and continued apace, sweeping doctors into coverups of cancer outbreaks, contaminated polio vaccine, the arrival of the AIDS virus, and biological weapon research using infected monkeys.

The fun, fast, portable way to review microbiology and infectious diseases Market: Medical Students (18,750); Physician Assistant Students (3,000); Nurse Practitioner Programs Great review tool for the boards and course exams Every card includes a board-style clinical vignette Format allows students to compare and contrast diseases 220 High Yield Cards

Kenneth D. Somers, Ph.D. Eastern Virginia Medical School, Norfolk, VA, and Stephen Morse, Center for Infectious Diseases, Center of Disease Control, Atlanta GA

★★★★★LEARNING STARTS WITH VIEWING THE WORLD DIFFERENTLY. ★★★★★

Knowledge flow- A mobile learning platform provides Apps and Books.

Knowledge flow provides learning book of Basics of Microbiology. This book is for all science students and professional across the world. Microbiology is the microscopic study of micro-organism like bacteria, viruses and protozoa. To understanding better key concepts of microbiology this book of microbiology is very helpful with effective illustrations.

Contents:

1.      Introduction to Microbiology

2.      Morphology of bacteria

3.      Reproduction and Growth

4.      Enzymes and their Regulations

5.      Microbial Metabolism

6.      Bacterial Genetics

7.      Fungi

8.      Algae

9.      Protozoa

10. Bacteriophages

11. Virus

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In this classic bestseller, Paul de Kruif dramatizes the pioneering bacteriological work of such scientists as Leeuwenhoek, Spallanzani, Koch, Pasteur, Reed, and Ehrlich. This seventieth anniversary edition features a new introduction by F. Gonzalez-Crussi.

The 1964 murder of a nationally known cancer researcher sets the stage for this gripping exposé of medical professionals enmeshed in covert government operations over the course of three decades. Following a trail of police records, FBI files, cancer statistics, and medical journals, this revealing book presents evidence of a web of medical secret-keeping that began with the handling of evidence in the JFK assassination and continued apace, sweeping doctors into cover-ups of cancer outbreaks, contaminated polio vaccine, the arrival of the AIDS virus, and biological weapon research using infected monkeys. This new edition includes a foreword from author Jim Marr.

Microbiology is the study of life itself, down to the smallestparticle

Microbiology is a fascinating field that explores life down tothe tiniest level. Did you know that your body contains morebacteria cells than human cells? It's true. Microbes are essentialto our everyday lives, from the food we eat to the very internalsystems that keep us alive. These microbes include bacteria, algae,fungi, viruses, and nematodes. Without microbes, life on Earthwould not survive. It's amazing to think that all life is sodependent on these microscopic creatures, but their impact on ourfuture is even more astonishing. Microbes are the tools that allowus to engineer hardier crops, create better medicines, and fuel ourtechnology in sustainable ways. Microbes may just help us save theworld.

Microbiology For Dummies is your guide to understandingthe fundamentals of this enormously-encompassing field. Whetheryour career plans include microbiology or another science or healthspecialty, you need to understand life at the cellular level beforeyou can understand anything on the macro scale.

Explore the difference between prokaryotic and eukaryoticcellsUnderstand the basics of cell function and metabolismDiscover the differences between pathogenic and symbioticrelationshipsStudy the mechanisms that keep different organisms active andalive

You need to know how cells work, how they get nutrients, and howthey die. You need to know the effects different microbes have ondifferent systems, and how certain microbes are integral toecosystem health. Microbes are literally the foundation of alllife, and they are everywhere. Microbiology For Dummies willhelp you understand them, appreciate them, and use them.

Immunology, 8th Edition makes it easy for you to learn all the basic and clinical concepts you need to know for your courses and USMLEs. This medical textbook’s highly visual, carefully structured approach makes immunology simple to understand and remember. Understand the building blocks of the immune system - cells, organs and major receptor molecules - as well as initiation and actions of the immune response, especially in a clinical context.

Visually grasp and retain difficult concepts easily

thanks to a user-friendly color-coded format, key concept boxes, explanatory diagrams, and over 190 photos to help you visualize tissues and diseases.

Put concepts into practice. "

Critical Thinking Boxes" and 25 online cases encourage you to "think immunologically" while anchoring your understanding of immunology through clinical application.

Gauge your mastery of the material

and build confidence with high-yield style chapter-opening summaries and case-based and USMLE-style questions that provide effective chapter review and quick practice for your exams.

Access the full contents online at www.studentconsult.com

where you'll find the complete text and illustrations, USMLE-style questions, clinical cases, and much more! Get the depth of coverage you need in a smaller, more manageably sized book. Through meticulous editing and reorganization, primary material remains in the book while more specialized and clinical material has been moved online.

Master the most cutting-edge concepts in immunology.

Thorough updates throughout provide the timely knowledge you need ace your exams.

Mims’ Microbiology makes it easy for you to learn the microbiology and basic immunology concepts you need to know for your courses and USMLE. Using a clinically relevant, systems-based approach, this popular medical textbook accessibly explains the microbiology of the agents that cause diseases and the diseases that affect individual organ systems. With lavish illustrations and straightforward, accessible explanations, Mims’ Microbiology makes this complex subject simple to understand and remember.Learn about infections in the context of major body systems and understand why these are environments in which microbes can establish themselves, flourish, and give rise to pathologic changes. This systems-based approach to microbiology employs integrated and case-based teaching that places the "bug parade" into a clinical context.

Grasp and retain vital concepts easily

thanks to a user-friendly color-coded format, succinct text, key concept boxes, and dynamic illustrations.

Effectively review for problem-based courses

with the help of chapter introductions and "Lessons in Microbiology" text boxes that highlight the clinical relevance of the material, offer easy access to key concepts, and provide valuable review tools.

Approach microbiology by body system or by pathogen

through an extensively cross-referenced "Pathogen Review" section.

Access the complete contents online at studentconsult.com

, along with downloadable illustrations...150 multiple choice review questions... "Pathogen Parade"...and many other features to enhance learning and retention. Enhance your learning and absorb complex information in an interactive, dynamic way with Pathogen Parade – a quickly searchable online glossary of viruses, bacteria, and fungi.

Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventive medicine.

A completely re-written chapter on this topic keeps abreast of the very latest findings.

"Here is a volume that should be required reading for policy makers and health professionals." - Kirkus Reviews

After four decades of assuming that the conquest of all infectous diseases was imminent, people on all continents now find themselves besieged by AIDS, drug-resistant tuberculosis, cholera that defies chlorine water treatment, and exotic viruses that can kill in a matter of hours.

Based on extensive interviews with leading experts in virology, molecular biology, disease ecology and medicine, as well as field research in sub-Saharan Africa, Western Europe, Central America and the United States, The Coming Plague takes readers from the savannas of eastern Bolivia to the rain forests of northern Zaire on a harrowing, fifty year journey through our battles with the microbes, and tells us what must be done to prevent the coming plague.

