The text first covers topics about various biological markers, such as neurochemical, enzymatic, membrane, receptors, endocrine, and physiological. Next, the selection examines the relationship between alcohol abuse and biological papers. The next part covers the genetic aspects of biological markers. The text also deals with use of tomography and modeling theory.
The book will be of great use to students, researchers, and practitioners of neurology and psychiatry. Psychologists will also benefit from the text.
Areas discussed include: mechanisms of degeneration of Parkinson's Disease; the interrelationships between gait and cognitive function; advances in gene transfer and pharmacological regulation of protein aggregation in the treatment of Alzheimer's and Parkinson's Diseases; Alzheimer pathology and ER stress; and stem cell strategies for Alzheimer's Disease.
Just two months before the September 11 terrorist attacks, Dr. Judy Melinek began her training as a New York City forensic pathologist. While her husband and their toddler held down the home front, Judy threw herself into the fascinating world of death investigation—performing autopsies, investigating death scenes, counseling grieving relatives. Working Stiff chronicles Judy’s two years of training, taking readers behind the police tape of some of the most harrowing deaths in the Big Apple, including a firsthand account of the events of September 11, the subsequent anthrax bio-terrorism attack, and the disastrous crash of American Airlines Flight 587.
An unvarnished portrait of the daily life of medical examiners—complete with grisly anecdotes, chilling crime scenes, and a welcome dose of gallows humor—Working Stiff offers a glimpse into the daily life of one of America’s most arduous professions, and the unexpected challenges of shuttling between the domains of the living and the dead. The body never lies—and through the murders, accidents, and suicides that land on her table, Dr. Melinek lays bare the truth behind the glamorized depictions of autopsy work on television to reveal the secret story of the real morgue. “Haunting and illuminating...the stories from her average workdays…transfix the reader with their demonstration that medical science can diagnose and console long after the heartbeat stops” (The New York Times).
Thousands of people have had near-death experiences, but scientists have argued that they are impossible. Dr. Eben Alexander was one of those scientists. A highly trained neurosurgeon, Alexander knew that NDEs feel real, but are simply fantasies produced by brains under extreme stress.
Then, Dr. Alexander’s own brain was attacked by a rare illness. The part of the brain that controls thought and emotion—and in essence makes us human—shut down completely. For seven days he lay in a coma. Then, as his doctors considered stopping treatment, Alexander’s eyes popped open. He had come back.
Alexander’s recovery is a medical miracle. But the real miracle of his story lies elsewhere. While his body lay in coma, Alexander journeyed beyond this world and encountered an angelic being who guided him into the deepest realms of super-physical existence. There he met, and spoke with, the Divine source of the universe itself.
Alexander’s story is not a fantasy. Before he underwent his journey, he could not reconcile his knowledge of neuroscience with any belief in heaven, God, or the soul. Today Alexander is a doctor who believes that true health can be achieved only when we realize that God and the soul are real and that death is not the end of personal existence but only a transition.
This story would be remarkable no matter who it happened to. That it happened to Dr. Alexander makes it revolutionary. No scientist or person of faith will be able to ignore it. Reading it will change your life.
The Future of the Mind brings a topic that once belonged solely to the province of science fiction into a startling new reality. This scientific tour de force unveils the astonishing research being done in top laboratories around the world—all based on the latest advancements in neuroscience and physics—including recent experiments in telepathy, mind control, avatars, telekinesis, and recording memories and dreams. The Future of the Mind is an extraordinary, mind-boggling exploration of the frontiers of neuroscience. Dr. Kaku looks toward the day when we may achieve the ability to upload the human brain to a computer, neuron for neuron; project thoughts and emotions around the world on a brain-net; take a “smart pill” to enhance cognition; send our consciousness across the universe; and push the very limits of immortality.
