Includes perspectives and reviews from recognized experts on nutraceuticals of scientific and public interest!
Recognizing the need to control the balance between environmental stressors and human health, Nutraceuticals in Health and Disease Prevention
presents developing areas of nutraceutical research with studies of effective examples
examines pathology treatments, including effects of S-adenosylmethionine (SAMe) on inflammatory disease and polyphenols on cardiovascular disease
investigates the role and benefits of vitamin E in aging and the antioxidant network
discusses the potency, multiple uses, and metabolic aspects of lipoic (thioctic) acid
reviews the second generation of carotenoid research and the disease prevention properties of lycopene and lutein
considers how polyunsaturated fatty acids (PUFAs) contribute to a healthy diet, from clinical and molecular perspectives
profiles the efficacy, safety, and use of creatine as an anabolic nutraceutical by athletes
analyzes identification methods for optimum delivery of nutrients, illustrated by the example of methyltetrahydrofolate
and much more!
Containing over 1100 valuable literature references, drawings, and tables, Nutraceuticals in Health and Disease Prevention functions as an indispensable reference in the libraries of nutritionists and dietitians, pharmacists, molecular and cell biologists and biochemists, oncologists, endocrinologists, dermatologists, physiologists, epidemiologists, neurochemists, pediatricians, and upper-level undergraduate, graduate, and medical school students in these disciplines.
An essential resource for researchers, students, and professionals in food science and nutrition, gerontology, physiology, pharmacology, and related areas.Health effects of antioxidant nutrientsNutrients of vitamins C and E, selenium, alpha-lipoic acid, coenzyme Q10, carotenoids, and flavonoidsNatural source antioxidants, including pine bark, ginko biloba, wine, herbs,uyaku, and carica papaya
The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Over 450 volumes have been published to date, and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences.Along with companion volume, provides a full overview of techniques necessary to the study of thiol redox in relation to cell signalingGathers tried and tested techniques from global labs, offering both new and tried-and-true methodsRelevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines
Organized into two parts with a total of 18 chapters, this book begins with an introduction to oxidative stress, elucidating specific topics on reactive oxygen species, detoxification system, and nature of oxidative damage. The first part focuses on models used with cells and tissues in the study of oxidative stress, whereas the second part describes the processes elicited by oxidative stress.
The chapters elucidate why studies undertaken to prevent diseases with selenium ended with disappointing outcomes and often with the opposite result, i.e. disease promotion. They show that benefit, failure, or side effects depend on:The chemical form and dose of selenium The selenium status of the individual ingesting selenium The capacity of selenium form to serve as a source for selenoprotein biosynthesis The function of selenoproteins reacting to a change in the selenium status The stage of the disease (mainly cancer) at the time point of intervention The genetic background of individuals to be treated
Bringing together the accumulated evidence regarding selenium biochemistry, the book covers aspects not found in available general monographs. The narrow focus on medical uses of Se helps resolve the present confusion about potential benefits and hazards of selenium in human health. The book gives you a solid scientific basis for optimum use of selenium in preventing or treating human diseases and answering the questions: Why is selenium essential? How much is required? What are the health consequences of low selenium and can selenium reduce cancer risk?
Offering over 4200 contemporary references-2000 more than the previous edition-the Second Edition of the Handbook of Antioxidants is an up-to-the-minute source for nutritionists and dietitians, cell biologists and biochemists, cardiologists, oncologists, dermatologists, and medical students in these disciplines.
This volume presents an extensive collection of new methodologies to aid progress in solving unanswered questions concerning the bioavailability and metabolism of flavonoids and polyphenols, their biochemical and molecular biological effects on cell regulation, and their effects on health. Major topics in this volume include sources, characterization, analytical methods, bioavailability, antioxidant action, and biological activity.
A state-of-the-science compilation, Lipoic Acid follows the history of this potent coenzyme and the latest discoveries regarding the chemistry, biological action, and significance in energy production, antioxidant activity, and health. The book is divided into three sections:
· Section I: Discovery and Molecular Structure reviews the early studies leading to the discovery of alpha-lipoic acid and explains the molecular structure, biosynthesis, and the characterization of lipoic acid and its chemical derivatives.
· Section II: Metabolic Aspects describes in detail the human pharmacokinetics of alpha-lipoic acid including the lipoic acid-derived dehydrogenase complexes and their roles in energy metabolism. It also explains antioxidant activity and redox modulation and how lipoic acid induces Phase II detoxification enzymes through activation of Nrf2-dependent gene expression.
