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Was diabetes evolution's response to the last Ice Age? Did a deadly genetic disease help our ancestors survive the bubonic plagues of Europe? Will a visit to the tanning salon help lower your cholesterol? Why do we age? Why are some people immune to HIV? Can your genes be turned on -- or off?

Joining the ranks of modern myth busters, Dr. Sharon Moalem turns our current understanding of illness on its head and challenges us to fundamentally change the way we think about our bodies, our health, and our relationship to just about every other living thing on earth, from plants and animals to insects and bacteria.

Through a fresh and engaging examination of our evolutionary history, Dr. Moalem reveals how many of the conditions that are diseases today actually gave our ancestors a leg up in the survival sweepstakes. When the option is a long life with a disease or a short one without it, evolution opts for disease almost every time.

Everything from the climate our ancestors lived in to the crops they planted and ate to their beverage of choice can be seen in our genetic inheritance. But Survival of the Sickest doesn't stop there. It goes on to demonstrate just how little modern medicine really understands about human health, and offers a new way of thinking that can help all of us live longer, healthier lives.

Survival of the Sickest is filled with fascinating insights and cutting-edge research, presented in a way that is both accessible and utterly absorbing. This is a book about the interconnectedness of all life on earth -- and, especially, what that means for us.

NEW YORK TIMES BESTSELLER

The New York Times bestselling author of The Hormone Cure and The Hormone Reset Diet shows every woman how to create a lifestyle that will help her look great, feel energized, and slow down the effects of aging.

Feel destined for cellulite, saddle bags, and belly fat? Does your family come from a long line of Alzheimer's, cancer, or heart disease? Will nothing help your aging skin or declining libido or flagging energy? This book is for you.

The body is magnificent but it doesn't come with a lifetime warranty, or an operating manual. You're the result of millions of years of evolution, but many of the adaptations that helped your ancestors survive are now working overtime to accelerate the aging process. The assumption here is that we are our genes and therefore trapped by the past. The good news is that your genetic code—the DNA sequence that is the biochemical basis of heredity—can play a minor role in the way you age.

The scientific reality is that 90 percent of the signs of aging and disease are caused by lifestyle choices, not your genes. In other words, you have the capability to overcome and transform your genetic history and tendencies. Harvard/MIT—trained physician Sara Gottfried, M.D. has created a revolutionary 7-week program that empowers us to make the critical choices necessary to not just look young, but also feel young.

Dr. Gottfried identifies and builds this book around the five-key factors that lead to accelerated aging -the muscle factor, the brain factor, the hormone factor, the gut factor, and the toxic fat factor. The 7-week program addresses these factors and treats them in an accessible and highly practical protocol and is as follows:

Feed—Week 1Sleep—Week 2Move—Week 3Release—Week 4Expose—Week 5Soothe—Week 6Think—Week 7

Younger increases not only your lifespan, but also your healthspan. Dr. Gottfried's program makes it possible to change the way you age, stay younger longer, and remain healthy and vibrant for all of your days.

An award-winning physician and New York Times bestselling author reveals how genetic breakthroughs are completely transforming our understanding of both the world and our lives.

Conventional wisdom dictates that our genetic destiny is fixed at conception. But Dr. Moalem's groundbreaking book shows us that the human genome is far more fluid and fascinating than your ninth grade biology teacher ever imagined. By bringing us to the bedside of his unique and complex patients, he masterfully demonstrates what rare genetic conditions can teach us all about our own health and well-being.

