Neurocutaneous Syndromesprovides the most updated and comprehensive resource on the disorders that lead to the growth of tumors in various parts of the body, those caused by the abnormal development of cells in an embryo and characterized by the presence of tumors in various parts of the body and eyes, including the nervous system, and by certain differences in the skin.
The most common neurocutaneous syndromes include, neurofibromatosis, Sturge-Weber syndrome, tuberous sclerosis, ataxia-telangiectasia, and von Hippel-Lindau disease. Symptoms vary widely and while present early may not express until later in life.
As molecular medicine and genetic science is continuing to impact our understanding of neurocutaneous syndromes, this book also includes the latest molecular and genetic science.Provides a comprehensive coverage of neurocutaneous syndromesDetails the latest molecular and genetic science related to neurocutaneous syndromesPresents a focused reference for clinical practitioners and the neuroscience, clinical neurology, and neurogenetics research communitiesIncludes updated sections on the latest molecular and genetic science
Nicotine Use in Mental Illness and Neurological Disorders, a volume in the International Review of Neurobiology series, is a comprehensive overview of the state-of-the-art research into nicotine use in mental illness and neurological disorders. It reviews current knowledge and understanding, also provides a starting point for researchers and practitioners entering the field.Provides a broad coverage of subject matterPresents a comprehensive overview of the state-of-the-art research into nicotine use in mental illness and neurological disordersIdeal for researchers and practitioners, and those just entering the field
The easy-to-use 'encyclopedic-dictionary' format of the Encyclopedia of the Neurological Sciences, Second Edition features alphabetic entries, extensive cross-referencing, and a thorough index for quick reference. The wealth of information provided by these four volumes makes this reference work a trusted source of valuable information for a wide range of researchers, from undergraduate students to academic researchers.Provides comprehensive coverage of the field of neurological science in over 1,000 entries in 4 volumes "Encyclopedic-dictionary" format provides for concise, readable entries and easy searching Presents complete, up-to-date information on 32 separate areas of neurology Entries are supplemented with extensive cross-referencing, useful references to primary research articles, and an extensive index
Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases.Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric diseaseDetailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brainDetailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations
This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases.Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatmentCovers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and painIllustrated in full colorEach chapter provides in-text summary points, special feature boxes, and research questionsProvides an up-to-date synthesis of primary source material
This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis.
In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance.Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importanceFeatures contributions from leading global basic and clinical investigators in the fieldProvides a great resource for researchers and practitioners interested in the basic science underlying neurological processesRelates and translates the current science to the understanding of neurological disorders and their treatment
Diseases of the Nervous System summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine.
This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system.2016 PROSE Award winner of the Best Textbook Award in Biological & Life SciencesProvides a focused tutorial introduction to the core diseases of the nervous systemIncludes comprehensive introductions to Stroke, Epilepsy, Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, ALS, Head and Spinal Cord Trauma, Multiple Sclerosis, Brain Tumors, Depression, Schizophrenia and many other diseases of the nervous systemCovers more than 40 diseases from the foundational science to the best treatment protocolsIncludes discussions of translational research, drug discovery, personalized medicine, ethics, and neuroscience
This invaluable information will help readers recognize the various neurological conditions presented, with the inclusion of their aetiologies and treatment in tropical areas. The book therefore fills a gap in the neuroepidemiology literature, with chapters written by an international collection of experienced authors in the field.Highlights differences and similarities between neuroepidemiology in tropical areas and temperate zones with a focus on methods and underlying factorsCovers environmental factors in the tropical world and their consequences for neurologyChapters include references (key articles, books, protocols) for additional detailed studyIncludes wide topics of neurological disease in the tropics, not only infectious diseases, but also nutrition and public health
