“Artfully envisions a breathtakingly better world.” —Los Angeles Times
“Elaborate, smart and persuasive.” —The Boston Globe
“A pleasure to read.” —The Wall Street Journal
One of CBS News’s Best Fall Books of 2005 • Among St Louis Post-Dispatch’s Best Nonfiction Books of 2005 • One of Amazon.com’s Best Science Books of 2005
A radical and optimistic view of the future course of human development from the bestselling author of How to Create a Mind and The Age of Spiritual Machines who Bill Gates calls “the best person I know at predicting the future of artificial intelligence”
For over three decades, Ray Kurzweil has been one of the most respected and provocative advocates of the role of technology in our future. In his classic The Age of Spiritual Machines, he argued that computers would soon rival the full range of human intelligence at its best. Now he examines the next step in this inexorable evolutionary process: the union of human and machine, in which the knowledge and skills embedded in our brains will be combined with the vastly greater capacity, speed, and knowledge-sharing ability of our creations.
From the Trade Paperback edition.
A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging.
Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach.
In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers, and will help address the world’s hunger crisis. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences—to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans.
Writing with fellow researcher Samuel Sternberg, Doudna shares the thrilling story of her discovery, and passionately argues that enormous responsibility comes with the ability to rewrite the code of life. With CRISPR, she shows, we have effectively taken control of evolution. What will we do with this unfathomable power?
Transhumanism is a movement pushing the limits of our bodies—our capabilities, intelligence, and lifespans—in the hopes that, through technology, we can become something better than ourselves. It has found support among Silicon Valley billionaires and some of the world’s biggest businesses.
In To Be a Machine, journalist Mark O'Connell explores the staggering possibilities and moral quandaries that present themselves when you of think of your body as a device. He visits the world's foremost cryonics facility to witness how some have chosen to forestall death. He discovers an underground collective of biohackers, implanting electronics under their skin to enhance their senses. He meets a team of scientists urgently investigating how to protect mankind from artificial superintelligence.
Where is our obsession with technology leading us? What does the rise of AI mean not just for our offices and homes, but for our humanity? Could the technologies we create to help us eventually bring us to harm? Addressing these questions, O'Connell presents a profound, provocative, often laugh-out-loud-funny look at an influential movement. In investigating what it means to be a machine, he offers a surprising meditation on what it means to be human.
Longlisted for the PEN/E.O. Wilson Literary Science Writing Award
One of Nature's Summer Book Picks
One of Publishers Weekly's Top Ten Spring 2013 Science Books
For centuries, we've toyed with our creature companions, breeding dogs that herd and hunt, housecats that look like tigers, and teacup pigs that fit snugly in our handbags. But what happens when we take animal alteration a step further, engineering a cat that glows green under ultraviolet light or cloning the beloved family Labrador? Science has given us a whole new toolbox for tinkering with life. How are we using it?
In Frankenstein's Cat, the journalist Emily Anthes takes us from petri dish to pet store as she explores how biotechnology is shaping the future of our furry and feathered friends. As she ventures from bucolic barnyards to a "frozen zoo" where scientists are storing DNA from the planet's most exotic creatures, she discovers how we can use cloning to protect endangered species, craft prosthetics to save injured animals, and employ genetic engineering to supply farms with disease-resistant livestock. Along the way, we meet some of the animals that are ushering in this astonishing age of enhancement, including sensor-wearing seals, cyborg beetles, a bionic bulldog, and the world's first cloned cat.
Through her encounters with scientists, conservationists, ethicists, and entrepreneurs, Anthes reveals that while some of our interventions may be trivial (behold: the GloFish), others could improve the lives of many species-including our own. So what does biotechnology really mean for the world's wild things? And what do our brave new beasts tell us about ourselves?
With keen insight and her trademark spunk, Anthes highlights both the peril and the promise of our scientific superpowers, taking us on an adventure into a world where our grandest science fiction fantasies are fast becoming reality.
But what about the average person? How will the Singularity affect our daily lives—our jobs, our families, and our wealth?
