The many case studies that form the core of this book deal with the development and translation of non-nuclear probes and radiotracers; other sections address critical topics such as In vitro studies, small animal research, and the application of targeted probes for nuclear, optical and MRI imaging. The chapters use a common format to demonstrate how various investigators approach the comprehensive task of validating a new targeted probe.
Targeted Molecular Imaging is a timely resource for a rapidly advancing field, and addresses:
Various methods of validating a new targeted probe through examples from human studies with imaging of breast cancer, cardiovascular disease, and neurodegenerative diseases Basic principles, disease models, imaging studies in animals, imaging in initial human studies, and the application of molecular imaging in pharmacy and drug discovery In vitro studies, small animal studies, and targeted radiopharmaceuticals
Using these case studies, investigators can generalize and apply the information to their own specific targeted probe. The insights provided by the contributors, experts who have developed these approaches in their own groups, help guide scientists planning to translate imaging agents from the concept stage to clinical application.
Author Sebastian Enfield had it all. A loving family, an up-and-coming career at a Fortune 500 company, good friends and an active social life. He was living the proverbial American dream. Until, that is, his life was sidetracked when he became addicted to painkillers. It all started with far-too-easy online purchases of narcotic pills, and eventually Sebastian “graduated” to heroin. As with most addicts, as his opiate habit developed his life began to unravel. Family, friends and career became less and less important. Maintaining his expensive addiction became the most important priority each day. But when a winter blizzard came one December and “his guy” stopped returning his phone calls, Sebastian knew another kind of storm was heading his way. Withdrawal. He suffered in bed for a few days before his dealer finally returned his calls and delivered the goods. But this was the final turning point. After all he had gone through, Sebastian knew things couldn’t continue like this. So he made arrangements to visit a Suboxone-prescribing doctor, and very shortly thereafter, he was finally on the long road to recovery.
But while being treated with Suboxone, Sebastian had some anxieties and a lot of questions. “How long should I really be on this stuff? Should I try to taper off or not? And if so, how do you do it so as to minimize any discomfort? What other things should I be doing to aid in my recovery?” He looked to the Internet for answers, but what he found was a lot of contradictory information, posts from people claiming that “this stuff is even worse than what I was on before!”, and even disagreement among doctors and other health professionals with regard to Suboxone treatment protocols. Sebastian suspected that if he found all this confusing, there were probably many others in the same boat.
And so, he set out to investigate all of this, and to write a book that explained his findings in clear and simple terms. Sebastian spoke with various doctors, Suboxone patients and therapists, and synthesized their views and opinions, along with his own experiences, into a book of tips and suggestions that would help doctors and patients best approach buprenorphine treatment.
Sebastian begins with his own compelling story, where he details the life journey that ultimately led to drug addiction. He then presents several suggestions and tips that cover a wide range of questions he knew Suboxone patients had. The book covers a variety of topics, such as how to best select a doctor, how to approach counseling (and whether you really need counseling), how to taper off the medication with minimal discomfort (and whether you even should taper off the medication), resources that may help with paying for treatment, and a variety of “lifestyle hacks” Sebastian found to be useful while being treated. Sebastian lays all of this out clearly, and provides a positive and motivating read that will help patients understand that treatment with buprenorphine need not be a scary and uncertain thing. On the contrary, it can be a constructive part of recovery from opiate addiction. As he put it, “This is the book I wish I had when I began buprenorphine treatment.”
For more than three decades, millions of consumers have trusted The Pill Book to provide official, FDA-approved information on more than 1,800 of the most commonly prescribed drugs in the United States with guidelines from leading pharmacists. Each drug is profiled in a concise, readable, easy-to-understand entry, making The Pill Book the perfect reference when you have questions about the medications your doctor prescribes. Inside you’ll discover
• generic and brand-name listings that can help you save money
• What each drug is for, and how it works
• usual dosages, and what to do if a dose is skipped
• side effects and possible adverse reactions, highlighted for quick reference
• interactions with other drugs and food
• overdose and addiction potential
• alcohol-free and sugar-free medications
• the most popular self-injected medications and their safe handling
• information for seniors, pregnant and breast-feeding women, children, and others with special needs
• cautions and warnings, and when to call your doctor
• 32 pages of actual-size color photographs of prescription pills*
No home should be without this book!
*Not all ereading devices will show the images in color and at the exact size.
This book of clinical pharmacology covers the science of drugs or pharmaceutical including their origin, composition, pharmacokinetics, mechanism of action, therapeutic use, side effects and toxicology with specific description of drugs followed by short headings makes it easy to understand and point-wise explanation of information. This clinical pharmacology book will be helpful for the medical students and practicing doctors.
