A fascinating Jazz Age tale of chemistry and detection, poison and murder, The Poisoner's Handbook is a page-turning account of a forgotten era. In early twentieth-century New York, poisons offered an easy path to the perfect crime. Science had no place in the Tammany Hall-controlled coroner's office, and corruption ran rampant. However, with the appointment of chief medical examiner Charles Norris in 1918, the poison game changed forever. Together with toxicologist Alexander Gettler, the duo set the justice system on fire with their trailblazing scientific detective work, triumphing over seemingly unbeatable odds to become the pioneers of forensic chemistry and the gatekeepers of justice.
In 2014, PBS's AMERICAN EXPERIENCE released a film based on The Poisoner's Handbook.
Includes DVD with image bank
A Doody's Core Title ESSENTIAL PURCHASE for 2011!
4 STAR DOODY'S REVIEW!
"This 12th edition of the most authoritative book in pharmacology is the best both in content and physical appearance....This edition of Goodman & Gilman's continues to be the most authoritative and widely used resource bridging the discipline of pharmacology with therapeutics. Moreover, readers will find this edition to be substantially improved from past editions in both content and physical appearance."--Doody's Review Service
The most universally respected and read medical text in all of pharmacology, Goodman & Gilman’s The Pharmacological Basis of Therapeutics represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease.
Enriched by a new full-color presentation and updated to reflect all critical new developments in drug action and drug-disease interaction, the twelfth edition includes more than 440 color illustrations depicting key principles and actions of specific pathways and therapeutic agents. The companion DVD includes all the images and tables in the text along with narrated animations.
Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12e is divided into nine sections, covering:
More than a textbook, Goodman & Gilman's is a working template for the effective and rational prescribing of drugs in daily practice.
From the Trade Paperback edition.
Fourteen novels. Fourteen poisons. Just because it's fiction doesn't mean it's all made-up ...
Agatha Christie revelled in the use of poison to kill off unfortunate victims in her books; indeed, she employed it more than any other murder method, with the poison itself often being a central part of the novel. Her choice of deadly substances was far from random – the characteristics of each often provide vital clues to the discovery of the murderer. With gunshots or stabbings the cause of death is obvious, but this is not the case with poisons. How is it that some compounds prove so deadly, and in such tiny amounts?
Christie's extensive chemical knowledge provides the backdrop for A is for Arsenic, in which Kathryn Harkup investigates the poisons used by the murderer in fourteen classic Agatha Christie mysteries. It looks at why certain chemicals kill, how they interact with the body, the cases that may have inspired Christie, and the feasibility of obtaining, administering and detecting these poisons, both at the time the novel was written and today. A is for Arsenic is a celebration of the use of science by the undisputed Queen of Crime.
A few years ago, journalism professor McKay Jenkins went in for a routine medical exam. What doctors found was not routine at all: a tumor, the size of a navel orange, was lurking in his abdomen. When Jenkins returned to the hospital to have the tumor removed, he was visited by a couple of researchers with clipboards. They had some questions for him. Odd questions. How much exposure had he had to toxic chemicals and other contaminants? Asbestos dust? Vinyl chlorine? Pesticides? A million questions, all about seemingly obscure chemicals. Jenkins, an exercise nut and an enviro-conscious, organic-garden kind of guy, suddenly realized he’d spent his life marinating in toxic stuff, from his wall-to-wall carpeting, to his dryer sheets, to his drinking water. And from the moment he left the hospital, he resolved to discover the truth about chemicals and the “healthy” levels of exposure we encounter each day as Americans.
Jenkins spent the next two years digging, exploring five frontiers of toxic exposure—the body, the home, the drinking water, the lawn, and the local box store—and asking how we allowed ourselves to get to this point. He soon learned that the giants of the chemical industry operate virtually unchecked, and a parent has almost no way of finding out what the toy her child is putting in his or her mouth is made of. Most important, though, Jenkins wanted to know what we can do to turn things around. Though toxins may be present in products we all use every day—from ant spray, perfume, and grass seed to shower curtains and, yes, baby shampoo—there are ways to lessen our exposure. ContamiNation is an eye-opening report from the front lines of consumer advocacy.
Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoringprovides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring.
The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity.
