Membrane-Bound Enzymes: Proceedings of an International Symposium held in Pavia, Italy May 29–30, 1970

Springer Science & Business Media
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The present volume contains all the papers presented at the International Conference on Membrane-Bound Enzymes held at Pavia in May 1910. The publication of its scientific content has been made possible by the collaboration of many scientists who have taken part at the Symposium and who deeply and actively discussed the lectures which were delivered. In order to ensure rapid pu blication, however, the discussion will not be reported here. The general subject of membrane-bound enzymic activity, its behavior, localization and regulation, was explored in depth from the standpoints of the various contributors in biophysics, bioche mistry, cytology and pharmacology. Each session was briefly in troduced by the session chairman's remarks about the field under discussion. At the end of the Conference, Dr.R.M.C.Dawson made some concluding remarks. The meeting is considered to have been very successful. It certainly gave a further stimulus to biochemical and physiological research workers in this field of study. The editors express their thanks to the authors of the papers and to the Plenum Publishing Corporation for the prompt response which has enabled the rapid publication of the volume, and to the auditorium of the meeting, which was attended by more than one hundred research workers con cerned with the problems of membrane biology. We are happy to acknowledge the financial support of various organizations, which have been listed in another part of this book.
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Springer Science & Business Media
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Nov 11, 2013
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Science / Life Sciences / Biochemistry
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Johnjoe McFadden
Geoffrey West
"This is science writing as wonder and as inspiration." —The Wall Street Journal

Wall Street Journal

From one of the most influential scientists of our time, a dazzling exploration of the hidden laws that govern the life cycle of everything from plants and animals to the cities we live in.

Visionary physicist Geoffrey West is a pioneer in the field of complexity science, the science of emergent systems and networks. The term “complexity” can be misleading, however, because what makes West’s discoveries so beautiful is that he has found an underlying simplicity that unites the seemingly complex and diverse phenomena of living systems, including our bodies, our cities and our businesses.

Fascinated by aging and mortality, West applied the rigor of a physicist to the biological question of why we live as long as we do and no longer. The result was astonishing, and changed science: West found that despite the riotous diversity in mammals, they are all, to a large degree, scaled versions of each other. If you know the size of a mammal, you can use scaling laws to learn everything from how much food it eats per day, what its heart-rate is, how long it will take to mature, its lifespan, and so on. Furthermore, the efficiency of the mammal’s circulatory systems scales up precisely based on weight: if you compare a mouse, a human and an elephant on a logarithmic graph, you find with every doubling of average weight, a species gets 25% more efficient—and lives 25% longer. Fundamentally, he has proven, the issue has to do with the fractal geometry of the networks that supply energy and remove waste from the organism’s body.

West’s work has been game-changing for biologists, but then he made the even bolder move of exploring his work’s applicability. Cities, too, are constellations of networks and laws of scalability relate with eerie precision to them. Recently, West has applied his revolutionary work to the business world. This investigation has led to powerful insights into why some companies thrive while others fail. The implications of these discoveries are far-reaching, and are just beginning to be explored. Scale is a thrilling scientific adventure story about the elemental natural laws that bind us together in simple but profound ways. Through the brilliant mind of Geoffrey West, we can envision how cities, companies and biological life alike are dancing to the same simple, powerful tune.
Ken Vos
Giuseppe Porcellati
The volume which is here presented reports all the lectures given at the International Satellite Meeting on Biochemical and Pharmacological Implications of Ganglioside Function held at Cor tona, Tuscany, Italy from 28 to 31 August, 1975. The Meeting was run just before the 5th International Congress of the International Society for Neurochemistry (Barcelona, 2-7 september, 1975) and was in fact organized on its frame. The general subject matter of gangliosides structure, biosyn thesis and degradation, of their functional role in neurochemistry, their pharmacological action and future potentialities, was deeply and throughly taken into consideration during the three-day Sympo sium, which was brilliantly directed and guided by Dr. L. Svenner holm. The meeting gave certainly, in our opinion, a valuable stimu lus to research workers interested in the biophysics, chemistry, biochemistry, physiology and pharmacology of gangliosides. The e ditors wish to express their thanhd to the speakers, the discussants, the Meeting Chairman, the section chairmen and to all the attendants who have taken part at the Symposium and who actively and deeply discussed the delivered lectures. Our final thank is also for Dr. Francesco della Valle, official representative of FIDIA Research Laboratories, Abano Terme, Padua, Italy, to whom we are grateful for his continuous and efficient support. The contribution of the Secretarial Staffs of both the v PREFACE Department of Biochemistry of Perugia University and FIDIA Labora tories to the editorial work is also gratefully acknowledged.
Giuseppe Porcellati
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