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This volume explores the myriad of techniques and methodological approaches that are being used in breast cancer research. The authors critically evaluate of the advantages and disadvantages of current methodologies, starting with the tools available for understanding the architecture of the human breast, including its tissue and cellular composition. The volume discusses the importance of functional studies in breast cancer research, especially with the help of laser capture microdissection, which allows the separation of small amounts of tissue, as well as specific cells, for biochemical analysis. In addition, the authors address methodologies including stem cell separation, which has helped in significantly understanding their role in normal breast development, but also further the understanding of breast cancer and its therapeutic management. The use of in vitro techniques and established cell lines for mechanistic studies in chemotherapeutic approaches have been invaluable will be discussed. Imaging techniques for evaluating in vitro and in vivo behavior of normal and cancerous breast tissue will be explored, as it provides a better understanding of the physiopathology of cancer. The volume will also discuss the molecular analysis of gene function in breast cancer through the transcriptomic and epigenomic profile. More importantly, the advancement of more refined techniques in sequencing will be covered. This monograph will be a comprehensive, authoritative and timely, as it addresses the emerging approaches used in breast cancer research.
After her diagnosis of hormone-negative breast cancer, health journalist Patricia Prijatel did what any reporter would do: start investigating the disease, how it occurs, how it's treated, and how to keep it from recurring. While she learned that important research on triple-negative breast cancer (TNBC) was emerging, she found a noticeable lack of resources on the disease, which differs from hormone-positive breast cancer in important ways, including prognosis and treatment options. Triple-negative breast cancer disproportionately affects younger women and African-American women-and some forms of it can be more dangerous than other types of breast cancer. But there are many reasons to be hopeful, as Prijatel shows in this book. Surviving Triple-Negative Breast Cancer delivers research-based information on the biology of TNBC; the role of genetics, family history, and race; how to navigate treatment options; understanding a pathology report; and a plethora of strategies to reduce the risk of recurrence, including diet and lifestyle changes. In clear, approachable language, Prijatel provides a fact-filled guide based on a vast array of scientific studies. Woven throughout the book are stories of women who have faced TNBC. These are mothers, wives, daughters, and sisters who went through a variety of medical treatments and then got on with life--one competes in triathlons, two had babies after being treated with chemo, one got remarried in her 50s, and one just celebrated the 30th birthday of the son she was nursing when she was diagnosed. Writing with honesty and humor, Prijatel delivers an inspiring message--that TNBC is a disease to take seriously, with proper and occasionally aggressive treatment, but it is not automatically a killer. Most women diagnosed with the disease survive and go on to live full lives. Surviving Triple-Negative Breast Cancer is a roadmap for women who want to be empowered through their treatment and recovery.
book, whose goal is to comprehensively review in ten During the past 30 years we have witnessed the emer chapters the fundamental knowledge on breast can gence of new disciplines whose contribution to the understanding of the biology of breast cancer have cer. The opening chapter links epidemiology, influ been enormous. Advances in the field of steroid hor ence of geographic and environmental exposures on mone nuclear receptors, which control the expression cancer incidence to the development of the organ and of genetic programs involved in cellular processes its role in cancer initiation. Central to this approach that are essential for normal and aberrant cell is the endocrine control of breast development, the growth, have been major contributors to the therapy relationship of cell proliferation with the presence of and prevention of hormone-dependent cancers. The steroid hormone receptors in the breast epithelium, and finally the importance of full differentiation as a discoveries of the association of hereditary breast cancers with mutations in the BRCAl and BRCA2 tool for protecting the breast from developing cancer. genes, and the concept that they essentially represent Reported are studies of the pathogenesis of breast a continuum of mutations with different degrees of cancer that have elucidated the site of origin of breast penetrance within given families, have added consid cancer and have been validated by in vitro experi erable understanding to the molecular basis of breast mentation.
A masterful synchronization of history and cutting-edge science shines new light on humanity's darkest diagnosis.