This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful.Focuses on the personalized management of immunosuppression therapy in individual transplant patientsPresents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathologyProvides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patientsReviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy
154 full-color flashcards teach you to recognize and treat drug overdoses and poisoningsThe most fun, engaging, and effective way to learn clinical toxicology Each card takes an illustrated approach to a particular syndrome or toxin reminding you of all you have to know On the back of each card, succinct text describes the typical presentation, signs and symptoms, mechanisms of action, treatment, and clinical pearls. Covers all major drug overdoses and poisons A great way to study on the go, quiz yourself, or brush up just before an exam
This is the first book that offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors, biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, prophylactic, therapeutic and countermeasures, and the role of homeland security.Presents a comprehensive look at all aspects of chemical warfare toxicology in one reference work. This saves researchers time in quickly accessing the very latest definitive details on toxicity of specific agents used in chemical warfare as opposed to searching through thousands of journal articles. Will include the most agent-specific information on the marketIncludes detailed coverage of the most exhaustive list of agents possibly used as chemical warfare agents in one source. Section 4: Agents That Can Be Used as Weapons of Mass Destruction ? 25 chapters long. Other books on the market only include a sample selection of specific agents. Offering all possible agents detailed under one cover makes this appealing to a wider audience and saves researchers timeThe Forward will be written by Dr. Tetsuo Satoh, Chiba University, Japan. He is one of the most respected, recognizable authorities on chemical warfare agents which will set the authoritative tone for the bookCovers risk to humans, animals and the environment equally. Researchers involved in assessing the risks involved with a possible chemical warfare attack and those who are developing response plans to such attacks must look at not only the risks to human health but to our wildlife and environment as well. The holistic approach taken in this book ensures that the researchers have ready access to the details no matter which aspect of the effects of CWA's they might be concerned with
Volume Four discusses:
The extent to which postnatal metal exposure through breastfeeding can impair an infant's health
Selenium bioavailability and metabolism, effects of selenium exposure, and mechanisms of selenium toxicity
The fate of toxic and nontoxic arsenic compounds in the human body upon ingestion
The biological role of sulfur, sulfur metabolism, deficiencies, and toxicity
The effects on fluoride on teeth, bones, kidneys, arteries, hormones, the brain, and the reproductive system
Food-borne disease outbreaks, microbial quality and risk assessment of food-borne microorganisms in ready to eat foods
Effect of T-2 toxin on DNA and chromosomes, circulatory system, skin, reproductive system, liver and spleen, gastrointestinal tract, brain and neurotransmitters, and more
Investigation of the interference of AFB1 with molecular components of cell cycle checkpoints
Analyzes cycad consumption and its effects on the neurological systems and its manifestations; describes bio-chemical changes and morphological or pathological outcomes through time in detail
Lectins in the human diet, toxicity and biological effects, immunomodulatory effects, modulation of immune function by dietary lectins in disease
This is a valuable resource for anyone involved in the food industry or academics researching food science and food technology.
This volume summarizes and evaluates the literature in the area of metal effects on fertility and reproduction in humans, laboratory animals, and wildlife. International experts have contributed chapters that explore how the ovary, testes, uterine system, and neuroendocrine system, among others, respond to metal exposure. Reviewing both current knowledge and cutting edge data, the chapters focus on either a particular metal or a particular population.
A massive amount of data on this subject has been generated, summarized, and reviewed over the years. While there are many books available on metals toxicity and on reproductive toxicity, no current book explores both in the same volume. Culling information from throughout the literature, Metals, Fertility, and Reproductive Toxicity supplies an in-depth look at the role of metals in endocrine disruption and the spectrum of mechanisms involving metals that can influence reproduction.
The book describes preparation of five distinct types of assessments:
Cumulative Impact Assessment (CIA) Preparing Greenhouse Emission Assessments Preparing Risk Assessments and Accident Analyses Social Impact Assessment (SIA) and Environmental Justice The International Environmental Impact Assessment Process Guiding Principles
To date, there is significant variation and disagreement about how such analyses should be prepared. The author introduces best professional practices (BPP) for preparing such EIAs that is intended to meet decision-making and regulatory expectations. He supplies a comprehensive and balanced skill set of tools, techniques, concepts, principles, and practices for preparing these assessments. He also includes directions for developing a comprehensive Environmental Management Systems which can be used to monitor and implement final decisions for such analyses. While the book references the U.S. National Environmental Policy Act (NEPA), most of this guidance is generally applicable to any international EIA process consistent with NEPA.
