This volume is aimed at researchers and educators in imaging sciences, radiological imaging, clinical and diagnostic imaging, physicists covering different medical imaging modalities, as well as researchers in biomedical engineering, applied mathematics, algorithmic development, computer vision, signal processing, computer graphics and multimedia in general, both in academia and industry .
- Principles of intra-vascular ultrasound (IVUS)
- Principles of positron emission tomography (PET)
- Physical principles of magnetic resonance angiography (MRA).
- Basic and advanced level set methods
- Shape for shading method for medical image analysis
- Wavelet transforms and other multi-scale analysis functions
- Three dimensional deformable surfaces
- Level Set application for CT lungs, brain MRI and MRA volume segmentation
- Segmentation of incomplete tomographic medical data sets
- Subjective level sets for missing boundaries for segmentation
There are many biochemistry textbooks in the market. Some of them are purely basic while others are applied, and there are very few books which cover both these aspects together. For this reason, the students learning biochemistry in their undergraduate courses have to depend on multiple books to acquire a sound knowledge of the subject.
This book, ‘Biochemistry’ is unique with a simultaneous and equal emphasis on basic and applied aspects of biochemistry. This textbook offers an integration of medical and pure sciences, comprehensively written to meet the curriculum requirements of undergraduate courses in medical, dental, pharmacy, life-sciences and other categories (agriculture, veterinary, etc.).
This book is designed to develop in students a sustained interest and enthusiasm to learn and develop the concepts in biochemistry in a logical and stepwise manner. It incorporates a variety of pedagogic aids, besides colour illustrations to help the students understand the subject quickly and to the maximum. The summary and biomedical/clinical concepts are intended for a rapid absorption and assimilation of the facts and concepts in biochemistry. The self-assessment exercises will stimulate the students to think rather than merely learn the subject. In addition, these exercises (essays, short notes, fill in the blanks, multiple choice questions) set at different difficulty levels, will cater to the needs of all the categories of learners.
New to This Edition
The book offers an integration of medical and pure sciences, and is comprehensively written, revised and updated to meet the curriculum requirements of Medical, Pharmacy, Dental, Veterinary, Biotechnology, Agricultural Sciences, Life Sciences, and others studying Biochemistry as one of the subjects.
It is the first text book on Biochemistry in English with multi-colour illustrations by an author from Asia. The use of multicolours is for a clearer understanding of the complicated biochemical reactions.
It is written in a lucid style with the subject being presented as an engaging story growing from elementary information to the most recent advances, and with theoretical discussions being supplemented with illustrations, flowcharts, and tables for easy understanding of Biochemistry.
It has each chapter beginning with a four-line verse followed by the text, biomedical concepts, a summary, and self-assessment exercises. The lively illustrations and text with appropriate headings and sub-headings in bold type faces facilitate reading path clarity and quick recall.
It provides the most recent and essential information on Molecular Biology and Biotechnology, Diabetes, Cancer, Free Radicals, Free radicals and Antioxidants, Prostaglandins, etc.
It describes a wide variety of case studies and biochemical correlations and several newer biomedical aspects- Metabolic syndrome, Therapeutic diets, Atkins diet, Trans fatty acids, Epigenetics, Nutrigenomics, Recombinant ribozymes, Membrane transport disorders, Pleural fluid etc.
It contains the basics (Bioorganic and Biophysical Chemistry, Tools of Biochemistry, Immunology, and Genetics) for beginners to learn easily Biochemistry, origins of biochemical words, confusables in Biochemistry, principles of Practical Biochemistry, and Clinical Biochemistry Laboratory.
--- Model-based brain tissue classification
--- Supervised texture classification for intravascular tissue characterization
--- Medical image segmentation: methods and applications in functional imaging
--- Automatic segmentation of pancreatic tumors in CT
--- Computerized analysis and vasodilation parameterization in flow-mediated dilation tests from ultrasonic image sequences
--- Adaptive approaches to optical segmentation in brain MRI Images
--- Automatic analysis of color fundus photographs and its application to the diagnosis of diabetic retinopathy
--- Segmentation issues of carotid plaque analysis in MRI
--- Accurate lumen identification, detection, and quantification in MR plaque volumes
--- Hessian-based multiscale enhancement, description, and quantification of second-order 3D local structures from medical volume data
--- A knowledge-based scheme for digital mammography
--- Simultaneous fuzzy segmentation
--- CAD of mammographic calicification: impact of segmentation
About the Editors:
Jasjit Suri, Ph.D. has spent over 20 years in the field of computer and electrical engineering, and more than a decade in imaging sciences. Dr. Suri has a masters degree in computer sciences from the University of Illinois and a doctorate in Electrical Engineering from the University of Washington, Seattle. Dr. Suri has published over 125 technical publications in medical imaging, as well as being a senior member of IEEE and a member of the engineering honor societies Eta-Kappa-Nu and Tau-Beta-Phi, and a recipient of the President's Gold Medal in 1980. He is also a fellow of American Institute of Medical and Biological Engineering.
