PKU (phenylketonuria) is a genetic disorder that causes severe cognitive impairment if it is not detected and treated with a strict and difficult diet. Programs to detect PKU and start treatment early are deservedly considered a public health success story. Some have traded on this success to urge expanded newborn screening, defend basic research in genetics, and confront proponents of genetic determinism. In this context, treatment for PKU is typically represented as a simple matter of adhering to a low-phenylalanine diet. In reality, the challenges of living with PKU are daunting.
In this first general history of PKU, a historian and a pediatrician explore how a rare genetic disease became the object of an unprecedented system for routine testing. The PKU Paradox is informed by interviews with scientists, clinicians, policymakers, and individuals who live with the disease. The questions it raises touch on ongoing controversies about newborn screening and what happens to blood samples collected at birth. -- M. Susan Lindee, University of Pennsylvania
Diane B. Paul is a professor emerita at the University of Massachusetts, Boston, and a research associate at the Museum of Comparative Zoology, Harvard University. Jeffrey P. Brosco, M.D., is a professor of clinical pediatrics at the Miller School of Medicine, University of Miami. He serves as chair of the Pediatric Bioethics Committee at Jackson Memorial Hospital and is associate director of the Mailman Center for Child Development.
The New York Times bestselling author of The Hormone Cure and The Hormone Reset Diet shows every woman how to create a lifestyle that will help her look great, feel energized, and slow down the effects of aging.
Feel destined for cellulite, saddle bags, and belly fat? Does your family come from a long line of Alzheimer's, cancer, or heart disease? Will nothing help your aging skin or declining libido or flagging energy? This book is for you.
The body is magnificent but it doesn't come with a lifetime warranty, or an operating manual. You're the result of millions of years of evolution, but many of the adaptations that helped your ancestors survive are now working overtime to accelerate the aging process. The assumption here is that we are our genes and therefore trapped by the past. The good news is that your genetic code—the DNA sequence that is the biochemical basis of heredity—can play a minor role in the way you age.
The scientific reality is that 90 percent of the signs of aging and disease are caused by lifestyle choices, not your genes. In other words, you have the capability to overcome and transform your genetic history and tendencies. Harvard/MIT—trained physician Sara Gottfried, M.D. has created a revolutionary 7-week program that empowers us to make the critical choices necessary to not just look young, but also feel young.
Dr. Gottfried identifies and builds this book around the five-key factors that lead to accelerated aging -the muscle factor, the brain factor, the hormone factor, the gut factor, and the toxic fat factor. The 7-week program addresses these factors and treats them in an accessible and highly practical protocol and is as follows:Feed—Week 1Sleep—Week 2Move—Week 3Release—Week 4Expose—Week 5Soothe—Week 6Think—Week 7
Younger increases not only your lifespan, but also your healthspan. Dr. Gottfried's program makes it possible to change the way you age, stay younger longer, and remain healthy and vibrant for all of your days.
You're already living it.
Was diabetes evolution's response to the last Ice Age? Did a deadly genetic disease help our ancestors survive the bubonic plagues of Europe? Will a visit to the tanning salon help lower your cholesterol? Why do we age? Why are some people immune to HIV? Can your genes be turned on -- or off?
Joining the ranks of modern myth busters, Dr. Sharon Moalem turns our current understanding of illness on its head and challenges us to fundamentally change the way we think about our bodies, our health, and our relationship to just about every other living thing on earth, from plants and animals to insects and bacteria.
Through a fresh and engaging examination of our evolutionary history, Dr. Moalem reveals how many of the conditions that are diseases today actually gave our ancestors a leg up in the survival sweepstakes. When the option is a long life with a disease or a short one without it, evolution opts for disease almost every time.
Everything from the climate our ancestors lived in to the crops they planted and ate to their beverage of choice can be seen in our genetic inheritance. But Survival of the Sickest doesn't stop there. It goes on to demonstrate just how little modern medicine really understands about human health, and offers a new way of thinking that can help all of us live longer, healthier lives.
Survival of the Sickest is filled with fascinating insights and cutting-edge research, presented in a way that is both accessible and utterly absorbing. This is a book about the interconnectedness of all life on earth -- and, especially, what that means for us.
The phone rings. The doctor from California is on the line. “Are you ready Amanda?” The two people Amanda Baxley loves the most had begged her not to be tested—at least, not now. But she had to find out.
