The successful Statistical Reasoning in Medicine: The Intuitive P-value Primer, with its novel emphasis on patient and community protection, illustrated the correct use of statistics in health care research for healthcare workers. Through clear explanations and examples, this book provided the non-mathematician with a foundation for understanding the underlying statistical reasoning process in clinical research, the core principles of research design, and the correct use of statistical inference and p-values.
The P-Value Primer 2nd Edition levels the learning curve of statistics for health care researchers by further de-emphasizing mathematical and computational devices, bringing the principles of statistical reasoning closer to the uninitiated. Adding to the updated discussions of research design, hypothesis testing, regression analysis, and Bayes procedures, are new discussions of absolute and relative risk, as well as a lucid description of the number needed to treat (NNT). The multiple analysis issue is clearly defined, and a new description of the correct use and interpretation of combined endpoints in health care research is offered in an easily digestible format.
The P-value Primer 2nd Edition demolishes other obstacles that have impeded a clear understanding of the application of statistics in medicine. The intertwined roles of epidemiology and biostatistics are depicted. In addition to a description of the non-technical history of statistics, a new discussion describes the active cultural forces that have historically argued against the use of probability and statistics, placing the current applications and controversies involving p-values in context. New illustrations of the difficulties physicians and health care providers face in research are offered, and the differences between research skills and statistical skills are distinguished. New discussion describing the process of scientific reasoning, p-values, and the law is included. All of this nonstandard content, so essential for a well rounded perspective on the modern use of statistics in medicine, makes this volume unique among introductory statistics books.
New figures, conversation, and illustrations fortify each chapter. In addition, three new appendices have been added on the normal distribution, sample size computations, and new requirements for the use of statistics in the courtroom.
* Easy-to-follow format incorporates medical examples, step-by-step methods, and check yourself exercises
* Two-part design features course material and a professional reference section
* Chapter summaries provide a review of formulas, method algorithms, and check lists
* Companion site links to statistical databases that can be downloaded and used to perform the exercises from the book and practice statistical methods
New in this Edition:
* New chapters on: multifactor tests on means of continuous data, equivalence testing, and advanced methods
* New topics include: trial randomization, treatment ethics in medical research, imputation of missing data, and making evidence-based medical decisions
* Updated database coverage and additional exercises
* Expanded coverage of numbers needed to treat and to benefit, and regression analysis including stepwise regression and Cox regression
Thorough discussion on required sample size
Summers covers the complex political and economic background of early twentieth-century Manchuria and then moves on to the plague itself, addressing the various contested stories of the plague's origins, development, and ecological ties. Ultimately, Summers shows how, because of Manchuria's importance to the world powers of its day, the plague brought together resources, knowledge, and people in ways that enacted in miniature the triumphs and challenges of transnational medical projects such as the World Health Organization.