The contributions collected in these proceedings cover several research fields, all of which deal with transport. Topics include highway, pedestrian and internet traffic, granular matter, biological transport, transport networks, data acquisition, data analysis and technological applications. Different perspectives, i.e. modeling, simulations, experiments and phenomenological observations, are considered.
Originally published in 1987.
The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
The contributions collected in these proceedings cover several research fields, all of which deal with transport. Topics include highway, pedestrian and internet traffic; granular matter; biological transport; transport networks; data acquisition; data analysis and technological applications. Different perspectives, i.e., modeling, simulations, experiments, and phenomenological observations are considered.
The Future of the Mind brings a topic that once belonged solely to the province of science fiction into a startling new reality. This scientific tour de force unveils the astonishing research being done in top laboratories around the world—all based on the latest advancements in neuroscience and physics—including recent experiments in telepathy, mind control, avatars, telekinesis, and recording memories and dreams. The Future of the Mind is an extraordinary, mind-boggling exploration of the frontiers of neuroscience. Dr. Kaku looks toward the day when we may achieve the ability to upload the human brain to a computer, neuron for neuron; project thoughts and emotions around the world on a brain-net; take a “smart pill” to enhance cognition; send our consciousness across the universe; and push the very limits of immortality.
From the Trade Paperback edition.
This edition includes greatly expanded focus on stem cells, including adult and embryonic stem cells and progenitor populations that may soon lead to new tissue engineering therapies for heart disease, diabetes, and a wide variety of other diseases that afflict humanity. This up-to-date coverage of stem cell biology and other emerging technologies is complemented by a series of new chapters on recent clinical experience in applying tissue engineering. The result is a comprehensive textbook that we believe will be useful to students and experts alike.
New to this edition:
*Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves
*Expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems
Kaku skillfully guides us through the latest innovations in string theory and its latest iteration, M-theory, which posits that our universe may be just one in an endless multiverse, a singular bubble floating in a sea of infinite bubble universes. If M-theory is proven correct, we may perhaps finally find answer to the question, “What happened before the big bang?” This is an exciting and unforgettable introduction into the new cutting-edge theories of physics and cosmology from one of the pre-eminent voices in the field.
From the Trade Paperback edition.
Richard Feynman, winner of the Nobel Prize in physics, thrived on outrageous adventures. Here he recounts in his inimitable voice his experience trading ideas on atomic physics with Einstein and Bohr and ideas on gambling with Nick the Greek; cracking the uncrackable safes guarding the most deeply held nuclear secrets; accompanying a ballet on his bongo drums; painting a naked female toreador. In short, here is Feynman's life in all its eccentric—a combustible mixture of high intelligence, unlimited curiosity, and raging chutzpah.
"Vivid . . . impressive. . . . Splendidly informative."—The New York Times
"A tour de force."—Salon
Already internationally acclaimed for his elegant, lucid writing on the most challenging notions in modern physics, Sean Carroll is emerging as one of the greatest humanist thinkers of his generation as he brings his extraordinary intellect to bear not only on Higgs bosons and extra dimensions but now also on our deepest personal questions: Where are we? Who are we? Are our emotions, our beliefs, and our hopes and dreams ultimately meaningless out there in the void? Do human purpose and meaning fit into a scientific worldview?
In short chapters filled with intriguing historical anecdotes, personal asides, and rigorous exposition, readers learn the difference between how the world works at the quantum level, the cosmic level, and the human level—and then how each connects to the other. Carroll's presentation of the principles that have guided the scientific revolution from Darwin and Einstein to the origins of life, consciousness, and the universe is dazzlingly unique.
Carroll shows how an avalanche of discoveries in the past few hundred years has changed our world and what really matters to us. Our lives are dwarfed like never before by the immensity of space and time, but they are redeemed by our capacity to comprehend it and give it meaning.
The Big Picture is an unprecedented scientific worldview, a tour de force that will sit on shelves alongside the works of Stephen Hawking, Carl Sagan, Daniel Dennett, and E. O. Wilson for years to come.