In the brave new world we're rapidly rocketing into, genetic knowledge has become absolutely crucial. Inheritance provides an indispensable roadmap for this journey by teaching you:

Why you may have recovered from the psychological trauma caused by childhood bullying-but your genes may remain scarred for life.How fructose is the sugar that makes fruits sweet-but if you have certain genes, consuming it can buy you a one-way trip to the coroner's office.Why ingesting common painkillers is like dosing yourself repeatedly with morphine -- if you have a certain set of genes.How insurance companies legally use your genetic data to predict the risk of disability for you and your children-and how that impacts the coverage decisions they make for your family.How to have the single most important conversation with your doctor -- one that can save your life.And finally, why people with rare genetic conditions hold the keys to medical problems affecting millions.In this trailblazing book, Dr. Moalem employs his wide-ranging and entertaining interdisciplinary approach to science and medicine -- explaining how art, history, superheroes, sex workers, and sports stars all help us understand the impact of our lives on our genes, and our genes on our lives. Inheritance will profoundly alter how you view your genes, your health -- and your life.
"[Kolata] is a gifted storyteller. Her account of the Baxleys... is both engrossing and distressing... Kolata's book raises crucial questions about knowledge that can be both vital and fatal, both pallative and dangerous." —Andrew Solomon, The New York Review of Books

New York Times science reporter Gina Kolata follows a family through genetic illness and one courageous daughter who decides her fate shall no longer be decided by a genetic flaw.

The phone rings. The doctor from California is on the line. “Are you ready Amanda?” The two people Amanda Baxley loves the most had begged her not to be tested—at least, not now. But she had to find out.

If your family carried a mutated gene that foretold a brutal illness and you were offered the chance to find out if you’d inherited it, would you do it? Would you walk toward the problem, bravely accepting whatever answer came your way? Or would you avoid the potential bad news as long as possible?

In Mercies in Disguise, acclaimed New York Times science reporter and bestselling author Gina Kolata tells the story of the Baxleys, an almost archetypal family in a small town in South Carolina. A proud and determined clan, many of them doctors, they are struck one by one with an inscrutable illness. They finally discover the cause of the disease after a remarkable sequence of events that many saw as providential. Meanwhile, science, progressing for a half a century along a parallel track, had handed the Baxleys a resolution—not a cure, but a blood test that would reveal who had the gene for the disease and who did not. And science would offer another dilemma—fertility specialists had created a way to spare the children through an expensive process.

A work of narrative nonfiction, Mercies in Disguise is the story of a family that took matters into its own hands when the medical world abandoned them. It’s a story of a family that had to deal with unspeakable tragedy and yet did not allow it to tear them apart. And it is the story of a young woman—Amanda Baxley—who faced the future head on, determined to find a way to disrupt her family’s destiny.

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Genetically modified organisms (GMOs) including plants and the foods made from them, are a hot topic of debate today, but soon related technology could go much further and literally change what it means to be human. Scientists are on the verge of being able to create people who are GMOs.

Should they do it? Could we become a healthier and ''better'' species or might eugenics go viral leading to a real, new world of genetic dystopia? GMO Sapiens tackles such questions by taking a fresh look at the cutting-edge biotech discoveries that have made genetically modified people possible.

Bioengineering, genomics, synthetic biology, and stem cells are changing sci-fi into reality before our eyes. This book will capture your imagination with its clear, approachable writing style. It will draw you into the fascinating discussion of the life-changing science of human genetic modification.

Contents:An Introduction to Playing GodThe Birth and Explosive Growth of GMOsHuman CloningBuild-a-Baby Better via GeneticsDIY Guide to Creating GMO SapiensEugenics and TranshumanismCultural Views on Human Genetic ModificationGMO Sapiens Today and Tomorrow
Readership: Undergraduate biology majors, graduate biology majors, non-experts interested in GMOs, biologists and teenagers interested in cloning and human genetic modification.
Key Features:Books on this hot new topic of creating GMO people are rare, tend to be out-of-date, or have narrow topic rangesThe goal of this book is to educate and entertain an educated lay audience about human genetic modificationKeywords:GMO;Genetically Modified Organism;GMO Sapien;Cloning;Genomics;Designer Babies;Mitochondrial Transfer;Stem Cells;Infertility

"What I find troubling, exciting but scary, is that I find myself agreeing with an undertone, I do not support human germline genetic modification but with all the new information and perspectives available to me I have found myself questioning my own views and will be watching any developments with a fascinated interest I would rather not admit to."