In the wake of the Cancer Genome Atlas project's failure to provide a legible roadmap to a cure for cancer, science writer Travis Christofferson illuminates a promising blend of old and new perspectives on the disease. Tripping over the Truth follows the story of cancer’s proposed metabolic origin from the vaunted halls of the German scientific golden age to modern laboratories around the world. The reader is taken on a journey through time and science that results in an unlikely connecting of the dots with profound therapeutic implications.

Transporting us on a rich narrative of humanity’s struggle to understand the cellular events that conspire to form malignancy, Tripping over the Truth reads like a detective novel, full of twists and cover-ups, blind-alleys and striking moments of discovery by men and women with uncommon vision, grit, and fortitude. Ultimately, Christofferson arrives at a conclusion that challenges everything we thought we knew about the disease, suggesting the reason for the failed war against cancer stems from a flawed paradigm that categorizes cancer as an exclusively genetic disease.

For anyone affected by this terrifying disease and the physicians who struggle to treat it, this book provides a fresh and hopeful perspective. It explores the new and exciting non-toxic therapies born from the emerging metabolic theory of cancer. These therapies may one day prove to be a turning point in the struggle against our ancient enemy. We are shown how the metabolic theory redraws the battle map, directing researchers to approach cancer treatment from a different angle, framing it more like a gentle rehabilitation rather than all-out combat. In a sharp departure from the current “targeted” revolution occurring in cancer pharmaceuticals, the metabolic therapies highlighted have one striking feature that sets them apart—the potential to treat all types of cancer because they exploit the one weakness that is common to every cancer cell: dysfunctional metabolism.

With a foreword by Dr. Dominic D'Agostino, PhD and contributions from Thomas Seyfried, PhD, author of Cancer as a Metabolic Disease; Miriam Kalamian, EdM, MS, CNS, author of Keto for Cancer; and Beth Zupec Kania, consultant nutritionist of The Charlie Foundation.

This book will provide the latest advances in molecular and cellular biology for establishing the foundation of a complete understanding of the mechanisms of breast differentiation leading to cancer prevention. The authors are based on the epidemiological evidence indicating that early first full term pregnancy is a protective factor in human against breast cancer and they have used this paradigm and developed experimental systems in both in vivo and in vitro that have demonstrated mechanistically how the differentiation at the organ and cellular level takes place. This knowledge has provided the blueprint for developing better understanding of the basis of cancer prevention. The transcriptoma analysis of the breast of pre and post-menopausal women has established a genomic signature imprinted in the breast that differs according to the reproductive history of the woman showing that early first full term pregnancy reprogram the organ. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non coding RNA sequences and posttranscriptional control driven by the splicesome. The plasticity of the genome of the human breast make possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones that mimic pregnancy without pregnancy. The author have established the basis of clinical trials for prevention and the discovery that short 15aa peptides of the chorionic gonadotropin hormone can be used in human breast cancer prevention based on preclinical and clinical data.
Essentials of Clinical Radiation Oncology is a comprehensive, user-friendly clinical review that summarizes up-to-date cancer care in an easy-to-read format. Each chapter is structured for straightforward navigability and information retention beginning with a “quick-hit” summary that contains an overview of each disease, its natural history, and general treatment options. Following each "quick-hit" are high-yield summaries covering epidemiology, risk factors, anatomy, pathology, genetics, screening, clinical presentation, workup, prognostic factors, staging, treatment paradigms, and medical management for each malignancy. Each treatment paradigm section describes the current standard of care for radiation therapy including indications, dose constraints, and side effects. Chapters conclude with an evidence-based question and answer section which summarizes practice-changing data to answer key information associated with radiation treatment outcomes. Flow diagrams and tables consolidate information throughout the book that all radiation oncologists and related practitioners will find extremely useful when approaching treatment planning and clinical care.

Essentials of Clinical Radiation Oncology has been designed to replicate a "house manual" created and used by residents in training and is a "one-stop" resource for practicing radiation oncologists, related practitioners, and radiation oncology residents entering the field.