For more than thirty years as a beloved professor at the Massachusetts Institute of Technology, Lewin honed his singular craft of making physics not only accessible but truly fun, whether putting his head in the path of a wrecking ball, supercharging himself with three hundred thousand volts of electricity, or demonstrating why the sky is blue and why clouds are white. Now, as Carl Sagan did for astronomy and Brian Green did for cosmology, Lewin takes readers on a marvelous journey in For the Love of Physics, opening our eyes as never before to the amazing beauty and power with which physics can reveal the hidden workings of the world all around us. “I introduce people to their own world,” writes Lewin, “the world they live in and are familiar with but don’t approach like a physicist—yet.”
Could it be true that we are shorter standing up than lying down? Why can we snorkel no deeper than about one foot below the surface? Why are the colors of a rainbow always in the same order, and would it be possible to put our hand out and touch one? Whether introducing why the air smells so fresh after a lightning storm, why we briefly lose (and gain) weight when we ride in an elevator, or what the big bang would have sounded like had anyone existed to hear it, Lewin never ceases to surprise and delight with the extraordinary ability of physics to answer even the most elusive questions.
Recounting his own exciting discoveries as a pioneer in the field of X-ray astronomy—arriving at MIT right at the start of an astonishing revolution in astronomy—he also brings to life the power of physics to reach into the vastness of space and unveil exotic uncharted territories, from the marvels of a supernova explosion in the Large Magellanic Cloud to the unseeable depths of black holes.
“For me,” Lewin writes, “physics is a way of seeing—the spectacular and the mundane, the immense and the minute—as a beautiful, thrillingly interwoven whole.” His wonderfully inventive and vivid ways of introducing us to the revelations of physics impart to us a new appreciation of the remarkable beauty and intricate harmonies of the forces that govern our lives.
The Olympics are the world's most prestigious stage for athletic competition. Fans both casual and hardcore tune in religiously every few years to watch as men and women push themselves to the limits of human performance. But what makes a champion? Is it genetics? Hours of training? A psychological advantage? Of all the athletes who dedicate their lives - and bodies - to achieving that perfect moment of triumph, why will one person or team win out over another? Science has some compelling answers, and in this book, The Science of Sports: Winning in the Olympics, Scientific American explores this topic from various angles. Beginning with Section 1: The Psychology of Winning, the book opens with a look inside the mind of an elite athlete and tackles questions of how to face a rivalry or maintain a positive attitude in the face of defeat. Other sections discuss the sticky issues surrounding genetic advantages and physical prowess, drugs and doping, injury and recovery, and - finally - the latest scientific advice for the rest of us mere mortals to be fit and healthy. You'll find both inspiration and answers in this indispensable book from the editors of Scientific American, the leading authority on science, technology and innovation.
This new edition discusses biological systems that can be analyzed quantitatively, and how advances in the life sciences have been aided by the knowledge of physical or engineering analysis techniques. The volume is organized into 18 chapters encompassing thermodynamics, electricity, optics, sound, solid mechanics, fluid mechanics, and atomic and nuclear physics. Each chapter provides a brief review of the background physics before focusing on the applications of physics to biology and medicine. Topics range from the role of diffusion in the functioning of cells to the effect of surface tension on the growth of plants in soil and the conduction of impulses along the nervous system. Each section contains problems that explore and expand some of the concepts. The text includes many figures, examples and illustrative problems and appendices which provide convenient access to the most important concepts of mechanics, electricity, and optics in the body.
Physics in Biology and Medicine will be a valuable resource for students and professors of physics, biology, and medicine, as well as for applied health workers.Provides practical techniques for applying knowledge of physics to the study of living systemsPresents material in a straight forward manner requiring very little background in physics or biologyIncludes many figures, examples and illustrative problems and appendices which provide convenient access to the most important concepts of mechanics, electricity, and optics in the body
Interested in unraveling the physics of living things? Here's your starting point. Biophysics Demystified is the fast and easy way to understand this fascinating topic.
Written in a step-by-step format, this practical guide begins with an introduction to the science of biophysics, covering biophysical techniques and applications. Next, you'll learn the principles of physics, biology, and chemistry required to understand biophysics, including free energy, entropy, and statistical mechanics. Biomolecules and the forces that influence their structure and conformation are also covered, as are protein, nucleic acid, and membrane biophysics. Detailed examples and concise explanations make it easy to understand the material, and end-of-chapter quizzes and a final exam help reinforce key concepts.