An instant bestseller that is poised to become a classic, Moonwalking with Einstein recounts Joshua Foer's yearlong quest to improve his memory under the tutelage of top "mental athletes." He draws on cutting-edge research, a surprising cultural history of remembering, and venerable tricks of the mentalist's trade to transform our understanding of human memory. From the United States Memory Championship to deep within the author's own mind, this is an electrifying work of journalism that reminds us that, in every way that matters, we are the sum of our memories.
From the Trade Paperback edition.
Ray Kurzweil is arguably today’s most influential—and often controversial—futurist. In How to Create a Mind, Kurzweil presents a provocative exploration of the most important project in human-machine civilization—reverse engineering the brain to understand precisely how it works and using that knowledge to create even more intelligent machines.
Kurzweil discusses how the brain functions, how the mind emerges from the brain, and the implications of vastly increasing the powers of our intelligence in addressing the world’s problems. He thoughtfully examines emotional and moral intelligence and the origins of consciousness and envisions the radical possibilities of our merging with the intelligent technology we are creating.
Certain to be one of the most widely discussed and debated science books of the year, How to Create a Mind is sure to take its place alongside Kurzweil’s previous classics which include Fantastic Voyage: Live Long Enough to Live Forever and The Age of Spiritual Machines.
From the Hardcover edition.
Jeff Hawkins, the man who created the PalmPilot, Treo smart phone, and other handheld devices, has reshaped our relationship to computers. Now he stands ready to revolutionize both neuroscience and computing in one stroke, with a new understanding of intelligence itself.
Hawkins develops a powerful theory of how the human brain works, explaining why computers are not intelligent and how, based on this new theory, we can finally build intelligent machines.
The brain is not a computer, but a memory system that stores experiences in a way that reflects the true structure of the world, remembering sequences of events and their nested relationships and making predictions based on those memories. It is this memory-prediction system that forms the basis of intelligence, perception, creativity, and even consciousness.
In an engaging style that will captivate audiences from the merely curious to the professional scientist, Hawkins shows how a clear understanding of how the brain works will make it possible for us to build intelligent machines, in silicon, that will exceed our human ability in surprising ways.
Written with acclaimed science writer Sandra Blakeslee, On Intelligence promises to completely transfigure the possibilities of the technology age. It is a landmark book in its scope and clarity.
Presents information in a concise, at-a-glance format.
Fits into your pocket, for a convenient reference any time.
Offers abundant page references to the parent text, making additional information easy to find.Completely updated to reflect the latest knowledge and techniques across all areas of pathology.
In contrast to the “baseline brain” that fulfills the tasks of everyday life, Chopra and Tanzi propose that, through a person’s increased self-awareness and conscious intention, the brain can be taught to reach far beyond its present limitations. “We are living in a golden age for brain research, but is this a golden age for your brain?” they ask.
Super Brain explains how it can be, by combining cutting-edge research and spiritual insights, demolishing the five most widespread myths about the brain that limit your potential, and then showing you methods to:
-Use your brain instead of letting it use you
-Create the ideal lifestyle for a healthy brain
-Reduce the risks of aging
-Promote happiness and well-being through the mind-body connection
-Access the enlightened brain, the gateway to freedom and bliss
-Overcome the most common challenges, such as memory loss, depression, anxiety, and obesity
Your brain is capable of incredible healing and constant reshaping. Through a new relationship with your brain you can transform your life. In Super Brain, Chopra and Tanzi guide you on a fascinating journey that envisions a leap in human evolution. The brain is not just the greatest gift that Nature has given us. It’s the gateway to an unlimited future that you can begin to live today.
the drama of the front lines.”
-Richard Danzig, former secretary of the navy
The first major bioterror event in the United States-the anthrax attacks in October 2001-was a clarion call for scientists who work with “hot” agents to find ways of protecting civilian populations against biological weapons. In The Demon in the Freezer, his first nonfiction book since The Hot Zone, a #1 New York Times bestseller, Richard Preston takes us into the heart of Usamriid, the United States Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland, once the headquarters of the U.S. biological weapons program and now the epicenter of national biodefense.