Singularity Rising: Surviving and Thriving in a Smarter, Richer, and More Dangerous World focuses on the implications of a future society faced with an abundance of human and artificial intelligence. James D. Miller, an economics professor and popular speaker on the Singularity, reveals how natural selection has been increasing human intelligence over the past few thousand years and speculates on how intelligence enhancements will shape civilization over the next forty years.
Miller considers several possible scenarios in this coming singularity:
• A merger of man and machine making society fantastically wealthy and nearly immortal
• Competition with billions of cheap AIs drive human wages to almost nothing while making investors rich
• Businesses rethink investment decisions to take into account an expected future period of intense creative destruction
• Inequality drops worldwide as technologies mitigate the cognitive cost of living in impoverished environments
• Drugs designed to fight Alzheimer's disease and keep soldiers alert on battlefields have the fortunate side effect of increasing all of their users’ IQs, which, in turn, adds a percentage points to worldwide economic growth
Singularity Rising offers predictions about the economic implications for a future of widely expanding intelligence and practical career and investment advice on flourishing on the way to the Singularity.
From the Trade Paperback edition.
In March 2010, the Affordable Care Act was signed into law. It was the most extensive reform of America's health care system since at least the creation of Medicare in 1965, and maybe ever. The ACA was controversial and highly political, and the law faced legal challenges reaching all the way to the Supreme Court; it even precipitated a government shutdown. It was a signature piece of legislation for President Obama's first term, and also a ball and chain for his second.
Ezekiel J. Emanuel, a professor of medical ethics and health policy at the University of Pennsylvania who also served as a special adviser to the White House on health care reform, has written a brilliant diagnostic explanation of why health care in America has become such a divisive social issue, how money and medicine have their own—quite distinct—American story, and why reform has bedeviled presidents of the left and right for more than one hundred years.
Emanuel also explains exactly how the ACA reforms are reshaping the health care system now. He forecasts the future, identifying six mega trends in health that will determine the market for health care to 2020 and beyond. His predictions are bold, provocative, and uniquely well-informed. Health care—one of America's largest employment sectors, with an economy the size of the GDP of France—has never had a more comprehensive or authoritative interpreter.
Following on from the Industrial or machine age, the space age and the digital age, the Augmented Age will be based on four key disruptive themes—Artificial Intelligence, Experience Design, Smart Infrastructure, and HealthTech. Historically the previous ‘ages’ bought significant disruption and changes, but on a net basis jobs were created, wealth was enhanced, and the health and security of society improved. What will the Augmented Age bring? Will robots take our jobs, and AI’s subsume us as inferior intelligences, or will this usher in a new age of abundance?
Augmented is a book on future history, but more than that, it is a story about how you will live your life in a world that will change more in the next 20 years than it has in the last 250 years. Are you ready to adapt? Because if history proves anything, you don't have much of a choice.
Eve Herold's Beyond Human examines the medical technologies taking shape at the nexus of computing, microelectronics, engineering, nanotechnology, cellular and gene therapies, and robotics. These technologies will dramatically transform our lives and allow us to live for hundreds of years. Yet, with these blessings come complicated practical and ethical issues, some of which we can predict, but many we cannot.
Beyond Human taps the minds of doctors, scientists, and engineers engaged in developing a host of new technologies while telling the stories of some of the patients courageously testing the radical new treatments about to come into the market.
Beyond Human asks the difficult questions of the scientists and bioethicists who seek to ensure that as our bodies and brains become ever more artificial, we hold onto our humanity. In this new world, will everyone have access to technological miracles, or will we end up living in a world of radical disparities? How will society accommodate life spans that extend into hundreds of years? Will we and our descendants be able to bring about the dream of a future liberated by technology, or will we end up merely serving the machines and devices that keep us healthy, smart, young, and alive?
Genetically modified organisms (GMOs) including plants and the foods made from them, are a hot topic of debate today, but soon related technology could go much further and literally change what it means to be human. Scientists are on the verge of being able to create people who are GMOs.
Should they do it? Could we become a healthier and ''better'' species or might eugenics go viral leading to a real, new world of genetic dystopia? GMO Sapiens tackles such questions by taking a fresh look at the cutting-edge biotech discoveries that have made genetically modified people possible.
