In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.
Junk DNA can play vital and unanticipated roles in the control of gene expression, from fine-tuning individual genes to switching off entire chromosomes. These functions have forced scientists to revisit the very meaning of the word "gene" and have engendered a spirited scientific battle over whether or not this genomic "nonsense" is the source of human biological complexity. Drawing on her experience with leading scientific investigators in Europe and North America, Nessa Carey provides a clear and compelling introduction to junk DNA and its critical involvement in phenomena as diverse as genetic diseases, viral infections, sex determination in mammals, and evolution. We are only now unlocking the secrets of junk DNA, and Nessa Carey's book is an essential resource for navigating the history and controversies of this fast-growing, hotly disputed field.
For centuries, we've toyed with our creature companions, breeding dogs that herd and hunt, housecats that look like tigers, and teacup pigs that fit snugly in our handbags. But what happens when we take animal alteration a step further, engineering a cat that glows green under ultraviolet light or cloning the beloved family Labrador? Science has given us a whole new toolbox for tinkering with life. How are we using it?
In Frankenstein's Cat, the journalist Emily Anthes takes us from petri dish to pet store as she explores how biotechnology is shaping the future of our furry and feathered friends. As she ventures from bucolic barnyards to a "frozen zoo" where scientists are storing DNA from the planet's most exotic creatures, she discovers how we can use cloning to protect endangered species, craft prosthetics to save injured animals, and employ genetic engineering to supply farms with disease-resistant livestock. Along the way, we meet some of the animals that are ushering in this astonishing age of enhancement, including sensor-wearing seals, cyborg beetles, a bionic bulldog, and the world's first cloned cat.
Through her encounters with scientists, conservationists, ethicists, and entrepreneurs, Anthes reveals that while some of our interventions may be trivial (behold: the GloFish), others could improve the lives of many species-including our own. So what does biotechnology really mean for the world's wild things? And what do our brave new beasts tell us about ourselves?
With keen insight and her trademark spunk, Anthes highlights both the peril and the promise of our scientific superpowers, taking us on an adventure into a world where our grandest science fiction fantasies are fast becoming reality.
This book, covers all the subjects of life science under 13 section namely, 1. Molecules and their interaction relevant to biology; 2. Cellular organization; 3. Fundamental processes; 4. Cell communication and cell signaling; 5. Developmental biology; 6. System physiology – Plant; 7. System physiology – Animal; 8. Inheritance biology; 9. Diversity of life forms; 10. Ecological principles; 11. Evolution and behavior; 12. Applied biology and 13. Methods in biology. Each Section has been further divided into two parts with 200 short tricky questions and 100 applied conceptual questions. Besides this, it also consist of ten full-length model practice test paper, each of 145 questions based on recent syllabus and examination pattern of CISR-UGC National Eligibility Test for Junior research fellowship and lecturership. Additional previous years solved question papers of the CSIR-UGC NET are also included to get acquainted with India's most competitive entry level exam.
The ultimate purpose of this book is to equip the reader with brainstorming challenges and solution for life science and applied aspect examinations. It contains predigested information on all the academic subject of life science for good understanding, assimilation, self-evaluation, and reproducibility.
Genetically modified organisms (GMOs) including plants and the foods made from them, are a hot topic of debate today, but soon related technology could go much further and literally change what it means to be human. Scientists are on the verge of being able to create people who are GMOs.
Should they do it? Could we become a healthier and ''better'' species or might eugenics go viral leading to a real, new world of genetic dystopia? GMO Sapiens tackles such questions by taking a fresh look at the cutting-edge biotech discoveries that have made genetically modified people possible.
Bioengineering, genomics, synthetic biology, and stem cells are changing sci-fi into reality before our eyes. This book will capture your imagination with its clear, approachable writing style. It will draw you into the fascinating discussion of the life-changing science of human genetic modification.Contents:An Introduction to Playing GodThe Birth and Explosive Growth of GMOsHuman CloningBuild-a-Baby Better via GeneticsDIY Guide to Creating GMO SapiensEugenics and TranshumanismCultural Views on Human Genetic ModificationGMO Sapiens Today and Tomorrow
"What I find troubling, exciting but scary, is that I find myself agreeing with an undertone, I do not support human germline genetic modification but with all the new information and perspectives available to me I have found myself questioning my own views and will be watching any developments with a fascinated interest I would rather not admit to."The NODE
R. Ford Denison shows how both biotechnology and traditional plant breeding can use Darwinian insights to identify promising routes for crop genetic improvement and avoid costly dead ends. Denison explains why plant traits that have been genetically optimized by individual selection--such as photosynthesis and drought tolerance--are bad candidates for genetic improvement. Traits like plant height and leaf angle, which determine the collective performance of plant communities, offer more room for improvement. Agriculturalists can also benefit from more sophisticated comparisons among natural communities and from the study of wild species in the landscapes where they evolved.