Peter Jahrling, the top scientist at Usamriid, a wry virologist who cut his teeth on Ebola, one of the world’s most lethal emerging viruses, has ORCON security clearance that gives him access to top secret information on bioweapons. His most urgent priority is to develop a drug that will take on smallpox-and win. Eradicated from the planet in 1979 in one of the great triumphs of modern science, the smallpox virus now resides, officially, in only two high-security freezers-at the Centers for Disease Control in Atlanta and in Siberia, at a Russian virology institute called Vector. But the demon in the freezer has been set loose. It is almost certain that illegal stocks are in the possession of hostile states, including Iraq and North Korea. Jahrling is haunted by the thought that biologists in secret labs are using genetic engineering to create a new superpox virus, a smallpox resistant to all vaccines.
Usamriid went into a state of Delta Alert on September 11 and activated its emergency response teams when the first anthrax letters were opened in New York and Washington, D.C. Preston reports, in unprecedented detail, on the government’s response to the attacks and takes us into the ongoing FBI investigation. His story is based on interviews with top-level FBI agents and with Dr. Steven Hatfill.
Jahrling is leading a team of scientists doing controversial experiments with live smallpox virus at CDC. Preston takes us into the lab where Jahrling is reawakening smallpox and explains, with cool and devastating precision, what may be at stake if his last bold experiment fails.
In the first book of its kind, journalist Donna Jackson Nakazawa examines nearly 100 debilitating autoimmune diseases—such as multiple sclerosis, lupus, Crohn’s disease, type 1 diabetes, and rheumatoid arthritis—that cause the body to destroy itself, mistakenly attacking healthy cells as the immune system fights off bacteria, viruses, and other invaders. As Nakazawa share the vivid, heartbreaking stories, including her own, of people living with these mysterious, chronic, and often hard-to-diagnose illnesses, she explores the alarming and unexpected connection between this deadly crisis and the countless environmental triggers we’re exposed to every day: heavy metals, toxins, pesticides, viruses, chemicals in the foods we eat, and more.
With the help of leading experts, Nakazawa explores revolutionary preventions, treatments, and cures emerging around the world and offers practical advice for protecting your immune system and reducing your risk of autoimmune disease in the future.
On December 10, 1996, Jill Bolte Taylor, a thirty-seven- year-old Harvard-trained brain scientist experienced a massive stroke in the left hemisphere of her brain. As she observed her mind deteriorate to the point that she could not walk, talk, read, write, or recall any of her life-all within four hours-Taylor alternated between the euphoria of the intuitive and kinesthetic right brain, in which she felt a sense of complete well-being and peace, and the logical, sequential left brain, which recognized she was having a stroke and enabled her to seek help before she was completely lost. It would take her eight years to fully recover.
For Taylor, her stroke was a blessing and a revelation. It taught her that by "stepping to the right" of our left brains, we can uncover feelings of well-being that are often sidelined by "brain chatter." Reaching wide audiences through her talk at the Technology, Entertainment, Design (TED) conference and her appearance on Oprah's online Soul Series, Taylor provides a valuable recovery guide for those touched by brain injury and an inspiring testimony that inner peace is accessible to anyone.
In this Pulitzer Prize finalist and national bestseller, one of the world's leading cognitive scientists tackles the workings of the human mind. What makes us rational—and why are we so often irrational? How do we see in three dimensions? What makes us happy, afraid, angry, disgusted, or sexually aroused? Why do we fall in love? And how do we grapple with the imponderables of morality, religion, and consciousness? How the Mind Works synthesizes the most satisfying explanations of our mental life from cognitive science, evolutionary biology, and other fields to explain what the mind is, how it evolved, and how it allows us to see, think, feel, laugh, interact, enjoy the arts, and contemplate the mysteries of life.
This edition of Pinker's bold and buoyant classic is updated with a new foreword by the author.
In fifteen easy-to-read chapters, featuring the humorous style and engaging analogies developed by Dr. Sompayrac, How the Immune System Works explains how the immune system players work together to protect us from disease – and, most importantly, why they do it this way.