· Section III Clinical Aspects discusses enzyme deficiency disorders and the effects of lipoic acid on insulin. It defines lipoic acid influence on signaling pathways and AMP-activated kinase, and considers the therapeutic implications for treatment of metabolic syndromes and the improvement of mitochondrial function by lipoic acid supplementation.
Contributions from leading international researchers make Lipoic Acid the most comprehensive, up-to-date account of the impact of this potentially key molecule in diminishing the damaging effects of aging and disease.
* Cellular Responses
* Tissues and Organs
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
This is another “must-have volume packed with robust methods from authors around the globe. Researchers interested in the detailed biochemistry of NO and its synthesis will have this indispensable volume on their shelves.
*Essential resource for every laboratory involved in NO-related work
*Gathers tried and tested techniques from global labs which eliminates searching through many different sources and avoids pitfalls so the same mistakes are not made over and over.
* Aids researchers in the design of medically important therapies for heart disease and cancer
*Coenzyme Q: Detection and Quinone Reductases
*Plasma Membrane Quinone Reductases
*Quinones, Cellular Signaling, and Modulation of Gene Expression
Organized into nine chapters, this volume begins with an overview of the contributions to the knowledge of membrane structure based on X-ray diffraction analysis. This text then examines the reactions of chlorophyll in model systems and the luminescence linked with light absorptions, which relate to the early events in photosynthesis. Other chapters relate spectroscopic and EPR measurements to redox changes linked with energy coupling in the mitochondrial electron carriers. This book discusses as well the role of soluble proteins in the energy transfer process of oxidative phosphorylation. The final chapter deals with the chemical and structural properties of the photoreceptors in the visual process.
This book is a valuable resource for biophysicists, physiologists, biologists, biochemists, physical chemists, and research workers.
Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome is designed to encourage the development of evidence-based nutritional and pharmacological therapies that can attenuate the impact of obesity-induced insulin resistance and ensuing metabolic syndrome. The book offers a deep understanding of the molecular mechanisms that underlie the process. Edited by leading authorities on oxidative stress, the book's chapters report on cutting-edge research that explores intracellular events mediating or preventing oxidative stress and pro-inflammatory processes in obesity and type 2 diabetes. It also brings together research on the molecular mechanisms inherent in the progression of metabolic stress, includes phenotypic perspectives, and discusses dietary factors, including the role of micronutrients.
The chapter authors, each a leading expert in his or her field, discuss different components of metabolic stress and obesity and their associations with oxidative stress and inflammation. The book fills a unique role as a base of knowledge for researchers seeking to develop nutritional and or pharmacological therapies, as well as clinicians seeking a better understanding of this increasingly common disease process.
With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:
Electron transport and energy production Mitochondrial biogenesis and dynamics Mitochondrial signaling Apoptosis and autophagy Pharmacology signaling Epigenetic signaling: mitochondrial methylation and acetylation reactions
An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Uses of nutritional interventions to target age-related neuronal and behavioral deficits Effects of various micronutrients on Alzheimer’s disease, including lipoic acid, green tea, and Ginkgo biloba extracts Nutrients specific to essential mitochondrial functions Cognitive and behavioral consequences of iron deficiency with specific emphasis on women of reproductive age Omega-3 fatty acids and their relation to brain function in the elderly Challenges inherent in the development of neuroprotective-neurorescue drugs
This book belongs to the groundbreaking CRC Press Series on Oxidative Stress and Disease. The series now includes more than two dozen volumes that address increasing evidence regarding the multiple ways that oxidative stress initiates and accelerates disease mechanisms. Most importantly, this book, like the series, offers invaluable information regarding nutritional and lifestyle choices, and pharmaceutical interventions that can be employed to prevent, control, and even ameliorate disease processes attributed to oxidative stress.
In this highly readable and provocative book, Dr. Jason Fung sets out an original, robust theory of obesity that provides startling insights into proper nutrition. In addition to his five basic steps, a set of lifelong habits that will improve your health and control your insulin levels, Dr. Fung explains how to use intermittent fasting to break the cycle of insulin resistance and reach a healthy weight—for good.
Testosterone is the most crucial hormone in the male body--and every man's T levels begin a slow, steady decline as he ages. The result? Loss of strength and muscle mass. Poor sugar metabolism. Increased body fat, especially around the waist. Loss of T also affects red blood cell production, vitality, bone density, mental acuity, and sex drive. In short: It slowly chops a man down.
Testosterone Transformation helps a man produce higher levels of T and reverse the downward spiral. By eating the right foods and adopting a new exercise approach, any man at any age can transform his life by starting a positive chain reaction: Raise T levels through the strategies in this book, improve workouts, get stronger, improve workouts even more, get even stronger, and enable the body to use muscle to process sugar--instead of storing it as fat.