It's a no-brainer! You'll get:Molecular, subcellular, physiological, anatomical, and environmental biophysics The laws of thermodynamics as they apply to biophysical systems Forces affecting conformation in biological molecules The composition and structure of carbohydrates, lipids, proteins, and nucleic acids The fluid mosaic model
Simple enough for a beginner, but challenging enough for an advanced student, Biophysics Demystified makes this interdisciplinary subject easy to master.
One of the most diverse of modern scientific disciplines, biophysics applies methods and technologies from physics to the study of biological systems and phenomena, from the human nervous system to soil erosion to global warming. What are the best options for satisfying the world's growing energy demands? How can we feed the world's growing population? How can we contain, or reverse, global warming? How can we vouchsafe a plentiful supply of potable water for future generations? These are among the critical questions to which biophysicists work to provide answers.Biophysics courses are increasingly taken by students of biology, physics, chemistry, biochemistry, physiology, statistics, bioengineering, neuroscience, computer science, pharmacology, agriculture,and many more Provides a friendly, unintimidating overview of the material covered in a typical college-level biophysics course A one-stop reference, course supplement and exam preparation tool for university students currently enrolled in an introductory biophysics courses An indispensable resource for those studying the natural sciences, biological sciences, and physics, as well as math, statistics,computer science, pharmacology and many other disciplines The current job market for people well versed in biophysics is very strong, and biophysics is currently listed as one of the fast-growing occupations in the North America
The handbook begins with a series of historical vignettes of pioneers from the last two centuries. It also presents the fundamentals of physics and biology as applied to photomedicine. It next examines conditions and diseases caused by light, including skin cancer, dermatoses, and immunosuppression.
The remainder of the book focuses on the most important clinical therapeutic applications of different kinds of light that vary in both wavelength and intensity. The book discusses ultraviolet phototherapy for skin diseases and infections and presents the basic science of photodynamic therapy and its use in cancer therapy and other medical specialties. It then covers mechanistic studies and clinical applications of low-level laser (light) therapy as well as the use of high power or surgical laser therapy in specialties, such as dentistry and dermatology. The book concludes with a collection of miscellaneous types of phototherapy.
This concise introductory paperback surveys and relates basic physics to living systems. It discusses biological systems that can be analyzed quantitatively, and how advances in the life sciences have been aided by the knowledge of physical or engineering analysis techniques.
This text is designed for premed students, doctors, nurses, physiologists, or other applied health workers, and other individuals who wish to understand the nature of the mechanics of our bodies.
- Provides practical techniques for applying knowledge of physics to the study of living systems
- Presents material in a straight forward manner requiring very little background in physics or biology
- Includes many figures, examples and illustrative problems and appendices which provide convenient access to the most important concepts of mechanics, electricity, and optics
As advances in algorithms and computer technology have bolstered the digital signal processing capabilities of real-time sonar, radar, and non-invasive medical diagnostics systems, cutting-edge military and defense research has established conceptual similarities in these areas. Now civilian enterprises can use government innovations to facilitate optimal functionality of complex real-time systems. Advanced Signal Processing details a cost-efficient generic processing structure that exploits these commonalities to benefit commercial applications.
Learn from a Renowned Defense Scientist, Researcher, and Innovator
The author preserves the mathematical focus and key information from the first edition that provided invaluable coverage of topics including adaptive systems, advanced beamformers, and volume visualization methods in medicine. Integrating the best features of non-linear and conventional algorithms and explaining their application in PC-based architectures, this text contains new data on:
Advances in biometrics, image segmentation, registration, and fusion techniques for 3D/4D ultrasound, CT, and MRI
Fully digital 3D/ (4D: 3D+time) ultrasound system technology, computing architecture requirements, and relevant implementation issues
State-of-the-art non-invasive medical procedures, non-destructive 3D tomography imaging and biometrics, and monitoring of vital signs
Cardiac motion correction in multi-slice X-ray CT imaging
Space-time adaptive processing and detection of targets interference-intense backgrounds comprised of clutter and jamming
With its detailed explanation of adaptive, synthetic-aperture, and fusion-processing schemes with near-instantaneous convergence in 2-D and 3-D sensors (including planar, circular, cylindrical, and spherical arrays), the quality and illustration of this text’s concepts and techniques will make it a favored reference.