Rigorously updated for this fifth edition, How the Immune System Works includes the latest information on subjects such as vaccines, the immunology of AIDS, and cancer. A highlight of this edition is a new chapter on the intestinal immune system – currently one of the hottest topics in immunology.
Whether you are completely new to immunology, or require a refresher, How the Immune System Works will provide you with a clear and engaging overview of this fascinating subject. But don’t take our word for it! Read what students have been saying about this classic book:
"What an exceptional book! It's clear you are in the hands of an expert."
"Possibly the Best Small Text of All Time!"
"This is a FUN book, and Lauren Sompayrac does a fantastic job of explaining the immune system using words that normal people can understand."
"Hands down the best immunology book I have read... a very enjoyable read."
"This is simply one of the best medical textbooks that I have ever read. Clear diagrams coupled with highly readable text make this whole subject easily understandable and engaging."
Now with a brand new website at www.wiley.com/go/sompayrac featuring Powerpoint files of the images from the book
Develop a thorough, clinically relevant understanding of immunologythrough a clear overview of immunology with a distinct focus on the management of human disease.
Visualize immunologic processes more effectively.Meticulously developed and updated illustrations, 3-dimensional art, and all-new animations provide a detailed, visual description of the key immunologic and molecular processes.
Grasp the details of experimental observationsthat form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions.
Find information more quickly and easilythrough an organized chapter structure and a more logical flow of material.
Glean all essential, up-to-date, need-to-know information about immunology and molecular biology through extensive updates that cover cytokines, innate immunity, leukocyte-endothelial interactions, signaling, costimulation, and more.
Benefit from numerous new figures and tablesthat facilitate easier retention of the material; quick summaries of each chapter; and nearly 400 illustrations that clarify key concepts.
Fields and Johnston tell real life stories that hinge on the inheritance of one tiny change rather than another in an individual's DNA: a mother wrongly accused of poisoning her young son when the true killer was a genetic disorder; the screen siren who could no longer remember her lines because of Alzheimer's disease; and the president who was treated with rat poison to prevent another heart attack. In an engaging and accessible style, Fields and Johnston explain what our personal DNA code is, how a few differences in its long list of DNA letters makes each of us unique, and how that code influences our appearance, our behavior, and our risk for such common diseases as diabetes or cancer.
Grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions.Stay abreast of the latest advances in immunology and molecular biology through extensive updates that cover cytokines, innate immunity, leukocyte-endothelial interactions, signaling, costimulation, and more.
Visualize immunologic processes more effectively through a completely revised art program with redrawn figures, a brighter color palette, and more 3-dimensional art.
Find information more quickly and easily through a reorganized chapter structure and a more logical flow of material.
There is a cure for all disease.
It is 100% Natural and costs only a few dollars each month.
Your body heals you by giving it what it needs and making sure you avoid the poisons that cause all disease.
Water is the very Essence of Life.
Without water there would no Life on this planet.
This is why I believe the quality of your health is equal to the quality of your water.
There are no cures with doctors and the medical profession.
They turned their backs on all cures and all real medicine once drug corporations began manufacturing synthetic man-made chemical "medicines” starting in 1939.
Cures ended with Dr. Jonas Salk's polio vaccine which he gave to mankind for free in 1954.
Poisons cause all disease. Without poisons, even germs and viruses could not make you sick.
All disease requires an acidic body to exist in. Your body becomes acidic by habitual consumption of poisons in your food, drinks and water; such as white flour, white sugar, high fructose corn syrup, red meats and the chlorine and fluoride in your water.
This book teaches you how to reverse the acidity of your body, correct your diet deficiencies and to value Water, the very Essence of Life.
There are also some quick cures for some major diseases like migraines, kidney stones, heartburn and others. These cures may seem like "miracle cures”, but they are just science that has been around since man began living on this Earth.
The thing that the Author adds to those centuries of proven healing science is how to recognize and avoid the saturation of poisons that have inundated our food, drinks and water supplies, as well as personal hygiene items.