The NODE
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Genetic differences in humans, like those between individuals of any animal or plant species and those between species, are all products of the evolutionary development of the living world. Th ese diff erences, with their behavioral consequences, can only be understood in the light of evolution. Our understanding of evolution, however, has itself evolved. Th e Darwin-Wallace theory of evolution appeared in the nineteenth century. Since then, development of evolutionary thought has gone through several stages. Th e contributions in this volume describe those stages.

The first four decades after Darwin were dominated by studies in comparative anatomy, embryology, systematics, zoogeography, phytogeography, and paleontology, all intended to discover and examine the evidences of evolution. But the phylogenies of the animal and plant kingdoms, that is, the history of the linkages of animal and plant organisms as they change through time, were less well documented. In particular, the phylogeny of humans is still not completely known.

The period following World War Two saw acceleration of activity in fi elds in and bordering on behavioral genetics. Research in neuroendocrinology showed that higher cortical centers could infl uence and be infl uenced by the hypothalamus, pituitary, thyroid, adrenals, and gonads. Genetic diversity in the function of these organs had obvious consequences for social and cultural behavior. Th e failure of some early and long-reinforced attempts at conditioning by students of comparative animal behavior showed species-specifi c innate behavior could not be ignored in any theory that attempts to combine psychology and anthropology. Th is classic volume summarizes the development of evolutionary thinking, and describes how what we know about genetic diversity links up with research on human behavior.

J. N. Spuhler was known for his pioneering work in the department of anthropological genetics. He taught in many universities including Ohio State University, the University of Michigan, and the University of Mexico. He received the National Academy of Science award for scientific reviewing and his work has appeared in scholarly journals including: Journal of Anthropological Research, Annual Review of Anthropology, and American Journal of Physical Anthropology.

New edition of the best-selling, practical guide to help dry eye sufferers improve their vision, reduce wrinkles and redness, and restore overall eye health, Includes up-to-date information on medications, procedures, testing, after-care, and more.

It can happen any time. Your eyes feel tired. You rub them. You look at yourself in the mirror and see lines, wrinkles, bags, redness that was never there before. Approximately 100 million people worldwide suffer from dry eye (also known as dysfunctional tear syndrome). Traditional solutions, such as eye drops and eyelid surgery, may actually make the problem worse.

Dry eye affects not only your eye’s appearance and your vision; it is often linked to skin conditions and other eye diseases such as glaucoma. The Dry Eye Remedy, Revised Edition brings the same wealth of knowledge from the first book on practical ways to restore eye health with new updates from the field put together expertly by Dr. Robert Latkany, the founder and director of the Dry Eye Clinic at the New York Eye & Ear Infirmary.

The Dry Eye Remedy, Revised Edition is the first book to give dry eye sufferers simple and
practical ways to restore eye health and appearance without surgery, including:
• New resources for dry eye sufferers, including new tests for dry eyes, after-care procedures, and major changes to future therapy
• The latest in cutting-edge research, including which medications and procedures may help and which to avoid
• Easy environmental and lifestyle changes to help you look and feel better

The Dry Eye Remedy, Revised Edition is the essential tool to ensure there is “not a dry eye in the house.”
Evolution and Medicine provides an accessible introduction to the new field of evolutionary medicine. Evolutionary concepts help explain why we remain vulnerable to disease, how pathogens and cancer cells evolve, and how the diseases that affected our evolutionary ancestors have shaped our biology. The book interweaves the presentation of evolutionary principles with examples that illustrate how an evolutionary perspective enhances our understanding of disease. It discusses the theory of evolution by natural selection, the genetic basis of evolutionary change, evolutionary life history theory, and host-pathogen coevolution, and uses these concepts to provide new insights into diseases such as cystic fibrosis, cancer, sexually transmitted diseases, and malaria, incorporating the latest research in rapidly developing fields such as epigenetics and the study of the human microbiome. The book concludes with a discussion of the ways in which recent, culturally constructed changes in the human environment are increasing the prevalence of man-made diseases such as diabetes and cardiovascular diseases, and are exacerbating socioeconomic disparities in health. Just as evolutionary biology is concerned with populations and with changes in populations over time, evolutionary medicine is concerned with the health of populations. Evolution and Medicine emphasizes the role of demographic processes in evolution and disease, and stresses the importance of improving population health as a strategy for improving the health of individuals. This accessible text is written primarily for physicians, biomedical scientists, and both premedical and medical students, and will appeal to all readers with a background or interest in medicine.
The most widely used and highly regarded textbook and reference of emergency medicine -- Endorsed by the American College of Emergency Physicians