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Kratom and Other Mitragynines: The Chemistry and Pharmacology of Opioids from a Non-Opium Sourcepresents an introduction to the chemical and biological properties of alkaloids isolated from M. speciosa as well as their synthetic analogs. The book covers various topics including phytochemistry, medicinal chemistry, and pharmacology. Current research, analgesic effects, and addiction potential are also discussed. As the first extensive text on the basic science and clinical use of Kratom, the book provides readers with a concise yet comprehensive introduction to nature’s "other opioid."
All these problems have been shielded from public scrutiny because they're too complex to capture in a sound bite. But Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct in the medical industry affects us on a global scale.
With Goldacre's characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for regulation. This is the pharmaceutical industry as it has never been seen before.
Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.
The style and presentation form has been maintained - simple diagrams, self-explanatory flow charts, tables and student friendly mnemonics. Some new topics like cognitive enhancers, CNS stimulants, Drugs for the treatment of Psoriasis and Acne vulgaris have been introduced. Definitions, treatment schedules as per WHO (for tuberculosis, leprosy, malaria, HIV), RNTCP (for TB) guidelines and classification of blood pressure as per JNC, 2003 guidelines have been included and we acknowledge the same. This extensively revised edition will be useful not only for the students of medicine but also for practicing doctors.
Format based upon the pattern which is followed by the examiners in framing questions in the exams- both theory and Practical.
Updated content with addition of new drugs
Addition of new flowcharts, Figures and tables to facilitate quick learning and greater retention of knowledge
Specific description of drugs under short headings makes it easy to understand.
Easy to understand and point-wise presentation of information, useful for exam going UG students.
Supplementing text with simple diagrams, self-explanatory flow charts, tables and student friendly mnemonics.
Included are practice exams for the following domains:
• Pharmacy Law and Regulations
• Sterile and Non-Sterile Compounding
• Medication Safety
• Pharmacy Quality Assurance
• Medication Order Entry and Fill Process
• Pharmacy Inventory Management
• Pharmacy Billing and Reimbursement
• Pharmacy Information Usage and Application
This innovative workbook includes:
• 100 pharmaceutical calculation questions including ratios and conversions, dimensional analysis, alligation, measurements for accurate drug doses, and business math
• Formulas to master the essential math you'll face on the exam
• Five separate 100 question comprehensive practice exams
• Detailed solutions to all practice questions to help you pinpoint your strengths and weaknesses and identify areas in need of further study
Millions of Americans take prescription drugs to treat diabetes, high blood pressure, heart disease, or other conditions. But beware: The foods you eat and the medications you take could be working against each other.
Don’t Eat This If You’re Taking That takes the mystery out of food and medication interactions. This easy-to-use guide details foods that can interfere with the action of the medication—whether taken for the short or long term. In this book, readers can easily find a medication, see what foods to avoid, and make smart swaps.
We all believe a diet rich in colorful fruits and vegetables, lean proteins, whole grains, and low-fat dairy products is part of healthy eating—right? Not always. Dr. Fernstrom explains exactly what foods to avoid when and why. For instance,
If you’re taking cholesterol medicine, you should cut out—or cut down on—grapefruit.
On a blood thinner? Avoid dark green veggies.
If you’re on thyroid medication, nix the soy.
And more small diet changes with big health payoffs!
As an added bonus, each chapter offers a “Dietary Supplements Alert” box, providing the most up-to-date information on interactions with vitamins, minerals, and other dietary supplements.
With this concise, scientifically based guide, consumers can easily personalize their eating plan to work with, not against, their medications.
Presenting theoretical knowledge and applied practical considerations, this title
provides an in-depth discussion of recent advances in sterilization
identifies obstacles that may be encountered at any stage of the validation program, and suggests the newest and most advanced solutions
explores distinctive and specific process steps, and identifies critical process control points to reach acceptable results
blends the use of theoretical knowledge with recent technological advancements to achieve applied practical solutions
• Trusted Pharmacology book with emphasis on pathophysiology, clinical pharmacology and therapeutics, presenting information in integrated manner.
• Up-to-date information supplemented with tables and diagrams, having: - therapy of important diseases presented in boxes. - current guidelines to support therapeutic decisions - tips for practising physicians.
• Uses integrated approach intertwining current knowledge of pathophysiology of the disease, pharmacology of available drugs and strategies for medical management of diseases. • Balances the complexity and simplicity of scientific content to provide students of medicine and/or pharmacy an insight into rational therapeutics.
