The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro.
A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type.Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and systemAuthored and edited by authorities in this emerging and multidisciplinary fieldIncludes valuable links to 5-10 minute YouTube© author videos that describe main points
Unlike more conventional titles on composite materials, this book covers the most innovative new developments in nanofiber-based composites, including polymers, ceramics, and metals, with particular emphasis on their preparation and characterization methodology.
Selected case studies illustrate new developments in clinical and preclinical use, making the information critical for the development of new medical materials and systems for use in human health care, and for the exploration of new design spaces based on these nanofibers. This book is essential reading for those working in biomedical science and engineering, materials science, nanoscience, biomedical nanotechnology, and biotechnology.Covers innovative new developments in nanofiber composites, including polymers, ceramics, and metals with particular emphasis on their preparation and characterization methodologyDeals with biomedical applications, including biomaterials developments, drug delivery, tissue engineering, and regenerative medicinePresents selected case studies on nanofiber composite materials in both clinical and preclinical use
Featuring contributions by experts in the field, the book explores important scientific and clinical aspects. It covers the basic science involved in structure and properties, techniques and technological innovations in processing and characterization, and applications of biomaterials and stem cells.
Topics include:Polymeric systems for stem cell delivery The potential of membranes and porous scaffolds in tissue repair, including myocardial, periodontal, ophthalmic, and bone tissues The optimization of the interaction between stem cells and biomaterial substrates The source and nature of stem cells for tissue engineering applications The clinical translation of stem cell–based tissue engineering for regenerative medicine
From fundamental principles to recent advances at the macro, micro, nano, and molecular scales, the book brings together current knowledge on biomaterials and stem cells in the context of regenerative medicine. It also stimulates discussion about future research directions.
This unique book offers a valuable benchmark for the current status of clinically relevant research and development in stem cells and regenerative medicine. It bridges the gaps in experimental approaches and understanding among the materials science and engineering, biological sciences, and biomedical science and engineering communities, making it a valuable reference for graduate students, researchers, and practitioners working in the multidisciplinary field of biomedical research.
Written by internationally renowned scientists, engineers, and clinicians, the chapters cover the following areas:
Nanobiomaterials and scaffolds—including nanocomposites and electrospun nanofibers Tissue mechanics Stem cells and nanobiomaterials Oral and cranial implants and regeneration of bone Cartilage tissue engineering Controlled release—DNA, RNA, and protein delivery Animal science and clinical medicine
The editors designed this textbook with a distinctive theme focusing on the utilization of nanotechnology, biomaterials science in tissue engineering, and regenerative medicine with the inclusion of important clinical aspects. In addition to injured veterans and other individuals, increased life expectancy in the industrialized world is creating a growing population that will require regenerative medicine, producing greater pressure to develop procedures and treatments to improve quality of life. This book bridges the gap between nanotechnology and tissue engineering and regenerative medicine, facilitating the merger of these two fields and the important transition from laboratory discoveries to clinical applications.
Clearly structured, the volume defines the scope and classification of the field, resulting in a broad overview from fundamental principles to current technological advances, and from materials synthesis to biomedical applications along with future trends.
Biomaterials: A Nano Approach is written from a multi-disciplinary point of view that integrates aspects of materials science and engineering, nanotechnology, bioengineering, and biosciences. The book fills a glaring void in the literature by providing a comprehensive discussion of biomaterials and a scientifically plausible extrapolation of likely scenarios in which nanotechnology could play a significant role. The authors introduce and examine basic concepts, processing methodologies, and techniques involved in the preparation and characterization of nanobiomaterials that are specific to biomedical applications.
A Self-Contained Book Illustrating Past, Present, and Future Trends in Biomaterials
Spanning from the historical development of biomaterials to cutting-edge advances in the field, the text describes how basic concepts in nanotechnology are applied to the processing of novel nanobiomaterials, including nanostructured metals and alloys. With its illustrative examples and presentation of applications, this text offers a solid framework for understanding present and future trends of biomaterials in human healthcare systems. It is an ideal companion resource for students, researchers, and industrial scientists who specialize in biomaterials and nanobiomaterials.
The area at the interface of micro/nanotechnology and stemcells/tissue engineering has seen an explosion of activity inrecent years. This book provides a much-needed overview of theseexciting developments, covering all aspects of micro andnanotechnologies, from the fundamental principles to the latestresearch to applications in regenerative medicine.