Quickly learn the microbiology fundamentals you need to know with Medical Microbiology, 7th Edition, by Dr. Patrick R. Murray, Dr. Ken S. Rosenthal, and Dr. Michael A. Pfaller. Newly reorganized to correspond with integrated curricula and changing study habits, this practical and manageable text is clearly written and easy to use, presenting clinically relevant information about microbes and their diseases in a succinct and engaging manner. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Master the essentials of medical microbiology, including basic principles, immunology, laboratory diagnosis, bacteriology, virology, mycology, and parasitology.Progress logically through consistently formatted chapters that examine etiology, epidemiology, disease presentation, host defenses, identification, diagnosis, prevention, and control for each microbe.Grasp complex material quickly with summary tables and text boxes that emphasize essential concepts and issues.Learn the most up-to-date and relevant information in medical microbiology.Study efficiently thanks to a reorganized format that places review chapters at the beginning of each section and review questions at the end of each chapter.Focus on clinical relevance with new interactive case presentations to introduce each of the microbial pathogens that illustrate the epidemiology, diagnosis, and treatment of infectious diseases.Visualize the clinical presentations of infections with new and updated clinical photographs, images, and illustrations.

Understand the clinically important aspects of microbiology with this full-color review

Includes more than 20 case studies

The twenty-seventh edition of Jawetz, Melnick & Adelberg’s Medical Microbiology delivers a concise, up-to-date overview of the roles microorganisms play in human health and illness. Linking fundamental principles with the diagnosis and treatment of microbial infections, this classic text has been updated throughout to reflect the tremendous expansion of medical knowledge afforded by molecular mechanisms, advances in our understanding of microbial pathogenesis, and the discovery of novel pathogens.

Along with brief descriptions of each organism, you will find vital perspectives on pathogenesis, diagnostic laboratory tests, clinical findings, treatment, and epidemiology. The book also includes an entire chapter of case studies that focuses on differential diagnosis and management of microbial infections.

Here’s why Jawetz, Melnick & Adelberg’s Medical Microbiology is essential for USMLE review:

650+ USMLE-style review questions 300+ informative tables and illustrations 23 case studies to sharpen you differential diagnosis and management skills An easy-to-access list of medically important microorganisms Coverage that reflects the latest techniques in laboratory and diagnostic technologies Full-color images and micrographs Chapter-ending summaries Chapter concept checks

Jawetz, Melnick & Adelberg’s Medical Microbiology introduces you to basic clinical microbiology through the fields of bacteriology, virology, mycology, and parasitology, giving you a thorough yet understandable review of the discipline.

Mycotic diseases are gaining importance because of the increase in opportunistic fungal infections in patients whose immune systems are compromised. The identification of fungi isolated from clinical material has posed a variety of problems to many laboratories because of lack of expertise and experience, especially in the identification of recently emerged rare fungi that had not been previously reported. A Guide to the Study of Basic Medical Mycology offers an overview of the basic characteristics of fungi frequently isolated from clinical specimens. This comprehensive guide, developed by authors Kee Peng Ng, Tuck Soon Soo-Hoo, and Shiang Ling Na from the Department of Medical Microbiology, University Malaya Medical Centre, Malaysia, details the macro- and microscopic features of each fungus through graphics and illustrations. Including specimens not often found in all teaching modules, A Guide to the Study of Basic Medical Mycology serves to help medical students identify and learn to deal with clinically important fungi and fungal pathogens.

A brilliant, cutting-edge exploration of the dramatic rise of allergic and autoimmune diseases and the controversial, potentially groundbreaking therapies that scientists are developing to correct these disorders

Whether it is asthma, food or pollen allergies, type-1 diabetes, lupus, multiple sclerosis, or Crohn’s disease, everyone knows someone who suffers from an allergic or autoimmune disorder. And if it appears that the prevalence of these maladies has increased recently, that’s because it has—to levels never before seen in human history. These days no fewer than one in five—and likely more—Americans suffers from one of these ailments. We seem newly, and bafflingly, vulnerable to immune system malfunction. Why? Science writer Moises Velasquez-Manoff explains the latest thinking about this problem and explores the remarkable new treatments in the works.

In the past 150 years, improved sanitation, water treatment, and the advent of vaccines and antibiotics have saved countless lives, nearly eradicating diseases that had plagued humanity for millennia. But now, a growing body of evidence suggests that the very steps we took to combat infections also eliminated organisms that kept our bodies in balance. The idea that we have systematically cleaned ourselves to illness challenges deeply entrenched notions about the value of societal hygiene and the harmful nature of microbes. Yet scientists investigating the rampant immune dysfunction in the developed world have inevitably arrived at this conclusion. To address this global “epidemic of absence,” they must restore the human ecosystem.

This groundbreaking book explores the promising but controversial “worm therapy”—deliberate infection with parasitic worms—in development to treat autoimmune disease. It explains why farmers’ children so rarely get hay fever, why allergy is less prevalent in former Eastern Bloc countries, and how one cancer-causing bacterium may be good for us. It probes the link between autism and a dysfunctional immune system. It investigates the newly apparent fetal origins of allergic disease—that a mother’s inflammatory response imprints on her unborn child, tipping the scales toward allergy. In the future, preventive treatment—something as simple as a probiotic—will necessarily begin before birth.

An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results.

An Epidemic of Absence considers the critical immune stimuli we inadvertently lost as we modernized, and the modern ills we may be able to correct by restoring them. At stake is nothing less than our health, and that of our loved ones. Researchers, meanwhile, have the good fortune of living through a paradigm shift, one of those occasional moments in the progress of science when a radically new way of thinking emerges, shakes things up, and suggests new avenues of treatment. You’ll discover that you’re not you at all, but a bustling collection of organisms, an ecosystem whose preservation and integrity require the utmost attention and care.

Imagine that we had some way to look directly at the molecules in a living organism. An x-ray microscope would do the trick, or since we’re dreaming, perhaps an Asimov-style nanosubmarine (unfortunately, neither is currently feasible). Think of the wonders we could witness firsthand: antibodies atta- ing a virus, electrical signals racing down nerve fibers, proteins building new strands of DNA. Many of the questions puzzling the current cadre of sci- tists would be answered at a glance. But the nanoscale world of molecules is separated from our everyday world of experience by a daunting million-fold difference in size, so the world of molecules is completely invisible. I created the illustrations in this book to help bridge this gulf and allow us to see the molecular structure of cells, if not directly, then in an artistic rendition. I have included two types of illustrations with this goal in mind: watercolor paintings which magnify a small portion of a living cell by one million times, showing the arrangement of molecules inside, and comput- generated pictures, which show the atomic details of individual molecules. In this second edition of The Machinery of Life, these illustrations are presented in full color, and they incorporate many of the exciting scientific advances of the 15 years since the first edition.