Bioengineering, genomics, synthetic biology, and stem cells are changing sci-fi into reality before our eyes. This book will capture your imagination with its clear, approachable writing style. It will draw you into the fascinating discussion of the life-changing science of human genetic modification.Contents:An Introduction to Playing GodThe Birth and Explosive Growth of GMOsHuman CloningBuild-a-Baby Better via GeneticsDIY Guide to Creating GMO SapiensEugenics and TranshumanismCultural Views on Human Genetic ModificationGMO Sapiens Today and Tomorrow
Readership: Undergraduate biology majors, graduate biology majors, non-experts interested in GMOs, biologists and teenagers interested in cloning and human genetic modification.
Key Features:Books on this hot new topic of creating GMO people are rare, tend to be out-of-date, or have narrow topic rangesThe goal of this book is to educate and entertain an educated lay audience about human genetic modificationKeywords:GMO;Genetically Modified Organism;GMO Sapien;Cloning;Genomics;Designer Babies;Mitochondrial Transfer;Stem Cells;Infertility
"What I find troubling, exciting but scary, is that I find myself agreeing with an undertone, I do not support human germline genetic modification but with all the new information and perspectives available to me I have found myself questioning my own views and will be watching any developments with a fascinated interest I would rather not admit to."The NODE
In Regenesis, Harvard biologist George Church and science writer Ed Regis explore the possibilities—and perils—of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies—far from the out-of-control nightmare depicted in science fiction—have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.
Robin reports that, following its long history of manufacturing hazardous chemicals and lethal herbicides, Monsanto is now marketing itself as a “life sciences” company, seemingly convinced about the virtues of sustainable development. However, Monsanto now controls the majority of the yield of the world’s genetically modified corn and soy—ingredients found in more than 95 percent of American households—and its alarming legal and political tactics to maintain this monopoly are the subject of worldwide concern.
Released to great acclaim and controversy in France, throughout Europe, and in Latin America alongside the documentary film of the same name, The World According to Monsanto is sure to change the way we think about food safety and the corporate control of our food supply.
In this magisterial look at some twenty-five years of scientific and social development, Sheila Jasanoff compares the politics and policy of the life sciences in Britain, Germany, the United States, and in the European Union as a whole. She shows how public and private actors in each setting evaluated new manifestations of biotechnology and tried to reassure themselves about their safety.
Three main themes emerge. First, core concepts of democratic theory, such as citizenship, deliberation, and accountability, cannot be understood satisfactorily without taking on board the politics of science and technology. Second, in all three countries, policies for the life sciences have been incorporated into "nation-building" projects that seek to reimagine what the nation stands for. Third, political culture influences democratic politics, and it works through the institutionalized ways in which citizens understand and evaluate public knowledge. These three aspects of contemporary politics, Jasanoff argues, help account not only for policy divergences but also for the perceived legitimacy of state actions.
Casey’s research into the Sun’s activity, which began almost a decade ago, resulted in discovery of a solar cycle that is now reversing from its global warming phase to that of dangerous global cooling for the next thirty years or more. This new cold climate will dramatically impact the world’s citizens. In Dark Winter, he provides evidence of the following:
• The end of global warming
• The beginning of a “solar hibernation,” a historic reduction in the energy output of the Sun
• A long-term drop in Earth’s temperatures
• The start of the next climate change to decades of dangerously cold weather
• The high probability of record earthquakes and volcanic eruptions
A sobering look at Earth’s future, Dark Winter predicts worldwide, crop- destroying cold; food shortages and riots in the United States and abroad; significant global loss of life; and social, political, and economic upheaval.