Key Features:

  • Offers digestible information as a learning guide for general practice
  • Examines essential clinical questions which are answered with evidence-based data from important clinical studies
  • Places clinical trials and data into historical context and points out relevance in current practice
  • Provides quick reference tables on treatment options and patient selection, workup, and prognostic factors by disease site
  • The Optimal Terrain Ten Protocol to Reboot Cellular Health

    Since the beginning of the twentieth century, cancer rates have increased exponentially—now affecting almost 50 percent of the American population. Conventional treatment continues to rely on chemotherapy, surgery, and radiation to attack cancer cells. Yet research has repeatedly shown that 95 percent of cancer cases are directly linked to diet and lifestyle. The Metabolic Approach to Cancer is the book we have been waiting for—it offers an innovative, metabolic-focused nutrition protocol that actually works. Naturopathic, integrative oncologist and cancer survivor Dr. Nasha Winters and nutrition therapist Jess Higgins Kelley have identified the ten key elements of a person’s “terrain” (think of it as a topographical map of our body) that are crucial to preventing and managing cancer. Each of the terrain ten elements—including epigenetics, the microbiome, the immune system, toxin exposures, and blood sugar balance—is illuminated as it relates to the cancer process, then given a heavily researched and tested, non-toxic and metabolic, focused nutrition prescription.

    The metabolic theory of cancer—that cancer is fueled by high carbohydrate diets, not “bad” genetics—was introduced by Nobel Prize-laureate and scientist Otto Warburg in 1931. It has been largely disregarded by conventional oncology ever since. But this theory is resurging as a result of research showing incredible clinical outcomes when cancer cells are deprived of their primary fuel source (glucose). The ketogenic diet—which relies on the body’s production of ketones as fuel—is the centerpiece of The Metabolic Approach to Cancer. Further, Winters and Kelley explain how to harness the anticancer potential of phytonutrients abundant in low-glycemic plant and animal foods to address the 10 hallmarks of cancer—an approach Western medicine does with drug based therapies.

    Their optimized, genetically-tuned diet shuns grains, legumes, sugar, genetically modified foods, pesticides, and synthetic ingredients while emphasizing whole, wild, local, organic, fermented, heirloom, and low-glycemic foods and herbs. Other components of their approach include harm-reductive herbal therapies like mistletoe (considered the original immunotherapy and common in European cancer care centers) and cannabinoids (which shrink tumors and increase quality of life, yet are illegal in more than half of the United States). Through addressing the ten root causes of cancer and approaching the disease from a nutrition-focused standpoint, we can slow cancer’s endemic spread and live optimized lives.

    Each week, people read about new and exciting cancer drugs. Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel—but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which

    • promote novel cancer therapies long before credible data are available to support such treatment; and
    • exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.

    Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.

    This is a book about how the actions of human beings—our policies, our standards of evidence, and our drug regulation—incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,

    • more cancer clinical trials should measure outcomes that actually matter to people with cancer;
    • patients on those trials should look more like actual global citizens;
    • we need drug regulators to raise, not perpetually lower, the bar for approval; and
    • we need unbiased patient advocates and experts.

    This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer—and how we can avoid repeating the policy and practice mistakes of the past.

    The Future Of Treating Cancer Has Finally Arrived.


    Cancer treatments can be torture! Surgery, chemotherapy, and radiation are not only extreme but can be just as painful and dangerous as the cancer itself.


    When doctors treat cancer aggressively it leaves the body in a weakened, susceptible state open to contracting other diseases or relapses. Most of the medical field refuses to acknowledge the major problems with the way they treat cancer.


    So is there really a better way to heal from cancer against all odds? YES!


    In this eye-opening book, Dr. Williams shares his most groundbreaking, shocking conclusions from his decades of in-depth research on cancer.


    He provides life-changing advice in the most critical and overlooked areas in cancer treatment and recovery. He has personally developed a revolutionary medical treatment that will change the way we treat cancer – forever.


    Dr. Jason R. Williams is a board-certified radiologist, image-guided oncologist, researcher, and professor. He is the Founder and Director of Interventional Oncology for the Williams Cancer Institute and adjunct professor at Case Western Reserve University. He has pioneered a brand new less invasive, less toxic solution to treating cancer.