David Wilson, Ph D. is a Professor of Biomedical Engineering and Radiology at Case Western Reserve University, having gained his doctorate from Rice University. He has over 60 refereed journal publications and is co-owner of several patents. Professor Wilson has actively developed biomedical imaging at CWRU. He has led a faculty recruitment effort, and he has served as PI or has been an active leader on multiple research and equipment developmental awards given to CWRU, including an NIH planning grant award for an in vivo Cellular and Molecular Imaging Center and an Ohio Wright Center of Innovation award. Swamy Laxminarayan, Dsc championed the field of Biomedical Engineering for over 30 years, having held a variety of senior positions within the industry. He is an internationally recognized scientist, engineer, and educator and has been published in over 200 technical publications in biomedical information technology, computation biology, signal and image processing, biotechnology, and physiological system modeling. Prof. Laxminarayan is a fellow of AIMBE and a recipient of IEEE 3rd Millennium Medal.
A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging.
Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach.
In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.
As a result of our fitness tech addiction, we've lost awareness of what we're doing, how we're feeling, and what's going on around us. This is bad enough in the gym, but when we get outside, the constant checking of a tiny screen truly wreaks havoc, downgrading what should be a rich experience into yet another task we need to complete to meet our daily goals. And if we fall short, we feel inadequate. There’s also the issue of data inaccuracy, with many device makers now admitting that their gadgets provide only estimates. So why do we continue to obsess over data and treat it as gospel truth?
It's time to stop, take a breath, and hit the reset button in a big way. Unplugged provides a blueprint for using technology to meet your health and performance goals in a much smarter way, while reconnecting to your instincts and the natural world. In addition to sharing the performance expertise of Brian Mackenzie and the scientific insight of Dr. Andy Galpin, Unplugged features exclusive stories and advice from elite athletes and world-renowned experts like Laird Hamilton, Tim Ferriss, Kai Lenny, Kelly Starrett, Steven Kotler, Erin Cafaro, Lenny Wiersma, Dr. Frank Merritt, and Brandon Rager.
Reading Unplugged will enable you to:
• Understand both the value and the limitations of technology in athletic performance, fitness, health, and lifestyle situations
• Know how and when to utilize physical activity technologies in your everyday life—and when not to
• Avoid the common mistakes that most people make with wearables and tracking apps
• Understand which technologies and tests are most effective and which are a waste of money
• End your addiction to fitness technology and start utilizing it as a tool for cueing, learning, and sensing instead of as a taskmaster that stresses you out
• Improve self-awareness and increase self-reliance
• Re-engage with nature by spending less time indoors and more time outside
• Rediscover the value of coaches' expertise, curation, and intuition, which technology can't replace
• Take back control of your health, fitness, and performance with the Unplugged training protocol.
Each chapter ends with clinical cases and the related questions, which evokes yet another method of active learning rather than didactic methods of imparting knowledge.
Key points have been highlighted and boxed at the end of each topic for quick revision of the core concepts.
This book comes with a free companion website which contains self-assessment exercises, detailed case discussions related to the clinical cases given inside the book, glossary and various other features for enhanced learning.
A Doody's Core Title for 2017!
THE BEST REVIEW FOR THE USMLE!
The Thirtieth Edition of Harper’s Illustrated Biochemistry combines outstanding full-colorillustrations with authoritative integrated coverage of biochemical disease and clinical information. Using brevity and numerous medically relevant examples, Harper's presents a clear, succinct review of the fundamentals of biochemistry that every student must understand in order to succeed in medical school.
All fifty-eight chapters emphasize the medical relevance of biochemistryFull-color presentation includes more than 600 illustrations Each chapter includes a section on BiomedicalImportance and a summary of the topics covered Review questions follow each of the eleven sections Case studies in every chapter emphasize the clinical relevance to biochemistry NEW coverage of toxic naturally-occurring amino acids; extraterrestrial biomolecules; computer-aided drug design; the role of complement cascade in bacterial and viral infection; secreted mediators of cell-cell signaling between leukocytes; the role of mast cells, basophils, andeosinophils; and the hazard of antioxidants that down-regulate radical signaling for apoptosis and increase risk of cancer
Applauded by medical students for its current and engaging style, Harper's Illustrated Biochemistry is an essential for USMLE review and the single best reference for learning the clinical relevance of any biochemistry topic.