Microbiology, the branch of biology that studies microorganisms and their effects on humans, is a key part of medical training curriculum. Written by a top professor of microbiology and an experienced science writer, this book is a basic microbiology course that can be understood by anyone, including medical students, profesisonals wanting to bone up of the subjects, and laypersons wanting to know about the topic. Prepared by a top professor of microbiology and an experienced popular science writer. Almost every student enrolled in medical school, nursing, dentistry, pharmacology, and veterinary medicine must take microbiology. Includes coverage on microbes and their relationship with each other, the body's immune system, infectious diseases, biotechnology, and bioterrorism.

Viruses are disarmingly small and simple. None the less, the smallpox virus killed over 300 million people in the 20th century prior to its eradication in 1980. The AIDS virus, HIV, is now the single most common cause of death in Africa. In recent years, the outbreaks of several lethal viruses such as Ebola and hanta virus have caused great public concern. In her fascinating and vividly written book, Dorothy Crawford describes all aspects of the natural history of these deadly parasites, explaining how they differ from other microorganisms. She looks at the havoc viruses have caused in the past, where they have come from, and the detective work involved in uncovering them. Finally, she considers whether a new virus could potentially wipe out the human race. This is an informative and highly readable book, which will be read by all those seeking a deeper understanding of these minute but remarkably efficient killers.

Making Peace with Microbes

Public sanitation and antibiotic drugs have brought about historic increases in the human life span; they have also unintentionally produced new health crises by disrupting the intimate, age-old balance between humans and the microorganisms that inhabit our bodies and our environment. As a result, antibiotic resistance now ranks among the gravest medical problems of modern times. Good Germs, Bad Germs addresses not only this issue but also what has become known as the "hygiene hypothesis"— an argument that links the over-sanitation of modern life to now-epidemic increases in immune and other disorders. In telling the story of what went terribly wrong in our war on germs, Jessica Snyder Sachs explores our emerging understanding of the symbiotic relationship between the human body and its resident microbes—which outnumber its human cells by a factor of nine to one! The book also offers a hopeful look into a future in which antibiotics will be designed and used more wisely, and beyond that, to a day when we may replace antibacterial drugs and cleansers with bacterial ones—each custom-designed for maximum health benefits.

Get the Big Picture of Medical Microbiology-and zero-in on what your really need to know to ace the course and board exams and prepare for clinical rotations!

Medical Microbiology: The Big Picture is a different kind of resource. With an emphasis on what you “need to know” versus “what's nice to know,” and featuring 300 full-color illustrations, it offers a focused, streamlined overview of clinical microbiology and immunology. You'll find a succinct, user-friendly presentation designed to make even the most complex concepts understandable in a short amount of time.

With just the right balance of information to give you the edge at exam time, Medical Microbiology: The Big Picture features:

A “Big Picture” perspective on precisely what you need to know Clinically oriented coverage of infections of the central nervous system, eyes and ears, respiratory tract, gastrointestinal tract, hematopoietic/lymphoreticular system, bone and joints, and more 300 labeled and fully-explained full-color illustrations Numerous summary tables and figures Key concepts at the end of each chapter 100 USMLE-type questions, answers, and explanations to help you prepare for the exams

Tough Test Questions? Missed Lectures? Not Enough Time?

Fortunately for you, there's Schaum's Outlines. More than 40 million students have trusted Schaum's to help them succeed in the classroom and on exams. Schaum's is the key to faster learning and higher grades in every subject. Each Outline presents all the essential course information in an easy-to-follow, topic-by-topic format. You also get hundreds of examples, solved problems, and practice exercises to test your skills.

This Schaum's Outline gives you:

Practice problems with full explanations that reinforce knowledge Coverage of the most up-to-date developments in your course field In-depth review of practices and applications

Fully compatible with your classroom text, Schaum's highlights all the important facts you need to know. Use Schaum's to shorten your study time-and get your best test scores!

Schaum's Outlines-Problem Solved.

The study of viruses necessarily involves dissecting the intimate details of cellular pathways. Viruses have often been employed as tools in studying cellular pathways, as was done by early retrovirologists such as Peyton Rous in attempting to understand the mechanism of cellular transformation and oncogenesis. On the other side of the coin, virologists seek to de?ne those cellular elements interacting intimatelywiththeir virus ofinterestinorder to better understand viral replication itself, and in some cases to develop antiviral strategies. It is in the intersection of virology and cell biology that many of us ?nd the most rewarding aspects of our research. When a new discovery yields insights into basic cellular mechanisms and presents new targets for int- vention to ?ght a serious pathogen, the impact can be high and the excitement intense. HIV has been no exception to the rule that viruses reveal many basic aspects of cellular biology. In recent years, in part because of the importance of HIV as a major cause of human suffering, numerous cellular processes have been elucidated through work on processes or proteins of this human retrovirus. The excitement in this ?eld is especially well illustrated by the discovery of new innate means of resisting viral replication, such as the work on APOBEC3G, TRIM5a, and BST-2/ tetherin presented in this volume.

In recent years, malaria has emerged as a cause célèbre for voguish philanthropists. Bill Gates, Bono, and Laura Bush are only a few of the personalities who have lent their names—and opened their pocketbooks—in hopes of curing the disease. Still, in a time when every emergent disease inspires waves of panic, why aren't we doing more to eradicate one of our oldest foes? And how does a parasitic disease that we've known how to prevent for more than a century still infect 500 million people every year, killing nearly 1 million of them?

In The Fever, the journalist Sonia Shah sets out to answer these questions, delivering a timely, inquisitive chronicle of the illness and its influence on human lives. Through the centuries, she finds, we've invested our hopes in a panoply of drugs and technologies, and invariably those hopes have been dashed. From the settling of the New World to the construction of the Panama Canal, through wars and the advances of the Industrial Revolution, Shah tracks malaria's jagged ascent and the tragedies in its wake, revealing a parasite every bit as persistent as the insects that carry it. With distinguished prose and original reporting from Panama, Malawi, Cameroon, India, and elsewhere, The Fever captures the curiously fascinating, devastating history of this long-standing thorn in the side of humanity.

A Best Book of the YearSeed Magazine • Granta Magazine • The Plain-DealerIn this fascinating and utterly engaging book, Carl Zimmer traces E. coli's pivotal role in the history of biology, from the discovery of DNA to the latest advances in biotechnology. He reveals the many surprising and alarming parallels between E. coli's life and our own. And he describes how E. coli changes in real time, revealing billions of years of history encoded within its genome. E. coli is also the most engineered species on Earth, and as scientists retool this microbe to produce life-saving drugs and clean fuel, they are discovering just how far the definition of life can be stretched.


