Der biologisch-chemische Katastrophenfall: Ein Handbuch für Einsatzkräfte

Springer-Verlag
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Die Ereignisse vom 11. September 2001 in den USA veränderten schlagartig die Welt. Plötzlich sind wir mit Szenarien, wie dem Einsatz von tödlichen biologischen Kampfmitteln konfrontiert und müssen erst lernen, wie wir uns in solchen Situationen verhalten sollen. Besonders der Helfer steht in solchen Fällen vor überlebenswichtigen Fragen: Zuerst absperren oder gleich helfen? Haben die Opfer eine "normale" Krankheit oder handelt es sich um einen Anschlag mit biologischen Kampfmitteln? Sind mit Chemikalien vergiftete Menschen eine Gefahr für die Helfer? Für die Antwort auf diese und ähnliche Fragen bleiben oft nur Sekunden. Dieses kompakte Handbuch richtet sich an Ersthelfer (Feuerwehrpersonal, Rot-Kreuz-Helfer, militärische Sanitäts- und ABC-Dienste, Angehörige des Zivilschutzes, Einsatzleiter der Polizei usw.) ebenso wie an Ärzte. Es dient aber auch all jenen, die im Zuge der Katastrophenhilfe mit der Planung und der Koordination von Einsätzen betraut sind und kann durch die umfassende Darstellung auch als passende Unterlage für die Ausbildung verwendet werden.
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Publisher
Springer-Verlag
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Published on
Nov 9, 2013
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Pages
164
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ISBN
9783709137420
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Best For
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Language
German
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Genres
Medical / Clinical Medicine
Medical / Emergency Medicine
Medical / Infectious Diseases
Medical / Microbiology
Medical / Nursing / General
Medical / Pharmacology
Science / Chemistry / General
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Diplomarbeit aus dem Jahr 2011 im Fachbereich Biologie - Mikrobiologie, Molekularbiologie, Note: 1, Universität Wien, Sprache: Deutsch, Abstract: The protozoan parasite Trichomonas vaginalis is the causative agent of trichomonosis which is – with more than 170 million new cases each year – the most prevalent non-viral sexually transmitted disease (STD) worldwide. Although trichomonosis is not a primarily lethal disease, the clinical picture can include severe urogenital inflammations. Chronic infections have been associated with cervical/prostate cancer and a predisposition of HIV infections. In case of pregnancy, chronic infections can also lead to preterm delivery and low birth weight. For more than 50 years, metronidazole, a nitroimidazole antibiotic, has been in use for the treatment of trichomonosis. It is applied orally and although it is mostly compliant, it can have serious side effects. It is also not applicable for pregnant women due to its ability to pass the placenta. Furthermore, an increasing number of emerging metronidazoleresistant T. vaginalis strains has lead to more treatment failures in the last few years. To this day, however, there is no effective alternative drug against trichomonosis available. Pentamycin is a polyene antimycotic and has been in use in the treatment of candidiasis, in preliminary studies it also turned out to be effective against trichomonads. The aim of this study was to evaluate the efficacy of pentamycin against T. vaginalis and the ability to develop resistances in vitro. For these purposes, the dose-effect relationship between pentamycin and four differently metronidazole-sensitive T. vaginalis strains was investigated. Moreover, the protein composition before and after the treatment was compared. To induce resistance, strains were treated with sublethal concentrations of pentamycin within a time of six months. It could be shown that pentamycin is highly effective against T. vaginalis. A 100% eradication of trichomonads was reached with a concentration of 15 ;g/ml and an incubation time of 1h. All four differently metronidazole-sensitive strains showed almost the same sensitivity to pentamycin. The comparison of the protein profiles of untreated and treated cells analysed by SDS-PAGE showed that the mode of action of pentamycin is based on an interaction and subsequent damage of the cell membrane which consequently leads to total lysis and death of the cell. [...]
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