Winston Churchill once said, “Men occasionally stumble across the truth, but most of them pick themselves up and hurry off as if nothing has happened.” Within the scientific community, a certain stigma is attached to chance discovery because it is wrongly seen as pure luck. Happy accidents certainly happen every day, but it takes intelligence, insight, and creativity to recognize a “Eureka, I found what I wasn't looking for!” moment and know what to do next. In discussing medical breakthroughs, Dr. Morton Meyers makes a cogent, highly engaging argument for a more creative, rather than purely linear, approach to science. And it may just save our lives!
Avoiding the hype of popular science and the pessimism of most social science, Nikolas Rose analyzes contemporary molecular biopolitics, examining developments in genomics, neuroscience, pharmacology, and psychopharmacology and the ways they have affected racial politics, crime control, and psychiatry. Rose analyzes the transformation of biomedicine from the practice of healing to the government of life; the new emphasis on treating disease susceptibilities rather than disease; the shift in our understanding of the patient; the emergence of new forms of medical activism; the rise of biocapital; and the mutations in biopower. He concludes that these developments have profound consequences for who we think we are, and who we want to be.
Imaging Informatics Professionals (IIPs) have come to play an indispensable role in modern medicine, and the scope of this profession has grown far beyond the boundaries of the PACS. A successful IIP must not only understand the PACS itself, but also have knowledge of clinical workflow, a base in several medical specialties, and a solid IT capability regarding software interactions and networking. With the introduction of a certification test for the IIP position, a single source was needed to explain the fundamentals of imaging informatics and to demonstrate how those fundamentals are applied in everyday practice. Practical Imaging Informatics describes the foundations of information technology and clinical image management, details typical daily operations, and discusses rarer complications and issues.
The book is a "constructive dialogue" between contributors selected from a multidisciplinary group of Muslim and non-Muslim scholars from different Islamic countries. The 11 chapters illuminate the diversity and complexity of the issues discussed in Islamic bioethics and pave the way to a better understanding of Islamic bioethics and dialogue in the global bioethics community. The chapters take both theoretical and practical approaches to the topic, and each covers an emerging issue in Islamic bioethics.
This book will be useful for academics and professional institutions in both Islamic and non-Islamic countries, and will be instrumental in providing researchers, scholars, students, policymakers and medical professionals with access to the latest issues and debates related to Islamic bioethics.
Contributors include: Tariq Ramadan, Abdallah Daar, Ali Albar, Mohsin Ebrahim, Baharouddin Azizan Alastair Campbel, Bagher Larijani, Carol Taylor, Gamal Serour, James Rusthoven, Ilhan Ilkilic, Ingrid Mattson, Hassan Chamsi-Pasha, Jonathan Crane, Hakan Ertin, Mehunisha Suleman.
Contents: Islamic Ethics: Sources, Methodology and Application (T Ramadan)Islamic Bioethics: Infrastructure and Capacity Building (A Bagheri)What Islamic Bioethics Can Offer to Global Bioethics (A Bagheri et al.)Gender and Sexuality in Islamic Bioethics (I Mattson)Physician-Patient Relationship in Islamic Context (M Al Bar & H Chamsi-Pasha)Islamic Perspective on Brain Death and Organ Transplantation (M Ebrahim)The Stem Cell Debate in Islamic Bioethics (H Ertin & I Ilkilic)Environmental Ethics in Islam (A Baharuddin & M N Musa)Animal Rights in Islam (B Larijani et al.)Biomedical Research Ethics in the Islamic Context: Reflections on and Challenges for Islamic Bioethics (M Suleman)Challenges in Islamic Bioethics (K Alali et al.)
Readership: Healthcare professionals, health policy makers, physicians and nurses, lawyers academics, researchers, graduate students and lay public.