Bioinformatics For Dummies is packed with valuable information that introduces you to this exciting new discipline. This easy-to-follow guide leads you step by step through every bioinformatics task that can be done over the Internet. Forget long equations, computer-geek gibberish, and installing bulky programs that slow down your computer. You’ll be amazed at all the things you can accomplish just by logging on and following these trusty directions. You get the tools you need to:Analyze all types of sequences Use all types of databases Work with DNA and protein sequences Conduct similarity searches Build a multiple sequence alignment Edit and publish alignments Visualize protein 3-D structures Construct phylogenetic trees
This up-to-date second edition includes newly created and popular databases and Internet programs as well as multiple new genomes. It provides tips for using servers and places to seek resources to find out about what’s going on in the bioinformatics world. Bioinformatics For Dummies will show you how to get the most out of your PC and the right Web tools so you’ll be searching databases and analyzing sequences like a pro!
New to this Edition:Updated and increased coverage of real time PCR and the mathematics used to measure gene expressionMore sample problems in every chapter for readers to practice concepts
Weaving together vivid storytelling and groundbreaking science, The Body Builders explores the current revolution in human augmentation, which is helping us to triumph over the limitations and constraints we have long accepted as an inevitable part of being human
For millennia, humans have tried—and often failed—to master nature and transcend our limits. But this has started to change. The new scientific frontier is the human body: the greatest engineers of our generation have turned their sights inward, and their work is beginning to revolutionize mankind.
In The Body Builders, Adam Piore takes us on a fascinating journey into the field of bioengineering—which can be used to reverse engineer, rebuild, and augment human beings—and paints a vivid portrait of the people at its center. Chronicling the ways new technology has retooled our physical expectations and mental processes, Piore visits people who have regrown parts of their fingers and legs in the wake of terrible traumas, tries on a muscle suit that allows him to lift ninety pounds with his fingertips, dips into the race to create “Viagra for the brain,” and shadows the doctors trying to give mute patients the ability to communicate telepathically.
As science continues to lay bare the mysteries of human performance, it is helping us to see—and exist—above our expectations. The Body Builders will take readers beyond the headlines and the hype to introduce them to the inner workings and the outer reaches of our bodies and minds, and explore how new developments are changing, and will forever change, what is possible for humankind.
An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.
Now internationally acclaimed award-winning journalist David Walsh gives an explosive account of the shadow side of professional sports. In this electrifying, controversial, and scrupulously documented exposé, Walsh explores the many facets of the cyclist doping scandals in the United States and abroad. He examines how performance-enhancing drugs can infiltrate a premier sports event–and why athletes succumb to the pressure to use them. In researching this book, Walsh conducted hundreds of hours of interviews with key figures in international cycling, doctors, and other insiders, including Emma O’Reilly, Armstrong’s longtime massage therapist; former U.S. Postal Service cycling team doctor Prentice Steffen; cycling legend Greg LeMond; and former teammates of both Landis and Armstrong.
Central to the story is Lance Armstrong’s relentless, all-consuming drive to be the best. Also essential to this narrative is Floyd Landis, the unassuming, sympathetic hero who was the first winner of the Tour de France after Lance–and the first ever to face the threat of having his title revoked. More than anything else, this book will ignite anew the debate about whether there is room in the current sports culture for athletes who compete honestly, whether sports can be saved from a scandal as widespread as this, and what changes will have to be made.
With a compelling narrative and revelations that will stun, enlighten, and haunt readers, David Walsh addresses numerous questions that arise in that crucial space where sports meet the larger American culture.
From the Hardcover edition.
Filling the void, Biotechnology Operations: Principles and Practices reflects this integrative philosophy, serving as a practical guide for students, professionals, or anyone else with interests in the biotech industry. Although many books emphasize specific technical aspects of biotech, this is perhaps the first to integrate essential concepts of product development and scientific and management skills with the seven functional areas of biotechnology:
Biomanufacturing Clinical trials Nonclinical studies Project management Quality assurance Quality control Regulatory affairs
A practical roadmap to optimizing biotechnology operations, this reference illustrates how to use specific product planning, design, and project management processes to seamlessly merge plans and efforts in the key functional areas. Applying lessons learned throughout the nascent history of biotech, author Michael Roy highlights developmental principles that could bring future products to market more safely and efficiently. Drawing from his experiences working in industry and teaching a graduate course at the University of Wisconsin, this hotly anticipated book clarifies basic methodologies and practices to help reduce risks and resolve problems as future technological discoveries are developed into tangible products.