This innovative workbook includes:
• Full-length 250 question practice exam, including multiple-response, constructed-response, and ordered-response questions
• Over 100 pharmaceutical calculation questions including ratios and conversions, alligation, total parenteral nutrition, and measurements for accurate drug doses
• Over 100 sterile & non-sterile compounding questions
• Detailed solutions to all practice questions to help you pinpoint your strengths and weaknesses and identify areas in need of further study
Included are practice exams for the following topics:
• Cardiovascular Disorders
• Infectious Diseases
• Hematologic & Oncologic Disorders
• Neurologic & Psychiatric Disorders
• Endocrine Disorders
• Gastrointestinal Disorders
• Respiratory Disorders
• Renal & Urologic Disorders
• Bone & Joint Disorders
• Ophthalmic, Otic & Dermatologic Disorders
• Women's Health
• Nutrition Support & Critical Care
• Over-the-Counter Medications & Dietary Supplements
Lanzkowsky’s Manual of Pediatric Hematology and Oncology, Sixth Edition,is a comprehensive book on patient management, replete with algorithms and flow diagrams on diagnosis and management. Reflecting the considerable advances in the treatment and management of hematologic and oncologic diseases in children, the sixth edition of this successful clinical manual has been entirely updated to incorporate all current treatment protocols, new drugs, and management approaches. Its concise and easy-to-read format will enable readers to make accurate diagnoses and permit them to treat patients without having to reference larger medical textbooks.
Based on the new standards of genetic classification and prognostic information that have arisen in the past five years, the sixth edition includes two new chapters (Diagnostic, Molecular, and Genomic Methodologies for the Hematologist, Transfusion Medicine) and several new expanded chapters that were previously sections in consolidated chapters (Myelodysplasia, Myeloid Leukemias, Lymphoid Leukemias, Hemolytic Anemia, and Disorders of Coagulation).Presents a concise, systematic approach to all pediatric hematologic and oncologic disorders in one manualOffers an alternative to bigger references which only cover either oncologic or hematologic disorders in twice as many pagesPresents an easy-to-read format: multiple tables, charts, and flow-diagrams for diagnosis and management of pediatric hematologic and oncologic disordersIncludes 2 new chapters and several expanded chapters: Diagnostic, Molecular and Genomic Methodologies for the Hematologist, Transfusion Medicine, Myelodysplasia, Myeloid Leukemias, and Lymphoid Leukemias
Get the essential pharmacology information you needfrom one authoritative source with an outstanding global reputation for excellence.
Progress confidently through all relevant aspects of pharmacology,beginning with a molecular understanding of receptors and drug actions through clinical uses of key groups of drugs.
Find important content quicklythanks to a color-coded layout that enables easy navigation and cross-referencing.
Master difficult conceptswith Key Points boxes, Clinical Uses boxes, and full-color illustrations throughout. Stay up to date with new information in the field, including an all-new chapter on drugs that affect the skin.
Take advantage of new and unique features online,including 500+ chapter-specific multiple choice questions for immediate self-assessment.
eBook version included!For the first time, you can access the entire book online or offline across all devices with the Student Consult eBook!
Includes New and Updated Material
Now in its second edition, this work is the culmination of research and discussions with technical experts, as well as USP and FDA representatives on various topics of interest to the pharmaceutical microbiologist and those responsible for the microbial quality of products, materials, equipment, and manufacturing facilities. New in this edition is an entire chapter dedicated to the topic of biofilms and their impact on pharmaceutical and biopharmaceutical operations. The subject of rapid methods in microbiology has been expanded and includes a discussion on the validation of alternative microbiological methods and a case study on microbial identification in support of a product contamination investigation.
Substantially updated and revised, this book assists readers in understanding the fundamental issues associated with pharmaceutical microbiology and provides them with tools to create effective microbial contamination control and microbial testing programs for the areas under their responsibility.
Exploring how this rather benign relationship with psychoactive drugs was transformed into one of confusion and chaos, The Cult of Pharmacology tells the dramatic story of how, as one legal drug after another fell from grace, new pharmaceutical substances took their place. Whether Valium or OxyContin at the pharmacy, cocaine or meth purchased on the street, or alcohol and tobacco from the corner store, drugs and drug use proliferated in twentieth-century America despite an escalating war on “drugs.”
Richard DeGrandpre, a past fellow of the National Institute on Drug Abuse and author of the best-selling book Ritalin Nation, delivers a remarkably original interpretation of drugs by examining the seductive but ill-fated belief that they are chemically predestined to be either good or evil. He argues that the determination to treat the medically sanctioned use of drugs such as Miltown or Seconal separately from the illicit use of substances like heroin or ecstasy has blinded America to how drugs are transformed by the manner in which a culture deals with them.
Bringing forth a wealth of scientific research showing the powerful influence of social and psychological factors on how the brain is affected by drugs, DeGrandpre demonstrates that psychoactive substances are not angels or demons irrespective of why, how, or by whom they are used. The Cult of Pharmacology is a bold and necessary new account of America’s complex relationship with drugs.
Updated Second Edition
500 Questions & Answers You Need to Know
This latest addition to our Health Sciences series of flashcards is designed to help PTCE candidates check their test-readiness before taking the Pharmacy Technician Certification Exam. Unlike most flashcards that come in a box, our cards are bound in an easy-to-use, organized book that makes it convenient to study anywhere.