In this work Einstein intended, as far as possible, to give an exact insight into the theory of relativity to those readers who, from a general and scientific philosophical point of view, are interested in the theory, but who are not conversant with the mathematical apparatus of theoretical physics. The theory of relativity enriched physics and astronomy during the 20th century.(Relativity: The Special and the General Theory by Albert Einstein, 9789380914220)
Developed at MIT in collaboration with award-winning high school teachers, BioBuilder teaches the foundational ideas of the emerging synthetic biology field, as well as key aspects of biological engineering that researchers are exploring in labs throughout the world. These lessons will empower teachers and students to explore and be part of solving persistent real-world challenges.Learn the fundamentals of biodesign and DNA engineeringExplore important ethical issues raised by examples of synthetic biologyInvestigate the BioBuilder labs that probe the design-build-test cycleTest synthetic living systems designed and built by engineersMeasure several variants of an enzyme-generating genetic circuitModel "bacterial photography" that changes a strain’s light sensitivityBuild living systems to produce purple or green pigmentOptimize baker’s yeast to produce ?-carotene
Each chapter of the book investigates a facet of the physical world, including the drag on small projectiles; the importance of diffusion and convection; the size-dependence of acceleration; the storage, conduction, and dissipation of heat; the relationship among pressure, flow, and choice in biological pumps; and how elongate structures tune their relative twistiness and bendiness. Vogel considers design-determining factors all too commonly ignored, and builds a bridge between the world described by physics books and the reality experienced by all creatures. Glimpses of Creatures in Their Physical Worlds contains a wealth of accessible information related to functional biology, and requires little more than a basic background in secondary-school science and mathematics.
Drawing examples from creatures of land, air, and water, the book demonstrates the many uses of biological diversity and how physical forces impact biological organisms.
This book provides a roadmap to the broad and varied career development opportunities in bioengineering, biotechnology, and related fields. Eminent practitioners lay out career paths related to academia, industry, government and regulatory affairs, healthcare, law, marketing, entrepreneurship, and more.
Lifetimes of experience and wisdom are shared, including "war stories," strategies for success, avoidance of common pitfalls, and discussions of the authors’ personal views and motivations. Career Development in Bioengineering and Biotechnology is an indispensable guide to some of the most exciting career and professional growth opportunities in science, engineering, and beyond, and a "must read" for anyone interested in a career related to this burgeoning field.
From the Foreword by U.S. National Medal of Science Laureate and Institute Professor Robert Langer, Massachusetts Institute of Technology: "This book provides a wealth of information and should serve as an excellent resource...The editors have gone to great effort to discuss a variety of critical topics in the burgeoning areas of bioengineering and biotechnology."
From the Introduction by Dr. Bruce Alberts, President Emeritus of the U.S. National Academy of Sciences and Co-chair of the InterAcademy Council: "I am very impressed with the enormous dedication and skill that created this major, highly-original contribution – I know of nothing like it."
From the Editorial by Dr. Joachim Nagel, President, International Union for Physical and Engineering Sciences in Medicine, and past president of the International Federation for Medical and Biological Engineering: "This book provides all the answers and can be highly recommended as the ultimate guide to anyone interested in bioengineering and biotechnology. The book arrives at a crucial time, and catapults bioengineering and biotechnology to the forefront of disciplines and to a rightly held pinnacle of inspiration for engineers, scientists, and technologists."
From the Afterword by Dr. Shu Chien, President, Biomedical Engineering Society and past president of the American Physiological Society and of the American Institute of Medical and Biological Engineering: "...this is truly an outstanding book that is the first of its kind...certainly a pioneering contribution."
Praise for the Book
"Bioengineering and Biotechnology are emerging as distinct disciplines amid the biological revolution and during a period of rapid globalization. These interesting times offer us unprecedented opportunities for professional and personal growth. This book covers many important areas of opportunity, including entrepreneurship, finance, law, and education, with a global perspective. The legacy of our times will include how well we used our rapidly advancing technologies to improve the world around us. This book provides a roadmap for the contributions of Bioengineering and Biotechnology in this quest."
-James E. Moore, PhD, Texas A&M University
"This book will be essential reading for all those seeking career guidance in bioengineering and biotechnology."