With thorough coverage of all aspects of assessments, the book presents a theoretical introduction to the subject as well as practical guidance. It delivers state-of-the-art tools, techniques, and approaches for resolving EIA problems.
Emergency Response Planning is designed to help corporate and municipal managers quickly understand their roles in proactive and reactive emergency management. Author Paul Erickson shows how to develop partnerships with federal, state, and local government agencies, as well as community groups in order to prevent, prepare for, and respond to natural disasters and manmade emergencies.
Emergency Response Planning provides essential information to help you comply with government regulations, design an emergency response plan, train personnel, use the proper safety equipment, safeguard information systems, and resume normal operations after an emergency as quickly as possible. It will also help consultants design emergency response plans for their clients, and provide practical information for students studying business continuity and emergency issues.
Is an important resource for:Corporate and municipal managers involved in emergency managementOrganizational safety committee membersIndustrial health and safety consultants and their clientsGraduate and undergraduate students studying emergency response issuesOutlines both proactive and reactive strategies to reduce risk to human life, health, and propertyDescribes how to form effective partnerships with government agencies and community support resourcesDefines the roles of corporate and municipal managers, planning team members, and response personnelExplains regulations and guidelines from key agencies including OSHA, EPA, FEMA, CDC, US Fire Administration, and moreMakes information easy to understand with dozens of tables, illustrations, and appendices
This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to illustrate these effects.
Applied Dermatotoxicology: Clinical Aspects is an essential reference for toxicologists in industry, and for those medical professionals who encounter cases of dermal exposure to toxic agents.A concise, yet inclusive review of effects of chemical exposureIncludes background on basic skin biologyProvides vital clinical reference for toxicologists in non-clinical settings
With 5 major sections, Long-term Ecological Change in the Northern Gulf of Alaska first describes the physical features, the atmosphere and physical oceanography, the annual production cycle, the forage base for higher animals and trophic transfer, and the adaptations for survival in this changing environment for 9 portal species. Then, the major forces of change are introduced: climate, geophysics, fisheries and harvesting, species interactions, disease and contaminants. Next, the long-term records of change in physical factors and biological populations are presented, as well as the potential reasons for the biological changes. Following is the history of the Exxon Valdez oil spill and its long-term effects. And, finally, the emergent properties of the ecosystem are discussed and an attempt is made to weigh the importance of the major forcing factors in terms of their temporal and spatial scales of influence.
* Examines important data on long-term change in the ecosystem and the forcing factors that are responsible for it
* Provides an account of the 1989 Exxon Valdez oil spill with emphasis on the long-term effects
* Describes the effects of climate change, geophysical change, species interactions, harvesting, disease, the 1989 oil spill, and marine contaminants on key populations of marine organisms
To make this groundbreaking volume, Dr. James Lyons-Weiler combed through the past fifty years of published research on autism, exploring subjects such as genetic variation, mechanisms of neurotoxicity of metals and pesticides, and the central and combined roles of each in causing autism.
Lyons-Weiler provides a major overview of all aspects of the condition of autism, reviews changes in diagnoses and treatments, and explains how genetic information can be used to tailor effective treatments, and sometimes reversals, of the symptoms. He also presents practical forward-looking suggestions on how to design future studies to facilitate the discovery of biomarkers for autism risk and how to classify the full range of autism spectrum disorders.
Autism is considered one of the most mystifying conditions of our day, and alarmed scientists, doctors, politicians, and parents are desperately trying to understand why the condition is escalating. According to the CDC, rates in the United States have risen from an estimated one in two thousand children in 1980, to one in sixty-eight in 2012, and a new National Health Interview Survey shows a rate of one in forty-five. By the time you read this book, that number may have changed yet again.
While most autism researchers focus on either environmental or genetic causes of autism, Lyons-Weiler’s opus demonstrates that to fully understand the condition and to finally put its rate on the decrease, it is essential to pay attention to the science showing how the two classes of factors interact.