Any farmer you talk to could tell you that we've been playing with the genetic makeup of our food for millennia, carefully coaxing nature to do our bidding. The practice officially dates back to Gregor Mendel -- who was not a renowned scientist, but a 19th century Augustinian monk. Mendel spent many hours toiling in his garden, testing and cultivating more than 28,000 pea plants, selectively determining very specific characteristics of the peas that were produced, ultimately giving birth to the idea of heredity -- and the now very common practice of artificially modifying our food.
But as science takes the helm, steering common field practices into the laboratory, the world is now keenly aware of how adept we have become at tinkering with nature --which in turn has produced a variety of questions. Are genetically modified foods really safe? Will the foods ultimately make us sick, perhaps in ways we can't even imagine? Isn't it genuinely dangerous to change the nature of nature itself?
Nina Fedoroff, a leading geneticist and recognized expert in biotechnology, answers these questions, and more. Addressing the fear and mistrust that is rapidly spreading, Federoff and her co-author, science writer Nancy Brown, weave a narrative rich in history, technology, and science to dispel myths and misunderstandings.
In the end, Fedoroff arues, plant biotechnology can help us to become better stewards of the earth while permitting us to feed ourselves and generations of children to come. Indeed, this new approach to agriculture holds the promise of being the most environmentally conservative way to increase our food supply.
A radical, how-to guide for using exponential technologies, moonshot thinking, and crowd-powered tools, Bold unfolds in three parts. Part One focuses on the exponential technologies that are disrupting today’s Fortune 500 companies and enabling upstart entrepreneurs to go from “I’ve got an idea” to “I run a billion-dollar company” far faster than ever before. The authors provide exceptional insight into the power of 3D printing, artificial intelligence, robotics, networks and sensors, and synthetic biology. Part Two draws on insights from billionaires such as Larry Page, Elon Musk, Richard Branson, and Jeff Bezos and reveals their entrepreneurial secrets. Finally, Bold closes with a look at the best practices that allow anyone to leverage today’s hyper-connected crowd like never before. Here, the authors teach how to design and use incentive competitions, launch million-dollar crowdfunding campaigns to tap into tens of billions of dollars of capital, and finally how to build communities—armies of exponentially enabled individuals willing and able to help today’s entrepreneurs make their boldest dreams come true.
Winner of a CHOICE Outstanding Academic Book Award 2011
"... takes the revolutionary concepts and techniques that have traditionally been fodder for graduate study and makes them accessible for all. ... outstanding introduction to the broad field of nanotechnology provides a solid foundation for further study. ... Highly recommended."
—N.M. Fahrenkopf, University at Albany, CHOICE Magazine 2011
Give your students the thorough grounding they need in nanotechnology. A rigorous yet accessible treatment of one of the world’s fastest growing fields, Nanotechnology: Understanding Small Systems, Third Edition provides an accessible introduction without sacrificing rigorous scientific details. This approach makes the subject matter accessible to students from a variety of disciplines. Building on the foundation set by the first two bestselling editions, this third edition maintains the features that made previous editions popular with students and professors alike.
See What’s New in the Third Edition:
Updated coverage of the eight main facets of nanotechnology Expanded treatment of health/environmental ramifications of nanomaterials Comparison of macroscale systems to those at the nanoscale, showing how scale phenomena affects behavior New chapter on nanomedicine New problems, examples, and an exhaustive nanotech glossary
Filled with real-world examples and original illustrations, the presentation makes the material fun and engaging. The systems-based approach gives students the tools to create systems with unique functions and characteristics. Fitting neatly between popular science books and high-level treatises, the book works from the ground up to provide a gateway into an exciting and rapidly evolving area of science.
Internationally best-selling poet Christian Bök has spent more than ten years writing what promises to be the first example of "living poetry." After successfully demonstrating his concept in a colony of E. coli, Bök is on the verge of enciphering a beautiful, anomalous poem into the genome of an unkillable bacterium (Deinococcus radiodurans), which can, in turn, "read" his text, responding to it by manufacturing a viable, benign protein, whose sequence of amino acids enciphers yet another poem. The engineered organism might conceivably serve as a post-apocalyptic archive, capable of outlasting our civilization.