-Tony Bradshaw, PhD, Director bioProcessUK - BioIndustry Association (BIA), Chairman, The Royal Academy of Engineering/BIA Life Scientists' Career Seminars
"...the topics [are] quite extensive covering definitions, core curriculum, career opportunities, including a wide range of alternative career pathways as well as social and ethical issues. The material covered is unlike any of the standard publications related to these fields of activity... [the book] can be read at different stages of one's career."
-Joseph D. Bronzino, PhD, Trinity College
"...once I started reading it, [I] could not put it down. In less than three days, I read it all, absorbing the stories and details as if I was consummed by watching a high action movie... The breath and depth of the wisdom is phenomenal, and the stories shared by the writers are moving, inspiring, and shine of intelligence in seizing one's own passion and talents and turning them into stellar professional careers."
-Nathalie Gosset, MS, MBA, Head of Marketing, Alfred Mann Institute for Biomedical Engineering, University of Southern California
"This is a functional book with immediate impact, and is very helpful to those who need and desperately want help in making a career choice."
- Jonathan Newman, Graduate Student in Biomedical Engineering, Georgia Institute of Technology, USA
"This is an exciting undertaking and very well thought through and balanced. I enjoyed very much reading the chapters I have reviewed. Congratulations to all contributors and the editors of this book."
- Gudrun Zahlmann, PhD, Director of Business Development, Siemens Medical Systems, Germany
"I am very excited about this book. As a bioengineering educator, I am always looking for information that can provide guidance for students as they prepare for their careers. The contributors in this book are so enthusiastic about their careers that many of the chapters made me want to switch careers on the spot! I believe that engineering students do not receive enough guidance on alternative career paths. This book will very much help fill the void."
- Judy Cezeaux, PhD, Professor of Biomedical Engineering, Western New England College, Massachusetts, USA
The volume is intended for graduate-level biology students as well as researchers who wish to gain a better understanding of applied bioinformatics and who wish to use bioinformatics technologies to assist in their research. The volume would also be of value to bioinformatics developers, particularly those from a computing background, who would like to understand the application of computational tools for biological research. Each chapter would include a comprehensive introduction giving an overview of the fundamentals, aimed at introducing graduate students and researchers from diverse backgrounds to the field and bring them up-to-date on the current state of knowledge. To accommodate the broad range of topics in applied bioinformatics, chapters have been grouped into themes: gene and genome analysis, molecular genetic analysis, gene expression analysis, protein and proteome analysis, metabolome analysis, phenome data analysis, literature mining and bioinformatics tool development. Each chapter and theme provides an introduction to the biology behind the data describes the requirements for data processing and details some of the methods applied to the data to enhance biological understanding.
Parallel universes are a staple of science fiction, and it's no wonder. They allow us to explore the question, "what if?" in a way that lets us step completely outside of the world we know, rather than question how that world might have turned out differently. For cosmologists, the question isn't "what if the South won the Civil War?" but "what if the constants that make up the fundamental building blocks of physics were different?" Physicists argue that any slight change to the laws of physics would mean a disruption in the evolution of the universe, and thus our existence. Take gravity, for example: too strong and stars would burn through their fuel far more quickly. If the universe expanded too fast, matter would spread out too thin for galaxies to form. The list of examples goes on – to the point where the laws of physics might seem finely tuned to make our existence possible. Short of a supernatural or divine explanation, one possibility is that our universe isn't the only one. That's the idea explored in this eBook, Possibilities in Parallel: Seeking the Multiverse. In Section 1, we explore why scientists think other universes could exist. After that, we get a look at the implications. Is it possible to have life in a universe with different physical laws? It would seem so. In "Cracking Open a Window," George Musser discusses the possibility that our universe has more than three spatial dimensions – the others happen to be very small. Other articles, including "The Universe's Unseen Dimensions," analyze the idea that our universe is one of many "branes" – three-dimensional structures stretched out over a higher-dimensional space. The concept of a parallel universe also touches time travel, and then there's the question of what the term "parallel universe" actually means. It's a triumph of the sciences that the very question of why the universe looks as it does can be asked at all. There are currently several possibilities for a multiverse, if it exists. Time and a lot of scientific spadework will reveal which one is right – and get us closer to answering those metaphysical questions: what if, why us, why now?