From the Trade Paperback edition.

Reflecting the current approach to joint postgraduate training programmes in infectious diseases (ID) and microbiology, the Oxford Handbook of Infectious Diseases and Microbiology takes an integrated approach to both subjects. It covers the basic principles of bacteriology and virology, along with specific guidance on individual diseases and conditions, all in the accessible Oxford Medical Handbook style. Practical and comprehensive, this handbook includes coverage of national and international guidelines, together with information on topical issues such as bioterrorism and preventative medicine. Fully reviewed by specialist senior readers, and with useful links to up-to-date clinical information and online resources, this is an important addition to the Oxford Medical Handbook Series.

Hepatitis A virus (HAV) is responsible for around half of the total number of hepatitis infections diagnosed worldwide. HAV infection is mainly propagated via the fecal-oral route, and as a consequence of globalization, transnational outbreaks of foodborne infections are reported with increasing frequency. Therefore, in this review, state-of-the-art information on the molecular procedures for HAV detection in food, and the efficacy of common food manufacturing processes are compiled. The purpose of this Brief is to consolidate basic information on various aspects of HAV and to provide a guideline for its prevention and control across the food supply chain from pre-harvest to manufacturing. ​

Histology and Cell Biology: An Introduction to Pathology uses a wealth of vivid, full-color images to help you master histology and cell biology. Dr. Abraham L. Kierszenbaum presents an integrated approach that correlates normal histology with cellular and molecular biology, pathology, and clinical medicine throughout the text. A unique pictorial approach—through illustrative diagrams, photomicrographs, and pathology photographs—paired with bolded words, key clinical terms in red, and clinical boxes and "Essential Concepts" boxes that summarize important facts give you everything you need to prepare for your course exams as well as the USMLE Step 1.Access to studentconsult.com, with USMLE-style multiple-choice review questions, downloadable images, and online only references.

Easily find and cross-reference information through a detailed table of contents that highlights clinical examples in red.

Review material quickly using pedagogical features, such as Essential Concept boxes, bolded words, and key clinical terms marked in red, that emphasize key details and reinforce your learning.

Integrate cell biology and histology with pathology thanks to vivid descriptive illustrations that compare micrographs with diagrams and pathological images.

Apply the latest developments in pathology through updated text and new illustrations that emphasize appropriate correlations.

Expand your understanding of clinical applications with additional clinical case boxes that focus on applying cell and molecular biology to clinical conditions.

Effectively review concepts and reinforce your learning using new Concept Map flow charts that provide a framework to illustrate the integration of cell-tissue-structure-function within a clinical-pathology context.

The groundbreaking science behind the surprising source of good health

Stanford University’s Justin and Erica Sonnenburg are pioneers in the most exciting and potentially transformative field in the entire realm of human health and wellness, the study of the relationship between our bodies and the trillions of organisms representing thousands of species to which our bodies play host, the microbes that we collectively call the microbiota. The microbiota interacts with our bodies in a number of powerful ways; the Sonnenburgs argue that it determines in no small part whether we’re sick or healthy, fit or obese, sunny or moody. The microbiota has always been with us, and in fact has coevolved with humans, entwining its functions with ours so deeply, the Sonnenburgs show us, humans are really composite organisms having both microbial and human parts. But now, they argue, because of changes to diet, antibiotic over-use, and over-sterilization, our gut microbiota is facing a “mass extinction event,” which is causing our bodies to go haywire, and may be behind the mysterious spike in some of our most troubling modern afflictions, from food allergies to autism, cancer to depression. It doesn’t have to be this way.

The Good Gut offers a new plan for health that focuses on how to nourish your microbiota, including recipes and a menu plan. In this groundbreaking work, the Sonnenburgs show how we can keep our microbiota off the endangered species list and how we can strengthen the community that inhabits our gut and thereby improve our own health. The answer is unique for each of us, and it changes as you age.

In this important and timely investigation, the Sonnenburgs look at safe alternatives to antibiotics; dietary and lifestyle choices to encourage microbial health; the management of the aging microbiota; and the nourishment of your own individual microbiome.

Caring for our gut microbes may be the most important health choice we can make.


From the Hardcover edition.

In recent years, the field of pharmaceutical microbiology has experienced numerous technological advances, accompanied by the publication of new and harmonized compendial methods. It is therefore imperative for those who are responsible for monitoring the microbial quality of pharmaceutical/biopharmaceutical products to keep abreast of the latest changes. Microbial Limit and Bioburden Tests: Validation Approaches and Global Requirements guides readers through the various microbiological methods listed in the compendia with easy-to-follow diagrams and approaches to validations of such test methodologies.

Includes New and Updated Material

Now in its second edition, this work is the culmination of research and discussions with technical experts, as well as USP and FDA representatives on various topics of interest to the pharmaceutical microbiologist and those responsible for the microbial quality of products, materials, equipment, and manufacturing facilities. New in this edition is an entire chapter dedicated to the topic of biofilms and their impact on pharmaceutical and biopharmaceutical operations. The subject of rapid methods in microbiology has been expanded and includes a discussion on the validation of alternative microbiological methods and a case study on microbial identification in support of a product contamination investigation.

Substantially updated and revised, this book assists readers in understanding the fundamental issues associated with pharmaceutical microbiology and provides them with tools to create effective microbial contamination control and microbial testing programs for the areas under their responsibility.

The new edition of Instant Notes in Molecular Biology has been revised and updated to include information on micro RNAs, RNA inhibition, functional genomics, proteomics, imaging, stem cells and bioinformatics. Written in an accessible style, the book will be a highly useful tool for studying molecular biology.

Research Paper (undergraduate) from the year 2011 in the subject Biology - Micro- and Molecular Biology, grade: A, Indian Institute of Science, course: Research Project - Microbe Fuel Cells, language: English, abstract: Biogeochemical cycling through microbial succession in Winogradsky columns generates electricity. Here we use all electricals tools possible to harness this electricity and power Light Emitting Diodes for a year or more. The setup, biochemical mechanisms are analysed.

“Engrossing … [An] expedition through the hidden and sometimes horrifying microbial domain.” —Wall Street Journal

“Fascinating—and full of the kind of factoids you can't wait to share.” —Scientific American
 
Parasites can live only inside another animal and, as Kathleen McAuliffe reveals, these tiny organisms have many evolutionary motives for manipulating the behavior of their hosts. With astonishing precision, parasites can coax rats to approach cats, spiders to transform the patterns of their webs, and fish to draw the attention of birds that then swoop down to feast on them. We humans are hardly immune to their influence. Organisms we pick up from our own pets are strongly suspected of changing our personality traits and contributing to recklessness and impulsivity—even suicide. Germs that cause colds and the flu may alter our behavior even before symptoms become apparent.
 
