There is Gavin Stewart, a twin who lives in his brothers shadow. Theres Andrew Apple Brookman, the jokester whose life is changed by loss. Theres Henry Sturtz, the rich boy whose words can be deadly. Theres Leonard Pulitzer Dorff, the poor boy sent to spend a summer in a world he can only dream about. And theres Nicki Polis, the girlfriend of the golden boy who is privy to a secret that will change all of them.
Gone the Sun traces the lives of these individuals over the course of thirty-five years, finally bringing them together again in a meeting where truth and illusion must be separated and secrets and lies exposed. Its a story about a bunch of kids who thought they knew it all at sixteen and how that hubris changed the course of their lives.
This fully revised and updated eighth edition provides essential information on new medications and treatment options and includes the latest research on side effects, contraindications, and efficacy of all major medications prescribed for mental health disorders. The book also features an important new chapter on the effects of withdrawing from psychopharmacological medications.
This handbook makes it simple to: get the facts about drug interactions and side effects; find out how medications affect adults, children, and adolescents differently; learn how different cultures view medical treatment, vital information for anyone who treats clients from a variety of backgrounds; and discontinue medication safely when needed.
This essential guide to psychopharmacology has been adopted as a textbook at universities nationwide and is an important resource for every therapist’s library.
"A major work of interpretation of medical and social thought . . . this volume is also to be commended for its skillful, absorbing presentation of the background and the effects of this dread disease."—I.B. Cohen, New York Times
"The Cholera Years is a masterful analysis of the moral and social interest attached to epidemic disease, providing generally applicable insights into how the connections between social change, changes in knowledge and changes in technical practice may be conceived."—Steven Shapin, Times Literary Supplement
"In a way that is all too rarely done, Rosenberg has skillfully interwoven medical, social, and intellectual history to show how medicine and society interacted and changed during the 19th century. The history of medicine here takes its rightful place in the tapestry of human history."—John B. Blake, Science
Cannabis is at the very beginning of a craft and educational renaissance. It is emerging from the legislative shadows and a second awakening is occurring: people are proactively seeking information about how to properly consume and enjoy it. And cannabis is a wildly diverse product, even more so than alcohol. Consumers can experience not only different flavor profiles, but also different cerebral and body effects; they can consume using different methods, from vaporization to combustion to topical application; and they can pick and choose between an ever-growing number of different strains and products. THE LEAFLY GUIDE TO CANNABIS provides all the best tips to navigating this growing market in a definitive guide that will enhance every user's enjoyment and high.
Illegal Drugs is the first comprehensive reference to offer timely, pertinent information on every drug currently prohibited by law in the United States. It includes their histories, chemical properties and effects, medical uses and recreational abuses, and associated health problems, as well as addiction and treatment information.
Additional survey chapters discuss general and historical information on illegal drug use, the effect of drugs on the brain, the war on drugs, drugs in the workplace, the economy and culture of illegal drugs, and information on thirty-three psychoactive drugs that are legal in the United States, from caffeine, alcohol and tobacco to betel nuts and kava kava.
The real story of AIDS—how it originated with a virus in a chimpanzee, jumped to one human, and then infected more than 60 million people—is very different from what most of us think we know. Recent research has revealed dark surprises and yielded a radically new scenario of how AIDS began and spread. Excerpted and adapted from the book Spillover, with a new introduction by the author, Quammen's hair-raising investigation tracks the virus from chimp populations in the jungles of southeastern Cameroon to laboratories across the globe, as he unravels the mysteries of when, where, and under what circumstances such a consequential "spillover" can happen. An audacious search for answers amid more than a century of data, The Chimp and the River tells the haunting tale of one of the most devastating pandemics of our time.