Life is the most extraordinary phenomenon in the known universe; but how did it come to be? Even in an age of cloning and artificial biology, the remarkable truth remains: nobody has ever made anything living entirely out of dead material. Life remains the only way to make life. Are we still missing a vital ingredient in its creation?
Like Richard Dawkins' The Selfish Gene, which provided a new perspective on how evolution works, Life on the Edge alters our understanding of our world's fundamental dynamics. Bringing together first-hand experience at the cutting edge of science with unparalleled gifts of explanation, Jim Al-Khalili and Johnjoe Macfadden reveal that missing ingredient to be quantum mechanics; the phenomena that lie at the heart of this most mysterious of sciences.
Drawing on recent ground-breaking experiments around the world, each chapter in Life on the Edge engages by illustrating one of life's puzzles: How do migrating birds know where to go? How do we really smell the scent of a rose? How do our genes copy themselves with such precision? Life on the Edge accessibly reveals how quantum mechanics can answer these probing questions of the universe.
Guiding the reader through the rapidly unfolding discoveries of the last few years, Al-Khalili and McFadden communicate the excitement of the explosive new field of quantum biology and its potentially revolutionary applications, while offering insights into the biggest puzzle of all: what is life? As they brilliantly demonstrate in these groundbreaking pages, life exists on the quantum edge.
– Winner, Stephen Hawking Medal for Science Communication
The authors outline how their positions have further diverged on a number of key issues, including the spatial geometry of the universe, inflationary versus cyclic theories of the cosmos, and the black-hole information-loss paradox. Though much progress has been made, Hawking and Penrose stress that physicists still have further to go in their quest for a quantum theory of gravity.
The Essentials For Dummies Series
Dummies is proud to present our new series, The Essentials For Dummies. Now students who are prepping for exams, preparing to study new material, or who just need a refresher can have a concise, easy-to-understand review guide that covers an entire course by concentrating solely on the most important concepts. From algebra and chemistry to grammar and Spanish, our expert authors focus on the skills students most need to succeed in a subject.
Each chapter includes a discussion of recent technological developments and the biological effects of the imaging modality. End-of-chapter problem sets, lists of relevant references, and suggested further reading are presented for each technique.X-ray imaging, including CT and digital radiographyRadionuclide imaging, including SPECT and PETUltrasound imagingMagnetic resonance imaging
In biomedical research, because of a dramatic increase in productivity, immunocytochemistry has emerged as a major technique. The proposed book will provide the first practical guide to planning, performing, and evaluating immunocytochemical experiments.
In today’s graduate education the emphasis is on doing research and not on formal class work. Graduate students therefore lack the background in many essential techniques necessary to perform research in fields in which they were not trained. As director of a university core microscopy facility which sees students and faculty from dozens of laboratories each year, Dr. Burry has surmised the vast majority of these novice microscope users need considerable help. In an attempt to educate users, Dr. Burry has initiated immunocytochemistry seminars and workshops which serve to train people in this powerful research tool. The proposed book is an outgrowth of these presentations and conversations with, by now, hundreds of people who have asked for help.
The philosophy which separates this book from other books in this field is that it is practical, rather than academic. In looking at other important immunocytochemistry titles, the predominant orientation is academic, with the author attempting to comprehensively discuss the topic. For example, one book with sample preparation lists ten fixatives which can be used; however, only two such fixatives are commonly used today. In this particular title, the detailed discussion of old methods might be seen as important in establishing the author as an expert. By contrast, the approach for Burry’s book would be to discuss methods based on what works in animal research laboratories today, and focus only on the most productive methods.
An additional distinction with this proposed book is the focus on animal research and not human pathology. There is a certification program for pathology technicians which requires them to learn a set body of material based on processing human tissue for examination by a pathologist. Many of the books on immunocytochemistry aim at this large pathology user base. Due to historical reasons, pathology laboratories process human tissues in a specific way and embed the tissue in paraffin, as has been done for over a century. In the last ten years, the power of immunocytochemistry in clinical diagnosis has become clear and has accordingly been adapted to pathology. However, the extensive processing needed for paraffin sections is not needed if the tissues are from research animals. Processing for animal-based tissues takes about a third of the time and results in higher quality images. The focus of this book is on processing these animal research tissues for immunocytochemistry. Today, there are no technique books which are aimed at this user base.