Parasites influence our species on the cultural level, too. Drawing on a huge body of research, McAuliffe argues that our dread of contamination is an evolved defense against parasites. The horror and revulsion we are programmed to feel when we come in contact with people who appear diseased or dirty helped pave the way for civilization, but may also be the basis for major divisions in societies that persist to this day. This Is Your Brain on Parasites is both a journey into cutting-edge science and a revelatory examination of what it means to be human.
 
“If you’ve ever doubted the power of microbes to shape society and offer us a grander view of life, read on and find yourself duly impressed.” —Heather Havrilesky, Bookforum 

Antimicrobial resistance can develop in any type of microbe (germ). Microbes can develop resistance to specific medicines. A common misconception is that a person’s body becomes resistant to specific drugs. However, it is microbes, not people that become resistant to the drugs. Drug resistance happens when microbes develop ways to survive the use of medicines meant to kill or weaken them. If a microbe is resistant to many drugs, treating the infections it causes can become difficult or even impossible. Someone with an infection that is resistant to a certain medicine can pass that resistant infection to another person. In this way, a hard-to-treat illness can be spread from person to person. In some cases, the illness can lead to serious disability or even death.

This comprehensive, up-to-date volume aims to define issues and potential solutions to the challenges of antimicrobial resistance. The chapter authors are leading international experts on antimicrobial resistance among a variety of bacteria (Streptococcus pneumoniae, enteroccoci, staphylococci, gram-negative bacilli, mycobacteria species) viruses (HIV, herpesviruses), and fungi (Candida species, fusarium etc.). The chapters will explore the molecular mechanisms of drug resistance, the immunology and epidemiology of resistance strains, clinical implications and implications on research and lack thereof, and prevention and future directions. This volume will also describe the steps that researchers are taking to develop molecular methods for detecting resistance; develop drugs and other means to deal with newly-resistant organisms. A special chapter to address the issues on strategies to limit antimicrobial resistance propagation will be included in this volume.

Whisky: Technology, Production and Marketing explains in technical terms, the science and technology of producing whisky, combined with information from industry experts on successfully marketing the product. World experts in Scotch whisky provide detailed insight into whisky production from the processing of raw materials, to the fermentation, distillation, maturation, blending, production of co-products and quality testing, as well as important information on the methodology used for packaging and marketing whisky in the twenty-first century. No other book covers the entire whisky process from raw material to delivery to the market in such a comprehensive manner and with such a high level of technical detail.

* Only available work to cover the entire whisky process from raw material to delivery to the market in such a comprehensive manner
* Includes a chapter on marketing and selling whisky
* Foreword written by Alan Rutherford, former Chairman and Managing Director of United Malt and Grain Distillers Ltd.

Pharmaceutical Microbiology: Essentials for Quality Assurance and Quality Control presents that latest information on protecting pharmaceutical and healthcare products from spoilage by microorganisms, and protecting patients and consumers. With both sterile and non-sterile products, the effects can range from discoloration to the potential for fatality.

The book provides an overview of the function of the pharmaceutical microbiologist and what they need to know, from regulatory filing and GMP, to laboratory design and management, and compendia tests and risk assessment tools and techniques. These key aspects are discussed through a series of dedicated chapters, with topics covering auditing, validation, data analysis, bioburden, toxins, microbial identification, culture media, and contamination control.

Contains the applications of pharmaceutical microbiology in sterile and non-sterile productsPresents the practical aspects of pharmaceutical microbiology testingProvides contamination control risks and remediation strategies, along with rapid microbiological methodsIncludes bioburden, endotoxin, and specific microbial risksHighlights relevant case studies and risk assessment scenarios

The increased emphasis on food safety during the past two decades has decreased the emphasis on the loss of food through spoilage, particularly in developed co- tries where food is more abundant. In these countries spoilage is a commercial issue that affects the pro?t or loss of producers and manufacturers. In lesser developed countries spoilage continues to be a major concern. The amount of food lost to spoilage is not known. As will be evident in this text, stability and the type of spoilage are in?uenced by the inherent properties of the food and many other factors. During the Second World War a major effort was given to developing the te- nologies needed to ship foods to different regions of the world without spoilage. The food was essential to the military and to populations in countries that could not provide for themselves. Since then, progress has been made in improved product formulations, processing, packaging, and distribution systems. New products have continued to evolve, but for many new perishable foods product stability continues to be a limiting factor. Many new products have failed to reach the marketplace because of spoilage issues.

Low water activity (aw) and dried foods such as dried dairy and meat products, grain-based and dried ready-to-eat cereal products, powdered infant formula, peanut and nut pastes, as well as flours and meals have increasingly been associated with product recalls and foodborne outbreaks due to contamination by pathogens such as Salmonella spp. and enterohemorrhagic E. coli. In particular, recent foodborne outbreaks and product recalls related to Salmonella-contaminated spices have raised the level of public health concern for spices as agents of foodborne illnesses. Presently, most spices are grown outside the U.S., mainly in 8 countries: India, Indonesia, China, Brazil, Peru, Madagascar, Mexico and Vietnam. Many of these countries are under-developed and spices are harvested and stored with little heed to sanitation. The FDA has regulatory oversight of spices in the United States; however, the agency’s control is largely limited to enforcing regulatory compliance through sampling and testing only after imported foodstuffs have crossed the U.S. border. Unfortunately, statistical sampling plans are inefficient tools for ensuring total food safety. As a result, the development and use of decontamination treatments is key.

This book provides an understanding of the microbial challenges to the safety of low aw foods, and a historic backdrop to the paradigm shift now highlighting low aw foods as vehicles for foodborne pathogens. Up-to-date facts and figures of foodborne illness outbreaks and product recalls are included. Special attention is given to the uncanny ability of Salmonella to persist under dry conditions in food processing plants and foods. A section is dedicated specifically to processing plant investigations, providing practical approaches to determining sources of persistent bacterial strains in the industrial food processing environment. Readers are guided through dry cleaning, wet cleaning and alternatives to processing plant hygiene and sanitation. Separate chapters are devoted to low aw food commodities of interest including spices, dried dairy-based products, low aw meat products, dried ready-to-eat cereal products, powdered infant formula, nuts and nut pastes, flours and meals, chocolate and confectionary, dried teas and herbs, and pet foods. The book provides regulatory testing guidelines and recommendations as well as guidance through methodological and sampling challenges to testing spices and low aw foods for the presence of foodborne pathogens. Chapters also address decontamination processes for low aw foods, including heat, steam, irradiation, microwave, and alternative energy-based treatments.