Over the past fifty years, more than three hundred infectious diseases have either newly emerged or reemerged, appearing in territories where they’ve never been seen before. Ninety percent of epidemiologists expect that one of them will cause a deadly pandemic sometime in the next two generations. It could be Ebola, avian flu, a drug-resistant superbug, or something completely new. While we can’t know which pathogen will cause the next pandemic, by unraveling the story of how pathogens have caused pandemics in the past, we can make predictions about the future. In Pandemic: Tracking Contagions, from Cholera to Ebola and Beyond, the prizewinning journalist Sonia Shah—whose book on malaria, The Fever, was called a “tour-de-force history” (The New York Times) and “revelatory” (The New Republic)—interweaves history, original reportage, and personal narrative to explore the origins of contagions, drawing parallels between cholera, one of history’s most deadly and disruptive pandemic-causing pathogens, and the new diseases that stalk humankind today.
To reveal how a new pandemic might develop, Sonia Shah tracks each stage of cholera’s dramatic journey, from its emergence in the South Asian hinterlands as a harmless microbe to its rapid dispersal across the nineteenth-century world, all the way to its latest beachhead in Haiti. Along the way she reports on the pathogens now following in cholera’s footsteps, from the MRSA bacterium that besieges her own family to the never-before-seen killers coming out of China’s wet markets, the surgical wards of New Delhi, and the suburban backyards of the East Coast.
By delving into the convoluted science, strange politics, and checkered history of one of the world’s deadliest diseases, Pandemic reveals what the next global contagion might look like— and what we can do to prevent it.
-Drug therapy for behavioral and anxiety disorders
-Clinical practice guidelines for treating psychological disorders
-Depression and the action of antidepressant drugs
-The use of newer anticonvulsants in the treatment of bipolar disorder, pain syndromes, and behavioral disorders
-Drug therapy for children, adolescents and the elderly
-"New generation" antipsychotic agents
Authoritative, comprehensive, and suitable for those with little background in biology, A Primer of Drug Action is an indispensable source of information for anyone interested in drug use, abuse, and education.
In 1976 a deadly virus emerged from the Congo forest. As swiftly as it came, it disappeared, leaving no trace. Over the four decades since, Ebola has emerged sporadically, each time to devastating effect. It can kill up to 90 percent of its victims. In between these outbreaks, it is untraceable, hiding deep in the jungle. The search is on to find Ebola’s elusive host animal. And until we find it, Ebola will continue to strike. Acclaimed science writer and explorer David Quammen first came near the virus while he was traveling in the jungles of Gabon, accompanied by local men whose village had been devastated by a recent outbreak. Here he tells the story of Ebola—its past, present, and its unknowable future.
Extracted from Spillover by David Quammen, updated and with additional material.
Psychiatrists have settled for treating symptoms rather than causes, embracing the apparent medical rigor of DSM diagnoses and prescription in place of learning the more challenging craft of therapeutic counseling, gaining only limited understanding of their patients’ lives. Talk therapy takes time, whereas the fifteen-minute "med check" allows for more patients and more insurance company reimbursement. Yet DSM diagnoses, he shows, are premised on a good deal less science than we would think.
Writing from an insider’s perspective, with refreshing forthrightness about his own daily struggles as a practitioner, Dr. Carlat shares a wealth of stories from his own practice and those of others that demonstrate the glaring shortcomings of the standard fifteen-minute patient visit. He also reveals the dangers of rampant diagnoses of bipolar disorder, ADHD, and other "popular" psychiatric disorders, and exposes the risks of the cocktails of medications so many patients are put on. Especially disturbing are the terrible consequences of overprescription of drugs to children of ever younger ages. Taking us on a tour of the world of pharmaceutical marketing, he also reveals the inner workings of collusion between psychiatrists and drug companies.
Concluding with a road map for exactly how the profession should be reformed, Unhinged is vital reading for all those in treatment or considering it, as well as a stirring call to action for the large community of psychiatrists themselves. As physicians and drug companies continue to work together in disquieting and harmful ways, and as diagnoses—and misdiagnoses—of mental disorders skyrocket, it’s essential that Dr. Carlat’s bold call for reform is heeded.
While the number of patients using medical marijuana increases every year, misconceptions about cannabis and whether it’s harmful or dangerous still exist. In Cannabis for Chronic Pain, Dr. Rav explains the potential of marijuana’s capacity for healing anyone afflicted with chronic pain. Medical marijuana is a safe, non-addictive alternative to dangerous opiate pain pills.