Book I of The Xenotext constitutes a kind of "demonic grimoire," providing a scientific framework for the project with a series of poems, texts, and illustrations. A Virgilian welcome to the Inferno, Book I is the "orphic" volume in a diptych, addressing the pastoral heritage of poets, who have sought to supplant nature in both beauty and terror. The book sets the conceptual groundwork for the second volume, which will document the experiment itself. The Xenotext is experimental poetry in the truest sense of the term.
Christian Bök is the author of Crystallography (1994) and Eunoia (2001), which won the Griffin Poetry Prize. He teaches at the University of Calgary in Alberta, Canada.
"Tell me and I ́ll forget; Show me and I may remember; Involve me and I ́ll understand”
Avoiding the hype of popular science and the pessimism of most social science, Nikolas Rose analyzes contemporary molecular biopolitics, examining developments in genomics, neuroscience, pharmacology, and psychopharmacology and the ways they have affected racial politics, crime control, and psychiatry. Rose analyzes the transformation of biomedicine from the practice of healing to the government of life; the new emphasis on treating disease susceptibilities rather than disease; the shift in our understanding of the patient; the emergence of new forms of medical activism; the rise of biocapital; and the mutations in biopower. He concludes that these developments have profound consequences for who we think we are, and who we want to be.
The layout of the book enables those readers with limited time to read the chapter summaries, while providing more detail and full references for those who require them. At 164 pages of paperback size, this new condensed version is shorter and more accessible than the authors’ 330-page report by the same name, which has been downloaded over half a million times.
The book shows that conventional breeding continues to outstrip GM in developing crops that deliver high yields, better nutrition, and tolerance to extreme weather conditions and poor soils. In agreement with over 400 international experts who co-authored a UN and World Bank-sponsored report on the future of farming, the authors conclude that modern agroecology, rather than GM, is the best path for feeding the world’s current and future populations in a safe and sustainable way.
Outlining fundamental concepts vital to graduate students and practitioners entering the biotech industry in management or in any entrepreneurial capacity, Biotechnology Entrepreneurship and Management provides tested strategies and hard-won lessons from a leading board of educators and practitioners.
It provides a ‘how-to’ for individuals training at any level for the biotech industry, from macro to micro. Coverage ranges from the initial challenge of translating a technology idea into a working business case, through securing angel investment, and in managing all aspects of the result: business valuation, business development, partnering, biological manufacturing, FDA approvals and regulatory requirements.
An engaging and user-friendly style is complemented by diverse diagrams, graphics and business flow charts with decision trees to support effective management and decision making.Provides tested strategies and lessons in an engaging and user-friendly style supplemented by tailored pedagogy, training tips and overview sidebarsCase studies are interspersed throughout each chapter to support key concepts and best practices.Enhanced by use of numerous detailed graphics, tables and flow charts
R. Ford Denison shows how both biotechnology and traditional plant breeding can use Darwinian insights to identify promising routes for crop genetic improvement and avoid costly dead ends. Denison explains why plant traits that have been genetically optimized by individual selection--such as photosynthesis and drought tolerance--are bad candidates for genetic improvement. Traits like plant height and leaf angle, which determine the collective performance of plant communities, offer more room for improvement. Agriculturalists can also benefit from more sophisticated comparisons among natural communities and from the study of wild species in the landscapes where they evolved.
Darwinian Agriculture reveals why it is sometimes better to slow or even reverse evolutionary trends when they are inconsistent with our present goals, and how we can glean new ideas from natural selection's marvelous innovations in wild species.