A history of the CRO industry, audit checklists, and overviews of both the pharmaceutical and medical device development processes create a comprehensive overview of how to successfully select and manage a CRO for your project. The book also discusses:
Guidance for selection, protocol and contract development, project management and monitoring of work
Common pitfalls and problems - how to avoid them, and how to solve them if they do occur
How to integrate efforts between groups to achieve the greatest cost effectiveness while maintaining quality and timely production
Prototype forms and templates for increasing coordination between multiple working groups
A series of appendices covering hundreds of prominent service providers worldwide, including contact information
Operative regulations and laws
In addition to providing fundamental guidance on how to select and manage a CRO in the product development process, this reference also includes a set of eight databases that contain contact information for prominent service providers in North America, Europe, and Japan, and overviews of services they offer. It is a complete resource for professionals in biotechnology, and pharmaceutical and medical device development.
Today, 20 years after the worst nuclear power plant accident in history, intrepid journalist Mary Mycio dons dosimeter and camouflage protective gear to explore the world's most infamous radioactive wilderness. As she tours the Zone to report on the disaster's long-term effects on its human, faunal, and floral inhabitants, she meets pockets of defiant local residents who have remained behind to survive and make a life in the Zone. And she is shocked to discover that the area surrounding Chernobyl has become Europe's largest wildlife sanctuary, a flourishing - at times unearthly - wilderness teeming with large animals and a variety of birds, many of them members of rare and endangered species. Like the forests, fields, and swamps of their unexpectedly inviting habitat, both the people and the animals are all radioactive. Cesium-137 is packed in their muscles and strontium-90 in their bones. But quite astonishingly, they are also thriving.
If fears of the Apocalypse and a lifeless, barren radioactive future have been constant companions of the nuclear age, Chernobyl now shows us a different view of the future. A vivid blend of reportage, popular science, and illuminating encounters that explode the myths of Chernobyl with facts that are at once beautiful and horrible, Wormwood Forest brings a remarkable land - and its people and animals - to life to tell a unique story of science, surprise and suspense.
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Dr. Hightower’s quest for answers led her to mercury, a poison that has been plaguing victims for centuries and is now showing up in seafood. But this “explanation” opened a Pandora’s Box of thornier questions. Why did some fish from supermarkets and restaurants contain such high levels of a powerful poison? Why did the FDA base its recommendations for “safe” mercury consumption on data supplied by Saddam Hussein’s Ba’athist extremists? And why wasn’t the government warning its citizens?
In Diagnosis: Mercury, Dr. Hightower retraces her investigation into the modern prevalence of mercury poisoning, revealing how political calculations, dubious studies, and industry lobbyists endanger our health. While mercury is a naturally occurring element, she learns there’s much that is unnatural about this poison’s prevalence in our seafood. Mercury is pumped into the air by coal-fired power plants and settles in our rivers and oceans, and has been dumped into our waterways by industry. It accumulates in the fish we eat, and ultimately in our own bodies. Yet government agencies and lawmakers have been slow to regulate pollution or even alert consumers.
Why? The trail of evidence leads to Canada, Japan, Iraq, and various U.S. institutions, and as Dr. Hightower puts the pieces together, she discovers questionable connections between ostensibly objective researchers and industries that fear regulation and bad press. Her tenacious inquiry sheds light on a system in which, too often, money trumps good science and responsible government. Exposing a threat that few recognize but that touches many, Diagnosis: Mercury should be required reading for everyone who cares about their health.
From cyanide to strychnine, from Botox to ricin and Sarin gas—have you ever wondered about their sources? Where do they come from? How do you detect something that can kill you in a matter of seconds? Macinnis methodically analyzes the science of these killing agents and their uses in medicine, cosmetics, war, and terrorism. With wit and precision, he weighs these questions and many more: Was Lincoln’s volatility caused by mercury poisoning? Was Jack the Ripper an arsenic eater? Can wallpaper kill? For anyone who has ever wondered and been afraid to ask, here is a rich miscellany for your secret questions about toxins.
Wide-ranging and practical, What's In This Stuff? examines everything from food additives, beauty products and household cleaners, to pharmaceutical products and garden and pet supplies. It also contains a glossary of chemicals and E numbers, a list of the 50 chemicals you should definitely avoid, and suggests non-toxic alternatives to conventional products.
