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Capelle et Renand

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Capelle et Renand
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Dec 31, 1805
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Optimizing Organization Design offers a comprehensiveresource and valued guide for anyone interested in improvingorganization performance. The book presents an approach tooptimizing organization design that is based on over 100 largescale projects and 23 research studies that have been completed byCapelle Associates over the past 25 years. In addition, the bookincludes insightful comments from executives on their success inusing this approach. Capelle’s research and client experiencereveal that optimizing organization design leads to betterfinancial performance, customer satisfaction and employeeengagement. It can provide a competitive advantage and asignificant return on investment. It can also become the foundationof both strategy implementation and human resources management.

Capelle shows that organization design includes the alignment ofa number of critical factors, including positions (vertical andfunctional); accountabilities and authorities (managerial and crossfunctional); people; deliverables and tasks. He shows that manager– direct report alignment is the single most importantorganization design variable. His research also shows that it issuboptimal nearly half the time. This is a horrendous waste oftalent and capability, but also provides a significant opportunityfor improvement in organization performance. 

Optimizing Organization Design clearly explains how toimplement organization design improvements. This approach includespeople change management, project management, and a cascading,iterative approach that is based on teams and involves education,doing real work and feedback.  In addition, OptimizingOrganization Design includes special sections on the role ofthe Board of Directors, project management, process management andcompensation. In addition, the author has included four casestudies and a useful glossary.

Bachelor Thesis from the year 2013 in the subject Psychology - Work, Business, Organisational and Economic Psychology, grade: 1,3, Otto-von-Guericke-University Magdeburg (Institut für Philosophie, Institut für Psychologie II), language: English, abstract: Did you have a New Year's resolution? What was it - loosing weight? Being more friendly to a colleague? Quitting to smoke? Maybe stopping to procrastinate the tasks at hand? And if that was the case: How successful have you been in prevailing your resolutions? Whatever it was, chances are good that by now you have had a relapse. But why is that so - that we are apparently not able to stick to (at least some of) our good intentions1? Obviously, this thesis will not be able to answer this question thoroughly. However, it does intend to provide a basis for a better understanding of this question. In folk psychology, the challenge of resisting a certain class of desires and the corresponding behaviors (like smoking) is often referred to with expressions like resisting temptations, exercising willpower, or self-discipline. And as it is often the case with terms or phrases that are widely used in everyday life, there is a variety of dierent concepts that underlie the same term, thus making it hard to eciently communicate about it. In example, while Peter might loud himself of his extraordinary self-control, for he considers it a heroic act of willpower to stay up an entire weekend to nish an essay that is due the next week, his friend might reproach him and argue that it has been his very lack of self-control that has brought him in the situation of having to pull "an all-nighter". Who is right then and why? "Nicht erst seit Walter Mischels bekannten Experimenten zum Belohnungsaufschub stehen die Konzepte Selbstbeherrschung, Selbstkontrolle und Willensstärke im Fokus sowohl der psychologischen als auch der philosophischen Forschung. Doch handelt es sich hier bei genauerem Hinsehen um ein ganzes Konvolut von Begriffen und familienähnlichen Konzepten, die bei verschiedenen Autoren in verschiedenen Forschungskulturen je unterschiedlich ausgelegt und verwendet werden. In dieser Situation ist es daher mehr als nützdienlich, ein wenig „begriffliche Aufräumarbeit“ zu leisten – und genau diesem Ziel widmet sich die vorliegende Bachelorarbeit von Jan Dirk Capelle in vorbildlicher Weise." (Kommentar Erstbetreuer)
Low-grade glioma (LGG) (grade 2 or G2G) is a brain infiltrative neoplasia, often invading cortical and subcortical functional structures, while displaying as a rule a somewhat indolent course initially (no patent deficit). It affects essentially young, fully active patients, who usually present with seizures. However, these lesions progress relentlessly, and their final fate is anaplastic transformation, leading to neurological impairment and death, with an overall median survival of around 10 years since the onset of symptoms. Due to their apparent biological variability, commonly admitted spontaneous prognostic factors are of limited use if not questionable; consequently, the management of LGGs remains difficult to define (individually), and subject to controversies in the literature. However, most studies have evaluated the eventual impact of treatment(s) independently of the individual natural history and of the global therapeutic strategy. Thus, the goal of the present review is to give new insights regarding the different therapeutic strategies that need to be considered for each patient, and the parameters that can help the decision making. First, it is now possible to benefit from data allowing a better understanding of the natural history of a given LGG: (1) initial tumoral volume (2) tumoral growth rate evaluated on at least two MRIs (3) tumoral metabolic profile, using new radiological methods such as PET and SRM (4) tumoral molecular biology, completing the information provided by classical histopathology. Second, it is mandatory to perform a complete neurological examination, extensive neuropsychological assessment and evaluation of the quality of life from the time of diagnosis throughout the follow-up. Moreover, the analysis of the brain functional (re)organisation and connectivity is needed via the use of new neurofunctional imaging methods (PET, MEG, fMRI, DTI), in order to understand the individual mechanisms of functional compensation in reaction to the glioma growth -- explaining the frequent lack of deficit despite a classical invasion of so called "eloquent" areas. Third, the advantages and limits of each treatment have to be considered for each patient. In this way, the use of intraoperative electrical functional mapping as well as the integration, up to the operating room, of preoperative anatomo-functional data, has allowed the minimisation of the risk of postoperative sequelae, while improving the quality of tumor removal, even in eloquent regions. However, the actual long-term impact of surgery on survival still remains to ascertain. Concerning radiotherapy, the adaptation of doses, fractionation and volume of irradiation has enabled to decrease its risks, especially regarding cognitive functions. Nevertheless, despite an impact on the progression free survival, the effect on the overall survival is not proven. Finally, the recent use of new chemotherapeutic drugs has allowed a better tolerance and a frequent improvement of the quality of life via an impact on seizures, with a stabilisation or even partial regression of the LGG; however, the follow-up is still too short to conclude. On the basis of these (non exhaustive) parameters, we propose in the last part of this book to consider not "a standard treatment", but rather alternative "multiple dynamic therapeutic strategies" adapted to each patient, to be evaluated according to the clinico-radiological evolution of the LGG.
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