Proven in the classroom and requiring only a background in high school math, Mathematics for the Life Sciences doesn't just focus on calculus as do most other textbooks on the subject. It covers deterministic methods and those that incorporate uncertainty, problems in discrete and continuous time, probability, graphing and data analysis, matrix modeling, difference equations, differential equations, and much more. The book uses MATLAB throughout, explaining how to use it, write code, and connect models to data in examples chosen from across the life sciences.Provides undergraduate life science students with a succinct overview of major mathematical concepts that are essential for modern biologyCovers all the major quantitative concepts that national reports have identified as the ideal components of an entry-level course for life science studentsProvides good background for the MCAT, which now includes data-based and statistical reasoningExplicitly links data and math modelingIncludes end-of-chapter homework problems, end-of-unit student projects, and select answers to homework problemsUses MATLAB throughout, and MATLAB m-files with an R supplement are available onlinePrepares students to read with comprehension the growing quantitative literature across the life sciencesA solutions manual for professors and an illustration package is available
This book provides an understanding of the microbial challenges to the safety of low aw foods, and a historic backdrop to the paradigm shift now highlighting low aw foods as vehicles for foodborne pathogens. Up-to-date facts and figures of foodborne illness outbreaks and product recalls are included. Special attention is given to the uncanny ability of Salmonella to persist under dry conditions in food processing plants and foods. A section is dedicated specifically to processing plant investigations, providing practical approaches to determining sources of persistent bacterial strains in the industrial food processing environment. Readers are guided through dry cleaning, wet cleaning and alternatives to processing plant hygiene and sanitation. Separate chapters are devoted to low aw food commodities of interest including spices, dried dairy-based products, low aw meat products, dried ready-to-eat cereal products, powdered infant formula, nuts and nut pastes, flours and meals, chocolate and confectionary, dried teas and herbs, and pet foods. The book provides regulatory testing guidelines and recommendations as well as guidance through methodological and sampling challenges to testing spices and low aw foods for the presence of foodborne pathogens. Chapters also address decontamination processes for low aw foods, including heat, steam, irradiation, microwave, and alternative energy-based treatments.
The author’s continual participation in FDA QSR inspections and Notified Body ISO audits is reflected in updates to all chapters and appendices of the book, now bursting at the seams with:
New coverage of ISO 9001 and 13485 design control requirements More real-world examples from the medical device industry Additional detail for greater understanding and clarity Fresh templates for practical implementation Extensive references for further study
The book addresses design control elements such as design planning, input, output, review, verification, validation, change, transfer, and history, as well as risk management inclusive of human factors and usability, biocompatibility, the FDA Quality System Inspection Technique (QSIT) for design controls, and medical device regulations and classes in the US, Canada, and Europe.
This new book from the Council for Responsible Genetics gathers the best, most thought-provoking essays by the leading scientists, science writers, and public health advocates. Collectively, they address such questions as:
Are GM foods safe and healthy for us?
Will GM food really solve world hunger?
Who really controls the power structure of food production?
Are GM foods ecologically safe and sustainable?
Why is it so difficult to get GM foods labeled in the US?
What kinds of regulations and policies should be instituted?
How is seed biodiversity, of lack thereof, affecting developing countries?
Should animals be genetically modified for food?
How are other countries handling GM crops?
Ultimately, this definitive book encourages us to think about the social, environmental, and moral ramifications of where this particular branch of biotechnology is taking us, and what we should do about it.
Grace offers a reader-friendly explanation of how we came to where we are--from the coining of the word "cell" in 1665 through Darwin's breakthrough insight on evolution and the unraveling of the DNA helix to the 1997 announcement of the cloning of Dolly the sheep.
This book uses everyday metaphors to help readers understand the genetic code and how it works to produce every form of life. Grace deals frankly with the reality that biotechnology is first and foremost a commercial activity. Focusing on the ethical implications, he looks at the scope of public opinion, the role of the media, the vulnerability of the poor to exploitation, and the problem of patenting life itself.