    Committed to further advance research in intra-tumoral immunotherapy and help those who are struggling financially to cover medical costs, Dr. Williams is donating all proceeds from this book for this cause.


    www.WilliamsCancerInstitute.com


    Grab your copy now, and discover the promising solution to cancer!

    Hematology Board Review: Blueprint Study Guide and Q&A is a concise, outline-based study guide covering all topics that appear on the Hematology Certification Exam. The book includes all topics listed in the American Board of Internal Medicine (ABIM) blueprint as essential material for the exam and highlights topic areas that are often found on the test.

    For hematology and oncology fellows as well as practicing clinicians needing a refresher before taking MOC, this handy study guide provides succinct overviews of all blood disorders, syndromes and diseases with practice questions on the go. Each disorder or disease-based chapter provides the same structure for ease of use beginning with the epidemiology, and followed by the etiology and risk factors, signs and symptoms, diagnostic criteria, indications for treatment, prognostic factors, treatment recommendations, and special considerations. The authors provide the most accurate and up-to-date information, including well-established treatment regimens for a variety of blood disorders, including iron disorders, bone marrow failure syndromes, platelet and megakaryocytic disorders, hemostasis, thrombosis, and hematologic malignancies. Later chapters review other major subspecialty areas found on the exam including transfusion medicine and hematopoietic cell transplantation. With 200 board-style questions and answers with detailed rationales, Hematology Board Review is the go-to, quick review for any trainee preparing for initial certification and for hematologists or oncologists preparing for recertification.

    Key Features:

    • Includes 200 board-style questions and answers with rationales
    • Provides key point summaries of each topic area for quick study and easy recall
    • Thorough coverage of hematologic malignancies, blood disorders, transfusion medicine, hematopoietic cell transplantation, and standard treatment regimens
    • Tables providing key data and information related to staging, treatment options, and disease classifications
    That pain is a serious clinical problem, which requires considerable effortsby physicians and the nursing staff, has been stressed in numerous publications. Transdermal application is well known for a variety of drugs, including cardiovascular drugs, antiemetics and hormones. Some years ago, first experience was also made with transdermally administered opiates from which the transdermal therapeutic system (TTS) fentanyl has now been approved by the American Food and Drug Administration. The book presents the results of the first international workshop "Transdermal Fentanyl", held September 27 -28, 1990 in Cologne, FRG. This workshop was intended to facilitate a critical evaluation of theoretical and clinical studies with the new, non-invasive fentanyl application and to provide an opportunity for an exchange of ideas about its value for pain management, anaesthesiology and future investigations in this field. Topics covered by the book are physiology of transdermal permeation, experience with other transdermal systems, the present state of acute and chronic pain management and experimental and clinical studies with transdermal fentanyl, with special concern to analgesic efficacy and side effects. Readers will easily find out that the experts appreciated transdermal analgesia but also warned against an uncritical optimism. TTS fentanyl can be a valuable tool in the clinicians' armentarium against pain. It should be kept in mind, however, that it represents a new administration mode, not a new drug, and that the sustained, non-invasive application requires well reflected diagnosis and good general standards of pain management.
    As the definitive diagnostic atlas of the diseases of the hematopoietic system, the Atlas of Hematopathology appeals to a wide range of people who are being trained in a variety of medical fields or practicing as non-hematopathologists, and therefore, are looking for a book which can provide information in a clear, focused format, with no excessive text or details. The atlas offers effective guidance in evaluating specimens from the lymph nodes, bone marrow, spleen, and peripheral blood, enabling clinicians to deliver more accurate and actionable pathology reports. Practicing physicians and those in pathology and hematology training also gain a better understanding of the nature of hematologic disorders and improve their diagnostic skills along the way.

    Taking a unique multi-disciplinary approach, the book covers conventional histopathology and cytopathology, as well as all important complementary diagnostic tests, such as immunophenotyping (immunohistochemical stains and flow cytometry), karyotyping, FISH and DNA/molecular studies. It offers concise textual and extensive visual coverage of both neoplastic and non-neoplastic hematology disorders, with the neoplastic hematology sections presented according to the most recent WHO classifications. There is also an introduction to the normal structures of hematopoietic tissues and the various multidisciplinary techniques.