As a subject matter expert in the area of the proposed book, Dr. Burry will make recommendations and offer opinions. Because this field is new and is emerging, there are numerous advantages of specific methods over other, more generalized methods. The purpose of this book is to show a novice how to do immunocytochemistry without engaging in a discussion of possible advanced methods. For the advanced user, there are several good books which discuss the unusual methods, yet for the novice there are currently none.
Main Author :
Richard W. Burry, The Ohio State University (United States).
The Outline of the Book :
Each chapter supplies a set of important principals and steps necessary for good immunocytochemistry. The information is distilled down to include only the most important points and does not attempt to cover infrequently used procedures or reagents. At the end of most chapters is a section on trouble-shooting many of the common problems using the Sherlock Holmes method. Each chapter also includes specific protocols which can be used. The goal of each chapter is to present the reader with enough information to successfully design experiments and solve many of the problems one may encounter. Using immunocytochemical protocols without the understanding of their workings is not advised, as the user will need to evaluate his or her results to determine whether the results are reliable. Such evaluation is extremely important for users who need reliable images which will clearly answer important scientific questions.
Definitions (immunocytochemistry and immunohistochemistry)
Scope: animal research and not human pathology, paraffin sections, epitope retrieval, or immunohistochemistry
Focus: fluorescence and enzyme detection
Why do immunocytochemistry?
Immunocytochemistry "individual study" rather than "population study"
Example of a two-label experiment
What is included in these chapters?
Overview of the theory
Background with enough information to help solve common problems.
Advantages and disadvantages of different options
Opinions and suggestions
2. Fixation and Sectioning
Chemistry of fixation
Denaturing vs cross-linking fixatives
Application of fixative
Perfusion, drop-in, cultures, fresh-frozen
Selection of sample section type
Rapid freezing, cryostat, freezing microtome, vibratome
Storage of tissue
Isoforms, structure, reactivity
Polyclonal vs monoclonal
Antibodies as reagents
Antibody specificity and sources
Storage and handling
4. Labels for antibodies
Fluorescence, enzymes and particulates
Fluorescent labels - four generations
Selecting enzymes vs. fluorescence
Selecting a label- advantages and disadvantages
5. Methods of applying antibodies
Antibody amplification methods
6. Blocking and Permeability
Theory of blocking
Theory of detergents
7. Procedure- Single primary antibody
Sample, fixation, sectioning
8. Multiple primary antibodies - primary antibodies of different species
9. Multiple primary antibodies-primary antibodies of same species
Wide-field fluorescence microscope
Bright field—enzyme chromogen
Size, intensity, and pixels
Manipulation—what is ethical?
11. Planning and Troubleshooting
Scheme for discussion-making in planning experiments
Case studies with Sherlock Holmes detective work
12. So you want to do electron microscopic ICC?
Criteria in decision-making
Summary of the two techniques
Instant New York Times Bestseller
“One of the year’s most entrancing books about science.”—The Wall Street Journal
“Clear, elegant...a whirlwind tour of some of the biggest ideas in physics.”—The New York Times Book Review
This playful, entertaining, and mind-bending introduction to modern physics briskly explains Einstein's general relativity, quantum mechanics, elementary particles, gravity, black holes, the complex architecture of the universe, and the role humans play in this weird and wonderful world. Carlo Rovelli, a renowned theoretical physicist, is a delightfully poetic and philosophical scientific guide. He takes us to the frontiers of our knowledge: to the most minute reaches of the fabric of space, back to the origins of the cosmos, and into the workings of our minds. The book celebrates the joy of discovery. “Here, on the edge of what we know, in contact with the ocean of the unknown, shines the mystery and the beauty of the world,” Rovelli writes. “And it’s breathtaking.”
Intended for science and engineering students with one year of introductory physics background, this textbook presents the medical applications of fundamental principles of physics to students who are considering careers in medical physics, biophysics, medicine, or nuclear engineering. It also serves as an excellent reference for advanced students, as well as medical and health researchers, practitioners, and technicians who are interested in developing the background required to understand the changing landscape of medical science. Practice exercises are included and solutions are available separately in an instructor's manual.Complete discussion of the fundamental physical principles underlying modern medicineAccessible exploration of the physics encountered in a typical visit to a doctorPractice exercises are included and solutions are provided in a separate instructor’s manual (available to professors)A companion website (modernphysicsinmedicine.com) presents supplementary materials
An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.