Written by a seasoned pharmacy technician instructor and based on the most recent exam, our study supplement covers everything you need to know for the PTCE: assisting the pharmacist in serving patients, maintaining medication and inventory control systems, and participating in the management of pharmacy practice.
The flashcards are broken down by PTCE test topics and include multiple-choice questions with detailed answer explanations. The questions are similar to what you may encounter on the PTCE. The 500 flashcards are divided as follows:
* 200 flashcards focused on the top 200 brand/generic drug names including their respective drug classes, indications, side effects, and special considerations
* 50 flashcards focused on pharmaceutical terms and abbreviations
* 250 flashcards focused on PTCE review material:
- 165 flashcards on Assisting the Pharmacist in Serving Patients
- 55 flashcards on Maintaining Medication and Inventory Control Systems
- 30 flashcards on Participating in the Administration and Management of Pharmacy Practice
After studying with the book, go online and review what you have learned at REA's Study Center. Our customizable e-flashcards and 3 practice quizzes give you the freedom to create your own PTCE study plan and study anywhere, anytime. You can also create your own unique flashcards for any sections of the test that give you difficulty.
This flashcard book and the online tools that come with it, will help you personalize your PTCE prep by testing your understanding, pinpointing your weaknesses, and delivering flashcard study materials unique to you.
If you're a pharmacy tech student and want extra practice and review before the exam, REA's PTCE Flashcard Book is the right Rx for your study needs.
A Doody's Core Title for 2017!
Pharmacotherapy: A Pathophysiologic Approach is written to help you advance the quality of patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. The scope of this trusted classic goes beyond drug indications and dosages to include the initial selection, proper administration, and monitoring of drugs. You will find everything you need to provide safe, effective drug therapy across the full range of therapeutic categories.
Presented in full-color, the Tenth Edition is enriched by more than 300 expert contributors, and every chapter has been updated to reflect the latest in evidence-based information and recommendations. This sweeping updates include tables, charts, algorithms, and practice guidelines. This edition is also enhanced by a timely all-new chapter on Travel Health.
Here’s why this is the perfect learning tool for students, patient-focused pharmacists, and other health care providers:
• All chapters have been updated to provide the most current, reliable, and relevant information possible
• Key Concepts at the beginning of each chapter
• Clinical Presentation Tables summarize disease signs and symptoms
• Clinical Controversies Boxes examine the complicated issues faced by students and clinicians in providing drug therapy
• Color coded diagnostic flow diagram, treatment algorithms, dosing recommendations, and monitoring approaches clearly distinguish treatment pathways
• Most disease-oriented chapters include updated evidence-based treatment guidelines that often include ratings of the level of evidence to support the key therapeutic approaches
Edition after trusted edition, Pharmacotherapy: A Pathophysiologic Approach has been unmatched in its ability to clearly and impartially impart core pathophysiological and therapeutic elements that students and practitioners must be familiar with.
Prozac. Millions of Americans are on it. And just about everyone else is wondering if they should be on it, too. The claims of the pro‐Prozac chorus are enticing: that it can cure everything from depression (the only disorder for which Prozac was originally approved) to fear of public speaking, PMS, obesity, shyness, migraine, and back pain—with few or no side effects. But is the reality quite different? At what price do we buy Prozac‐induced euphoria and a shiny new personality?
Psychiatrist Peter Breggin, MD, and coauthor Ginger Ross Breggin answer these and other crucial questions in Talking Back to Prozac. They explain what Prozac is and how it works, and they take a hard look at the real story behind today’s most controversial drug: The fact that Prozac was tested in trials of four to six weeks in length before receiving FDA approvalThe difficulty Prozac’s manufacturer had in proving its effectiveness during these testsThe information on side effects that the FDA failed to include in its final labeling requirementsHow Prozac acts as a stimulant not unlike the addictive drugs cocaine and amphetamineThe dangers of possible Prozac addiction and abuseThe seriousness and frequency of Prozac’s side effects, including agitation, insomnia, nausea, diarrhea, loss of libido, and difficulty reaching orgasmThe growing evidence that Prozac can cause violence and suicideThe social and workplace implications of using the drug not to cure depression but to change personality and enhance performance Using dramatic case histories as well as scientific research and carefully documented evidence, the Breggins expose the potentially damaging effects of Prozac. They also describe the resounding success that has been achieved with more humane alternatives for the treatment of depression.
Talking Back to Prozac provides essential information for anyone who takes Prozac or is considering taking it, and for those who prescribe it.
The most up-to-date, comprehensive, and authoritative pharmacology text in health medicine—enhanced by a new full-color illustrations
Organized to reflect the syllabi in many pharmacology courses and in integrated curricula, Basic & Clinical Pharmacology, Fourteenth Edition covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. Selection of the subject matter and order of its presentation are based on the authors’ many years’ experience in teaching this material to thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students.