The session topics comprised:
Theme 1: Arsenic in environmental matrices (air, water and soil)
Theme 2: Arsenic in food
Theme 3: Arsenic and health
Theme 4: Removal technologies
Theme 5: Mitigation management and policy
Hosting this Congress in Argentina was especially relevant because 2014, marks 100 years since the discovery of the disease Hidroarsenicismo Crónico Regional Endémico (HACRE) or arsenicosis by Dr. Goyenechea and Dr. Ayerza in the city of Bell Ville, Province of Córdoba, Argentina. Dr. Ayerza was the first person to relate skin disorders to the consumption of groundwater with high concentrations of arsenic. It is estimated that more than 14 million people in Latin America are at risk, of whom nearly 4 million are exposed to drinking water with high arsenic concentration in Argentina, and further in Chile, El Salvador, Mexico, Nicaragua and Peru. A vast area of the Chaco-Pampean Plain in Argentina, mostly in the semi-arid regions, is affected not only by arsenic exposure from drinking water but also through other exposure pathways, e.g. through food and other dietary intake. The Congress has gathered professionals involved in different segments of interdisciplinary research in an open forum, and strengthens relations between academia, industry, research laboratories, government agencies and the private sector to share an optimal atmosphere for exchange of knowledge, discoveries and discussions about the problem of arsenic in the environment.
—From the Foreword, Donald H. Pfister, Harvard University and Harvard University Herbaria, Cambridge, Massachusetts
The CRC World Dictionary of Medicinal and Poisonous Plants: Common Names, Scientific Names, Eponyms, Synonyms, and Etymology provides the starting point for better access to data on plants used around the world in medicine, food, and cultural practices. The material found in the five volumes has been painstakingly gathered from papers of general interest, reports and records, taxonomic revisions, field studies, herbaria and herbarium collections, notes, monographs, pamphlets, botanical literature, and literature tout court. It includes sources available at various natural history libraries, floras and standard flora works, local floras and local histories, nomenclatural histories, and the International Code of Botanical Nomenclature.
Much more than a dictionary, the book provides the names of thousands of genera and species of economically important plants, concise summaries of plant properties, and appropriate observations about medicinal uses. Drawing from a tremendous range of primary and secondary sources, it is an indispensable time-saving guide for all those involved with botany, herbal medicine, pharmacognosy, toxicology, medicinal and natural product chemistry, and agriculture.
Features:Addresses standards from all international regulatory agencies Presents the steps in risk assessment, including hazard identification, exposure assessment, and risk characterization Covers the assessment of multiple chemical exposures or chemical mixtures Contains data from both human and animal studies Explains the linearized multi-stage mathematical model widely used by the US EPA for characterizing
Intended for just that purpose, International Poisonous Plant Checklist: An Evidence-Based Reference successfully addresses the deficiencies and gaps in the current literature. Using accepted botanic names, the book defines the known set of toxic vascular plants. The use of botanic names satisfies the need for an international standard of identity to support worldwide communication and commerce. Also, taxonomy based on common ancestry and genetic connections provides a rational basis for studying and using plant relationships.
The author supports toxicity information with references to the primary literature. Each entry includes referenced citations supporting the toxicity of the plant, symptoms and circumstances of toxic exposure, dosage and potency, chemical analysis, botany, pharmacology, mechanism and metabolism, and control.
Finally, the book cross-references selected synonyms and common names. The checklist is organized alphabetically with two types of entries. The main entry documents the toxic plants themselves and a secondary entry lists selected synonyms and common names cross-referenced to the main entries.
Including virtually all common animal feed plants, human food plants, and many plants that are sources of herbal products and dietary supplements, tonics, and therapeutic agents, this timely checklist compiles and verifies the known data on toxic vascular plants from around the world.