Keywords: Islamic Bioethics;Bioethics;Biomedical Ethics;Medical Ethics;IslamReview: Key Features: Provides a platform for a better understanding of bioethical issues in Islamic context and how an ethical dilemma is dealt with and how decisions are made in Islamic bioethics from a multidisciplinary group of scholarsBioethical topics presented in this volume are the most critical issues in Islamic bioethics as well as global bioethicsEach chapter presents an update of a bioethical topic and/or challenges in Islamic bioethics from an authoritative bioethics/religious scholarIn an innovative approach this volume presents a constructive dialogue between prominent Muslim and Non-Muslim scholars on Islamic bioethics
Uses a convenient format arranged by body system Contains high-quality images demonstrating the key features of basic anatomy Supplies both conventional imaging and cross-sectional CT and MRI anatomy to aid preparation for the FRCA 2A modules Presents guidelines on how to interpret images Includes case studies in each chapter to illustrate the application of anatomy Discusses commonly encountered pitfalls Matches the current curriculum of the FRCA Part 1 and Part 2A exams
The essential revision book for doctors training in radiology and preparing for the First FRCA exam, Practical Radiological Anatomy is also of great value to advanced radiology practitioners, nurse practitioners, emergency medicine doctors, and radiographers.
A refresher for more experienced readers, the first part of the book presents an introduction to Python, Python modules, reading and writing images using Python, and an introduction to images. The second part discusses the basics of image processing, including pre/post processing using filters, segmentation, morphological operations, and measurements. The last part describes image acquisition using various modalities, such as x-ray, CT, MRI, light microscopy, and electron microscopy. These modalities encompass most of the common image acquisition methods currently used by researchers in academia and industry.
Filling the void, Biotechnology Operations: Principles and Practices reflects this integrative philosophy, serving as a practical guide for students, professionals, or anyone else with interests in the biotech industry. Although many books emphasize specific technical aspects of biotech, this is perhaps the first to integrate essential concepts of product development and scientific and management skills with the seven functional areas of biotechnology:
Biomanufacturing Clinical trials Nonclinical studies Project management Quality assurance Quality control Regulatory affairs
A practical roadmap to optimizing biotechnology operations, this reference illustrates how to use specific product planning, design, and project management processes to seamlessly merge plans and efforts in the key functional areas. Applying lessons learned throughout the nascent history of biotech, author Michael Roy highlights developmental principles that could bring future products to market more safely and efficiently. Drawing from his experiences working in industry and teaching a graduate course at the University of Wisconsin, this hotly anticipated book clarifies basic methodologies and practices to help reduce risks and resolve problems as future technological discoveries are developed into tangible products.
The first 20 chapters are medical device technology chapters; the remaining eight chapters focus on medical device laboratory experiments. Each medical device chapter begins with an exposition of appropriate physiology, mathematical modeling or biocompatibility issues, and clinical need. A device system description and system diagram provide details on technology function and administration of diagnosis and/or therapy. The systems approach lets students quickly identify the relationships between devices.
Device key features are based on five applicable consensus standard requirements from organizations such as ISO and the Association for the Advancement of Medical Instrumentation (AAMI).The medical devices discussed are Nobel Prize or Lasker Clinical Prize winners, vital signs devices, and devices in high industry growth areasThree significant Food and Drug Administration (FDA) recall case studies which have impacted FDA medical device regulation are included in appropriate device chaptersExercises at the end of each chapter include traditional homework problems, analysis exercises, and four questions from assigned primary literatureEight laboratory experiments are detailed that provide hands-on reinforcement of device concepts
Biomaterials: A Basic Introduction is a definitive resource for students entering biomedical or bioengineering disciplines. This text offers a detailed exploration of engineering and materials science, and examines the boundary and relationship between the two. Based on the author’s course lecture notes and many years of research, it presents students with the knowledge needed to select and design biomaterials used in medical devices. Placing special emphasis on metallic, ceramic, polymeric, and composite biomaterials, it explains the difference between materials science and materials engineering, introduces basic concepts and principles, and analyzes the critically important properties of biomaterials.
Explains Complex Theories Using Aspects of Daily Life
This text provides an appropriate balance between depth and broadness of coverage, and offers an understanding of the most important concepts and principles to students from a wide academic spectrum. It delivers the science of biomaterials in laymen terms, from a material standpoint, as well as a clinical applications point of view. It equips students majoring in materials science/engineering with knowledge on the fundamentals of how biomaterials behave at a biological level, and provides students majoring in medicine with information that is generally unavailable in traditional medical courses. The authors incorporate learning objectives at the beginning of each chapter, as well as chapter highlights, problems, and exercises at the end of each chapter. In addition, they present objectives, suggested activities, and reference material for further reading.Contains an overview of medical science vis-à-vis materials science, describes anatomy, histology, and cell biology Highlights health issues and diseases where biomaterials can easily find medical applications Presents knowledge of the relationship between the biomaterials and the living body Evaluates medical devices and looks into their respective regulations
Biomaterials: A Basic Introduction contains an overview of basic biomaterials and concepts, and is written for upper-division students in the US/Canada, and second-level students in universities worldwide.
