Before its departure for Japan, the Mississippi made calls at several ports on the East Coast and also devoted more than a month to investigating problems involving fishing rights in Canadian waters. On 24 November 1852, following a visit from President Millard Fillmore, the Mississippi headed across the Atlantic Ocean. After a brief stop at Madeira and a visit ashore at St. Helena, where Napoleon’s gravesite was described and sketched, the Mississippi headed for the Cape of Good Hope. Cape Town was reached on 24 January 1853, and after a stay of ten days, where Speiden visited the countryside remarking on the turmoil between the English and the Xhosa tribes, the voyage was continued across the Indian Ocean by way of Mauritius, Ceylon, Malacca, and Singapore to Macao and Hong Kong.
On 31 March 1854, Speiden was among the few select officers in the landing party on the great occasion, the signing of the treaty between the United States and Japan. As a young purser’s clerk Speiden played only a minor role in these historic undertakings but he was enthusiastic and alert, and made the most of his situation and the opportunities it presented. A return visit, occupying most of June, was made to Shimoda before sailing for Hong Kong by way of the Loo Choo Islands. On 12 September 1854, Speiden and the Mississippi went to sea the following day, and the remainder of his journal, filling thirty-two pages, recounts visits to Honolulu, San Francisco (including a trip to the gold fields near Sacramento), and Valparaiso.