Biotechnology is one of the major technologies of the twenty-first century. Its wide-ranging, multi-disciplinary activities include recombinant DNA techniques, cloning and the application of microbiology to the production of goods from bread to antibiotics. In this new edition of the textbook Basic Biotechnology, biology and bioprocessing topics are uniquely combined to provide a complete overview of biotechnology. The fundamental principles that underpin all biotechnology are explained and a full range of examples are discussed to show how these principles are applied; from starting substrate to final product. A distinctive feature of this text are the discussions of the public perception of biotechnology and the business of biotechnology, which set the science in a broader context. This comprehensive textbook is essential reading for all students of biotechnology and applied microbiology, and for researchers in biotechnology industries.

An extraordinary array of infectious agents affects humans; from worms, arthopods, and fungi to bacteria, viruses, and prions. In this compendium of the curious and fascinating organisms that cause disease, including Legionnaire's disease, mumps, CJD, and chlamydia, David I. Grove provides a lively, fact-filled account of the nature of each organism, their life cycle, the ingenious ways in which they infect humans, and the human stories behind their discovery.

Lecture Notes: Tropical Medicine is a comprehensiveintroduction to tropical medicine. The new edition is in fullcolour throughout with over 40 colour images integrated with thetext. There is a new chapter on syndromes of undernutrition (inboth children and adults), and the section on non-communicablediseases has been extended to include mental health problems in thetropics.

The core information is presented in a clear and concise way,with extensive use of diagrams, algorithms, tables and boxes. Allchapters have been updated to reflect current best practice and theannotated bibliographies and lists of web-based resources have beenextended. The chapters on HIV, tuberculosis and malaria haveundergone particularly extensive revision, reflecting rapid changesin these areas since the last edition.

Lecture Notes: Tropical Medicine is particularlyaimed at postgraduate doctors attending tropical medicine courses,as well as medical students taking a tropical medicine electiveperiod. It will also be useful to a wide range of other healthprofessionals involved with medicine in the tropics, or importedtropical disease.

In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals.

Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as adjuvant, mercury, aluminum and autoimmunity. The following section reviews literature on vaccines that have induced autoimmune conditions such as MMR and HBV, among others. The final section covers diseases in which vaccines were known to be the solicitor – for instance, systemic lupus erythematosus – and whether it can be induced by vaccines for MMR, HBV, HCV, and others.

Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.

Maurice Hilleman's mother died a day after he was born and his twin sister stillborn. As an adult, he said that he felt he had escaped an appointment with death. He made it his life's work to see that others could do the same. Born into the life of a Montana chicken farmer, Hilleman ran off to the University of Chicago to become a microbiologist, and eventually joined Merck, the pharmaceutical company, to pursue his goal of eliminating childhood disease. Chief among his accomplishments are nine vaccines that practically every child gets, rendering formerly dread diseases—including often devastating ones such as mumps and rubella—practically toothless and nearly forgotten; his measles vaccine alone saves several million lives every year.

Vaccinated is not a biography; Hilleman's experience forms the basis for a rich and lively narrative of two hundred years of medical history, ranging across the globe and throughout time to take in a cast of hundreds, all caught up, intentionally or otherwise, in the story of vaccines. It is an inspiring and triumphant tale, but one with a cautionary aspect, as vaccines come under assault from people blaming vaccines for autism and worse. Paul Offit clearly and compellingly rebuts those arguments, and, by demonstrating how much the work of Hilleman and others has gained for humanity, shows us how much we have to lose.

2012 PROSE Award, Clinical Medicine: Honorable Mention

The vast majority of medically important pathogens infect their host across a body surface such as the skin, or across a mucosal tissue such as the respiratory tract or intestines, as these sites are the ones exposed to the external environment. By focusing on immunity at mucosal and body surfaces this book presents a fresh, new approach to the teaching of immunology.

After an introduction to the basic structure of the immune system, the book looks at two important families of signalling molecules: cytokines and chemokines, before covering the workings of the mucosal immune system. It continues by examining immunity against the four major groups of pathogens - viruses, bacteria, fungi and parasites, and concludes by looking at disorders of the immune system, mucosal tumour immunology and the process of vaccination.

A fresh, new approach to the subject focusing on mucosal and body surfaces.Describes the mucosal immune systems of the gastrointestinal, respiratory and urogenital tracts, as well as the skin.Details the important roles of cytokines and chemokines in an immune response.Separate chapters devoted to immunity against viruses, bacteria, fungi and parasites.Includes chapter summaries, boxes with topics of special interest and an extensive glossary.Clearly written and well- illustrated in full colour throughout.

Students across a range of disciplines, including biology, biochemistry, biomedicine, medicine and veterinary sciences, will find this book invaluable, both as an introduction to basic immunology and as a guide to mucosal immune defence mechanisms.

With 30 revised and updated chapters, the new edition of this classic text brings benefits to professors and students alike who will find new sections on proteobacteria, bottled water, food sanitizers (eletrolyzed oxidating water, ozone, chlorine, activin, chitosans, endolysins, etc.), bicontrol, biosensors quorum sensing, molecular genetic methods of analysis, food safety objectives, noroviruses, and prions. The book builds on the trusted and established sections on food preservation by modified atmosphere, high pressure and pulsed electric field processing, food-borne pathogens, food regulations, fresh-cut produce, new food products, and risk assessment and analysis. In-depth references, appendixes, illustrations, index and thorough updating of taxonomies make this an essential for every food scientist.

Medical microbiology concerns the nature, distribution and activities of microbes and how they impact on health and wellbeing, most particularly as agents of infection. Infections remain a major global cause of mortality and in most hospitals around one in ten of those admitted will suffer from an infection acquired during their stay. The evolution of microbes presents a massive challenge to modern medicine and public health. The constant changes in viruses such as influenza, HIV, tuberculosis, malaria and SARS demand vigilance and insight into the underlying process.

Building on the huge success of previous editions, Medical Microbiology 18/e will inform and inspire a new generation of readers. Now fully revised and updated, initial sections cover the basic biology of microbes, infection and immunity and are followed by a systematic review of infective agents, their associated diseases and their control. A final integrating section addresses the essential principles of diagnosis, treatment and management. An unrivalled collection of international contributors continues to ensure the relevance of the book worldwide and complementary access to the complete online version on Student Consult further enhances the learning experience.

Medical Microbiology

is explicitly geared to clinical practice and is an ideal textbook for medical and biomedical students and specialist trainees. It will also prove invaluable to medical laboratory scientists and all other busy professionals who require a clear, current and most trusted guide to this fascinating field.

For almost four billion years, microbes had the primordial oceans all to themselves. The stewards of Earth, these organisms transformed the chemistry of our planet to make it habitable for plants, animals, and us. Life's Engines takes readers deep into the microscopic world to explore how these marvelous creatures made life on Earth possible—and how human life today would cease to exist without them.