This comprehensive, time-saving tool is ideal for toxicologists, pharmacologists, drug companies, testing labs, libraries, poison control centers, physicians, legal and regulatory professionals, and chemists.Serves as an all-in-one resource for toxicology informationNew edition includes information on publishers, grants and other funding opportunities, physical hazards, patent literature, and technical reportsUpdated to include the latest internet and electronic sources, e-mail addresses, etc.Provides valuable data about the new fields that have emerged within toxicological research; namely, the biochemical, cellular, molecular, and genetic aspects
From one of the world's top CO experts, Carbon Monoxide Toxicity examines the latest basic science and clinical research from around the world. It addresses the gamut of health-related CO issues, from the history of CO studies to the hidden threat of chronic low-level exposure. The broad themes center on clinical management of various forms of CO poisoning and education of the public on the constant dangers of CO.
Thanks to the success of CO environmental health regulations in the U.S., society is much more aware of the threat of CO poisoning. Increasing numbers of people use CO detectors in public buildings, homes, pleasure boats, and aircraft. Carbon Monoxide Toxicity meets the need for current research on the clinical management of CO poisoning.
Visit the author's Web site at www.coheadquarters.com
Aquatic Effects of Acidic Deposition summarizes and synthesizes these major advancements, particularly those topics that are directly relevant to policy making. It offers complete coverage of recent findings that have substantiated, deepened, modified, or in some cases, revolutionized scientific understanding in environmental research.
This resource addresses the quantification of effects and recent developments in predictive modeling capabilities. It covers virtually all aspects of nitrogen effects research, the importance of natural sources of acidity, the influence of land use and landscape change on drainage water chemistry, and the role of short-term episodic events.
This comprehensive update thoroughly illustrates the progression and refinement in the field. Aquatic Effects of Acidic Deposition helps you make educated decisions based on the most recent, reliable data for air pollution sensitivities, effects, remediation, and future research.
The National Estuarine Research Reserve System (NERRS) is a federally funded initiative that addresses these critical estuarine problems and coastal resource issues at 25 sites in 21 states.
Now estuarine and watershed scientists, resource managers, community planners, and other professionals dealing with coastal zone issues have an expert resource describing the NERRS program, organization, goals, and management strategy. Estuarine Research, Monitoring, and Restoration first defines the components and technical aspects of the NERRS program, then provides valuable insight into the program through the presentation of six case studies of NERRS sites.
This book examines estuarine problems including degraded water quality, reduction of biodiversity, and problematic invasive species, then analyzes the human impacts affecting estuaries. The comprehensive analysis of the six estuarine reserve locations characterizes each region's physical, chemical, and biological conditions from the perspective of the NERRS program. These case studies include a cross section of sites from three coasts, each study emphasizing the importance of unified efforts of government and citizens to successfully maintain the ecology of these critical areas.
See what's new in the Second Edition:
Coverage of environmental hormone disrupters
Section on Multiple Chemical Sensitivity
Expanded discussion of the controversy over genetically modified foods
New information on mechanisms of action of marine venoms and poisons
Ecosystems and Human Health: Toxicology and Environmental Hazards, Second Edition explores the broad range of environmental and human health aspects of chemical and biological hazards. The author covers the basic principles of pharmacology and toxicology as well as risk analysis, air and water pollution, and various toxicants, hazards, and poisons. He presents numerous examples of the intimate relationship between ecosystem health and human health and of the need to consider this relationship whenever human activities are likely to have a significant environmental impact.
The hemopoietic cells of man and the rhesus monkey display an intimate homogeneity. Their functional activities are close and at times identical. The cynomolgus monkey was enlisted in biomedical studies at a time when rhesus monkeys were not available in sufficient quantities. It has gained increased use in the Far East and in the Western world. It is, for example, employed in the current development of a vaccine against the deadly Ebola virus.
The authors of the book discuss the erythropoietic profiles of normal and abnormal macaques of both sexes and of all age groups as investigated with contemporary electronic methodologies. They cover the role of stress as it is perceived by the monkey and how it impacts erythrocellular values, and how to train the monkey to be a cooperative, unperturbed subject for hematologic study. Additional topics include the role of medication in deriving normal physiologic erythrocellular data, the development of the precursors of the erythrocyte (normoblasts), the morphologic analysis of the megaloblastic series of abnormal erythroid cells, the analysis of erythropoiesis in bone marrow, the relationship of the simian immunodeficiency virus and erythropoiesis, erythrocyte life span, and parasitic invasion of the red cell.