· cerebrovascular and transcranial
· lower and upper limb arterial
· deep vein thrombosis
· deep and superficial venous reflux
· renal, hepatoportal, mesenteric and penile.
Making Sense of Vascular Ultrasound is designed to give users a hands-on, practical approach to the diagnosis of vascular disease. This pocket-sized handbook provides easy to read, concise, point-form text and includes high-resolution ultrasound images and informative line diagrams.
Each regional chapter covers
· clinical presentations
· differential diagnosis
· what the doctor needs to know
· normal findings and criteria for disease as seen by ultrasound
· comprehensive protocols
· ultrasound images to collect for reports
The book also provides an overview of the physical principles of ultrasound, the physiology of blood flow, vascular pathology, setting up a vascular ultrasound diagnostic service, and interventional vascular ultrasound procedures.
The author’s continual participation in FDA QSR inspections and Notified Body ISO audits is reflected in updates to all chapters and appendices of the book, now bursting at the seams with:
New coverage of ISO 9001 and 13485 design control requirements More real-world examples from the medical device industry Additional detail for greater understanding and clarity Fresh templates for practical implementation Extensive references for further study
The book addresses design control elements such as design planning, input, output, review, verification, validation, change, transfer, and history, as well as risk management inclusive of human factors and usability, biocompatibility, the FDA Quality System Inspection Technique (QSIT) for design controls, and medical device regulations and classes in the US, Canada, and Europe.
Most books on regulatory affairs present regulations in each jurisdiction separately: European Union, USA, Australia, Canada, and Japan. This book proposes practical solutions for a coherent, one-size-fits-all (or most) set of systems and processes in compliance with regulations in all key markets, throughout the life cycle of a medical device. It also contains key information about international harmonization efforts and recent regulatory trends in emerging markets; important terminology needed to understand the regulators’ language; and examples, case studies, and practical recommendations that bridge the gap between regulatory theory and practice.
Part I deals with the principles, mode of operation, and uses of various biomedical instruments and devices, including transducers, electrocardiograph, implantable electrical devices, biotelemetry, patient monitoring systems, hearing aids, and implantable insulin delivery systems. Parts II and III describe the basic principle of medical imaging devices and the application of computers in medicine, particularly in the fields of data management, critical care, clinical laboratory, radiology, artificial intelligence, and research. Part IV focuses on the application of biomaterials and biomechanics in orthopedic and accident investigation, while Part V considers the major functions of clinical engineering. Part VI provides the principles and application of mathematical models in physiological systems analysis.
This book is valuable as a general reference for courses in a biomedical engineering curriculum.
Computer Vision: Algorithms and Applications explores the variety of techniques commonly used to analyze and interpret images. It also describes challenging real-world applications where vision is being successfully used, both for specialized applications such as medical imaging, and for fun, consumer-level tasks such as image editing and stitching, which students can apply to their own personal photos and videos.
More than just a source of “recipes,” this exceptionally authoritative and comprehensive textbook/reference also takes a scientific approach to basic vision problems, formulating physical models of the imaging process before inverting them to produce descriptions of a scene. These problems are also analyzed using statistical models and solved using rigorous engineering techniques
Topics and features:Structured to support active curricula and project-oriented courses, with tips in the Introduction for using the book in a variety of customized courses Presents exercises at the end of each chapter with a heavy emphasis on testing algorithms and containing numerous suggestions for small mid-term projects Provides additional material and more detailed mathematical topics in the Appendices, which cover linear algebra, numerical techniques, and Bayesian estimation theory Suggests additional reading at the end of each chapter, including the latest research in each sub-field, in addition to a full Bibliography at the end of the book Supplies supplementary course material for students at the associated website, http://szeliski.org/Book/
Suitable for an upper-level undergraduate or graduate-level course in computer science or engineering, this textbook focuses on basic techniques that work under real-world conditions and encourages students to push their creative boundaries. Its design and exposition also make it eminently suitable as a unique reference to the fundamental techniques and current research literature in computer vision.