Paul Falkowski looks "under the hood" of microbes to find the engines of life, the actual working parts that do the biochemical heavy lifting for every living organism on Earth. With insight and humor, he explains how these miniature engines are built—and how they have been appropriated by and assembled like Lego sets within every creature that walks, swims, or flies. Falkowski shows how evolution works to maintain this core machinery of life, and how we and other animals are veritable conglomerations of microbes.

A vibrantly entertaining book about the microbes that support our very existence, Life's Engines will inspire wonder about these elegantly complex nanomachines that have driven life since its origin. It also issues a timely warning about the dangers of tinkering with that machinery to make it more "efficient" at meeting the ever-growing demands of humans in the coming century.

Suppose someone claimed that we are not running out of petroleum? Or that life on Earth began below the surface of our planet? Or that oil and gas are not "fossil fuels"? Or that if we find extraterrestrial life it is likely to be within, not on, other planets? You might expect to hear statements like these from an author of science fiction. But what if they came from a renowned physicist, an indisputably brilliant scientist who has been called "one of the world's most original minds"? In the The Deep Hot Biosphere, Thomas Gold sets forth truly controversial and astonishing theories about where oil and gas come from, and how they acquire their organic "signatures." The conclusions he reaches in this book might be at first difficult to believe, but they are supported by a growing body of evidence, and by the indisputabel stature and seriousness Gold brings to any scientific enterprise. In this book we see a brilliant and boldly orginal thinker, increasingly a rarity in modern science, as he developes a revolutionary new view about the fundamental workings of our planet. Thomas Gold is a member of the National Academy of Sciences, a Fellow of the Royal Society, and an Emertius Professor at Cornell University. Regarded as one of the most creative and wide-ranging scientists of his generation, he has taughtat Cambridge University and Harvard, and for 20 years was the Director of the Cornell Center for Radiophysics and Space Research.

Primer to The Immune Response is an invaluable resource for college students, university undergraduates and students in medicine and other health professions who need a concise but complete and understandable introduction to immunology.

This book is written in the same engaging conversational style as the published reference book The Immune Response: Basic and Clinical Principles and conveys the same fascinating appeal of immunology. The authors bring clarity, readability and continuity of voice to an audience that requires only a brief survey of the most fundamental concepts in basic and clinical immunology. Primer to The Immune Response is beautifully illustrated with over 200 superb figures and 36 full-color plates, and further enhanced by the inclusion of 60 tables and 6 Appendices. Included with purchase of the book is website access to a captivating “Immunomovie" that truly brings the immune response to pathogens to life. This new and unique immunology textbook compactly but elegantly covers both basic and clinical principles.

Over 200 elegant 2-4 color illustrations36 full-color plates of basic and clinical items of interestTake-home message and “Did You Get It? self-test quiz at the end of each chapter6 Appendices that provide topic enrichment60-minute "Immunomovie" illustrating the immune response to bacterial, viral and parasitic infections

The past year has been one of viral panic—panic about viruses, that is. Through headlines, public health warnings, and at least one homemade hazmat suit, we were reminded of the powerful force of viruses. They are the smallest living things known to science, yet they can hold the entire planet in their sway.
A Planet of Viruses is Carl Zimmer’s eye-opening look at the hidden world of viruses. Zimmer, the popular science writer and author of National Geographic’s award-winning blog The Loom, has updated this edition to include the stories of new outbreaks, such as Ebola, MERS, and chikungunya virus; new scientific discoveries, such as a hundred-million-year-old virus that infected the common ancestor of armadillos, elephants, and humans; and new findings that show why climate change may lead to even deadlier outbreaks. Zimmer’s lucid explanations and fascinating stories demonstrate how deeply humans and viruses are intertwined. Viruses helped give rise to the first life-forms, are responsible for many of our most devastating diseases, and will continue to control our fate for centuries. Thoroughly readable, and as reassuring as it is frightening, A Planet of Viruses is a fascinating tour of a formidable hidden world.

Known world-wide as the standard introductory text to thisimportant and exciting area, the sixth edition of Gene Cloningand DNA Analysis addresses new and growing areas of researchwhilst retaining the philosophy of the previous editions. Assumingthe reader has little prior knowledge of the subject, itsimportance, the principles of the techniques used and theirapplications are all carefully laid out, with over 250 clearlypresented four-colour illustrations.

In addition to a number of informative changes to the textthroughout the book, the final four chapters have beensignificantly updated and extended to reflect the striking advancesmade in recent years in the applications of gene cloning and DNAanalysis in biotechnology.

Gene Cloning and DNA Analysis remains an essentialintroductory text to a wide range of biological sciences students;including genetics and genomics, molecular biology, biochemistry,immunology and applied biology. It is also a perfect introductorytext for any professional needing to learn the basics of thesubject. All libraries in universities where medical, life andbiological sciences are studied and taught should have copiesavailable on their shelves.

"… the book content is elegantly illustrated and wellorganized in clear-cut chapters and subsections… there is aFurther Reading section after each chapter that contains severalkey references… What is extremely useful, almost everyreference is furnished with the short but distinct author'sremark."
–Journal of Heredity, 2007 (on the previousedition)

The second edition of Microorganisms in Foods 6: Microbial Ecology of Food Commodities is intended for those primarily in applied aspects of food microbiology. For 17 commodity areas it describes the initial microbial flora and the prevalence of pathogens, the microbiological consequences of processing, typical spoilage patterns, episodes implicating those commodities with foodborne illness, and measures to control pathogens and limit spoilage. The control measures are presented in a standardized format in line with international developments in risk management. A comprehensive index has also been added.

Microorganisms in Foods 5, 7, and the second edition of Microorganisms in Foods 6 are for anyone using microbiological testing and/or engaged in setting Microbiological Criteria, whether for the purpose of Governmental Food Inspection and Control or in Industry, and for those identifying the most effective use of microbiological testing in the food chain. The contents are essential reading for food processors, food microbiologists, food technologists, veterinarians, public health workers and regulatory officials. For students in Food Science and Technology they offer a wealth of information on Food Microbiology and Food Safety Management, with many references for further study.

The information has been prepared by the International Commission on Microbiological Specifications for Foods (ICMSF). The ICMSF was formed in response to the need for internationally acceptable and authoritative decisions on microbiological limits for foods moving in international commerce. Currently the membership consists of eighteen food microbiologists from eleven countries, drawn from governmental laboratories in public health, agriculture, and food technology, from universities and from the food industry.