Testosterone Transformation is a life-changer: a serious exercise and strategic diet plan that uses the science of a man's own body to help him recharge his sex drive, increase vitality, and reduce health risks across the board.
Are you exhausted all the time, plagued by brain fog, and unable to lose weight? Do you struggle with insomnia, panic attacks, and tremors? But does your doctor insist that your labs are normal, and that you just need to eat less and exercise more? As anyone who has been there knows, nothing is more frustrating, stressful, and emotionally draining than feeling unwell and being told you're fine by the very person who is supposed to heal you.
The truth is, your symptoms could be triggered by a thyroid disorder--the hidden cause behind a wide array of health problems that can threaten to ruin your life. Thyroid dysfunctions like Hashimoto's disease, hypothyroidism, and hyperthyroidism affect at least 20 million Americans and yet conventional medicine frequently misses the diagnosis. The scariest part? Most doctors won't even order thyroid tests unless you specifically ask.
Now, in The Thyroid Connection, Dr. Amy Myers teaches you how to take your health into your own hands. Dr. Myers, originally misdiagnosed herself, understands the struggles of thyroid dysfunction firsthand. Fortunately, she also knows how achievable recovery and well-being are, and just how to get you there. In The Thyroid Connection, you'll discover:
How to work with your doctor to get the correct diagnosisWhat blood tests to ask for, as well as what they meanHow to find the right type and dose of supplemental thyroid hormone for youThe role of gut health, diet, toxins, infections, and stress in thyroid dysfunctionA complete 28-day plan to jumpstart your health and reverse your thyroid symptoms
Complete with advice on diet and nutrition, supplements, exercise, stress relief, and sleep, The Thyroid Connection is the ultimate roadmap back to your happiest, healthiest self.
What Grain Brain did for wheat, this book by a leading peripheral nerve surgeon now does for sugar, revealing how it causes crippling nerve damage throughout the body—in our feet, organs, and brain—why sugar and carbohydrates are harmful to the body's nerves, and how eliminating them can mitigate and even reverse the damage.
If you suffer from ailments your doctors can’t seem to diagnose or help—mysterious rashes, unpredictable digestive problems, debilitating headaches, mood and energy swings, constant tiredness—nerve compression is the likely cause. Sugar Crush exposes the shocking truth about how a diet high in sugar, processed carbohydrates, and wheat compresses and damages the peripheral nerves of the body, leading to pain, numbness, and tingling in the hands and feet, along with a host of related conditions, including migraines, gall bladder disease, and diabetes.
Over the years, Dr. Richard Jacoby has treated thousands of patients with peripheral neuropathy. Now, he shares his insights as well as the story of how he connected the dots to determine how sugar is the common denominator of many chronic diseases. In Sugar Crush, he offers a unique holistic approach to understanding the exacting toll sugar and carbs take on the body. Based on his clinical work, he breaks down his highly effective methods, showing how dietary changes reducing sugar and wheat, coinciding with an increase of good fats, can dramatically help regenerate nerves and rehabilitate their normal function.
Sugar Crush includes a quiz to assess your nerve damage, practical dietary advice, and the latest thinking on ways to prevent and reverse neuropathy. If you have diabetes, this essential guide will help you understand the dangers and give you the tools you need to make a difference beyond your doctor’s prescriptions. If you have the metabolic syndrome or prediabetes, or are just concerned about your health, it will help you reverse and prevent nerve damage.
the drama of the front lines.”
-Richard Danzig, former secretary of the navy
The first major bioterror event in the United States-the anthrax attacks in October 2001-was a clarion call for scientists who work with “hot” agents to find ways of protecting civilian populations against biological weapons. In The Demon in the Freezer, his first nonfiction book since The Hot Zone, a #1 New York Times bestseller, Richard Preston takes us into the heart of Usamriid, the United States Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland, once the headquarters of the U.S. biological weapons program and now the epicenter of national biodefense.
Peter Jahrling, the top scientist at Usamriid, a wry virologist who cut his teeth on Ebola, one of the world’s most lethal emerging viruses, has ORCON security clearance that gives him access to top secret information on bioweapons. His most urgent priority is to develop a drug that will take on smallpox-and win. Eradicated from the planet in 1979 in one of the great triumphs of modern science, the smallpox virus now resides, officially, in only two high-security freezers-at the Centers for Disease Control in Atlanta and in Siberia, at a Russian virology institute called Vector. But the demon in the freezer has been set loose. It is almost certain that illegal stocks are in the possession of hostile states, including Iraq and North Korea. Jahrling is haunted by the thought that biologists in secret labs are using genetic engineering to create a new superpox virus, a smallpox resistant to all vaccines.