    The atlas contains more than 900 high-quality color images that mirror the findings that fellows and clinicians encounter in practice. It provides information in a quick, simple and user-friendly manner, attracting those who are in training or are not considered experts in the field. Residents, fellows, practicing clinicians, and researchers in pathology, hematology, hematology/oncology, as well as graduate students in pathology and other clinicians workings in clinical hematology laboratories will all find it useful.

    • Saves clinicians and researchers time in quickly accessing the very latest details on the diverse clinical and scientific aspects of hematopathology, as opposed to searching through thousands of journal articles
    • For clinicians, fellows, and residents, correct diagnosis (and therefore correct treatment) of diseases depends on a strong understanding of the molecular basis for the disease – hematologists, pathologists, oncologists, and other clinicians will benefit from this clear, focused, annotated format
    • Companion web site features over 900 images from the book!

    An Amazon Best of the Month Book

    "For all the insight he offers into the hard science and thorny logistics of studying cancer, Dr. Scadden’s most moving passages consider the effect of the disease on the people who suffer from it and those who care for them." The Wall Street Journal

    A doctor’s riveting story of loss and hope in the world of cancer.

    What is it like to encounter cancer? How does it feel to face the unknown, to enter a world of hope, loss, and dread?

    From the diagnosis of his childhood friend’s mother to his poignant memories in the lab, David Scadden’s seen the unknown world of cancer from the lens of a young boy, a classmate, a researcher, a friend, a doctor, and a neighbor. Scadden chronicles his personal memories of cancer – his visits to his sick neighbor and his classmate who left school and never came back.

    Now Dr. David Scadden, co-founder of the Harvard Stem Cell Institute and one of the world's leading experts on immunology and oncology, writes his memoir, Cancerland, with Pulitzer Prize-winning journalist Michael D'Antonio. With riveting stories and moving compassion, Scadden and D’Antonio paint a still rapidly changing landscape in the context of all too common stories of loss. Ranging from Scadden’s personal childhood memories to his triumphs and regrets as a doctor, Scadden illuminates a light at the end of a dark tunnel.

    Through opening a window into the science of medicine in the world of the unknown, Scadden and D’Antonio humanize cancer while inspiring action that we all so desperately need.
    The field of oncology benefits from several large-scale reference books and a host of monographs dedicated to specific cancers. However, truly excellent practice and review books are, surprisingly, quite scarce. Outside of a scant handful of books and online reference tools that offer clinical response practice and board review in a basic question and answer format, there are no resources that offer a robust, engaging, fully referenced tool for these vital activities in every oncologist’s and oncology trainee’s work. This print and electronic book seeks to fill that void, offering comprehensive question-and-answer style content that covers the entire specialty of oncology and provides practicing oncologists with a fascinating and immediately applicable compendium of vital information dealing with a well-balanced selection of common and uncommon cancers. At the heart of this book is the editor’s and authors’ desire to overcome the controversies and barriers to practice that usually emerge following the appearance of new data. In every section, the user is guided toward collaboration in ongoing clinical research – for example, via discussions of well-designed ongoing clinical trials in each specific area.

    Developed with both the teacher and learner in mind, this book also offers trainees and fellows an excellent opportunity to enhance their preparation for the ABIM oncology fellowship exam as well as for the oncology boards. It will also be an extremely useful tool for oncologists working toward the recertification exam. This comprehensive, beefy book includes hundreds of painstakingly developed multiple-choice and mini-case-based questions covering the principles of medical oncology, malignant hematology, surgical oncology, and radiation oncology. It also contains mini-cases and questions dealing with the biology, diagnosis, classification, staging, and multidisciplinary treatment of cancers at every anatomic site. The very latest topics are included, such as molecular techniques, targeted therapies, and translational cancer research. Concise but detailed answers are referenced to key journals and books, and evidence-based wherever possible. NCCN guidelines are also referenced as appropriate. With its powerful focus on take-home messages from and for actual clinical work, this book will help keep oncologists up to date, bridging the gaps between journal and reference literature, conferences, and their existing knowledge base.

