When we were approached by the publishers of the Handbook of Experimental Pharmacology to prepare a new volume on antipsychotics, our intention was to capture both, the accumulated preclinical and clinical knowledge about current antipsychotics as well as prospects for new and potentially more specific antischizophrenia principles. These efforts should be based on the pathophysiology of the diseases and the affected neurotransmitter systems. Since preclinical research on antipsychotic compounds is only reliable when intimately linked through translational aspects to clinical results, we decided to include clinical science as well. It turned out that that this endeavor could not be covered by a single volume. We thank the editorial board and the publishers for supporting our decision to prepare two volumes: Current Antipsychotics and Novel Antischizophrenia Treatments. These topics cannot really be separated from one another and should be seen as a composite entity despite the somewhat arbitrary separation of contributions into two volumes. The continuing challenges of developing improved and safer antipsychotic medications remain of concern and are discussed in the first volume. The new opportunities for the field to develop and license adjunctive treatments for the negative symptoms and cognitive deficits that are treated inadequately by existing compounds have been incentivized recently and provide the focus for the second volume. We hope these collective contributions will facilitate the development of improved treatments for the full range of symptomatology seen in the group of schizophrenias and other major psychotic disorders.
Gerhard Gross, Ludwigshafen, Germany
Mark A. Geyer, La Jolla, CA
This volume will try to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters will also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. Non-schizophrenia indications will be covered to some extent, but not exhaustively.
The first part of the book covers definition, classification, pathophysiology, pathology, biomarkers and animal models of pulmonary hypertension, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The concluding section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotides homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to clinical applications of these experimental therapies.
Now in its sixth edition, this best-selling, multi-disciplinary textbook continues to draw on the skills of pharmacists, clinicians and nurses to present optimal drug regimens. The authors integrate an understanding of the disease processes with an appreciation of the pathophysiological processes, clinical pharmacy and the evidence base. Each chapter is co-written by a pharmacist and a clinician, and each chapter begins with key points and ends with cases to test understanding. The sixth edition is now on StudentConsult for the first time, giving online access to the full text.Key points boxes at the beginning of each chapter
Case-study boxes throughout the chapters
Each chapter co-written by a pharmacist and a clinician
In-depth treatment of therapeutics to support pharmaceutical prescribing
Logical order and format: key points, epidemiology, aetiology, disease, clinical manifestations, investigations and treatment, drugs used in treatment.
Dosage reference sources given where appropriate, along with useful websites and further reading for each chapter.New co-editor, Karen Hodson
Over 10 new authors
Now in 4-colour
On StudentConsult for the first time
New chapter on Dementia
Many new and revised illustrations
Chapters revised to include advances in therapeutics and changes to dose regimens and licensed indications
Updated case studies
Clinical Neuroanatomy, Twenty-Eighth Edition offers an accessible, easy-to-remember synopsis of neuroanatomy and its functional and clinical implications. Since many of us learn and remember better when material is presented visually, this acclaimed resource includes not only clinical material such as brain scans and pathological specimens, but also hundreds of diagrams and tables that are designed to be clear and memorable.
Here's why Clinical Neuroanatomy is essential for board review or as a clinical refresher:
• NEW SECTION summarizes the most important take-away lessons from each chapter
• More than 300 full-color illustrations
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• Numerous CT and MRI scans
• Block diagrams illustrate actions of each muscle (essential for the clinical motor examination)
• Hundreds of diagrams and tables encapsulate important information
• Essentials for the Clinical Neuroanatomist list appears in each chapter
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• Appendices include The Neurologic Examination, Testing Muscle Function, Spinal Nerves and Plexuses, and Questions and Answers
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If your practice or education would benefit from an engagingly written, well-illustrated overview of neuroanatomy and its functional underpinnings, this trusted resource belongs on your desk.