Grace explores the promises and realities of biotechnology in major arenas:
The human body. The medical industry is today's biggest customer for biotechnology, and Grace presents its application as a continuum from the earliest experiments with skin grafting in the 1800s. He reports on the progress of gene therapy and other medical marvels--yet Grace argues that high-tech medicine does not guarantee longer, healthier lives any more than high-tech weapons guarantee world peace. The farm. Is biotechnology the answer to world hunger or is it self-serving rhetoric from agribusiness? Grace explores the reality between these two points of view through examples, including the controversy over bovine growth hormone, increased use of herbicides and pesticides, and genetic modification of plants. The environment. Biotechnology Unzipped looks at the promise of microbes cleaning up pollutants such as the Exxon Valdez spill. Alternate Selection, Newbridge Science Book Club
At a time when speculative fiction seems less and less far-fetched, Margaret Atwood lends her distinctive voice and singular point of view to the genre in a series of essays that brilliantly illuminates the essential truths about the modern world. This is an exploration of her relationship with the literary form we have come to know as "science fiction,” a relationship that has been lifelong, stretching from her days as a child reader in the 1940s, through her time as a graduate student at Harvard, where she worked on the Victorian ancestor of the form, and continuing as a writer and reviewer. This book brings together her three heretofore unpublished Ellmann Lectures from 2010: "Flying Rabbits," which begins with Atwood's early rabbit superhero creations, and goes on to speculate about masks, capes, weakling alter egos, and Things with Wings; "Burning Bushes," which follows her into Victorian otherlands and beyond; and "Dire Cartographies," which investigates Utopias and Dystopias. In Other Worlds also includes some of Atwood's key reviews and thoughts about the form. Among those writers discussed are Marge Piercy, Rider Haggard, Ursula Le Guin, Ishiguro, Bryher, Huxley, and Jonathan Swift. She elucidates the differences (as she sees them) between "science fiction" proper, and "speculative fiction," as well as between "sword and sorcery/fantasy" and "slipstream fiction." For all readers who have loved The Handmaid's Tale, Oryx and Crake, and The Year of the Flood, In Other Worlds is a must.
Note: The electronic version of this title contains over thirty additional, illuminating eBook-exclusive illustrations by the author.
New material in the third edition covers topics relevant to modern recombinant cell fermentation, mammalian cell culture, and biorefinery, ensuring that the book will remain applicable around the globe. It uniquely demonstrates the relationships between the synthetic processes for small molecules such as active ingredients, drugs and chemicals, and the biotechnology of protein, vaccine, hormone, and antibiotic production. This major revision also includes new material on membrane pervaporation technologies for biofuels and nanofiltration, and recent developments in instrumentation such as optical-based dissolved oxygen probes, capacitance-based culture viability probes, and in situ real-time fermentation monitoring with wireless technology. It addresses topical environmental considerations, including the use of new (bio)technologies to treat and utilize waste streams and produce renewable energy from wastewaters. Options for bioremediation are also explained.Fully updated to cover the latest advances in recombinant cell fermentation, mammalian cell culture and biorefinery, along with developments in instrumentation Industrial contributors from leading global companies, including Merck, Eli Lilly, Amgen, and Bristol-Myers SquibbCovers synthetic processes for both small and large molecules
New to the Second Edition
Completely updated and double the size of its predecessor, this timely second edition replaces the commercial software with the open source R and Bioconductor environments. Fourteen new chapters cover such topics as the basic mechanisms of the cell, reliability and reproducibility issues in DNA microarrays, basic statistics and linear models in R, experiment design, multiple comparisons, quality control, data pre-processing and normalization, Gene Ontology analysis, pathway analysis, and machine learning techniques. Methods are illustrated with toy examples and real data and the R code for all routines is available on an accompanying CD-ROM.
With all the necessary prerequisites included, this best-selling book guides students from very basic notions to advanced analysis techniques in R and Bioconductor. The first half of the text presents an overview of microarrays and the statistical elements that form the building blocks of any data analysis. The second half introduces the techniques most commonly used in the analysis of microarray data.
This book will enable the reader to:
* Specify and design the loop requirements for a plant using PID control
* Identify and apply the essential building blocks in automatic control
* Apply the procedures for open and closed loop tuning
* Tune control loops with significant dead-times
* Demonstrate a clear understanding of analog process control and how to tune analog loops
* Explain concepts used by major manufacturers who use the most up-to-date technology in the process control field
· A practical focus on the optimization of process and plant
· Readers develop professional competencies, not just theoretical knowledge
· Reduce dead-time with loop tuning techniques