Stem Cell Biology and Regenerative Medicine

River Publishers
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The study of stem cell biology is under intensive investigations. Because stem cells have the unique capability to self-renew and differentiate into one or several cell types, they play a critical role in development, tissue homeostasis and regeneration. Stem cells also constitute promising cell candidates for cell therapy.


The aim of this book is to provide an accurate knowledge on stem cell biology and regenerative medicine. This book will cover many topics in the field and is based on seminars given by recognized scientists involved the international master program on stem cell biology at the University Pierre and Marie Curie (UPMC) in Paris.



Preface. Pierre Charbord and Charles Durand.


1) General concepts 


1.Stem cell concepts. Charles Durand and Pierre Charbord.

2.Transcriptional regulation in stem cells. Eric Soler and Frank Grosveld.

3.DNA repair in stem cells. Leyla Vahidi Ferdousi and Miria Ricchetti.

4. Stem cells and epigenetic regulation. Emma L. Walton and Claire Francastel.

5. Hydra and the evolution of stem cells. Alexander Klimovich, Anna Marei Böhm and Thomas C.G. Bosch.

6. Ontogeny of stem cells. Thierry Jaffredo.

7. Regeneration in anamniotic vertebrates. Dunja Knapp.

8. Computational models of spatio-temporal stem cell organization. Peter Buske and Joerg Galle.



2) Pluripotent stem cells 


9. X chromosome inactivation in stem cells and development. Agnese Loda, Friedemann Loos and Joost Gribnau.

10. Molecular machinery of reprogramming. Romain Desprat, Ollivier Milhavet and Jean-Marc Lemaitre.

11. Modeling human genetic disorders using induced pluripotent stem cells. Franck Lebrin.



3) Adult stem cells 


12. Developmental biology of hematopoietic stem cells : Cellular aspects. Laurent Yvernogeau, Jean-Charles Boisset and Catherine Robin.

13. Developmental biology of haematopoietic stem cells: Cell intrinsic and extrinsic regulators of their emergence. Katrin Ottersbach.

14. Biology of hematopoietic stem cells in the adult. Marie-Laure Arcangeli, Rima Haddad, Francoise Pflumio.

15. Epithelial stem cells in the skin. Romain Fontaine, Mathieu Castela and Selim Aractingi.

16. Skeletal muscle stem cells. Elisa Negroni, Maximilien Bencze, Stéphanie Duguez, Gillian Butler-Browne and Vincent Mouly.

17. Mammary stem cells. Marie-Ange Deugnier, Marisa M. Faraldo and Marina A. Glukhova.

18. Intestinal stem cells. Silvia Fre.

19. Neural stem cells. Nathalie Kubis and Martin Catala.

20. Dental stem cells. Anne Poliard.

21. Bone marrow Mesenchymal Stem Cells: from stemness to stromal property of hematopoietic support. Pierre Charbord and Bruno Delorme.

22. Retinal stem cells. Olivier Goureau, Angélique Terray, Katherine S. Matho, Sacha Reichman, and Gael Orieux.



4) Stem cell-related diseases and therapy using stem cells


23. Leukemic stem cells: what the concept brings to disease and patient management. Berent Lunden and Christine Chomienne.

24. Stem cells for cardiac repair. Philippe Menasché.

25. Stem cells for red blood cell production. Christelle Mazurier, Guillaume F Rousseau, Luc Douay and Hélène Lapillonne.

26. Prospectives for therapy with stem cells in skeletal muscular diseases. Maximilien Bencze, Elisa Negroni, Vincent Mouly and Gillian Butler-Browne.



5) Regulatory and philosophical aspects


27. Legal framework for research on Human Embryonic Stem Cells in France and in Europe. Arnaud de Guerra, Emmanuelle Prada-Bordenave

28. Stem cell epistemological issues. Lucie Laplane.

29. Future outlook. Pierre Charbord and Charles Durand.


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About the author

 Charles Durand received his PhD in Developmental Biology from the University Pierre and Marie Curie (UPMC, Paris). He did his PhD in the laboratory of Prof. Jacques Charlemagne where he studied the development of the immune system in the amphibian embryo. He did his postdoctoral training in the laboratory of Prof. Elaine Dzierzak (Erasmus Medical Center, The Netherlands) where he analyzed the molecular identity and cellular complexity of the AGM (Aorta-Gonads-Mesonephros) hematopoietic microenvironment in the mouse embryo. Since 2005, he became Associate Professor at UPMC in the laboratory of Dr. Thierry Jaffredo. His main research interests are the identification of the molecular mechanisms involved in the cross-talk between hematopoietic stem cells and stromal cells. He is the chairperson of the MSc Stem Cell Biology at UPMC.