If your family carried a mutated gene that foretold a brutal illness and you were offered the chance to find out if you’d inherited it, would you do it? Would you walk toward the problem, bravely accepting whatever answer came your way? Or would you avoid the potential bad news as long as possible?
In Mercies in Disguise, acclaimed New York Times science reporter and bestselling author Gina Kolata tells the story of the Baxleys, an almost archetypal family in a small town in South Carolina. A proud and determined clan, many of them doctors, they are struck one by one with an inscrutable illness. They finally discover the cause of the disease after a remarkable sequence of events that many saw as providential. Meanwhile, science, progressing for a half a century along a parallel track, had handed the Baxleys a resolution—not a cure, but a blood test that would reveal who had the gene for the disease and who did not. And science would offer another dilemma—fertility specialists had created a way to spare the children through an expensive process.
A work of narrative nonfiction, Mercies in Disguise is the story of a family that took matters into its own hands when the medical world abandoned them. It’s a story of a family that had to deal with unspeakable tragedy and yet did not allow it to tear them apart. And it is the story of a young woman—Amanda Baxley—who faced the future head on, determined to find a way to disrupt her family’s destiny.
In the summer of 1623, ten cardinals and hundreds of their attendants, engaged in electing a new Pope, died from the 'mal'aria' or 'bad air' of the Roman marshes. Their choice, Pope Urban VIII, determined that a cure should be found for the fever that was the scourge of the Mediterranean, northern Europe and America, and in 1631 a young Jesuit apothecarist in Peru sent to the Old World a cure that had been found in the New – where the disease was unknown.
The cure was quinine, an alkaloid made of the bitter red bark of the cinchona tree, which grows in the Andes. Both disease and cure have an extraordinary history. Malaria badly weakened the Roman Empire. It killed thousands of British troops fighting Napoleon during the Walcheren raid on Holland in 1809 and many soldiers on both sides of the American Civil War. It turned back many of the travellers who explored west Africa and brought the building of the Panama Canal to a standstill. When, after a thousand years, a cure was finally found, Europe's Protestants, among them Oliver Cromwell, who suffered badly from malaria, feared it was nothing more than a Popish poison. More than any previous medicine, though, quinine forced physicians to change their ideas about treating illness. Before long, it would change the face of Western medicine.
Using fresh research from the Vatican and the Indian Archives in Seville, as well as hitherto undiscovered documents in Peru, Fiammetta Rocco describes the ravages of the disease, the quest of the three Englishmen who smuggled cinchona seeds out of South America, the way quinine opened the door to Western imperial adventure in Asia, Africa and beyond, and why, even today, quinine grown in the eastern Congo still saves so many people suffering from malaria.
Note that it has not been possible to include the same picture content that appeared in the original print version.
The 8th edition of Tintinalli’s Emergency Medicine provides the depth and breadth of coverage that reflects the complexity and expertise needed to practice emergency medicine successfully in today’s fast–paced environments. It is an important contemporary clinical emergency care resource for physicians, NPs, and PAs who practice emergency medicine and for emergency medicine and pediatric emergency medicine fellows. It remains the preferred study guide for in-training and board examinations and recertification.
NEW to this edition:
• Full-color design with more tables than ever to succinctly present key information
• Extensive updates to all sections, incorporating the latest guidelines, evidence-based protocols, and relevant research
• Expanded pediatric section, with complete clinical information for general and pediatric emergency physicians
• Expanded coverage of common emergency department procedures, with improved illustrations
• Online access to more than 30 videos, covering a wide range of procedural and diagnostic topics and focusing on the latest ultrasound-guided techniques
From the reviews of the seventh edition:
"Collectively, they have once again produced an excellent text that manages to cover the broad scope of emergency medicine while remaining an easily readable and practical resource....Last, for the inevitable comparison of this current edition of Tintinalli's Emergency Medicine with other available emergency medicine textbooks available: in my opinion, Tintinalli’s still comes out on top. It is more concise and easier to read than some, yet it covers the breadth of emergency medicine practice more comprehensively than others....Just as previous editions did, the seventh presents all of the most pertinent and up-to-date information in a well-organized format that is comprehensive yet easy to read. That and many of the attractive new features in this current edition will ensure its place on my bookshelf for years to come."—JAMA