The aim of this book is to provide an accurate knowledge on stem cell biology and regenerative medicine. This book will cover many topics in the field and is based on seminars given by recognized scientists involved the international master program on stem cell biology at the University Pierre and Marie Curie (UPMC) in Paris.
Preface. Pierre Charbord and Charles Durand.
1) General concepts
1.Stem cell concepts. Charles Durand and Pierre Charbord.
2.Transcriptional regulation in stem cells. Eric Soler and Frank Grosveld.
3.DNA repair in stem cells. Leyla Vahidi Ferdousi and Miria Ricchetti.
4. Stem cells and epigenetic regulation. Emma L. Walton and Claire Francastel.
5. Hydra and the evolution of stem cells. Alexander Klimovich, Anna Marei Böhm and Thomas C.G. Bosch.
6. Ontogeny of stem cells. Thierry Jaffredo.
7. Regeneration in anamniotic vertebrates. Dunja Knapp.
8. Computational models of spatio-temporal stem cell organization. Peter Buske and Joerg Galle.
2) Pluripotent stem cells
9. X chromosome inactivation in stem cells and development. Agnese Loda, Friedemann Loos and Joost Gribnau.
10. Molecular machinery of reprogramming. Romain Desprat, Ollivier Milhavet and Jean-Marc Lemaitre.
11. Modeling human genetic disorders using induced pluripotent stem cells. Franck Lebrin.
3) Adult stem cells
12. Developmental biology of hematopoietic stem cells : Cellular aspects. Laurent Yvernogeau, Jean-Charles Boisset and Catherine Robin.
13. Developmental biology of haematopoietic stem cells: Cell intrinsic and extrinsic regulators of their emergence. Katrin Ottersbach.
14. Biology of hematopoietic stem cells in the adult. Marie-Laure Arcangeli, Rima Haddad, Francoise Pflumio.
15. Epithelial stem cells in the skin. Romain Fontaine, Mathieu Castela and Selim Aractingi.
16. Skeletal muscle stem cells. Elisa Negroni, Maximilien Bencze, Stéphanie Duguez, Gillian Butler-Browne and Vincent Mouly.
17. Mammary stem cells. Marie-Ange Deugnier, Marisa M. Faraldo and Marina A. Glukhova.
18. Intestinal stem cells. Silvia Fre.
19. Neural stem cells. Nathalie Kubis and Martin Catala.
20. Dental stem cells. Anne Poliard.
21. Bone marrow Mesenchymal Stem Cells: from stemness to stromal property of hematopoietic support. Pierre Charbord and Bruno Delorme.
22. Retinal stem cells. Olivier Goureau, Angélique Terray, Katherine S. Matho, Sacha Reichman, and Gael Orieux.
4) Stem cell-related diseases and therapy using stem cells
23. Leukemic stem cells: what the concept brings to disease and patient management. Berent Lunden and Christine Chomienne.
24. Stem cells for cardiac repair. Philippe Menasché.
25. Stem cells for red blood cell production. Christelle Mazurier, Guillaume F Rousseau, Luc Douay and Hélène Lapillonne.
26. Prospectives for therapy with stem cells in skeletal muscular diseases. Maximilien Bencze, Elisa Negroni, Vincent Mouly and Gillian Butler-Browne.
5) Regulatory and philosophical aspects
27. Legal framework for research on Human Embryonic Stem Cells in France and in Europe. Arnaud de Guerra, Emmanuelle Prada-Bordenave
28. Stem cell epistemological issues. Lucie Laplane.
29. Future outlook. Pierre Charbord and Charles Durand.
Charles Durand received his PhD in Developmental Biology from the University Pierre and Marie Curie (UPMC, Paris). He did his PhD in the laboratory of Prof. Jacques Charlemagne where he studied the development of the immune system in the amphibian embryo. He did his postdoctoral training in the laboratory of Prof. Elaine Dzierzak (Erasmus Medical Center, The Netherlands) where he analyzed the molecular identity and cellular complexity of the AGM (Aorta-Gonads-Mesonephros) hematopoietic microenvironment in the mouse embryo. Since 2005, he became Associate Professor at UPMC in the laboratory of Dr. Thierry Jaffredo. His main research interests are the identification of the molecular mechanisms involved in the cross-talk between hematopoietic stem cells and stromal cells. He is the chairperson of the MSc Stem Cell Biology at UPMC.
Pierre Charbord is an emeritus Inserm scientist. After his training as MD, he has joined the French National Health Institute (Inserm) in 1979 and since that date has conducted research on both hematopoietic and mesenchymal stem cells, investigating their differentiation potentials, the niche formation and their potential implication in human diseases such as cancer. He has been visiting scientist in Seattle from 1983 to 1986, where he has collaborated with Jack W Singer, studying the generation of stem cells in long-term bone marrow cultures. In 2000 and 2001, he has been visiting scientist in Princeton where he has collaborated with Kateri Moore and Ihor Lemischka, studying the transcriptome of fetal liver stromal cells. He has contributed to more that 120 original publications and to several book chapters.
The area at the interface of micro/nanotechnology and stem cells/tissue engineering has seen an explosion of activity in recent years. This book provides a much-needed overview of these exciting developments, covering all aspects of micro and nanotechnologies, from the fundamental principles to the latest research to applications in regenerative medicine.
Written and edited by the top researchers in the field, Micro and Nanotechnologies in Engineering Stem Cells and Tissues describes advances in material systems along with current techniques available for cell, tissue, and organ studies. Readers will gain tremendous insight into the state of the art of stem cells and tissue engineering, and learn how to use the technology in their own research or clinical trials. Coverage includes:Technologies for controlling or regulating stem cell and tissue growth Various engineering approaches for stem cell, vascular tissue, and bone regeneration The design and processing of biocompatible polymers and other biomaterials Characterization of the interactions between cells and biomaterials
Unrivaled among books of this kind, Micro and Nanotechnologies in Engineering Stem Cells and Tissues is the ultimate forward-looking reference for researchers in numerous disciplines, from engineering and materials science to biomedicine, and for anyone wishing to understand the trends in this transformative field.