The book highlights the live biological constituents that make up the soil, exploring the changes made by agricultural operations and other human activities that lead to changes in the environment and our natural ecosystem. These include causes, effects, and solutions for acid rain, global warming, and destruction of the ozone layer. The author also provides extensive coverage of soilless agriculture, hydroponics, fish farming, vanishing biodiversity due to the destruction of jungles and the rain forest, and what to do about it.
New in the Third Edition:
Al Gore’s Nobel Prize winning politics on global warming and apocalyptic predictions Biofuel production from agricultural trash and the controversy over using corn for alcohol production Advances in biotechnology and the issues surrounding golden rice, flavr savr tomato, roundup ready plants, and GM crops The effects of agricultural operations and other human activities on changing soil properties and environment Introduction of a new soil group, Paddy soils, a unique man made soil formed by centuries of rice cultivation Blue Revolution and marine biodiversity Use of eutrophication in aquaculture
Growing ecological awareness has put the spotlight on all environmental disciplines, and environmental soil science is no exception. This has created broader interest in what has traditionally been a fundamental subject. This book tackles matters which must be urgently addressed due to the mounting evidence of climate change.
The book answers one of the key problems in pesticide analysis: the diversity of chemical functional groups, with varying polarity and physicochemical properties. Pesticides and their metabolites have received particular attention during the last few years in environmental trace-organic analysis. For instance, in the case of groundwater, the use of pesticides has become a cause for concern. Under the right conditions, pesticides, such as fertilizer nitrogen, can move through the soil into groundwater, a phenomenon once thought improbable. The movement of agrochemicals in surface water flow can be, in some instances, a major problem, specially in the case of water soluble pesticides that are generally transported to estuarine and coastal waters. Estuarine waters feature gradients of both pollutant concentrations and physicochemical characteristics such as salinity, turbidity and pH, and all these parameters must be carefully considered when developing methods of analysis for trace organics in estuarine waters.
One of the key parameters in analytical determination is the environmental sampling. Different protocols and devices are needed for sampling sea-water samples - usually using large sample volumes of more than 50 litres either with LLE or SPE, with the problems encountered due to dissolved and particulate matter - which is different from drinking water and well water sampling. The representativeness of the sampling is also of concern.
The sample preparation of organic compounds from water matrices has been recognized to be a bottleneck and it has been traditionally neglected in the literature. We should comment following R.W. Frie's ideas - that the most sophisticated hardware is useless if the chemistry in the protocol does not work. During the last few years new adsorbents have appeared - carbon type, polymeric sorbents with high capacity and immunosorbents - which can more efficiently trap the more polar compounds.
The development of advanced automation methods based, usually on solid phase extraction techniques - PROSPEKT, OSP-2 and ASPEC XL - are examples of commercially available equipment that are of growing importance. These systems are generally coupled to LC and GC techniques.
Sampling and sample handling can not be regarded as separate techniques in the analytical process and both should be integrated into the whole analytical determination. For this reason, validation and confirmation methods, such as mass spectrometry, either GC-MS and/or LC-MS, are needed. These serve to check the quality assurance of the developed method. The discussion between multiscreening versus specific methods of analysis and the influence of the matrix (ground-, surface- and estuarine-water), is also a point of concern due to the diversity of chemical classes within the compounds of study.
Although conventional treatment processes can be effective for the removal of HAB cells and some HAB toxins under optimal conditions, the potential exists for significant breakthrough of toxins during normal operation. As a result, there is a recognized need for more advanced techniques. Possible advanced processes for removing HAB toxins include granular activated carbon (GAC), powdered activated carbon (PAC), or oxidative processes. This book reviews both conventional and advanced treatment processes and presents clear and easy-to-understand procedures for the design of systems for optimal cell or toxin removal.
Population-Level Ecological Risk Assessment establishes a framework for goals, methods, and data needs for different assessment applications and for integrating population-level risk assessment into risk management decisions. Beginning with a summary of legal, regulatory, business, and other contexts, the book presents population-level ecological risk assessment as an internationally recognized, science-based tool and offers specific recommendations for using this tool to support environmental management decisions. It gives clear, explicit, operational population assessment definitions and explains the relevance of density dependence, genetics, and spatial considerations, as well as applicable lessons from conservation biology and natural resource management.