Along with sharing his own story of using medical marijuana to heal from a severe case of shingles, Dr. Rav guides you through the cannabis and holistic treatment for your specific chronic pain condition. If you are suffering from arthritis, back pain, migraines, fibromyalgia, menstrual cramps, IBS, Crohn’s Disease, anxiety, depression, or pain from cancer or its treatment, this may be the book for you.
Dr. Rav offers step by step instruction on the benefits and appropriate use of medical marijuana. And he dispels many of the misconceptions. Did you know that you don’t have to smoke or eat cannabis for it to be effective? There are now patches and drops. We are entering a new age of acceptance and perhaps most importantly, as Dr. Rav highlights, it is now possible to create a distinct cannabis prescription for different types of chronic pain. Find what works for you and finally get the relief you need.
Cannabis for Chronic Pain is the new, definitive guide for anyone who suffers from chronic pain.
• Examines 414 psychoactive plants and related substances
• Explores how using psychoactive plants in a culturally sanctioned context can produce important insights into the nature of reality
• Contains 797 color photographs and 645 black-and-white illustrations
In the traditions of every culture, plants have been highly valued for their nourishing, healing, and transformative properties. The most powerful plants--those known to transport the human mind into other dimensions of consciousness--have traditionally been regarded as sacred. In The Encyclopedia of Psychoactive Plants Christian Rätsch details the botany, history, distribution, cultivation, and preparation and dosage of more than 400 psychoactive plants. He discusses their ritual and medicinal usage, cultural artifacts made from these plants, and works of art that either represent or have been inspired by them. The author begins with 168 of the most well-known psychoactives--such as cannabis, datura, and papaver--then presents 133 lesser known substances as well as additional plants known as “legal highs,” plants known only from mythological contexts and literature, and plant products that include substances such as ayahuasca, incense, and soma. The text is lavishly illustrated with 797 color photographs--many of which are from the author’s extensive fieldwork around the world--showing the people, ceremonies, and art related to the ritual use of the world’s sacred psychoactives.
The Spanish flu of 1918-1920 was one of the greatest human disasters of all time. It infected a third of the people on Earth--from the poorest immigrants of New York City to the king of Spain, Franz Kafka, Mahatma Gandhi and Woodrow Wilson. But despite a death toll of between 50 and 100 million people, it exists in our memory as an afterthought to World War I.
In this gripping narrative history, Laura Spinney traces the overlooked pandemic to reveal how the virus travelled across the globe, exposing mankind's vulnerability and putting our ingenuity to the test. As socially significant as both world wars, the Spanish flu dramatically disrupted--and often permanently altered--global politics, race relations and family structures, while spurring innovation in medicine, religion and the arts. It was partly responsible, Spinney argues, for pushing India to independence, South Africa to apartheid and Switzerland to the brink of civil war. It also created the true "lost generation." Drawing on the latest research in history, virology, epidemiology, psychology and economics, Pale Rider masterfully recounts the little-known catastrophe that forever changed humanity.
Unlike natural disasters, whose destruction is concentrated in a limited area over a period of days, and illnesses, which have devastating effects but are limited to individuals and their families, infectious disease has the terrifying power to disrupt everyday life on a global scale, overwhelming public and private resources and bringing trade and transportation to a grinding halt.
In today's world, it's easier than ever to move people, animals, and materials around the planet, but the same advances that make modern infrastructure so efficient have made epidemics and even pandemics nearly inevitable. And as outbreaks of Ebola, MERS, yellow fever, and Zika have demonstrated, we are woefully underprepared to deal with the fallout. So what can -- and must -- we do in order to protect ourselves from mankind's deadliest enemy?
Drawing on the latest medical science, case studies, policy research, and hard-earned epidemiological lessons, Deadliest Enemy explores the resources and programs we need to develop if we are to keep ourselves safe from infectious disease. The authors show how we could wake up to a reality in which many antibiotics no longer cure, bioterror is a certainty, and the threat of a disastrous influenza pandemic looms ever larger. Only by understanding the challenges we face can we prevent the unthinkable from becoming the inevitable.