Over 800 problems (a 44% increase from the third edition) are included to test the student's understanding and to provide additional biological examples. A solutions manual is available to instructors. Each chapter has an extensive list of references as well as useful bibliographies for further reading. Intermediate Physics for Medicine and Biology is also ideal for self study and as a reference for workers in medical and biological research.
KEY FEATURES:Provides an excellent background in physics for physicians, biomedical engineers, and biologists Includes a new chapter on sound and ultrasound and presents stochastic processes as an integral part of biological systems Emphasizes applications of physics to biomedicine rather than molecular biophysics Contains numerous problems and exercises for course use and as a reference for self study
Science Matters is a rare exception-a science book for the general reader that is informative enough to be a popular textbook for introductory courses in high school and college, and yet well-written enough to appeal to general readers uncomfortable with scientific jargon and complicated mathematics. And now, revised and expanded for the first time in nearly two decades, it is up-to-date, so that readers can enjoy Hazen and Trefil's refreshingly accessible explanations of the most recent developments in science, from particle physics to biotechnology.
A New York Times Notable Book.
The Babylonians invented it, the Greeks banned it, the Hindus worshiped it, and the Church used it to fend off heretics. Now it threatens the foundations of modern physics. For centuries the power of zero savored of the demonic; once harnessed, it became the most important tool in mathematics. For zero, infinity's twin, is not like other numbers. It is both nothing and everything.
In Zero, Science Journalist Charles Seife follows this innocent-looking number from its birth as an Eastern philosophical concept to its struggle for acceptance in Europe, its rise and transcendence in the West, and its ever-present threat to modern physics. Here are the legendary thinkers—from Pythagoras to Newton to Heisenberg, from the Kabalists to today's astrophysicists—who have tried to understand it and whose clashes shook the foundations of philosophy, science, mathematics, and religion. Zero has pitted East against West and faith against reason, and its intransigence persists in the dark core of a black hole and the brilliant flash of the Big Bang. Today, zero lies at the heart of one of the biggest scientific controversies of all time: the quest for a theory of everything.
We live in complicated, dangerous times. Present and future presidents need to know if North Korea's nascent nuclear capability is a genuine threat to the West, if biochemical weapons are likely to be developed by terrorists, if there are viable alternatives to fossil fuels that should be nurtured and supported by the government, if private companies should be allowed to lead the way on space exploration, and what the actual facts are about the worsening threats from climate change. This is "must-have" information for all presidents—and citizens—of the twenty-first century.
Winner of the 2009 Northern California Book Award for General Nonfiction.
Stumped trying to make sense of physics? Here's your solution. Physics Demystified, Second Edition helps you grasp the essential concepts with ease.
Written in a step-by-step format, this practical guide begins by covering classical physics, including mass, force, motion, momentum, work, energy, and power, as well as the temperature and states of matter. Electricity, magnetism, and electronics are discussed as are waves, particles, space, and time. Detailed examples, concise explanations, and worked problems make it easy to understand the material, and end-of-chapter quizzes and a final exam help reinforce learning.
It's a no-brainer! You'll learn about:Scientific notation, units, and constants Newton's laws of motion Kirchhoff's laws Alternating current and semiconductors Optics Relativity theory
Simple enough for a beginner, but detailed enough for an advanced student, Physics Demystified, Second Edition helps you master this challenging and diverse subject. It's also the perfect resource to prepare you for higher-level physics classes and college placement tests.
From the Trade Paperback edition.
In The Universe, today's most influential science writers explain the science behind our evolving understanding of the universe and everything in it, including the cutting edge research and discoveries that are shaping our knowledge.
Lee Smolin reveals how math and cosmology are helping us create a theory of the whole universe. Benoit Mandelbrot looks back on a career devoted to fractal geometry. Neil Turok analyzes the fundamental laws of nature, what came before the big bang, and the possibility of a unified theory.
Seth Lloyd investigates the impact of computational revolutions and the informational revolution. Lawrence Krauss provides fresh insight into gravity, dark matter, and the energy of empty space. Brian Greene and Walter Isaacson illuminate the genius who revolutionized modern science: Albert Einstein. And much more.
Explore the universe with some of today's greatest minds: what it is, how it came into being, and what may happen next.