The Author teaches you how to clean up your current diet and also gives you details on other things you can do to improve your health and speed you on to freedom from disease.
This book was written by a man who cured himself of 10 diseases doctors REFUSE to cure. And did so after doctors said he would be on dialysis or dead by 2009.
Before then, the Author did not know that doctors cure no one.
YOU must decide whether to remain without hope as you have with all doctors - OR...
Learn how to use Natural Science to restore your Natural body to health to rid it of all disease.
For those who choose Life and freedom from sickness, this book was written for YOU!
...A short and to the point book to get you cured of all disease as quickly as possible -
The Cure For All Disease
When Temple Grandin was born in 1947, autism had only just been named. Today it is more prevalent than ever, with one in 88 children diagnosed on the spectrum. And our thinking about it has undergone a transformation in her lifetime: Autism studies have moved from the realm of psychology to neurology and genetics, and there is far more hope today than ever before thanks to groundbreaking new research into causes and treatments. Now Temple Grandin reports from the forefront of autism science, bringing her singular perspective to a thrilling journey into the heart of the autism revolution.
Weaving her own experience with remarkable new discoveries, Grandin introduces the neuroimaging advances and genetic research that link brain science to behavior, even sharing her own brain scan to show us which anomalies might explain common symptoms. We meet the scientists and self-advocates who are exploring innovative theories of what causes autism and how we can diagnose and best treat it. Grandin also highlights long-ignored sensory problems and the transformative effects we can have by treating autism symptom by symptom, rather than with an umbrella diagnosis. Most exciting, she argues that raising and educating kids on the spectrum isn’t just a matter of focusing on their weaknesses; in the science that reveals their long-overlooked strengths she shows us new ways to foster their unique contributions.
From the “aspies” in Silicon Valley to the five-year-old without language, Grandin understands the true meaning of the word spectrum. The Autistic Brain is essential reading from the most respected and beloved voices in the field.
The AJCC Cancer Staging Atlas, 2nd Edition, is an official publication of the American Joint Committee on Cancer, the recognized international leader in state-of-the-art information on cancer staging. This Atlas has been created as a companion to the updated 7th Edition of the AJCC Cancer Staging Manual, which continues to disseminate the importance of anatomical and pathological staging in the management of cancer. This state-of-the-art, invaluable 2nd Edition includes a CD containing PowerPoint slides of all illustrations, additional color, and a user-friendly, easy-to-read layout. The AJCC Cancer Staging Atlas, 2nd Edition will serve as an indispensable reference for clinicians, registrars, students, trainees, and patients.
Lange Pathology Flash Cards, Third EditionComplete coverage of all major topics covered in medical school pathology courses Each disease-specific card features a clinical vignette and details of the disorder, including: Etiology and epidemiology Pathologic or histologic findings Classic clinical presentations Current medical treatments Perfect for disease comparisons
Growing up in the high desert of California, Jim Doty was poor, with an alcoholic father and a mother chronically depressed and paralyzed by a stroke. Today he is the director of the Center for Compassion and Altruism Research and Education (CCARE) at Stanford University, of which the Dalai Lama is a founding benefactor. But back then his life was at a dead end until at twelve he wandered into a magic shop looking for a plastic thumb. Instead he met Ruth, a woman who taught him a series of exercises to ease his own suffering and manifest his greatest desires. Her final mandate was that he keep his heart open and teach these techniques to others. She gave him his first glimpse of the unique relationship between the brain and the heart.
Doty would go on to put Ruth’s practices to work with extraordinary results—power and wealth that he could only imagine as a twelve-year-old, riding his orange Sting-Ray bike. But he neglects Ruth’s most important lesson, to keep his heart open, with disastrous results—until he has the opportunity to make a spectacular charitable contribution that will virtually ruin him. Part memoir, part science, part inspiration, and part practical instruction, Into the Magic Shop shows us how we can fundamentally change our lives by first changing our brains and our hearts.
How many times have you seen a murder on the news or on a TV show like CSI: Crime Scene Investigation, and said to yourself, “How could someone do something like that?”