Written and edited by the top researchers in the field, Microand Nanotechnologies in Engineering Stem Cells and Tissuesdescribes advances in material systems along with currenttechniques available for cell, tissue, and organ studies. Readerswill gain tremendous insight into the state of the art of stemcells and tissue engineering, and learn how to use the technologyin their own research or clinical trials. Coverage includes:Technologies for controlling or regulating stem cell and tissuegrowthVarious engineering approaches for stem cell, vascular tissue,and bone regenerationThe design and processing of biocompatible polymers and otherbiomaterialsCharacterization of the interactions between cells andbiomaterials
Unrivaled among books of this kind, Micro andNanotechnologies in Engineering Stem Cells and Tissues is theultimate forward-looking reference for researchers in numerousdisciplines, from engineering and materials science to biomedicine,and for anyone wishing to understand the trends in thistransformative field.
This book acts as a self-contained resource for understandingthe current technological advancement of biomaterials towardstissue engineering applications. It covers impact ofbiomaterials at different length scales such as macro/micro/nano/level and offers extensive discussion on cell-biomaterialinteractions with illustrative examples.
This resource offer a multi-disciplinary approach for theadaptability of integrated biomaterials in tissue repair andreconstruction.
In The Disappearing Spoon, bestselling author Sam Kean unlocked the mysteries of the periodic table. In THE VIOLINIST'S THUMB, he explores the wonders of the magical building block of life: DNA.
There are genes to explain crazy cat ladies, why other people have no fingerprints, and why some people survive nuclear bombs. Genes illuminate everything from JFK's bronze skin (it wasn't a tan) to Einstein's genius. They prove that Neanderthals and humans bred thousands of years more recently than any of us would feel comfortable thinking. They can even allow some people, because of the exceptional flexibility of their thumbs and fingers, to become truly singular violinists.
Kean's vibrant storytelling once again makes science entertaining, explaining human history and whimsy while showing how DNA will influence our species' future.
–Mehmet Oz, M.D.
Does losing weight and staying healthy feel like a battle? Well, it’s really a war. Your enemies are your own genes, backed by millions of years of evolution, and the only way to win is to outsmart them. Renowned surgeon and founder of Gundry MD, Dr. Steven Gundry’s revolutionary book shares the health secrets other doctors won’t tell you:
• Why plants are “good” for you because they’re “bad” for you, and meat is “bad” because it’s “good” for you
• Why plateauing on this diet is actually a sign that you’re on the right track
• Why artificial sweeteners have the same effects as sugar on your health and your waistline
• Why taking antacids, statins, and drugs for high blood pressure and arthritis masks health issues instead of addressing them
Along with the meal planner, 70 delicious recipes, and inspirational stories, Dr. Gundry’s easy-to-memorize tips will keep you healthy and on course.
OUTSTANDING FEATURES Special atlas sections break down complex information accompanied by descriptive diagrams and photographs to further explain sources of occlusal disorders and related pain. Hundreds of full-color photographs and illustrations show problems and procedures. Procedure boxes offer step-by-step explanations of specific procedures. Important Considerations boxes in the Treatment chapters outline treatment plans and describe what is to be accomplished. Programmed treatment planning, a specific process that guides a clinician through every step for solving even the most complex restorative or esthetic challenge. The role of TMJs and occlusion in "everyday" dentistry. The role of occlusion in orofacial pain and TMD, and in anterior esthetics. Simplified occlusal equilibration and how to explain this process to patients. The functional matrix concept for exceptional, foolproof smile design. The five options for occlusal correction and how to apply them to practice. Use and abuse of occlusal sprints. Coordinating occlusal treatment with specialists for a fully interdisciplinary approach. Specific criteria for success and how to test for each.
A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging.
Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach.
In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.
Treatment supported by clinical evidence equips students with a more targeted evidence-based approach to patient procedures.NEW! Emphasis on treatment planning helps decrease the number of visits while providing effective, long-term results for the patient.NEW! Focus on the patient presentation offers the latest treatment options for bone harvesting, restoration and recovery.NEW! Original illustrations and photos highlight and clarify key clinical concepts and techniques.