To be as clinically relevant as possible, the book includes sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effects, and case studies that introduce clinical problems in many chapters. Presented in full color and enhanced by more than three hundred illustrations (many new to this edition), Basic & Clinical Pharmacology features numerous summary tables and diagrams that encapsulate important information.
• Student-acclaimed summary tables conclude each chapter
• Everything students need to know about the science of pharmacology and its application to clinical practice
• Strong emphasis on drug groups and prototypes
• NEW! 100 new drug tables
• Includes 330 full-color illustrations, case studies, and chapter-ending summary tables
• Organized to reflect the syllabi of pharmacology courses
• Descriptions of important new drugs
This book is your starting point. It is a direct response to requests from students for a compendium of the 100 most important drugs in the NHS. Key information about the clinical pharmacology and practical prescribing of each drug is presented side-by-side, allowing you to direct your attention as appropriate for your stage of training. Drugs can be accessed alphabetically when you need quick information on the wards and by organ system or clinical indication when you are at your desk.
Research led by Professor Emma Baker has identified the ‘top 100 drugs’ by their importance and prescribing frequency. She has shown that the list changes little over time, making it a stable resource upon which to base learning.The top 100 drugs and the five most important intravenous fluids are presented using a clear, consistent layout across double-page spreads.
Drugs are arranged alphabetically and also listed by organ system and clinical indication, providing multiple pathways into the information.
Clinical pharmacologyis discussed under the headings: common indications; mechanisms of action; important adverse effects; warnings; and important interactions.
Practical prescribingis discussed under the headings: prescription; administration; communication; monitoring; and cost.
A clinical tip is presented for every drug.
Single-best-answer questionsare provided for self-assessment and to show how information from several drugs may be integrated.
The authors offer a basic introduction to pharmacological concepts, embedded in specific conditions, through case studies and self-assessment questions. By utilising a case study approach, they enable the reader to link pharmacological concepts with clinical practice.
Many of the conditions presented will be seen across all healthcare settings. In addition, the comprehensive glossary and list of abbreviations will enable students to understand some of the more technical terms used in the British National Formulary (BNF) and other prescribing sources.
Reading this book, and carrying out the numerous self-assessment activities, will give the reader an appreciation of the value of having a sound pharmacological knowledge base in order to deliver safe practice, effective prescribing and improved patient care.
How the body affects drugs
How drugs affect the body
Types of adverse drug reactions and interactions
Understanding and using the British National Formulary
Chronic obstructive pulmonary disease
Incontinence in adults
Mental health problems
Complex health needs and polypharmacy
The challenges of non-medical prescribing
McGraw-Hill's EMT Flashcards offer a succint, comprehensive, and easy-to-carry review of the essential concepts students need to remember for their certification exam. Each two-sided care features a question on one side with a detailed answer on the flip side. Answers are presented in text, lists, tables, and images.
McGraw-Hill's Paramedic Flashcards offer a succint, comprehensive, and easy to carry review of the must-know concepts that students need to remember for their certification exam.Cards cover high-yield content for the certification exam. Succinct questions on the front of the card test students on important concepts Answers on the back of the card are explained with text, lists, tables and/or images Cards include tips and mnemonics to enhance memory
The Ultimate Guide to Getting into Physician Assistant School is a unique, step-by-step blueprint for succeeding at every stage of the PA application process. Written by Andrew Rodican, a former member of Yale University School of Medicine’s Admissions Committee, this is the best book available on how to maximize your chance of acceptance into the PA school of your choice.
Completely updated to include coverage of the Central Application Service for Physician Assistants (CASPA), Getting Into the Physician Assistant School of Your Choice covers all the essentials – from selecting a program all the way through to acing the interview. Clear and candid, this book provides insights, information, and advice you won’t find anyplace else – but may well make the difference between the acceptance or rejection of your application.
Make-or-break advice on:
Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Thirteenth Edition represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease.
The Thirteenth Edition includes more than 500 color illustrations, with many new figures emphasizing mechanisms of drug action. More than 30 new contributors have added to this edition, while the focus on basic principles is undiminished.
This edition is enhanced by timely new content:
•NEW chapters including Treatment of Pulmonary Arterial Hypertension, Immunity and Inflammation, Immunoglobulins and Vaccines, and Treatment of Viral Hepatitis
•Expanded coverage of cardiovascular disease, with separate chapters on myocardial ischemia, hypertension, and heart failure
•Increased emphasis on cellular signaling pathways involved in drug action
•Summary tables at the end of each chapter that organize drugs discussed in that chapter into relevant categories and detail therapeutic usage, clinical pharmacology, and tips
•Chapter Content Outlines at the beginning of each chapter
•Abbreviation boxes in every chapter to easily identify the abbreviations appearing in that chapter
More than a textbook, Goodman & Gilman’s is a working template for the effective and rational prescribing of drugs in daily practice.