Darwinian Agriculture reveals why it is sometimes better to slow or even reverse evolutionary trends when they are inconsistent with our present goals, and how we can glean new ideas from natural selection's marvelous innovations in wild species.
Any farmer you talk to could tell you that we've been playing with the genetic makeup of our food for millennia, carefully coaxing nature to do our bidding. The practice officially dates back to Gregor Mendel -- who was not a renowned scientist, but a 19th century Augustinian monk. Mendel spent many hours toiling in his garden, testing and cultivating more than 28,000 pea plants, selectively determining very specific characteristics of the peas that were produced, ultimately giving birth to the idea of heredity -- and the now very common practice of artificially modifying our food.
But as science takes the helm, steering common field practices into the laboratory, the world is now keenly aware of how adept we have become at tinkering with nature --which in turn has produced a variety of questions. Are genetically modified foods really safe? Will the foods ultimately make us sick, perhaps in ways we can't even imagine? Isn't it genuinely dangerous to change the nature of nature itself?
Nina Fedoroff, a leading geneticist and recognized expert in biotechnology, answers these questions, and more. Addressing the fear and mistrust that is rapidly spreading, Federoff and her co-author, science writer Nancy Brown, weave a narrative rich in history, technology, and science to dispel myths and misunderstandings.
In the end, Fedoroff arues, plant biotechnology can help us to become better stewards of the earth while permitting us to feed ourselves and generations of children to come. Indeed, this new approach to agriculture holds the promise of being the most environmentally conservative way to increase our food supply.
Humanity has reached a critical moment. Our world is unsettled and rapidly changing, and we face existential risks over the next century. Various outcomes—good and bad—are possible. Yet our approach to the future is characterized by short-term thinking, polarizing debates, alarmist rhetoric, and pessimism. In this short, exhilarating book, renowned scientist and bestselling author Martin Rees argues that humanity’s prospects depend on our taking a very different approach to planning for tomorrow.
The future of humanity is bound to the future of science and hinges on how successfully we harness technological advances to address our challenges. If we are to use science to solve our problems while avoiding its dystopian risks, we must think rationally, globally, collectively, and optimistically about the long term. Advances in biotechnology, cybertechnology, robotics, and artificial intelligence—if pursued and applied wisely—could empower us to boost the developing and developed world and overcome the threats humanity faces on Earth, from climate change to nuclear war. At the same time, further advances in space science will allow humans to explore the solar system and beyond with robots and AI. But there is no “Plan B” for Earth—no viable alternative within reach if we do not care for our home planet.
Rich with fascinating insights into cutting-edge science and technology, this accessible book will captivate anyone who wants to understand the critical issues that will define the future of humanity on Earth and beyond.
Advances in the fundamental knowledge surrounding biotechnology, novel materials, and advanced engineering approaches continue to be translated into bioprocesses that bring new products to market at a significantly faster pace than most other industries. Industrial scale biotechnology and new manufacturing methods are revolutionizing medicine, environmental monitoring and remediation, consumer products, food production, agriculture, and forestry, and continue to be a major area of research.
The downstream stage in industrial biotechnology refers to recovery, isolation, and purification of the microbial products from cell debris, processing medium and contaminating biomolecules from the upstream process into a finished product such as biopharmaceuticals and vaccines.
Downstream process design has the greatest impact on overall biomanufacturing cost because not only does the biochemistry of different products ( e.g., peptides, proteins, hormones, antibiotics, and complex antigens) dictate different methods for the isolation and purification of these products, but contaminating byproducts can also reduce overall process yield, and may have serious consequences on clinical safety and efficacy. Therefore downstream separation scientists and engineers are continually seeking to eliminate, or combine, unit operations to minimize the number of process steps in order to maximize product recovery at a specified concentration and purity.