Usamriid went into a state of Delta Alert on September 11 and activated its emergency response teams when the first anthrax letters were opened in New York and Washington, D.C. Preston reports, in unprecedented detail, on the government’s response to the attacks and takes us into the ongoing FBI investigation. His story is based on interviews with top-level FBI agents and with Dr. Steven Hatfill.
Jahrling is leading a team of scientists doing controversial experiments with live smallpox virus at CDC. Preston takes us into the lab where Jahrling is reawakening smallpox and explains, with cool and devastating precision, what may be at stake if his last bold experiment fails.
If you answered yes to any or all of these questions, you're not alone. In fact, hundreds of thousands of women are fighting these same feelings as they strive to live the lives they want.
Is It Me or My Adrenals? - formerly titled Are You Tired and Wired? - gives you the knowledge and tools to overcome this epidemic of fatigue. In it, Marcelle Pick uncovers the root cause of these symptoms: adrenal dysfunction. In our modern lives, the adrenal glands, which provide the fight-or-flight hormones in response to stress, are triggered much more often that they should be. Everything from challenges at home and at work, to environmental toxins, to chronic health problems cause the adrenal glands to produce a constant flood of stress hormones that can ultimately lead to multiple health issues, especially severe fatigue.
The good news is that through diet, lifestyle adjustments and reprogramming of stressful emotional patterns, this can all be fixed!
Pick helps you identify which of the three adrenal profiles you fit--Racehorse, Workhorse, or Flatliner--and then lays out an easy-to-follow, scientifically based program to help you restore adrenal balance, regear your metabolism, and regain your natural energy to live a happier and less-stressed life.
Millions of women struggle every day with problems like low energy, unexplained weight gain, and dull moods, yet too often diet, exercise, and pharmaceutical drugs are thought to be the only available options. Hormones—the chemical messengers of the body—influence every single process in our bodies: they govern our growth, weight, and energy, as well as fight stress and anxiety, relieve depression, and maintain personal drive.
Based on Dr. Kristy Vermeulen’s popular six-week online course, Happy Hormones explains how hormones affect your day-to-day routine and provides expert guidance to help you identify your hormonal imbalances and treat them in a natural, healthy way.
Happy Hormones also includes:
• Simple and effective self-assessments to help you diagnose your hormonal imbalances
• Six-step hormonal balancing programs for adrenal, thyroid, progesterone, estrogen, and testosterone imbalances
• Tools to help you read your own hormonal messages so you can stay in tune with your body and improve your overall well-being
• FAQs of bioidentical and synthetic hormones, along with guidelines to help you safely and effectively apply them in your treatment program
• Nutrition program with over 45 delicious, healthy, and hormone-friendly recipes
• Expert guidance to feeling and looking young, healthy, and fabulous
Happy Hormones is a comprehensive, practical guide for any woman interested in balancing their hormones. It will help you get back to your energetic, vibrant, and healthy self. Representing an important application of a fast-growing branch of health science, Happy Hormones will allow you to shed unwanted weight and regain your energy for a healthy, fabulous life.
Drawing extensively on interviews with adults with intersex conditions, parents, and physicians, Karkazis moves beyond the heated rhetoric to reveal the complex reality of how intersexuality is understood, treated, and experienced today. As she unravels the historical, technological, social, and political forces that have culminated in debates surrounding intersexuality, Karkazis exposes the contentious disagreements among theorists, physicians, intersex adults, activists, and parents—and all that those debates imply about gender and the changing landscape of intersex management. She argues that by viewing intersexuality exclusively through a narrow medical lens we avoid much more difficult questions. Do gender atypical bodies require treatment? Should physicians intervene to control the “sex” of the body? As this illuminating book reveals, debates over treatment for intersexuality force reassessment of the seemingly natural connections between gender, biology, and the body.
Metabolism is a complicated subject involving complex molecules and interrelated pathways. These metabolic pathways are usually taught separately with the result that the student develops a detailed but compartmentalised approach to metabolism and frequently fails to see the overall picture and its physiological significance.
Using the at a Glance format, the book takes the student through a complete course in intermediary metabolism in an integrated manner. The same chart is repeated throughout the book with the individual pathway under study highlighted.
The book is an ideal text for introductory biochemistry courses and has established itself as an enormously popular book amongst lecturers and students alike. This third edition is fully updated and includes five new chapters to mirror those topics currently taught at undergraduate level:
1. Metabolic Channelling
2. Glucose homeostasis and Reye's Disease
3. Pentose phosphate pathway and the prodcution of NADPH
4. Tryptophan metabolism in health and disease
5. Tyrosine metabolism in health and disease