The 8th edition of Tintinalli’s Emergency Medicine provides the depth and breadth of coverage that reflects the complexity and expertise needed to practice emergency medicine successfully in today’s fast–paced environments. It is an important contemporary clinical emergency care resource for physicians, NPs, and PAs who practice emergency medicine and for emergency medicine and pediatric emergency medicine fellows. It remains the preferred study guide for in-training and board examinations and recertification.

NEW to this edition:
• Full-color design with more tables than ever to succinctly present key information
• Extensive updates to all sections, incorporating the latest guidelines, evidence-based protocols, and relevant research
• Expanded pediatric section, with complete clinical information for general and pediatric emergency physicians
• Expanded coverage of common emergency department procedures, with improved illustrations
• Online access to more than 30 videos, covering a wide range of procedural and diagnostic topics and focusing on the latest ultrasound-guided techniques

From the reviews of the seventh edition:
"Collectively, they have once again produced an excellent text that manages to cover the broad scope of emergency medicine while remaining an easily readable and practical resource....Last, for the inevitable comparison of this current edition of Tintinalli's Emergency Medicine with other available emergency medicine textbooks available: in my opinion, Tintinalli’s still comes out on top. It is more concise and easier to read than some, yet it covers the breadth of emergency medicine practice more comprehensively than others....Just as previous editions did, the seventh presents all of the most pertinent and up-to-date information in a well-organized format that is comprehensive yet easy to read. That and many of the attractive new features in this current edition will ensure its place on my bookshelf for years to come."—JAMA

Freeman, is your go-to resource for practical, up-to-date guidance on ocular diseases, surgical procedures, medications, and equipment, as well as paramedical procedures and office management in the ophthalmology, optometry, opticianry or eye care settings. Thoroughly updated content and more than 1,000 full-color illustrations cover all the knowledge and skills you need for your day-to-day duties as well as success on certification and recertification exams. This comprehensive text provides essential learning and practical guidance for ophthalmic assistants, technicians, medical technologists, physician assistants, and all others involved in ocular care, helping each become a valuable asset to the eye care team.Full-color visual guidance for identification of ophthalmic disorders, explanations of difficult concepts, and depictions of the newest equipment used in ophthalmology and optometry.

Quick-reference appendices provide hospital/practice forms for more efficient patient record keeping, conversion tables, and numerous language translations, plus information on ocular emergencies, pharmaceuticals, and more. Updated throughout with the latest information on basic science, new testing procedures, new equipment, the role of the assistant in the practice, and an expanded chapter on OCT imaging.

A new bonus color image atlas tests your clinical recognition of disease and disorders of the eye.

Four brand-new chapters cover the latest industry advances regarding dry eye, vision function and impairment, uveitis, and surgical correction of presbyopia.
HELPS YOU DEVELOP AND ASSESS PEDIGREES TO MAKE DIAGNOSES, EVALUATE RISK, AND COUNSEL PATIENTS

The Second Edition of The Practical Guide to the Genetic Family History not only shows how to take a medical-family history and record a pedigree, but also explains why each bit of information gathered is important. It provides essential support in diagnosing conditions with a genetic component. Moreover, it aids in recommending genetic testing, referring patients for genetic counseling, determining patterns of inheritance, calculating risk of disease, making decisions for medical management and surveillance, and informing and educating patients. Based on the author's twenty-five years as a genetic counselor, the book also helps readers deal with the psychological, social, cultural, and ethical problems that arise in gathering a medical-family history and sharing findings with patients.