Based on Wiley's Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, this volume features fifty articles that provide information on down- stream recovery of cells and protein capture; process development and facility design; equipment; PAT in downstream processes; downstream cGMP operations; and regulatory compliance.
It covers:Cell wall disruption and lysis Cell recovery by centrifugation and filtration Large-scale protein chromatography Scale down of biopharmaceutical purification operations Lipopolysaccharide removal Porous media in biotechnology Equipment used in industrial protein purification Affinity chromatography Antibody purification, monoclonal and polyclonal Protein aggregation, precipitation and crystallization Freeze-drying of biopharmaceuticals Biopharmaceutical facility design and validation Pharmaceutical bioburden testing Regulatory requirements
Ideal for graduate and advanced undergraduate courses on biomanufacturing, biochemical engineering, biophar- maceutical facility design, biochemistry, industrial microbiology, gene expression technology, and cell culture technology, Downstream Industrial Biotechnology is also a highly recommended resource for industry professionals and libraries.
The life sciences deal with a vast array of problems at different spatial, temporal, and organizational scales. The mathematics necessary to describe, model, and analyze these problems is similarly diverse, incorporating quantitative techniques that are rarely taught in standard undergraduate courses. This textbook provides an accessible introduction to these critical mathematical concepts, linking them to biological observation and theory while also presenting the computational tools needed to address problems not readily investigated using mathematics alone.
Proven in the classroom and requiring only a background in high school math, Mathematics for the Life Sciences doesn't just focus on calculus as do most other textbooks on the subject. It covers deterministic methods and those that incorporate uncertainty, problems in discrete and continuous time, probability, graphing and data analysis, matrix modeling, difference equations, differential equations, and much more. The book uses MATLAB throughout, explaining how to use it, write code, and connect models to data in examples chosen from across the life sciences.
Filling the void, Biotechnology Operations: Principles and Practices reflects this integrative philosophy, serving as a practical guide for students, professionals, or anyone else with interests in the biotech industry. Although many books emphasize specific technical aspects of biotech, this is perhaps the first to integrate essential concepts of product development and scientific and management skills with the seven functional areas of biotechnology:
Biomanufacturing Clinical trials Nonclinical studies Project management Quality assurance Quality control Regulatory affairs
A practical roadmap to optimizing biotechnology operations, this reference illustrates how to use specific product planning, design, and project management processes to seamlessly merge plans and efforts in the key functional areas. Applying lessons learned throughout the nascent history of biotech, author Michael Roy highlights developmental principles that could bring future products to market more safely and efficiently. Drawing from his experiences working in industry and teaching a graduate course at the University of Wisconsin, this hotly anticipated book clarifies basic methodologies and practices to help reduce risks and resolve problems as future technological discoveries are developed into tangible products.
At a time when speculative fiction seems less and less far-fetched, Margaret Atwood lends her distinctive voice and singular point of view to the genre in a series of essays that brilliantly illuminates the essential truths about the modern world. This is an exploration of her relationship with the literary form we have come to know as "science fiction,” a relationship that has been lifelong, stretching from her days as a child reader in the 1940s, through her time as a graduate student at Harvard, where she worked on the Victorian ancestor of the form, and continuing as a writer and reviewer. This book brings together her three heretofore unpublished Ellmann Lectures from 2010: "Flying Rabbits," which begins with Atwood's early rabbit superhero creations, and goes on to speculate about masks, capes, weakling alter egos, and Things with Wings; "Burning Bushes," which follows her into Victorian otherlands and beyond; and "Dire Cartographies," which investigates Utopias and Dystopias. In Other Worlds also includes some of Atwood's key reviews and thoughts about the form. Among those writers discussed are Marge Piercy, Rider Haggard, Ursula Le Guin, Ishiguro, Bryher, Huxley, and Jonathan Swift. She elucidates the differences (as she sees them) between "science fiction" proper, and "speculative fiction," as well as between "sword and sorcery/fantasy" and "slipstream fiction." For all readers who have loved The Handmaid's Tale, Oryx and Crake, and The Year of the Flood, In Other Worlds is a must.
Note: The electronic version of this title contains over thirty additional, illuminating eBook-exclusive illustrations by the author.
