Membrane-Bound Enzymes

Advances in Experimental Medicine and Biology

Book 14
Springer Science & Business Media
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The present volume contains all the papers presented at the International Conference on Membrane-Bound Enzymes held at Pavia in May 1910. The publication of its scientific content has been made possible by the collaboration of many scientists who have taken part at the Symposium and who deeply and actively discussed the lectures which were delivered. In order to ensure rapid pu blication, however, the discussion will not be reported here. The general subject of membrane-bound enzymic activity, its behavior, localization and regulation, was explored in depth from the standpoints of the various contributors in biophysics, bioche mistry, cytology and pharmacology. Each session was briefly in troduced by the session chairman's remarks about the field under discussion. At the end of the Conference, Dr.R.M.C.Dawson made some concluding remarks. The meeting is considered to have been very successful. It certainly gave a further stimulus to biochemical and physiological research workers in this field of study. The editors express their thanks to the authors of the papers and to the Plenum Publishing Corporation for the prompt response which has enabled the rapid publication of the volume, and to the auditorium of the meeting, which was attended by more than one hundred research workers con cerned with the problems of membrane biology. We are happy to acknowledge the financial support of various organizations, which have been listed in another part of this book.
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Springer Science & Business Media
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Nov 11, 2013
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Science / Life Sciences / Biochemistry
Science / Life Sciences / Biophysics
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The circulatory system is usually considered to be composed of tubes of various diameters, characterized by collateral and terminal branches. There is also a tendency to treat blood vessels merely as conducting tubes in which the various structures of the wall act as mechanical pumps wlrich modify their diameter. This is, of course, not so. In fact, we know that blood vessels, and in particular arteries, are organs with personalities of their own and a particular susceptibility to several diseases. In addition, blood vessels differ in structure, according to their localization, and age at differing rates. The experimental work car ried out so far clearly confirms the data that have come from spontaneous human pathology; experimentally induced arterial lesions have a definite tendency to appear in certain arteries and not in others, depending on the experimental procedures used, and in each specific artery the lesions appear to have a specific location. We now know that the arterial wall is a metabo licallyactive structure, in which a number of enzyme activities have been clearly demonstrated. It possesses a sensitive vasa vasorum apparatus and a specific reactivity to various lesion-inducing stimuli. We must also remember that the arterial wall is in continuous contact with the blood circulating through the endothelial cells lining the vascular bed. It is obvious, therefore, that any variation in the circulating blood mass can modify the morphology as well as the function of the vessel wall.
The volume which is here presented reports all the lectures given at the International Satellite Meeting on Biochemical and Pharmacological Implications of Ganglioside Function held at Cor tona, Tuscany, Italy from 28 to 31 August, 1975. The Meeting was run just before the 5th International Congress of the International Society for Neurochemistry (Barcelona, 2-7 september, 1975) and was in fact organized on its frame. The general subject matter of gangliosides structure, biosyn thesis and degradation, of their functional role in neurochemistry, their pharmacological action and future potentialities, was deeply and throughly taken into consideration during the three-day Sympo sium, which was brilliantly directed and guided by Dr. L. Svenner holm. The meeting gave certainly, in our opinion, a valuable stimu lus to research workers interested in the biophysics, chemistry, biochemistry, physiology and pharmacology of gangliosides. The e ditors wish to express their thanhd to the speakers, the discussants, the Meeting Chairman, the section chairmen and to all the attendants who have taken part at the Symposium and who actively and deeply discussed the delivered lectures. Our final thank is also for Dr. Francesco della Valle, official representative of FIDIA Research Laboratories, Abano Terme, Padua, Italy, to whom we are grateful for his continuous and efficient support. The contribution of the Secretarial Staffs of both the v PREFACE Department of Biochemistry of Perugia University and FIDIA Labora tories to the editorial work is also gratefully acknowledged.
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