"This book contains extremely detailed and informative contenton structure and function of ligands, receptors, and signallingintermediates plus interactions … the extent of detail andappropriate referencing is impressive." –MicrobiologyToday, July 2009

"A very well-written book suitable for use as a reference ortextbook for an undergraduate subject in cell signalling. Forresearchers interested in the molecular basis of cell signallingand how aberrant regulation of cell signalling proteins causesdiseases, this is an excellent resource of biochemical andstructural information." –Australian Biochemist, August2009

"From basics to details, this is an elegantly written andcarefully edited book. The chapters on cell cycle control andoncogenesis are particularly fascinating and valuable to biomedicalresearch. This is the book to have if you are interested inmolecular mechanisms of signal transduction. It is a greatintroduction to the literature that will be welcomed by studentsand experts alike." –Doody's, January 2009

This text is a concise and accessible introduction to thedynamic but complex field of signal transduction. Rather thansimply cataloguing all signalling molecules and delineating everyknown pathway, this book aims to break signalling down into commonelements and activities – the ‘nuts and bolts’ ofcellular information exchange.

With an emphasis on clarity of presentation throughout, the bookteaches the basic principles focusing on a mature core ofknowledge, providing students with a foundation of learning in thiscomplex and potentially confusing subject. It also addresses theissue of variation in the numbering of key amino acids as well asfeaturing interaction with RasMol software, and exercises to aidunderstanding.

An accessible introduction to the complex field of cellsignallingInteracts with RasMol software – freely downloadable forviewing structures in 3DIncludes exercises and clear instructions in the use ofRasMolWell illustrated in full colour throughout

Structure and Function in Cell Signalling is aninvaluable resource to students across a range of life sciencedegree programmes including biochemistry, cell and molecularbiology, physiology, biomedicine and oncology. This book provides aclear, accessible introduction to this rapidly expanding field.

This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.

Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.

Completely updated, the 2e presents recent advances driven by new information on the genetics and genomics of the pathogenProvides the latest information concerning the epidemiology, diagnosis, treatment and prevention of toxoplasmosisOffers a single-source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians, and food scientists

An extraordinary array of infectious agents affects humans; from worms, arthopods, and fungi to bacteria, viruses, and prions. In this compendium of the curious and fascinating organisms that cause disease, including Legionnaire's disease, mumps, CJD, and chlamydia, David I. Grove provides a lively, fact-filled account of the nature of each organism, their life cycle, the ingenious ways in which they infect humans, and the human stories behind their discovery.

The accelerated globalization of the food supply, coupled with toughening government standards, is putting global food production, distribution, and retail industries under a high-intensity spotlight. High publicity cases about foodborne illnesses over recent years have heightened public awareness of food safety issues, and momentum has been building to find new ways to detect and identify foodborne pathogens and eliminate food-related infections and intoxications. This extensively revised Third Edition covers how the incidence and impact of foodborne diseases is determined, foodborne intoxications with an introduction that notes common features among these diseases and control measures that are applicable before and after the basic foodstuff is harvested.

* A summary of the foods most association with human infections
* A discussion of the principles of laboratory detection of the agent considering the advantages and disadvantages of various procedure
* A 'historical to present-day' section
* A description of the infection in humans and animals, including reservoirs and the mode of transmission

The present book presents a comprehensive review of Human Herpesvirus-6 (HHV-6) infects up to 90% of the world’s population and can cause potentially life-threatening diseases. Clinicians typically do not search for HHV-6, and if they do, they will find only few laboratories providing the necessary diagnostic tests that can differentiate between active and latent infection. Adding to this problem is that scientists still disagree about whether serological or molecular assays will be the best diagnostic test, yet there is no disagreement about the inadequacy of many of the currently existing assays. Consequently, our knowledge of etiology and pathogenesis of HHV-6 associated diseases can only come from the combined efforts of clinicians, virologists, molecular biologists and pathologists. It is the prime task of this book to summarize the status quo of HHV-6 research and to further stimulate such a collaboration. It will be a valuable reference for both clinical and basic scientists including epidemiologists, virologists, practicing clinicians and infectiologists, pathologists and essentially all scientists entering the field of herpes virus research.

Bioconjugate Techniques, 2nd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or cross linking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers.

*A one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab
*Step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates
*More than 600 figures that visually describe the complex reactions associated with the synthesis of bioconjugates
*Includes entirely new chapters on the latest areas in the field of bioconjugation as follows:
Microparticles and nanoparticles
Silane coupling agents
Dendrimers and dendrons
Chemoselective ligation
Quantum dots
Lanthanide chelates
Cyanine dyes
Discrete PEG compounds
Buckyballs,fullerenes, and carbon nanotubes
Mass tags and isotope tags
Bioconjugation in the study of protein interactions

This volume provides comprehensive up-to-date descriptions of the principles and practices of in situ chemical oxidation (ISCO) for groundwater remediation based on a decade of intensive research, development, and demonstrations, and lessons learned from commercial field applications.

Today’s synthetic biologists are in the early stages of engineering living cells to help treat diseases, sense toxic compounds in the environment, and produce valuable drugs. With this manual, you can be part of it. Based on the BioBuilder curriculum, this valuable book provides open-access, modular, hands-on lessons in synthetic biology for secondary and post-secondary classrooms and laboratories. It also serves as an introduction to the field for science and engineering enthusiasts.

Developed at MIT in collaboration with award-winning high school teachers, BioBuilder teaches the foundational ideas of the emerging synthetic biology field, as well as key aspects of biological engineering that researchers are exploring in labs throughout the world. These lessons will empower teachers and students to explore and be part of solving persistent real-world challenges.

Learn the fundamentals of biodesign and DNA engineeringExplore important ethical issues raised by examples of synthetic biologyInvestigate the BioBuilder labs that probe the design-build-test cycleTest synthetic living systems designed and built by engineersMeasure several variants of an enzyme-generating genetic circuitModel "bacterial photography" that changes a strain’s light sensitivityBuild living systems to produce purple or green pigmentOptimize baker’s yeast to produce ?-carotene

When a parasite invades an ant, does the ant behave like other ants? Maybe not-and if it doesn't, who, if anyone, benefits from the altered behaviors? The parasite? The ant? Parasites and the Behavior of Animals shows that parasite-induced behavioral alterations are more common than we might realize, and it places these alterations in an evolutionary and ecological context. Emphasizing eukaryotic parasites, the book examines the adaptive nature of behavioral changes associated with parasitism, exploring the effects of these changes on parasite transmission, parasite avoidance, and the fitness of both host and parasite. The behavioral changes and their effects are not always straightforward. To the extent that virulence, for instance, is linked to parasite transmission, the evolutionary interests of parasite and host will diverge, and the current winner of the contest to maximize reproductive rates may not be clear, or, for that matter, inevitable. Nonetheless, by affecting susceptibility, host/parasite lifespan and fecundity, and transmission itself, host behavior influences parameters that are basic to our comprehension of how parasites invade host populations, and fundamentally, how parasites evolve. Such an understanding is important for a wide range of scientists, from ecologists and parasitologists to evolutionary, conservation and behavioral biologists: The behavioral alterations that parasites induce can subtly and profoundly affect the distribution and abundance of animals.