Weaving together vivid storytelling and groundbreaking science, The Body Builders explores the current revolution in human augmentation, which is helping us to triumph over the limitations and constraints we have long accepted as an inevitable part of being human
For millennia, humans have tried—and often failed—to master nature and transcend our limits. But this has started to change. The new scientific frontier is the human body: the greatest engineers of our generation have turned their sights inward, and their work is beginning to revolutionize mankind.
In The Body Builders, Adam Piore takes us on a fascinating journey into the field of bioengineering—which can be used to reverse engineer, rebuild, and augment human beings—and paints a vivid portrait of the people at its center. Chronicling the ways new technology has retooled our physical expectations and mental processes, Piore visits people who have regrown parts of their fingers and legs in the wake of terrible traumas, tries on a muscle suit that allows him to lift ninety pounds with his fingertips, dips into the race to create “Viagra for the brain,” and shadows the doctors trying to give mute patients the ability to communicate telepathically.
As science continues to lay bare the mysteries of human performance, it is helping us to see—and exist—above our expectations. The Body Builders will take readers beyond the headlines and the hype to introduce them to the inner workings and the outer reaches of our bodies and minds, and explore how new developments are changing, and will forever change, what is possible for humankind.
As horrifying as such possibilities are, Genes, Giants, Monsters, and Men sets forth a plausible theory revealing a hidden history of mankind and a possible reason that it has remained veiled for hundreds of thousands of years. With his well-documented style and breathtaking conclusions, Dr. Joseph P. Farrell pulls back the veil and takes the reader on an odyssey behind the mysterious history and myths of the human race.
Joseph P. Farrell is a recognized scholar whose credentials include a PhD in philosophy from the University of Oxford. His literary contribution is a veritable resumé unto itself covering such fields as Nazi Germany, sacred literature, physics, finances, the Giza pyramids, and music theory. A renowned researcher with an eye to assimilate a tremendous amount of background material, Farrell is able to condense the best scholastic research in publication and draw insightful new conclusions on complex and controversial subjects.
A century ago, discoveries in physics came together with engineering to produce an array of astonishing new technologies: radios, telephones, televisions, aircraft, radar, nuclear power, computers, the Internet, and a host of still-evolving digital tools. These technologies so radically reshaped our world that we can no longer conceive of life without them.
Today, the world’s population is projected to rise to well over 9.5 billion by 2050, and we are currently faced with the consequences of producing the energy that fuels, heats, and cools us. With temperatures and sea levels rising, and large portions of the globe plagued with drought, famine, and drug-resistant diseases, we need new technologies to tackle these problems.
But we are on the cusp of a new convergence, argues world-renowned neuroscientist Susan Hockfield, with discoveries in biology coming together with engineering to produce another array of almost inconceivable technologies—next-generation products that have the potential to be every bit as paradigm shifting as the twentieth century’s digital wonders.
The Age of Living Machines describes some of the most exciting new developments and the scientists and engineers who helped create them. Virus-built batteries. Protein-based water filters. Cancer-detecting nanoparticles. Mind-reading bionic limbs. Computer-engineered crops. Together they highlight the promise of the technology revolution of the twenty-first century to overcome some of the greatest humanitarian, medical, and environmental challenges of our time.
Bioinformatics For Dummies is packed with valuable information that introduces you to this exciting new discipline. This easy-to-follow guide leads you step by step through every bioinformatics task that can be done over the Internet. Forget long equations, computer-geek gibberish, and installing bulky programs that slow down your computer. You’ll be amazed at all the things you can accomplish just by logging on and following these trusty directions. You get the tools you need to:Analyze all types of sequences Use all types of databases Work with DNA and protein sequences Conduct similarity searches Build a multiple sequence alignment Edit and publish alignments Visualize protein 3-D structures Construct phylogenetic trees
This up-to-date second edition includes newly created and popular databases and Internet programs as well as multiple new genomes. It provides tips for using servers and places to seek resources to find out about what’s going on in the bioinformatics world. Bioinformatics For Dummies will show you how to get the most out of your PC and the right Web tools so you’ll be searching databases and analyzing sequences like a pro!
An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.