This highly anticipated new edition of the Handbook of Face Recognition provides a comprehensive account of face recognition research and technology, spanning the full range of topics needed for designing operational face recognition systems. After a thorough introductory chapter, each of the following 26 chapters focus on a specific topic, reviewing background information, up-to-date techniques, and recent results, as well as offering challenges and future directions.
Topics and features: fully updated, revised and expanded, covering the entire spectrum of concepts, methods, and algorithms for automated face detection and recognition systems; examines the design of accurate, reliable, and secure face recognition systems; provides comprehensive coverage of face detection, tracking, alignment, feature extraction, and recognition technologies, and issues in evaluation, systems, security, and applications; contains numerous step-by-step algorithms; describes a broad range of applications from person verification, surveillance, and security, to entertainment; presents contributions from an international selection of preeminent experts; integrates numerous supporting graphs, tables, charts, and performance data.
This practical and authoritative reference is the essential resource for researchers, professionals and students involved in image processing, computer vision, biometrics, security, Internet, mobile devices, human-computer interface, E-services, computer graphics and animation, and the computer game industry.
Used by thousands of medical students each year to succeed on USMLE Step 1, Kaplan's official lecture notes are packed with full-color diagrams and clear review.
The Best Review
Organized in outline format with high-yield summary boxes for efficient study.Clinical correlations and bridges between disciplines highlighted throughout.Full-color diagrams and charts for better comprehension and retention.Updated annually by Kaplan's all-star expert faculty
Looking for more prep? Our USMLE Step 1 Lecture Notes 2018: 7-Book Set has this book, plus the rest of the 7-book series.
The stratum corneum is the interface between the sometimes harsh environment and the internal turmoil of the human body. Based on a large number of recent publications, this book explains the mechanisms involved in stratum corneum barrier function and hydration. It reflects 10 years of progress not only of the non-invasive biophysical assessment of skin physiology parameter, but also of the perfection of the available devices. It brings all research on epidermal water and transepidermal water loss in health and disease up-to-date with the revision of existing chapters as well as added chapters from new contributors on hydration and itching. This edition also includes new guidelines on the standardization of measurements.
Bioengineering of the Skin will enhance communication within the research community and will be useful for scientists in the skin bioengineering field by presenting methods that offer reliable and reproducible approaches for product testing in the pharmaceutical and cosmetic industries, as well as for basic research.
Because the number of Centers for Pediatric Radiology is small, students as well as pediatricians and general radiologists lack training in pediatric radiology and are often not sufficiently aware of these differences.
Active radiation protection and avoidance of unnecessary high contrast media doses are number one priority in diagnosing and treating children and can be achieved through: Avoidance of X-rays and CT scans. Substitution with non-ionizing radiation such as ultrasonography and MRI where possible while ensuring diagnostic reliability; Reduction of the radiation dose and number of views. This can be realized by following the ALARA principle: “as low as reasonably achievable”; Weight and indication tailored contrast media dosing.
This CME accredited Manual provides a comprehensive overview on the field of pediatric radiology and suggests imaging strategies for the most common clinical indications in children and adolescents.
In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced with talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?
Never before have two revolutions with so much potential to save and prolong human life occurred simultaneously. The converging, synergistic power of the biochemical and digital revolutions now allows us to read every letter of life's code, create precisely targeted drugs to control it, and tailor their use to individual patients. Cancer, diabetes, Alzheimer's and countless other killers can be vanquished—if we make full use of the tools of modern drug design and allow doctors the use of modern data gathering and analytical tools when prescribing drugs to their patients.
But Washington stands in the way, clinging to outdated drug-approval protocols developed decades ago during medicine's long battle with the infectious epidemics of the past. Peter Huber, an expert in science, technology, and public policy, demonstrates why Washington's one-size-fits-all drug policies can't deal with diseases rooted in the complex molecular diversity of human bodies. Washington is ill-equipped to handle the torrents of data that now propel the advance of molecular medicine and is reluctant to embrace the statistical methods of the digital age that can. Obsolete economic policies, often rationalized as cost-saving measures, stifle innovation and suppress investment in the medicine that can provide the best cures at the lowest cost.
In the 1980s, an AIDS diagnosis was a death sentence, until the FDA loosened its throttling grip and began streamlining and accelerating approval of life-saving drugs. The Cure in the Code shows patients, doctors, investors, and policy makers what we must now do to capture the full life-saving and cost-saving potential of the revolution in molecular medicine. America has to choose. At stake for America is the power to lead the world in mastering the most free, fecund, competitive, dynamic, and intelligent natural resource on the planet—the molecular code that spawns human life and controls our health.