Immunological Aspects of the Liver and Gastrointestinal Tract

Springer Science & Business Media
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We have been privileged to start our academic careers at the begin ning of the decade in which the immunological roles and hypersensitivity diseases of the gastrointestinal tract and liver have been defined. In the early 1960s IgA was reported to be the main secretory immunoglobulin, immunoblasts were shown to home to the intestinal mucosa and certain serum autoantibodies were described in patients with chronic liver disease. Shortly thereafter IgE and Australia antigen were discovered. Parallel advances in clinical investigation, in particular closed biopsy techniques, facilitated correlation of morphological changes with im munological mechanisms in disease of the gastrointestinal tract and liver. Only 10 years later, the concepts of immunity and hypersensitivity are regularly applied to the pathogenesis, diagnosis, treatment and prog nosis of many chronic diseases in these organs. In designing this book we have attempted to integrate theorectical and clinical immunology as they pertain in 1975; our ultimate aim is aptly described by Brachet as quoted by Professor Paronetto (page 319). We would like to think that this review provides a basis for the next major advances in the fields of gastrointestinal and hepatic immunology. As we see it, the outstanding problem in both sites is how to produce protective immunity without hypersensitivity.
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Springer Science & Business Media
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Published on
Dec 6, 2012
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Medical / Clinical Medicine
Medical / Gastroenterology
Medical / Hepatology
Medical / Immunology
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──塞謬爾.約翰遜 Samuel Johnson


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然而,為什麼一群知識份子面對同樣的事實,會得出如何不同的見解?這就是本書試著要回答的。即便是受過教育的美國人,當他們想要做出懲罰時,他們常常不知道自己在做什麼,儘管他們對懲罰這件事充滿理想與激情。這樣的矛盾很重要,因為相較於其他現代化民主國家,美國社會更常對犯罪者科以刑罰,且刑責偏重。判刑入獄率(incarceration rate),在歐洲國家大約是1:1000,在美國是1:143,刑期較長且監禁條件較差。






──保羅.卡恩Paul W. Kahn(耶魯大學法學院)


──洛依德.溫瑞柏Lloyd Weinreb(哈佛大學法學院)


──出版人週刊書評Publishers Weekly


──科克斯書評Kirkus Reviews


──約書亞.都柏利Joshua Dubler(高等教育紀事報Chronicle of Higher Education)

出版社 商周出版(城邦)

In der letzten Auflage des Handbuchs der inneren Medizin aus dem Jahre 1953 wurden im Rahmen der Abhandlung der Verdauungskrankheiten dem Dünn- und Dickdarm von NORBERT HENNING und W. BAUMANN insgesamt 270 Seiten gewidmet. Nach 30 Jahren haben unsere Kenntnisse über Funktion, Pathophysiologie, Ätiologie, Pathogenese, Diagnostik und Therapie von Er krankungen des Dünndarmes so erheblich zugenommen, daß den Erkrankungen des Dünndarmes ein eigener Doppelband gewidmet werden mußte. Der Dünndarm hat eine zentrale Stellung nicht nur in der Assimilation von Nahrungsstoffen, sondern spielt auch eine wichtige Rolle als Immunorgan, ist inzwischen zu einem der größten hormonproduzierenden Organ geworden, Sekretionsmechanismen sind von eminenter Bedeutung bei Diarrhöen, der Dünndarm spielt eine wichtige Rolle im Lipidstoffwechsel. Die Gliederung und Zusammenstellung des Bandes basiert auf zwei Prinzi pien, die vom Herausgeber als wesentlich erachtet werden: 1. Die Qualität der praktischen Medizin ist abhängig vom Verständnis medi zinisch-wissenschaftlicher Grundlagen, denn Fortschritte in der klinischen Medi zin basieren fast immer auf wissenschaftlicher Grundlage. 2. Krankheiten oder Störungen physiologischer Zustände sollten kritisch betrachtet werden, bevor über sie einer professionellen Leser- oder Zuhö rerschaft berichtet wird. Langerwiesene Konzepte der Pathogenese und Therapie müssen immer wie der neu und kritisch auf ihre Gültigkeit geprüft werden. Besonderer Wert wurde deshalb vom Herausgeber auf die profunde Erarbei tung pathophysiologischer Grundlagen gelegt, die Voraussetzung sind für eine rationale Diagnostik und Therapie.
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