Deadliest Enemy is high scientific drama, a chronicle of medical mystery and discovery, a reality check, and a practical plan of action.
Until recently, Zika—once considered a mild disease—was hardly a cause for global panic. But as early as August 2015, doctors in northeast Brazil began to notice a trend: many mothers who had recently experienced symptoms of the Zika virus were giving birth to babies with microcephaly, a serious disorder characterized by unusually small heads and brain damage.
By early 2016, Zika was making headlines as evidence mounted—and eventually confirmed—that microcephaly is caused by the virus, which can be contracted through mosquito bites or sexually transmitted.
The first death on American soil, in February 2016, was confirmed in Puerto Rico in April. The first case of microcephaly in Puerto Rico was confirmed on May 13, 2016. The virus has been known to be transmitted by the Aedes aegypti or Yellow Fever mosquito, but now Aedes albopictus, the Asian Tiger mosquito, has been found to carry it as well, which means it might affect regions as far north as New England and the Great Lakes. Right now, at least 298 million people in the Americas live in areas “conducive to Zika transmission,” according to a recent study. Over the next year, more than 5 million babies will be born.
In Zika: The Emerging Epidemic, Donald G. McNeil Jr. sets the facts straight in a fascinating exploration of Zika’s origins, how it’s spreading, the race for a cure, and what we can do to protect ourselves now.
Each diagnosis includes appropriate drug choices listed alphabetically by generic name with trade name, FDA pregnancy category, drug availability in generic or over-the-counter forms, adult and pediatric dosing regimens, dosage forms, drug additives, and more. Thirty easy-to-use tables in the appendices include childhood and adult immunization schedules, contraceptive guidance, categories of glucocorticosteroids, anti-infectives by class, and more. An index of drugs by generic and brand name, with FDA pregnancy category and controlled drug schedule, facilitates quick identification of drugs by alternate names, and relative safety during pregnancy.
KEY FEATURES:Includes free ebook and electronic updates with registration.Facilitates speedy drug prescribing information retrieval for primary care providers in all settingsOrganizes over 500 diagnoses alphabetically for ease of useHighlights clinically important information such as lab values to monitor, contraindications, and safety informationIncludes an appendix of 30 tables for quick access to FDA pregnancy categories, the U.S. Schedule of Controlled Substances, childhood and adult immunization schedules, and moreProvides generic/trade name index
New to This Edition:
*Chapters on the political ecology of health; emerging infectious diseases and landscape genetics; food, diet, and nutrition; and urban health.
*Coverage of Middle East respiratory syndrome, Ebola, and Zika; impacts on health of global climate change; contaminated water crises in economically developed countries, including in Flint, Michigan; China's rapid industrial growth; and other timely topics.
*Updated throughout with current data and concepts plus advances in GIS.
*End-of-chapter review questions and suggestions for further reading.
*Section Introductions that describe each chapter.
*"Quick Reviews"--within-chapter recaps of key concepts.
*Bold-faced key terms and an end-of-book glossary.
Recent scandals involving diabetes drugs, Vioxx, and many other medications reveal the serious and undisclosed risks of some of the most commonly used prescription drugs in this country. In Before You Take That Pill, Dr. J. Douglas Bremner, a researcher and clinician at Emory University whose study on Accutane and depression made headlines, offers an inside look at the pharmaceutical industry, as well as a scientifically backed assessment of the risks of more than three hundred prescribed medications, vitamins, and supplements.
While many drugs are essential to the health of consumers, as Dr. Bremner explains, for many people, the benefits may not outweigh the potential side effects. This book contains warnings that are not on the drug labels. It also exposes tricks of the trade that demonstrate how the profit-making interests of "big pharma" may not always be in line with the safety of the public - from the corruption that exists in the drug approval process to the tactics drug companies use to encourage doctors to prescribe their products. Most important, Before You Take That Pill empowers readers by giving them sound information on specific medications so they can understand and weigh the potential risk themselves. Backed by the latest studies, as well as insight from a doctor who is in the trenches, this book should be on the shelf of every drug consumer.