From the authors of Basic and Clinical Pharmacology, the leading pharmacology textbook, here is the newest edition of the best review book available for medical pharmacology course exams and board examinations. This skill-building guide comes with more than 1,000 questions and answers –- far more than most other pharmacology reviews –- and a chapter-based approach that facilitates use with course notes or larger texts.
Presented in full color and organized to match the syllabi of pharmacology courses, the book is highlighted by concise discussion of the major concepts the underlie basic pharmacology principles or specific drug groups, and learning aids that include numerous tables and figures, high-yield terms and definitions, summary tables, test-taking strategies, and two complete practice exams with answer explanations in the appendix.Delivers the most up-to-date information on all drugs, including retrovirals, immunologic agents, and chemotherapies. Includes two comprehensive 100-question examinations
—Robert Harrington, Professor of Medicine, Director,Duke Clinical Research Institute, Durham, North Carolina, USA
The Duke Clinical Research Institute (DCRI) is one of theworld's leading academic clinical research organizations; itsmission is to develop and share knowledge that improves the care ofpatients around the world through innovative clinical research.This concise handbook provides a practical "nuts and bolts"approach to the process of conducting clinical trials, identifyingmethods and techniques that can be replicated at other institutionsand medical practices.
Designed for investigators, research coordinators, CROpersonnel, students, and others who have a desire to learn aboutclinical trials, this manual begins with an overview of thehistorical framework of clinical research, and leads the readerthrough a discussion of safety concerns and resulting regulations.Topics include Good Clinical Practice, informed consent, managementof subject safety and data, as well as monitoring and reportingadverse events.
Updated to reflect recent regulatory and clinical developments,the manual reviews the conduct of clinical trials research in anincreasingly global context. This new edition has been furtherexpanded to include:In-depth information on conducting clinical trials of medicaldevices and biologicsThe role and responsibilities of Institutional Review Boards,andRecent developments regarding subject privacy concerns andregulations.
Ethical documents such as the Belmont Report and the Declarationof Helsinki are reviewed in relation to all aspects of clinicalresearch, with a discussion of how researchers should apply theprinciples outlined in these important documents. This graphicallyappealing and eminently readable manual also provides sample formsand worksheets to facilitate data management and regulatory recordretention; these can be modified and adapted for use atinvestigative sites.
Sponsored by the American Board of Funeral Service Education
Comprehensive and thoroughly updated in this fifth edition, Embalming: History, Theory, and Practice is the leading text in the field. The trusted classic covers the long history of embalming, explains embalming theory, and describes present practice, including the latest trends.
Special attention has been given to the creation of a safe working environment – from the standpoint of ergonomics, personal hygiene, and the use of embalming chemicals. Expanded technical areas of the book will assist you in the preparation of the body for viewing without using standard embalming chemicals. The fifth edition is also enhanced by a full-color 12-page insert demonstrating restorative arts and mortuary cosmetology.
Turn to the field’s leading text for unmatched coverage of:Legal, social, and technical considerations of embalming Health and regulatory standards Chemicals and methods Specific conditions and causes of death that influence the type of embalming Special cosmetic applications and restorative procedures Preparation of organ and tissue donors Embalming for shipping
Soto Laveaga traces the political, economic, and scientific development of the global barbasco industry from its emergence in the 1940s, through its appropriation by a populist Mexican state in 1970, to its obsolescence in the mid-1990s. She focuses primarily on the rural southern region of Tuxtepec, Oaxaca, where the yam grew most freely and where scientists relied on local, indigenous knowledge to cultivate and harvest the plant. Rural Mexicans, at first unaware of the pharmaceutical and financial value of barbasco, later acquired and deployed scientific knowledge to negotiate with pharmaceutical companies, lobby the Mexican government, and ultimately transform how urban Mexicans perceived them. By illuminating how the yam made its way from the jungles of Mexico, to domestic and foreign scientific laboratories where it was transformed into pills, to the medicine cabinets of millions of women across the globe, Jungle Laboratories urges us to recognize the ways that Mexican peasants attained social and political legitimacy in the twentieth century, and positions Latin America as a major producer of scientific knowledge.
“Prescient . . . a landmark work of investigative journalism.”—David A. Kessler, former commissioner of the Food and Drug Administration and author of The End of Overeating
Between 1999 and 2017, an estimated 250,000 Americans died from overdoses involving prescription painkillers, a plague ignited by Purdue Pharma’s aggressive marketing of OxyContin. Families, working class and wealthy, have been torn apart, businesses destroyed, and public officials pushed to the brink.