Featuring a new Foreword by Arno Motulsky, widely recognized as the founder of medical genetics, and completely updated to reflect the most recent findings in genetic medicine, this Second Edition presents the latest information and methods for preparing and assessing a pedigree, including:

Value and utility of a thorough medical-family history Directed questions to ask when developing a medical-family history for specific disease conditions Use of pedigrees to identify individuals with an increased susceptibility to cancer Verification of family medical information Special considerations when adoptions or gamete donors are involved Ethical issues that may arise in recording a pedigree

Throughout the book, clinical examples based on hypothetical families illustrate key concepts, helping readers understand how real issues present themselves and how they can be resolved.

This book will enable all healthcare providers, including physicians, nurses, medical social workers, and physician assistants, as well as genetic counselors, to take full advantage of the pedigree as a primary tool for making a genetic risk assessment and providing counseling for patients and their families.

A riveting medical mystery about a young woman’s quest to uncover the truth about her likely fatal genetic disorder that opens a window onto the exploding field of genomic medicine

When Joselin Linder was in her twenties her legs suddenly started to swell. After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find  an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. Delving further into the past, she discovered that her great-grandmother had displayed symptoms similar to hers before her death. Clearly, this was more than a fluke.

Setting out to build a more complete picture of the illness that haunted her family, Joselin approached Dr. Christine Seidman, the head of a group of world-class genetic researchers at Harvard Medical School, for help. Dr. Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation. Here, Joselin tells the story of their gene: the lives it claimed and the future of genomic medicine with the potential to save those that remain. 

Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write a gripping and unforgettable exploration of family, history, and love. A compelling chronicle of survival and perseverance, The Family Gene is an important story of a young woman reckoning with her father’s death, her own mortality, and her ethical obligations to herself and those closest to her.

The Slit Lamp Primer is the complete book on the slit lamp for the ophthalmic and optometric office. Now updated into a second edition, this user-friendly introduction to the slit lamp microscope highlights the instrument's basic parts as well as examination and illumination techniques.

Janice Ledford and Valerie Sanders explain more than just the fundamentals of the slit lamp. Written in a conversational style with supplemental photographs and diagrams, The Slit Lamp Primer delves into issues concerning the normal, postoperative, and problematic eye. Features of the patient history, including medications, are examined in light of the possible slit lamp findings. Detailed notes for proper documentation are included, along with tables to give guidelines for subjective grading of the findings.

Updated and key features:
The examination of patients on various systemic medications with a list of drugs that may have side effects visible with the slit lamp
The examination of post-operative patients, with a new section that focuses on patients who have undergone refractive surgery
Up-to-date study icons, key points listed at the beginning of each chapter, and "What the Patient Needs to Know" sidebars
Photographs and descriptions of parts and care of the slit lamp
Atlas of photographs of the normal eye
Photographs of pathology
Tables to assist in contact lens evaluation


The Slit Lamp Primer, Second Edition is a valuable addition to the reference library of any ophthalmic and optometric paraprofessional or student. Explore the workings of a useful and effective instrument with the most practical and user-friendly book on the subject available today.

All of us have lurking in our DNA a most remarkable gene, which has a crucial job – it protects us from cancer. Known simply as p53, this gene constantly scans our cells to ensure that they grow and divide without mishap, as part of the routine maintenance of our bodies. If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, summoning a repair team before allowing the cell to carry on dividing. If the mistake is irreparable and the rogue cell threatens to grow out of control, p53 commands the cell to commit suicide. Cancer cannot develop unless p53 itself is damaged or prevented from functioning normally.

Perhaps unsurprisingly, p53 is the most studied single gene in history.

This book tells the story of medical science's mission to unravel the mysteries of this crucial gene, and to get to the heart of what happens in our cells when they turn cancerous. Through the personal accounts of key researchers, p53: The Gene that Cracked the Cancer Code reveals the fascination of the quest for scientific understanding, as well as the huge excitement of the chase for new cures – the hype, the enthusiasm, the lost opportunities, the blind alleys, and the thrilling breakthroughs. And as the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms begins to take off at last, p53 remains at the cutting edge.

This timely tale of scientific discovery highlights the tremendous recent advances made in our understanding of cancer, a disease that affects more than one in three of us at some point in our lives.
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