But what does it mean?
Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life.
Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.
Filling the void, Biotechnology Operations: Principles and Practices reflects this integrative philosophy, serving as a practical guide for students, professionals, or anyone else with interests in the biotech industry. Although many books emphasize specific technical aspects of biotech, this is perhaps the first to integrate essential concepts of product development and scientific and management skills with the seven functional areas of biotechnology:
Biomanufacturing Clinical trials Nonclinical studies Project management Quality assurance Quality control Regulatory affairs
A practical roadmap to optimizing biotechnology operations, this reference illustrates how to use specific product planning, design, and project management processes to seamlessly merge plans and efforts in the key functional areas. Applying lessons learned throughout the nascent history of biotech, author Michael Roy highlights developmental principles that could bring future products to market more safely and efficiently. Drawing from his experiences working in industry and teaching a graduate course at the University of Wisconsin, this hotly anticipated book clarifies basic methodologies and practices to help reduce risks and resolve problems as future technological discoveries are developed into tangible products.
The drugs are grouped according to their class of action or use for a specific condition. Every effort has been made to ensure that drug selection and dosage is in accordance with current recommendations and practice. It is not intended to be all-inclusive, but is provided to give an overview at the pharmaceuticals available and the protocols that have been developed. The number at medications within each category has intentionally been limited so that the booklet may be conveniently placed in an apparel pocket. Oral pathologists and other clinicians who have an interest in oral medicine have successfully used the specialized protocols listed. Some regimens are off-label use.
Detailed how-to information on clinical examination, data gathering, and differential diagnosis for temporomandibular disorders helps you learn to correctly plan treatment.
Clinical Comment boxes give you critical thinking points and instructions on how to apply these to everyday clinical practice.NEW! Robust Q-website features an image library, case studies, and NBDE-style questions.
NEW! Full-color design offers more vivid clinical photos, illustrations, and information.
NEW! Major revisions to Part II with specific detail to Etiology provides more up-to-date information on this critical area.
NEW! Patient education sheets include the most common TMDs. NEW! Updated treatment algorithms are included for each TMD.
Prepared by authors of international renown, the Handbook of Paediatric Dentistry presents a volume that takes the reader far beyond the technical skills that are needed to treat disorders of the childhood dentition and instead delivers a whole philosophy of integrative patient care.
Richly illustrated and in full colour throughout, the Handbook of Paediatric Dentistry is written in a friendly ‘how to’ manner and contains useful ‘pull out’ boxes to act as useful aide-mémoires. Exploring a variety of topics, the book includes discussion of child development, practical communication skills and advice on how to deal with behavioural problems. Clinical topics include the management of caries, fluoridation, restorative dentistry, pulp therapy, trauma management, oral medicine and pathology, dental anomalies, and the treatment of medically compromised children. Chapters also explore the use of orthodontics, the management of cleft lip and palate and speech, language and swallowing.
The Handbook of Paediatric Dentistry has become an essential chairside and bedside companion for all practitioners caring for children and is suitable for undergraduate dental students, general dental practitioners, specialist paediatric dentists, orthodontists and paediatricians.Established as the foremost available comprehensive handbook on paediatric dentistry
Prepared in an ‘easy-to-digest’ fashion – which allows for quick reference and easy reading
Contains over 550 full colour line artworks, photographs and tables together with ‘Clinical Hints’ boxes to act as useful aide-mémoires
Sets out the essentials for managing conditions such as clefting disorders, haematological and endocrine disorders, congenital cardiac disease, disorders of metabolism, organ transplantation and cancer in children as well as more familiar presentations such as dental trauma, oral infections and caries
Detailed appendices provide the reader with information that is often difficult to find and which may be overlooked
Designed specifically to give all practitioners confidence when managing children
Convenient handbook size ensures that the book can be easily referred to in the clinical setting
Endorsed by the Australasian Academy of Paediatric Dentistry~Improved layout and completely new colour illustrations
Expanded section on sedation and use of nitrous oxide
Includes details from the most recent international guidelines
Cases expanded to show 20 year follow-up
Includes the latest research findings in orthodontics
Fully updated section on clefting problems
It is a definite book for all dental undergraduates and an excellent supplement for all students undergoing postgraduate specialist training in orthodontics.Covers syllabi prescribed by Dental Council of India (DCI) and International schools of dentistry
Provides more than 1500 line arts, flowcharts, tables and clinical photographs for easy perception of the subject and to illustrate vital principles and techniques
Chapters contain Clinical Significance boxes that encourage readers to relate and channelize the theory knowledge into clinical practice
Learning Exercises furnished in each chapter facilitates the students to assess themselves and reflect on what had been learnt
Synopsis of Treatment Planning for Different Malocclusions, the last chapter serves not only as a guide to recap the depth and breadth of factual comprehension but also to promote analysis, evaluation and judgment in orthodontic treatment philosophies
Procedures are organized by sections to include: dentoalveolar and implant surgery, odontogenic head and neck infections, maxillofacial trauma surgery, orthognathic and craniofacial surgery, tempomandibular joint surgery, infections of the head and neck, facial cosmetic surgery, and pathology and reconstructive surgery.