    Cancer: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in cancer and then the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component of this.

    Oncologists, cancer researchers, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While oncologists and cancer researchers may study the underlying pathogenesis of cancer, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of oncology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of cancer.

    • Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease
    • Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments
    • Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams
    • Nutritionists and dietitians will gain an understanding of cell signaling, and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods
    Why do we get cancer? Is it our modern diets and unhealthy habits? Chemicals in the environment? An unwelcome genetic inheritance? Or is it just bad luck?

    The answer is all of these and none of them. We get cancer because we can’t avoid it—it’s a bug in the system of life itself.

    Cancer exists in nearly every animal and has afflicted humans as long as our species has walked the earth. In Rebel Cell: Cancer, Evolution, and the New Science of Life's Oldest Betrayal, Kat Arney reveals the secrets of our most formidable medical enemy, most notably the fact that it isn’t so much a foreign invader as a double agent: cancer is hardwired into the fundamental processes of life. New evidence shows that this disease is the result of the same evolutionary changes that allowed us to thrive. Evolution helped us outsmart our environment, and it helps cancer outsmart its environment as well—alas, that environment is us.

    Explaining why “everything we know about cancer is wrong,” Arney, a geneticist and award-winning science writer, guides readers with her trademark wit and clarity through the latest research into the cellular mavericks that rebel against the rigid biological “society” of the body and make a leap towards anarchy.

    We need to be a lot smarter to defeat such a wily foe—smarter even than Darwin himself. In this new world, where we know that every cancer is unique and can evolve its way out of trouble, the old models of treatment have reached their limits. But we are starting to decipher cancer’s secret evolutionary playbook, mapping the landscapes in which these rogue cells survive, thrive, or die, and using this knowledge to predict and confound cancer’s next move.

    Rebel Cell is a story about life and death, hope and hubris, nature and nurture. It’s about a new way of thinking about what this disease really is and the role it plays in human life. Above all, it’s a story about where cancer came from, where it’s going, and how we can stop it.

    Print version of the book includes free access to the app (web, iOS, and Android), which offers interactive Q&A review plus the entire text of the print book! Please note the app is included with print purchase only.

    Oncology Board Review: Blueprint Study Guide and Q&A is a concise, outline-based study guide covering the topics that appear on the Medical Oncology Certification Exam. This second edition has been thoroughly revised to include new treatment regimens, clinical guidelines, and other updates impacting the field and reflected on the test.

    The book includes all topics listed in the American Board of Internal Medicine (ABIM) blueprint as essential material for the Medical Oncology Certification Exam. The coverage spans all hematologic malignancies and solid tumors, beginning with the epidemiology, and followed by the etiology and risk factors of the disease, staging, signs and symptoms, diagnostic criteria, indications for treatment, prognostic factors, treatment recommendations, and special considerations. Later chapters review other major subspecialty areas found on the exam including cancer genetics and tumor biology, supportive and palliative care, bone marrow transplantation, and biostatistics. Each chapter includes key points summarized in digestible bullets for easy recall and self-assessment. And, now containing over 230 board style questions with answers and detailed rationales, Oncology Board Review, Second Edition is the go-to, quick review for any trainee preparing for initial certification and for oncologists preparing for recertification.