In Pain Killer, Pulitzer Prize–winning New York Times reporter Barry Meier exposes the roots of the most pressing health epidemic of the twenty-first century. Powerful narcotic painkillers, or opioids, were once used as drugs of last resort for pain sufferers. Purdue turned OxyContin into a billion-dollar blockbuster by launching an unprecedented marketing campaign claiming that the drug’s long-acting formulation made it safer to use than traditional painkillers for many types of pain. That illusion was quickly shattered as drug abusers learned that crushing an Oxy could release its narcotic payload all at once. Even in its prescribed form, Oxy proved fiercely addictive. As OxyContin’s use and abuse grew, Purdue concealed what it knew from regulators, doctors, and patients.
Here are the people who profited from the crisis and those who paid the price, those who plotted in boardrooms and those who tried to sound alarm bells. A country doctor in rural Virginia, Art Van Zee, took on Purdue and warned officials about OxyContin abuse. An ebullient high school cheerleader, Lindsey Myers, was reduced to stealing from her parents to feed her escalating Oxy habit. A hard-charging DEA official, Laura Nagel, tried to hold Purdue executives to account. The drugmaker’s owners, Raymond and Mortimer Sackler, whose names adorn museums worldwide, made enormous fortunes from the commercial success of OxyContin.
In this updated edition of Pain Killer, Barry Meier breaks new ground in his decades-long investigation into the opioid epidemic. He takes readers inside Purdue to show how long the company withheld information about the abuse of OxyContin and gives a shocking account of the Justice Department’s failure to alter the trajectory of the opioid epidemic and protect thousands of lives. Equal parts crime thriller, medical detective story, and business exposé, Pain Killer is a hard-hitting look at how a supposed wonder drug became the gateway drug to a national tragedy.
The Hands-on Guide to Clinical Pharmacology is theperfect companion for students, doctors, nurses, pharmacists andother health care professionals who need help on the ward or arepreparing for exams. It includes sections containing both treatmentregimens of common conditions and detailed information on therelevant drugs that help you obtain a better understanding oftherapeutic management.
The benefits include:A-Z of over 100 key drugs in a one-drug-per-page formatA systems-based approachFully indexed textClear explanations of drug mechanisms - a regular feature ofpharmacology examsManagement guidelines for common conditions within eachsystemBrand new two-colour design to help with informationretrievalA new chapter on chemotherapy agents
Take the stress out of clinical pharmacology with TheHands-on Guide!
Speed-Speed-Speedfreak traces the criminal and cultural use of amphetamine and its growing use through each new and destructive cycle. The book will be printed in rounded pill capsule form, like the vaunted “black beauty” of pharmaceutical history.
Mick Farren is the former lead singer of The Deviants and the author of more than forty books.
A Doody's Core Title for 2017!General Principles of Toxicology Disposition of Toxicants Nonorgan-directed Toxicity Target Organ Toxicity Toxic Agents Environmental Toxicology Applications of Toxicology
Casarett & Doull’s Essentials of Toxicology is an easy-to-absorb distillation of the major principles and concepts that were presented in depth in Casarett & Doull’s Toxicology: The Basic Science of Poisons, Eighth Edition, the field’s gold-standard text.
Presented in full color, the book concisely describes the science of toxicology, and includes important concepts from anatomy, physiology, and biochemistry to facilitate the understanding of the principles and mechanisms of toxicant action on specific organ systems. A summary of key points at the beginning and review questions at the end of each chapter help you study, understand, and memorize the material.
Reflecting the expertise of more than sixty renowned contributors, Casarett & Doull’s Essentials of Toxicology is logically divided into seven sections:
Succinct and comprehensive, there is no better text for gaining an understanding of essential principles, toxicokinetics, how toxic effects are passed on to succeeding generations, how each body system responds to poisons, and the specific effects of a wide range of toxic agents than Casarett & Doull’s Essentials of Toxicology.
This second edition of the Handbook of Poisonous and Injurious Plants is created to assist the clinician in the initial response to the needs of a child or adult exposed to a poisonous or injurious plant. It lists common plants that might lead to the development of the symptom complex and describes the mechanisms of action of the implicated toxin, additional clinical manifestations, and specific therapeutics for each presentation. It has methodically enhanced the previous edition’s botanical rigor with insights from both pharmacognosy and clinical medicine to make it a truly comprehensive source.
With its thorough references and full-color photos of hundreds of potentially toxic and injurious plants inside the home, anyone who has an interest in plants will find this book useful outside in the garden or out in the wild.
This book will fascinate botanists, horticulturists, and naturalists as well as hikers, gardeners, and all those who simply enjoy the wonders of nature and the great outdoors!