The combination of concise text, more than 1,000 color clinical illustrations and images, and case reports makes the Atlas of Operative Oral and Maxillofacial Surgery a key reference to all oral and maxillofacial surgeons, head and neck surgeons, and facial plastic surgeons and will serve as a foundation for residency training, board certification and the recently implemented recertification examinations.
See the practical important of anatomy from illustrated clinical examples in each chapter.
Review essential concepts easily with tables that display the maximum amount of information in an at-a-glance format.
Master anatomy for the head and neck and beyond, including upper limbs, thorax, and abdomen.
Stay current on hot topics like cone beam CT imaging, intraoral injections, and anesthesia.
Recognize the context and clinical relevance of head and neck anatomy through additional coverage of dental procedures.
Prepare effectively for the dental boards with over 100 multiple-choice questions.
Chapter 1: Synopsis of Preclinical Prosthodontics: discusses Complete Dentures, Removable Partial Dentures and Fixed Partial Dentures
Chapter 2: Instruments and Materials: includes clear description of every instruments and material a student is expected to know, identify and use before entering the clinical section
Chapter 3: Preclinical Exercise: provides step-by-step representation along with explanation of all laboratory exercises a student has to perform with relevant figures
Chapter 4: Common Viva Questions: provides commonly asked questions to help students prepare for their viva voce exam
Chapter 5: Glossary of Prosthodontic Terms: contains an exhaustive list of commonly asked prosthodontic terms
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers, and will help address the world’s hunger crisis. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences—to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans.
Writing with fellow researcher Samuel Sternberg, Doudna shares the thrilling story of her discovery, and passionately argues that enormous responsibility comes with the ability to rewrite the code of life. With CRISPR, she shows, we have effectively taken control of evolution. What will we do with this unfathomable power?
The book presents actual clinical cases, accompanied by academiccommentary, that question and educate the reader about essentialtopics in restorative and reconstructive dentistry. The book beginsby laying the groundwork of the fundamental principles that applyto all cases and outlining the ten decisions to be made with allcases. The main sections of the book cover the cases themselves,examining them both by type of restoration / solution, and by typeof problem. This unique approach enables the reader to build theirskills, aiding the ability to think critically andindependently.
Clinical Cases in Restorative and ReconstructiveDentistry’s case-based format is particularly useful forpre-doctoral dental students, post-graduate residents andpractitioners, both as a textbook from which to learn about thechallenging and absorbing nature of restorative and reconstructivedentistry, and also as a reference tool to help with treatmentplanning when perplexing cases arise in the dental office.
Competency sheetsare included for all procedures, each outlining the performance objective, grading criteria, and steps necessary to master the procedure.
Removable flashcardsmake it easy to review anywhere, anytime. NEW! Content incorporates additional information in areas such as digital imaging, dental materials, and caries prevention.
Techniques in Complete Denture Technology discusses all the various elements that are essential for optimum denture provision, including fit, retention, stability, occlusion, muscular control, aesthetics and materials. It is essential reading for dental technicians, clinical dental technicians and maxillo-facial prosthetists, as well as providing a valuable resource for dentists and students.
KEY FEATURESProvides techniques for achieving the ideal properties of complete denturesDiscusses fit, retention, stability, occlusion, muscular control, aesthetics and materialsFull of easy to follow step-by-step proceduresWritten by an experienced and established author teamHighly illustrated with full colour clinical photos
Full-color photographs and line drawings are included throughout the book.