      New to this Edition:
    • Includes over 230 board style questions and answers with rationales
    • New chapter on Bone Marrow Transplantation
    • Thoroughly updated and revised chapters with all new treatment recommendations and FDA approvals for solid tumors and hematologic malignancies included.
    Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up.
    • Includes new chapters on Cancer Metabolism and Clinical Trial Designs in Oncology and a standalone chapter on lifestyles and cancer prevention.
    • Features extensive updates including the latest clinical practice guidelines, decision-making algorithms, and clinical trial implications, as well as new content on precision medicine, genetics, and PET/CT imaging.
    • Includes revised diagnostic and treatment protocols for medical management, surgical considerations, and radiation oncology therapies, stressing a multispecialty, integrated approach to care.
    • Helps you find information quickly with updated indexing related to management recommendations, focused fact summaries, updated key points at the beginning of each chapter ideal for quick reference and board review, and algorithms for patient evaluation, diagnosis, and treatment options.
    • Offers more patient care coverage in disease chapters, plus new information on cancer as a chronic illness and cancer survivorship.
    • Discusses today’s key topics such as immuno-oncology, functional imaging, precision medicine, the application of genetics in pathologic diagnosis and sub-categorization of tumors as well as the association of chronic infectious diseases such as HIV and cancer.
    Get outstanding guidance from the world's most trusted reference on OB/GYN ultrasound. Now brought to you by lead editor Dr. Mary Norton, Callen’s Ultrasonography in Obstetrics and Gynecology has been completely and exhaustively updated by a team of obstetric, gynecologic, and radiology experts to reflect the most recent advances in the field. It addresses the shift in today's practice to a collaborative effort among radiologists, perinatologists, and OB/GYNs, with new emphasis placed on genetics and clinical management. This must-have resource covers virtually all aspects of fetal, obstetric and gynecologic ultrasound — from the common to the rare — in one essential clinical reference, allowing you to practice with absolute confidence.
    • Highly templated, full-color format allows you to locate information more quickly.
    • Full-color medical illustrations present key anatomic details in a clear manner.
    • Thousands of digital-quality images depict the complete range of normal and abnormal imaging presentations.
    • Provides extensive updates of text and images
    • , including the latest in imaging, Doppler techniques, genetic testing, and clinical management.
    • Brand new chapters provide up-to-date, comprehensive coverage of topics relevant to current practice:

    -First Trimester Fetal Anatomy

    -Obstetric Ultrasound and the Obese Patient

    -Evaluation of Pelvic Pain in the Reproductive Age Patient

    -Gynecologic Ultrasound in the Pediatric and Adolescent Patient

    -Ultrasound and Magnetic Resonance Imaging in Urogynecology

    -The Role of Ultrasound in Gynecologic Interventions

    • Highlights significant new genetic testing content
    • , including correlation with ultrasound evaluation of the fetus.
    • Places increased emphasis on 3-dimensional imaging and correlative imaging with magnetic resonance (MR).
    • Features new practice guidelines for obstetric evaluation (including first trimester assessment) and gynecologic management (including evaluation of the endometrium and of ovarian masses).
    • Features new information about fetal imaging guidelines from the National Institute of Child Health and Human Development (NICHD).
    • Provides expanded discussion of fetal, obstetric, and gynecologic interventions with new emphasis on clinical use and application of ultrasound imaging.
    • Includes key and comprehensive reference data used for evaluation of fetal growth and other specialized measurements.
    Expanding on the highly successful first edition, this second edition of Proton Therapy Physics has been completely restructured and updated throughout, and includes several new chapters. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, this book provides an in-depth overview of the physics of this radiation therapy modality, eliminating the need to dig through information scattered across medical physics literature.

    After tracing the history of proton therapy, the book explores the atomic and nuclear physics background necessary for understanding proton interactions with tissue. The text then covers dosimetry, including beam delivery, shielding aspects, computer simulations, detector systems and measuring techniques for reference dosimetry. Important for daily operations, acceptance testing, commissioning, quality assurance and monitor unit calibrations are outlined. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. Imaging for treatment guidance as well as treatment monitoring is outlined. Finally, the biological implications of using protons from a physics perspective are discussed.

    This book is an ideal practical guide for physicians, dosimetrists, radiation therapists, and physicists who already have some experience in radiation oncology. It is also an invaluable reference for graduate students in medical physics programs, physicians in their last year of medical school or residency, and those considering a career in medical physics.

    Features:

    • Updated with the latest technologies and methods in the field, covering all delivery methods of proton therapy, including beam scanning and passive scattering
    • Discusses clinical aspects, such as treatment planning and quality assurance
    • Offers insight on the past, present, and future of proton therapy from a physics perspective
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