With Foreword by Lewis R. Goldfrank, MD and Introduction by Andrew Weil, MD
Experience with clinical cases is key to excelling on the USMLE Step 1 and shelf exams, and ultimately to providing patients with competent clinical care. Case Files: Pharmacology provides 56 true-to-life clinical cases that illustrate essential concepts in pharmacology. Each case includes an easy-to-understand discussion correlated to key basic science concepts, definitions of key terms, pharmacology pearls, and USMLE-style review questions. With Case Files, you'll learn instead of memorize.Learn from 56 high-yield cases, each with board-style questions Master key concepts with clinical pearls Polish your approach to clinical problems and to patient care Maximize your board scores with the proven Case Files system
Miracle Medicines goes behind the scenes of the pharmaceutical industry and into the high-security laboratories to tell the stories of the men and women---chemists, physiologists, medical and clinical researchers, engineers---who have chosen to toil for years in the lab in order to transform scientific theories into new lifesaving medicines.
You’ll witness the day-to-day labors, victories and defeats of the dedicated professionals who are waging a war against the diseases that still plague mankind. From the confines of their laboratories, these pharmaceutical adventurers explore unknown territories in health and science.
Miracle Medicines reveals what really happens during the long and uncertain journey that each new drug and its creators must endure from theory, to research, to testing and, finally, FDA approval and delivery to the public. It’s a very human story within the context of fascinating scientific innovation.
Through first hand interviews you’ll also meet the patients who benefit from these manmade miracles and learn how, within their bloodstreams, an ongoing battle is raging. The drugs profiled are:Advair: GlaxoSmithKline’s revolutionary asthma medication, the first packaged as both a control and emergency drug.Gleevec: The Novartis’ chronic myeloid leukemia treatment born from decades of medical research in a field of study that was once considered hopeless.Humalog: Eli Lilly’s reinvention of insulin to control diabetes has been described as being better than natureLipitor: Pfizer’s miracle antidote for high cholesterol that was nearly lost to the pharmaceutical vaults and has since become the world’s top-selling medicine.Norvir: Abbott’s contribution to the fight against HIV that nearly erases all traces of the disease from the bloodstream and prolongs the life of patients.Remicade: Created for the treatment of Crohn’s disease, rheumatoid arthritis and other Immune Mediated Inflammatory Diseases, Johnson & Johnson’s revolutionary biomedicine was developed from technology that once was only found in science fiction.Seroquel: AstraZeneca’s treatment for both schizophrenia and bipolar mania that has given millions of psychiatrics a new lease on life.
This compelling and truth-revealing book will forever change the way you view the medicines in your medicine cabinet, and the people who create them.
The first volume provides a foundation of knowledge in the clinical practice of complementary medicine.
It emphasises safe practice with strategies to prevent adverse drug reactions, guidelines in assessing benefit, risk and harm and the evaluation of research.Comprehensive review of herbal medicine, clinical nutrition, aromatherapy, and food as medicinePatient safety and wellnessConsiderations in preoperative care and pregnancyUse in the treatment of cancerHerb/nutrient – drug interactions.Provides up-to-date evidence on the latest research impacting on herbal and natural medicine by top leaders within the fields of Pharmacy, Herbal Medicine and Natural Medicine.
Development and use of robust analytical methods is critical for the ability to generate accurate analytical data. Sample preparation is an integral part of the analytical method. In a survey conducted by LC-GC1, responses indicated that approximately two-thirds of the time spent testing and analyzing samples was spent on the sample preparation portion of the method. In addition, issues related to sample preparation accounted for one-third of the errors generated while performing an analytical method.
A number of challenges exist in the sample preparation/extraction of pharmaceutical dosage forms for potency and purity analysis as well as isolation and identification of impurities and degradants. These challenges increase for complex dosage forms such as some controlled release formulations and other challenging formulations such as suspensions, ointments, transdermal patches, etc. Challenges in developing rapid and rugged sample preparation methods include complete dispersion of the dosage form to facilitate extraction and solubilization of the analytes of interest, dealing with extracted interfering components and addressing drug-excipient interactions. A number of factors must be considered and addressed in each of these areas.
The objective of Sample Preparation of Pharmaceutical Dosage Forms is to provide an overview of the various sample preparation and extraction techniques available for pharmaceutical dosage forms. In addition to the review and discussion of specific techniques, sample preparation method development and trouble shooting strategies are discussed. Multiple examples and case studies are presented to highlight various potential issues and solutions.
• Introduces requisite background to using NonlinearMixed Effects Modeling (NONMEM), covering data requirements, modelbuilding and evaluation, and quality control aspects
• Provides examples of nonlinear modeling concepts andestimation basics with discussion on the model buildingprocess and applications of empirical Bayesian estimates in thedrug development environment
• Includes detailed chapters on data set structure,developing control streams for modeling and simulation, modelapplications, interpretation of NONMEM output and results, andquality control
• Has datasets, programming code, and practice exerciseswith solutions, available on a supplementary website