Today, neuroscientists are imaging, mapping, testing and dissecting the source of the worst behavior imaginable in the brains of the people who lack a conscience: psychopaths. Neuroscientist Dean Haycock examines the behavior of real life psychopaths and discusses how their actions can be explained in scientific terms, from research that literally looks inside their brains to understanding how psychopaths, without empathy but very goal-oriented, think and act the way they do. Some don’t commit crimes at all, but rather make use of their skills in the boardroom.
But what does this mean for lawyers, judges, psychiatrists, victims, and readers—for anyone who has ever wondered how some people can be so bad. Could your nine-year-old be a psychopath? What about your co-worker? The ability to recognize psychopaths using the scientific method has vast implications for society, and yet is still loaded with consequences.
Genetics Demystified offers an up-to-date, highly readable explanation of the basic principles of genetics, covering key topics such as human genetics, DNA, heredity, mutations, traits, chromosomes, and much more. This self-teaching guide comes complete with key points, background information, quizzes at the end of each chapter, and even a final exam. Simple enough for beginners but challenging enough for advanced students, this is a lively and entertaining brush-up, introductory text, or classroom supplement.
Designed to complement Robbins and Cotran Pathologic Basis of Disease, 8th Edition and Robbins Basic Pathology, 8th Edition, this full-color atlas offers more than 1,500 outstanding full-color illustrations that vividly depict the diseases you need to know for pathology courses and USMLE exams. A quick visual reference or review of material for students and professionals alike.Includes gross, microscopic, and radiologic images correlated with examples of normal organs and tissues for comparison.Extensive legends summarize the key information you need to know.Correlates pathology with clinical history, physical exam findings, and clinical laboratory tests.A perfect study complement to Robbins and Cotran Review of Pathology. Includes many new and improved images.
Visually grasp and retain difficult concepts easilythanks to a user-friendly color-coded format, key concept boxes, explanatory diagrams, and over 190 photos to help you visualize tissues and diseases.
Put concepts into practice. "Critical Thinking Boxes" and 25 online cases encourage you to "think immunologically" while anchoring your understanding of immunology through clinical application.
Gauge your mastery of the materialand build confidence with high-yield style chapter-opening summaries and case-based and USMLE-style questions that provide effective chapter review and quick practice for your exams.
Access the full contents online at www.studentconsult.comwhere you'll find the complete text and illustrations, USMLE-style questions, clinical cases, and much more! Get the depth of coverage you need in a smaller, more manageably sized book. Through meticulous editing and reorganization, primary material remains in the book while more specialized and clinical material has been moved online.
Master the most cutting-edge concepts in immunology.Thorough updates throughout provide the timely knowledge you need ace your exams.
Grasp and retain vital concepts easilythanks to a user-friendly color-coded format, succinct text, key concept boxes, and dynamic illustrations.
Effectively review for problem-based courseswith the help of chapter introductions and "Lessons in Microbiology" text boxes that highlight the clinical relevance of the material, offer easy access to key concepts, and provide valuable review tools.
Approach microbiology by body system or by pathogenthrough an extensively cross-referenced "Pathogen Review" section.
Access the complete contents online at studentconsult.com, along with downloadable illustrations...150 multiple choice review questions... "Pathogen Parade"...and many other features to enhance learning and retention. Enhance your learning and absorb complex information in an interactive, dynamic way with Pathogen Parade a quickly searchable online glossary of viruses, bacteria, and fungi.
Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventive medicine.A completely re-written chapter on this topic keeps abreast of the very latest findings.
Genetically modified organisms (GMOs) including plants and the foods made from them, are a hot topic of debate today, but soon related technology could go much further and literally change what it means to be human. Scientists are on the verge of being able to create people who are GMOs.
Should they do it? Could we become a healthier and ''better'' species or might eugenics go viral leading to a real, new world of genetic dystopia? GMO Sapiens tackles such questions by taking a fresh look at the cutting-edge biotech discoveries that have made genetically modified people possible.