• A broad perspective traces CAM therapies from their beginnings to present day practices.
• Clinical guidesfor selecting therapies, and new advances for matching the appropriate therapy to the individual patient, enables you to offer and/or recommend individualized patient care.
• Expert contributorsinclude well-known writers such as Kevin Ergil, Patch Adams, Joseph Pizzorno, and Marc Micozzi himself.
• A unique synthesisof information, including historical usage, cultural and social analysis, current basic science theory and research, and a wide range of clinical investigations and observations, makes this text a focused, authoritative resource.
• Suggested readings and referencesin each chapter list the best resources for further research and study.
• Coverage of CAM therapies and systemsincludes those most commonly encountered or growing in popularity, so you can carefully evaluate each treatment.
• An evidence-based approachfocuses on treatments best supported by clinical trials and scientific evidence.
• Observations from mechanisms of action to evidence of clinical efficacyanswers questions of how, why, and when CAM therapies work.
• Global coverageincludes discussions of traditional healing arts from Europe, Asia, Africa, and the Americas.
• NEW! Updated chapters feature new content and topics, including: challenges in integrative medicine, legal issues, CAM in the community, psychometric evaluation, placebo effect, stress management, and much more!
• NEW! Updated guides on common herbal remedies in clinical practice, East and Southeast Asia, and native North and South America deliver the latest information.
• NEW! Revised chapters with new contributors offer fresh perspectives on these important and relevant topics.
• EXPANDED! Basic science content and new theory and research studies cover a wide range of sciences such as biophysics, biology and ecology, ethnomedicine, psychometrics, neurosciences, and systems theory.
• NEW! New and expanded global ethnomedical systems include new content on Shamanism and Neo-Shamanism, Central and North Asia, Southeast Asia, Nepal and Tibet, Hawaii and South Pacific, Alaska and Pacific Northwest, and contemporary global healthcare.
· Downloadable data sets
· Library of computer programs in SAS, SPSS, Stata, HLM, MLwiN, and more
· Additional material for data analysis
•Questions and answers about the history, research, and treatments related to psychedelic drugs
•Makes a case for the re-evaluation of psychedelics — LSD, MDMA (‘ecstasy’), DMT, psilocybin, ayahuasca, peyote, ibogaine, and more — and their clinical potential for treating a range of conditions from post-traumatic stress disorder and depression to autism and cluster headaches.
•Includes numerous in-text resources such as links to Web sites, videos, articles, blogs, etc. from NIH, FDA, YouTube, and university/clinical studies
Includes practical examples from recent trials
Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple comparison research with an emphasis on pharmaceutical applications. In each chapter, the expert contributors describe important multiplicity problems encountered in pre-clinical and clinical trial settings.
The book begins with a broad introduction from a regulatory perspective to different types of multiplicity problems that commonly arise in confirmatory controlled clinical trials, before giving an overview of the concepts, principles, and procedures of multiple testing. It then presents statistical methods for analyzing clinical dose response studies that compare several dose levels with a control as well as statistical methods for analyzing multiple endpoints in clinical trials. After covering gatekeeping procedures for testing hierarchically ordered hypotheses, the book discusses statistical approaches for the design and analysis of adaptive designs and related confirmatory hypothesis testing problems. The final chapter focuses on the design of pharmacogenomic studies based on established statistical principles. It also describes the analysis of data collected in these studies, taking into account the numerous multiplicity issues that occur.
This volume explains how to solve critical issues in multiple testing encountered in pre-clinical and clinical trial applications. It presents the necessary statistical methodology, along with examples and software code to show how to use the methods in practice.
Treating these topics together takes advantage of all they have in common. The authors point out the many-shared elements in the methods they present for selecting, estimating, checking, and interpreting each of these models. They also show that these regression methods deal with confounding, mediation, and interaction of causal effects in essentially the same way.
The examples, analyzed using Stata, are drawn from the biomedical context but generalize to other areas of application. While a first course in statistics is assumed, a chapter reviewing basic statistical methods is included. Some advanced topics are covered but the presentation remains intuitive. A brief introduction to regression analysis of complex surveys and notes for further reading are provided. For many students and researchers learning to use these methods, this one book may be all they need to conduct and interpret multipredictor regression analyses.