Finally, the book provides an outlook for potential directions that can be explored to improve the various aspects of CSF research with the ultimate goal of being incorporated in clinical practice.Provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarkerAddresses relevant research in context with the most important diagnostic entities in neurologyEdited by leading authors in CSF research from around the globe, presenting the broadest, most expert coverage available
The beneficial effects of curcumin have been observed both in cultured cells and in animal models, thus paving the way for ongoing present and future human clinical trials. Curcumin produces antioxidant and anti-inflammatory effects not only by blocking oxidative stress and neuroinflammation in neurotraumatic and neurodegenerative diseases, but also by restoring cellular homeostasis and rebalancing redox equilibrium.Identifies molecular mechanisms of curcumin effects in neurological diseasesIncludes effects on neurotraumatic, neurodegenerative and psychiatric diseasesCovers the antioxidant, anti-inflammatory and immunomodulatory effects of curcuminExamines curcumin’s potential in developing new therapeutic drugs
In addition, the book covers the physiology and neuroanatomy of the thermoregulation system and provides descriptions of how the regulation of body temperature intervenes with other physiological functions (such as sleep, osmoregulation, and immunity), stress, exercise and aging. Basic sections serve as an introduction to the four clinical sections: Body Temperature, Clinical Significance, Abnormal Body Temperature, Thermoregulation in Neurological Disease and Therapeutic Interventions.Presents a clear, logical pathway from the fundamental physiology of thermoregulation, through neurobiology, to clinical applications and diseaseEnables researchers and clinicians to better understand the value of temperature measurement in disease and the use of temperature as a therapy Integrates content from a broad field of research, including topics on the molecular physiology of temperature receptors, to the management of accidental hypothermia
This handbook sets the new standard for comprehensive multi-authored textbooks in the field of neuro-otology. The volume is divided into three sections, including basic aspects, diagnostic and therapeutic management, and neuro-otologic disorders. Internationally acclaimed chapter authors represent a broad spectrum of areas of expertise, chosen for their ability to write clearly and concisely with an eye toward a clinical audience.
The Basic Aspects section is brief and covers the material in sufficient depth necessary for understanding later translational and clinical material. The Diagnostic and Therapeutic Management section covers all of the essential topics in the evaluation and treatment of patients with dizziness and disequilibrium. The section on Neuro-otologic Disorders is the largest portion of the volume and addresses every major diagnostic category in the field.Synthesizes widely dispersed information on the anatomy and physiology of neuro-otologic conditions into one comprehensive resourceFeatures input from renowned international authors in basic science, otology, and neurosciencePresents the latest assessment of the techniques needed to diagnose and treat patients with dizziness, vertigo, and imbalanceProvides the reader with an updated, in-depth review of the clinically relevant science and the clinical approach to those disorders of the peripheral and central vestibular system
This book draws from and builds upon the original conference presentations, and incorporates the most up-to-date science behind brain degeneration as well as actual case reports. Each of the book’s six sections off er the reader a deeper understanding of brain degeneration as it exists in Sub-Saharan Africa.
In Chapter 1 the fundamentals of imaging transplanted cells is discussed with emphasis on animal models as well as the horizon for clinical trials. Then, detailed methods on the culture of neural stem cells is reviewed as a foundation for approaching therapeutic goals. Chapter 3 presents the broad scope of animal models that serve as the foundation for developmental and pre-clinical investigation, with mention of recent genetically engineered mouse models that represent the best models for studying disease development and treatment. Chapter 4 provides background on the delivery techniques to animals and patients that are available, providing vital information on the subtleties of technique necessary for optimal cellular grafting. Chapters 5 and 6 discuss new and evolving information on the origins of brain tumors and the indelible role of stromal and microenvironmental influences on oncogenesis and tumor progression. Subsequently, the utility of neural stem cells as cellular vehicles to deliver chemotherapeutics to broad neuropathology is reviewed. In Chapter 8 the scope of treating brain tumors is expanded beyond stem cells, to present the best biological interventions to improve upon current treatment options for brain malignancy. The last two chapters present a comprehensive review on stem cell and gene therapy options for treating cerebrovascular and neurovascular pathology.
In amassing this collection, my intention has been to provide the reader with a broad introduction into molecular imaging, stem cell biology, cell therapy, animal models, central nervous system malignancies, stroke, and neurodegeneration. My hope is that Frontiers of Brain Repair will be the intellectual soil from which a deeply rooted and well-nourished vintage of neuroscience will arise.