Bioengineering, genomics, synthetic biology, and stem cells are changing sci-fi into reality before our eyes. This book will capture your imagination with its clear, approachable writing style. It will draw you into the fascinating discussion of the life-changing science of human genetic modification.Contents:An Introduction to Playing GodThe Birth and Explosive Growth of GMOsHuman CloningBuild-a-Baby Better via GeneticsDIY Guide to Creating GMO SapiensEugenics and TranshumanismCultural Views on Human Genetic ModificationGMO Sapiens Today and Tomorrow
Readership: Undergraduate biology majors, graduate biology majors, non-experts interested in GMOs, biologists and teenagers interested in cloning and human genetic modification.
Key Features:Books on this hot new topic of creating GMO people are rare, tend to be out-of-date, or have narrow topic rangesThe goal of this book is to educate and entertain an educated lay audience about human genetic modificationKeywords:GMO;Genetically Modified Organism;GMO Sapien;Cloning;Genomics;Designer Babies;Mitochondrial Transfer;Stem Cells;Infertility
"What I find troubling, exciting but scary, is that I find myself agreeing with an undertone, I do not support human germline genetic modification but with all the new information and perspectives available to me I have found myself questioning my own views and will be watching any developments with a fascinated interest I would rather not admit to."The NODE
This new edition of Immunology: A Short Course:
• Has been fully revised and updated, with a brand new art program to help reinforce learning
• Includes a new chapter on Innate Immunity to reflect the growth in knowledge in this area
• Highlights important therapeutic successes resulting from targeted antibody therapies
• Includes end of chapter summaries and review questions, a companion website at www.wileyimmunology.com/coico featuring interactive flashcards, USMLE-style interactive MCQs, figures as PowerPoint slides, and case-based material to help understand clinical applications
PKU (phenylketonuria) is a genetic disorder that causes severe cognitive impairment if it is not detected and treated with a strict and difficult diet. Programs to detect PKU and start treatment early are deservedly considered a public health success story. Some have traded on this success to urge expanded newborn screening, defend basic research in genetics, and confront proponents of genetic determinism. In this context, treatment for PKU is typically represented as a simple matter of adhering to a low-phenylalanine diet. In reality, the challenges of living with PKU are daunting.
In this first general history of PKU, a historian and a pediatrician explore how a rare genetic disease became the object of an unprecedented system for routine testing. The PKU Paradox is informed by interviews with scientists, clinicians, policymakers, and individuals who live with the disease. The questions it raises touch on ongoing controversies about newborn screening and what happens to blood samples collected at birth. -- M. Susan Lindee, University of Pennsylvania
New to this Edition: • Features expanded coverage of the evolution of parasitism and an extensive update to immunology of parasite–host interactions • Offers an enhanced art program featuring life-cycle illustrations and additional SEM and TEM micrographs • New Host Immune Response section for each organismPresents various parasites and examines how they interact with their hosts and respond to new treatmentsEasy to read with photographs, diagrams, and clinical case pictures throughout
Thoroughly revised and up-dated edition of the standard reference work in histotechnology that successfully integrates both theory and practice.Provides a single comprehensive resource on the tried and tested investigative techniques as well as coverage of the latest technical developments.
Over 30 international expert contributors all of whom are involved in teaching, research and practice.Provides authoritative guidance on principles and practice of fixation and staining.
Extensive use of summary tables, charts and boxes.Information is well set out and easy to retrieve.
Six useful appendices included (SI units, solution preparation, specimen mounting, solubility). Provides practical information on measurements, preparation solutions that are used in daily laboratory practice.
Color photomicrographs used extensively throughout. Better replicates the actual appearance of the specimen under the microscope.
Brand new co-editors.
New material on immunohistochemical and molecular diagnostic techniques.Enables user to keep abreast of latest advances in the field.
Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoringprovides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring.
The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity.
This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful.Focuses on the personalized management of immunosuppression therapy in individual transplant patientsPresents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathologyProvides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patientsReviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy