Diabetes: Chapter 26. Antioxidants, Oxidative Stress and Preeclampsia in Type 1 Diabetes

Elsevier Inc. Chapters
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The prevalence of preeclampsia (PE), a pregnancy-specific hypertensive disorder, is significantly higher in women with type 1 diabetes mellitus (T1DM) than in non-diabetic women. Observational studies, mostly cross-sectional in non-diabetic women, have associated higher levels of oxidative stress and lower antioxidant enzymes and vitamins in PE cases versus controls. The prospective study reported by our group is the first to correlate α- and β-carotene deficiencies in pregnant T1DM women with subsequent development of PE. Among antioxidant nutrients of interest in PE, vitamins C and E have been most extensively studied in experimental models and clinical trials. The largest clinical trial on vitamins C and E supplementation in women with T1DM revealed no overall reduction in risk for PE, but a significant reduction was found in the subgroup of women with low baseline levels of these vitamins. Emerging research shows potential effects for l-arginine, a combination of B vitamins and trace minerals, and vitamin D in reducing risk for PE, although their effects in pregnancies complicated by diabetes remain to be clarified.
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Publisher
Elsevier Inc. Chapters
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Published on
Oct 29, 2013
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Pages
280
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ISBN
9780128069875
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Language
English
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Genres
Medical / General
Medical / Nursing / Nutrition
Medical / Nutrition
Medical / Public Health
Science / Life Sciences / Biology
Science / Life Sciences / General
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Content Protection
This content is DRM protected.
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Available on Android devices
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Eligible for Family Library

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