 Pierre Charbord is an emeritus Inserm scientist. After his training as MD, he has joined the French National Health Institute (Inserm) in 1979 and since that date has conducted research on both hematopoietic and mesenchymal stem cells, investigating their differentiation potentials, the niche formation and their potential implication in human diseases such as cancer. He has been visiting scientist in Seattle from 1983 to 1986, where he has collaborated with Jack W Singer, studying the generation of stem cells in long-term bone marrow cultures. In 2000 and 2001, he has been visiting scientist in Princeton where he has collaborated with Kateri Moore and Ihor Lemischka, studying the transcriptome of fetal liver stromal cells. He has contributed to more that 120 original publications and to several book chapters.


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Additional Information

River Publishers
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Published on
Jan 1, 2015
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Medical / Biotechnology
Science / Biotechnology
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Stem cell bioprocessing describes the main large-scale bioprocessing strategies for both stem cell culture and purification, envisaging the application of these cells for regenerative medicine and drug screening. Bioreactor configurations are described, including their applications for stem cell expansion, and stem cell separation techniques such as isolation and purification are discussed. Basic definitions are provided concerning the different types of stem cells, from adult stem cells to the more recent induced pluripotent stem cells. The main characteristics of these different stem cell types are described, alongside the molecular mechanisms underlying their self-renewal and differentiation. The book also focuses on methodologies currently used for in vitro stem cell culture under static conditions, including the challenge of xeno-free culture conditions, as well as culture parameters that influence stem cell culture. Approaches for both stem cell culture and separation in micro-scale conditions are presented, including the use of cellular microarrays for high-throughput screening of the effect of both soluble and extracellular matrix molecules. A further section is dedicated to application of stem cells for regenerative medicine.Maintains a unique focus on both the basic stem cell biology concepts, and their translation to large-scale bioprocessing approachesEnvisages the use of stem cells in regenerative medicine and drug screening applicationsDiscusses the application of microscale techniques as a tool to perform basic stem cell biology studies
A cutting-edge look at the application of micro and nanotechnologies in regenerative medicine

The area at the interface of micro/nanotechnology and stem cells/tissue engineering has seen an explosion of activity in recent years. This book provides a much-needed overview of these exciting developments, covering all aspects of micro and nanotechnologies, from the fundamental principles to the latest research to applications in regenerative medicine.

Written and edited by the top researchers in the field, Micro and Nanotechnologies in Engineering Stem Cells and Tissues describes advances in material systems along with current techniques available for cell, tissue, and organ studies. Readers will gain tremendous insight into the state of the art of stem cells and tissue engineering, and learn how to use the technology in their own research or clinical trials. Coverage includes:

Technologies for controlling or regulating stem cell and tissue growth Various engineering approaches for stem cell, vascular tissue, and bone regeneration The design and processing of biocompatible polymers and other biomaterials Characterization of the interactions between cells and biomaterials

Unrivaled among books of this kind, Micro and Nanotechnologies in Engineering Stem Cells and Tissues is the ultimate forward-looking reference for researchers in numerous disciplines, from engineering and materials science to biomedicine, and for anyone wishing to understand the trends in this transformative field.

In most of the doctors’ perception the term ‘regenerative medicine’ is associated with tissue reconstruction after severe injuries, burns or trauma. And that is absolutely correct except the fact that tissues and organs deteriorate and lose their function not only due to mechanical or physical damage, but as a result of chronic diseases, inflammation, age-related degeneration as well as genetic abnormalities and cellular dysfunction. The profound understanding of tissue morphology on the cellular level and studying of the ontogenesis open magnificent opportunities to restoration of structural and functional integrity of human organism.
Throughout centuries scientists and healthcare practitioners were in a constant pursuit of longevity—from Avicenna and Paracelsus to Brown-Sequad, Serge Voronoff and Paul Niehans. Not so long ago, in 1990’s, when the term regenerative medicine was tailored by Dr. Leland Kaiser and propagated by William Haseltine it was considered to be a medicine of the Future, «a new branch of medicine will develop that attempts to change the course of chronic disease and in many instances will regenerate tired and failing organ systems», as Dr. Leland Kaiser described it. A new hope spurred up that almost any condition can be at least improved if not cured by means of regenerative medicine, including those cases where conventional medicine is powerless or ineffective.
The Future Dr. Kaiser was talking about is certainly a Present today. Though relatively small amount of practitioners are aware of today’s regenerative medicine capabilities and many still consider it more like science fiction.
This book reveals concepts and protocols of successful approach to regenerative medicine by means of stem cell therapy. It also highlights important aspects of manufacturing and culturing of cell therapy products and administration of different types of stem cells in various systemic disorders.
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