In-depth discussions cover the anesthetic agents used in dentistry, along with their clinical actions.
Routes of administration are described for all anesthetics.
The proper care and handling of equipment is addressed, along with the problems that may be encountered.
Requirements for pain control and local anesthesia within various dental specialties are included.
Comprehensive information on Articaine is included, a local anesthetic that is gaining widespread use in the United States.
Numerous boxes and tables provide a quick reference and comparison of techniques, drugs, and dosages.
Dosage charts, injection techniques, information on duration of action, and contraindications for local anesthetics are included at the end of the book for quick reference.Updated discussions of the armamentarium needed to succeed in local anesthesia delivery reflect the latest available drugs and devices.
Updated discussions of the techniques needed to provide successful pain control.
Updated step-by-step procedures cover the techniques for administering intraoral anesthesia.
The latest advances in science, technology, and pain control techniques are covered.
CURRENT Medical Diagnosis and Treatment Study Guide facilitates your analysis of test cases and enhances your recall of internal medicine topics, making it invaluable preparation for any internal medicine examination. Organized according the Core Curriculum of the Clerkship Directors in Internal Medicine, this study-enhancing resource covers over 30 core topics that encompass essentials, conditions, presentations, treatment approaches, and diseases seen by general practitioners in the inpatient and outpatient settings.
Features case-based coverage of 80 must-know diseases and disorders, from skin and hematologic disorders to infectious disorders For each topic, the study guide includes learning objectives; an expanded list of questions to prompt case analysis; a more detailed emphasis on signs and symptoms, lab findings, imaging studies, and medications; additional discussions on therapeutic procedures and outcomes; and full references
The study guide utilizes content from CMDT, Quick Answers, and Lange Pathophysiology to provide a case-based application that tests key concepts in clinical reasoning, clinical problem-solving, and recognition of essential clinical facts. The second edition of CURRENT Medical Diagnosis and Treatment Study Guide is extensively updated and examines the most fundamental issues you need to know to succeed on the clerkship shelf exam in Internal Medicine. The study guide includes an expanded format for a more formal and in-depth review and is perfect for instructors utilizing the main CMDT text.
Each chapter is supported by well-documented clinical cases and high-quality illustrations for better understanding
Exclusive chapters include: Digital Imaging in Orthodontics, Interdisciplinary Orthodontics, Excellence in Finishing, Functional Occlusion Goals in Orthodontics, Lingual Orthodontics, Role of Skeletal Anchorage in Modern Orthodontics, Optimizing Orthodontic Treatment, and Management of an Orthodontic Practice
Chapter contributions by a dynamic group of leading world-class clinicians, researchers, teachers and authors, delivering cutting-edge informationCraniofacial Growth: A Clinical Perspective
Role of Skeletal Anchorage in Modern Orthodontics
Optimizing Orthodontic Treatment
Organization by clinical appearance -- such as including all red-blue lesions in one chapter along with possible causes -- matches what you would expect to see upon a patient's presentation, and provides a practical tool for developing differential diagnoses and planning treatment.
Hundreds of full-color clinical photographs and radiographs depict specific conditions for easier identification in real clinical scenarios.
Full-color photomicrographs help you identify pathologic elements and provide correct diagnoses and treatment plans.
Boxes and tables offer clear, at-a-glance information on the clinical features, diagnosis, and treatment for many conditions.
Student resources on a companion Evolve website include 30 case studies, a 150-question practice exam, and case-based learning to prepare you for the NBDE and for clinical practice.Advanced imaging techniques include images such as CBCTs (cone beam computed tomography), regular CTs, and MRIs, reflecting the transition from a 2-dimensional to a 3-dimensional approach in acquiring data and reconstructing images, and helping you identify and assess disease entities -- especially tumors of the salivary glands, jaws, and soft tissues.
Expanded sections on etiology, treatment, and diagnosis of oral cancer (HPV) describe how subtypes can play an important role in the development and natural history of some head and neck cancers, most notably those arising in the oropharynx.
Expanded section on bisphosphonate-related osteonecrosis of the jaws helps you effectively manage patients taking bisphosphonates to prevent bone loss, including information on oral complications, risk factors, and benefits.