The authors are on the faculty in the Division of Biostatistics, Department of Epidemiology and Biostatistics, University of California, San Francisco, and are authors or co-authors of more than 200 methodological as well as applied papers in the biological and biomedical sciences. The senior author, Charles E. McCulloch, is head of the Division and author of Generalized Linear Mixed Models (2003), Generalized, Linear, and Mixed Models (2000), and Variance Components (1992).
From the reviews:
"This book provides a unified introduction to the regression methods listed in the title...The methods are well illustrated by data drawn from medical studies...A real strength of this book is the careful discussion of issues common to all of the multipredictor methods covered." Journal of Biopharmaceutical Statistics, 2005
"This book is not just for biostatisticians. It is, in fact, a very good, and relatively nonmathematical, overview of multipredictor regression models. Although the examples are biologically oriented, they are generally easy to understand and follow...I heartily recommend the book" Technometrics, February 2006
"Overall, the text provides an overview of regression methods that is particularly strong in its breadth of coverage and emphasis on insight in place of mathematical detail. As intended, this well-unified approach should appeal to students who learn conceptually and verbally." Journal of the American Statistical Association, March 2006
This volume provides formulas and procedures for determination of sample size required not only for testing equality, but also for testing non-inferiority/superiority, and equivalence (similarity) based on both untransformed (raw) data and log-transformed data under a parallel-group design or a crossover design with equal or unequal ratio of treatment allocations. It contains a comprehensive and unified presentation of statistical procedures for sample size calculation that are commonly employed at various phases of clinical development. Each chapter includes, whenever possible, real examples of clinical studies from therapeutic areas such as cardiovascular, central nervous system, anti-infective, oncology, and women's health to demonstrate the clinical and statistical concepts, interpretations, and their relationships and interactions.
The book highlights statistical procedures for sample size calculation and justification that are commonly employed in clinical research and development. It provides clear, illustrated explanations of how the derived formulas and/or statistical procedures can be used.
"A clinical 'must' in today's busy practice environment ... brilliantly linking the most common disease entities with a most user friendly and extremely well laid out prescribing guide...."- Keith Lafferty, MD, FAAEMCo-Director, Department of Emergency Medicine, Director of Education, Gulf Coast Medical Center, Fort Myers, Florida
This is a concise, easy-to-read prescribing reference for advanced health care providers involved in the primary care management of patients with acute, episodic, and chronic health problems. Organized alphabetically by clinical diagnosis for quick access in all clinical settings, the guide encompasses CDC- and FDA-approved pharmacotherapy regimens for more than 500 clinical diagnoses along with clinically useful information in a convenient, quick-access format. Another outstanding feature is the inclusion of Comments throughout the guide highlighting such clinically important information as laboratory values to be monitored, precautions and contraindications, patient teaching points, pediatric usage and dosages, and safety information.
Each diagnosis includes appropriate drug choices listed alphabetically by generic name and trade name, FDA pregnancy category, drug availability in generic or over-the-counter forms, adult and pediatric dosing regimens, dosage forms, drug additives, and more. Thirty easy-to-use tables in the appendices include FDA pregnancy categories, U.S. Schedule of Controlled Substances, Childhood and Adult Immunization Schedules, Contraceptive Guidance, categories of Glucocorticosteroids, Anti-infectives by class, and more. An alphabetical cross-reference index of drugs by generic and trade name, with FDA pregnancy category and controlled drug schedule, facilitates quick identification of drugs by alternate names and relative safety during pregnancy.
Key Features:Facilitates speedy drug information retrieval for primary care providers in all settingsOrganizes over 500 diagnoses alphabetically by alternate names for ease of useHighlights clinically important information such as lab values to monitor, patient education points, and safety informationIncludes an appendix of 30 tables for quick access to key drug classifications, FDA pregnancy categories, Schedule of Controlled Substances, Childhood and Adult Immunization Schedules, and moreProvides generic/trade name cross referencesIncludes free e-book and electronic updates