The authors provide a "tool box" of empirical and modeling methods and describe the general approaches, assumptions, data requirements, strengths, and limitations of each method. They establish a working foundation for designing and conducting population-level ecological risk assessments consistent with North American, European, and Japanese risk management approaches. The book concludes by highlighting key considerations needed to improve the scientific quality and interpretation of assessments. Detailed appendices include examples of population-level assessment approaches applicable to specific environmental management contexts, a modeling case study, and a supplemental reading list.
In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides.Describes everything you need to know about Organophosphates and CarbamatesExtensively covers pesticides, nerve agents, therapeutic drugs, and flame retardantsDescribes epidemiology of the world's major disasters involving Organophosphates and CarbamatesCovers animal, human, aquatic, and wildlife toxicity of AnticholinesterasesInsights into in-depth cholinergic and noncholinergic mechanisms of toxicityDescribes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesisProvides in vitro and in vivo models for neurotoxicity testingIntegrates knowledge of studies in lab animals and humansOffers risk/safety assessment and national/international guidelines for permissible levels of pesticide residuesDescribes management of Anticholinesterase poisoning in humans
The chapters in this book are written by hydrogeologists and hydrochemists as well as medical doctors and include: methods of investigation of calcium and magnesium in groundwaters, distribution and behaviour of calcium and magnesium in different aquifers, calcium and magnesium in bottled mineral and spring waters, and the significance of calcium and magnesium in waters for human health.
Toxicology of Marine Mammals focuses on the effects of natural and introduced toxicants on organs and systems in marine mammals. It provides overviews on health status and contamination, with subsequent chapters devoted to whales, pinnipeds, dolphins, polar bears, manatees, and sea otters. Internationally renowned researchers assess the mounting evidence for adverse effects on reproduction and the chemically-induced increased susceptibility to death from infectious diseases. The concluding chapter addresses perspectives and issues for the future.
This compelling book features research from a vast geographic landscape ranging from the tropics to the Arctic, with case studies on intriguing areas of contamination such as the St. Lawrence River and the Baltic Sea. It identifies the severe threats that environmental contaminants pose to the health and future of marine mammals. It also makes an urgent call for legislation to regulate the incessant pollution ravaging our seas and devastating the marine mammal population worldwide. Toxicologists working in marine biology and veterinary medicine, conservation scientists, fisheries scientists, environmental scientists, and wildlife managers will all benefit from this comprehensive resource.
Addresses Emerging Wildlife Threats in One Concise Volume
A decade ago, many of these threats existed but were either unrecognized or considered minor issues, and all have now snowballed into major challenges for the conservation of wildlife populations. This is the first book to address these dangers in a single volume and recommend proven mitigation techniques to protect and sustain Earth’s wildlife populations.
Examines Species Range Shifts, Ocean Acidification, Coral Bleaching, & Impacts of Heightened UV Influx
This comprehensive reference identifies and documents examples of chemical stressor exposures and responses among ecosystem receptors worldwide. Chapters discuss emerging diseases and the expansion of pesticide/contaminant use, as well as agricultural trends and biofuels, and the widespread use of munitions and explosives from military and industrial-related activities. With the aid of several solid case studies, the book also addresses atmospheric contaminants and climate change, population modeling, and emerging transnational issues in ecotoxicology.
Wildlife Toxicology: Emerging Contaminant and Biodiversity Issues stimulates dialogue among the academic and research communities and environmental public policy decision makers. The book challenges these groups to think more globally about environmental contaminants and their potential impacts on biodiversity and environmental degradation.
Check out Ronald J. Kendall's Advances in Biological and Chemical Terrorism Countermeasures.
Professor Kendall has been quoted recently in several news outlets in connection with the Gulf Oil Spill. Check out these articles on the CRC Press Ning page.
With more than 1150 entries, this second edition has been expanded in length, breadth and depth, and provides an extensive overview of the many facets of toxicology.
Also available online via ScienceDirect – featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com.
*Second edition has been expanded to 4 volumes
*Encyclopedic A-Z arrangement of chemicals and all core areas of the science of toxicology
*Covers related areas such as organizations, toxic accidents, historical and social issues, and laws
*New topics covered include computational toxicology, cancer potency factors, chemical accidents, non-lethal chemical weapons, drugs of abuse, and consumer products and many more!