Biomanufacturing facilities that are designed and built today are radically different than in the past. The vital information and knowledge needed to design and construct these increasingly sophisticated biopharmaceutical manufacturing facilities is difficult to find in published literature—and it’s rarely taught in architecture or design schools. This is the first book for architects and designers that fills this void. Process Architecture in Biomanufacturing Facility Design provides information on design principles of biopharmaceutical manufacturing facilities that support emerging innovative processes and technologies, use state-of-the-art equipment, are energy efficient and sustainable, and meet regulatory requirements.
Relying on their many years of hands-on design and operations experience, the authors emphasize concepts and practical approaches toward design, construction, and operation of biomanufacturing facilities, including product-process-facility relationships, closed systems and single use equipment, aseptic manufacturing considerations, design of biocontainment facility and process based laboratory, and sustainability considerations, as well as an outlook on the facility of the future.Provides guidelines for meeting licensing and regulatory requirements for biomanufacturing facilities in the U.S.A and WHO—especially in emerging global markets in India, China, Latin America, and the Asia/Pacific regions Focuses on innovative design and equipment, to speed construction and time to market, increase energy efficiency, and reduce footprint, construction and operational costs, as well as the financial risks associated with construction of a new facility prior to the approval of the manufactured products by regulatory agencies Includes many diagrams that clarify the design approach
Process Architecture in Biomanufacturing Facility Design is an ideal text for professionals involved in the design of facilities for manufacturing of biopharmaceuticals and vaccines, biotechnology, and life-science industry, including architects and designers of industrial facilities, construction, equipment vendors, and mechanical engineers. It is also recommended for university instructors, advanced undergraduates, and graduate students in architecture, industrial engineering, mechanical engineering, industrial design, and industrial interior design.
DNA Nanotechnology for Bioanalysis provides a concise and rigorous description for the fabrication of various types of functional nanostructures by optimized software-aided high-yield synthesis. Following this is the explanation of methods to decorate these nanostructures with molecules such as proteins, metal nanoparticles or bioorganic moieties covalently bonded onto DNA via self-assemblage processes. Also provided is a concise review on non-canonical DNA structures (such as G-quadruplexes) and their targeting by small molecules for applications in pharmacology. Finally, it describes the exciting applications of DNA nanostructures in life sciences and nanomedicine, including ultraspecific molecular delivery, control of cell behavior, analysis of cell lysate and DNA-based nano-tools for super-resolution sub-cellular imaging.Contents: Nanotechnology and the Unique Role of DNA (Elisa-C Schöneweiβ, Andreas Jaekel and Barbara Saccà)DNA as Building Material at the Nanoscale: From Concepts to Software-aided Design (Wolfgang Pfeifer, Georg Homa, Giuseppe Arrabito and Barbara Saccà)DNA Sensors for the Detection of Biomolecules and Biochemical Conditions (Birgitta R Knudsen, Anni H Andersen, Magnus Stougaard, Giuseppe Arrabito, Raffaella Suriano and Yi-Ping Ho)DNA Nanostructures in Cell Biology and Medicine (Liqian Wang and Giuseppe Arrabito)Targeting G-quadruplex DNA as Potential Anti-cancer Therapy (Riccardo Bonsignore, Elisa Trippodo and Giampaolo Barone)DNA-aided Super-resolution Bioimaging (JiaJun Li, Giuseppe Arrabito and ZhaoShuai Gao)
Fear, Wonder, and Science in the New Age of Reproductive Biotechnology first covers the most recent and well-grounded scientific conclusions about fertilization and early human embryology. It then discusses the reasons why some of the major forms of assisted reproductive technologies were invented, how they are used, and what they can and cannot accomplish. Most important, the authors explore the emotional side of using these technologies, focusing on those who have emptied their emotions and bank accounts in a valiant effort to conceive a child. This work of science and human biology is informed by a moral concern for our common humanity.
To re-orient contemporary debate, Fukuyama underlines man's changing understanding of human nature through history: from Plato and Aristotle's belief that man had "natural ends," to the ideals of utopians and dictators of the modern age who sought to remake mankind for ideological ends. Fukuyama persuasively argues that the ultimate prize of the biotechnology revolution-intervention in the "germ-line," the ability to manipulate the DNA of all of one person's descendents-will have profound, and potentially terrible, consequences for our political order, even if undertaken by ordinary parents seeking to "improve" their children.
In Our Posthuman Future, our greatest social philosopher begins to describe the potential effects of exploration on the foundation of liberal democracy: the belief that human beings are equal by nature.