Drugs and Their Biological Targets

Walter de Gruyter GmbH & Co KG
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This two volume book is an excellent introduction to this interdisciplinary area, lying on the interface between organic chemistry, biochemistry and medicine. The authors give a comprehensive overview of the field and outline the actual challenges in pharmaceutical science and industry. Volume 2 covers neurotransmitters, antihistamines, enzymatic inhibitors and nonsteroidal anti-inflammatory drugs.
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About the author

Prof. Joaquín M. Campos Rosa, Prof. Encarnación Camacho Quesada, University of Granada, Granada, Spain.
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Additional Information

Publisher
Walter de Gruyter GmbH & Co KG
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Published on
Nov 7, 2017
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Pages
275
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ISBN
9783110528527
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Best For
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Language
English
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Genres
Medical / Pharmacology
Medical / Pharmacy
Science / Chemistry / General
Science / Chemistry / Organic
Science / Life Sciences / Biochemistry
Technology & Engineering / Chemical & Biochemical
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Content Protection
This content is DRM protected.
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The vast majority of drugs are organic molecular entities. A clear understanding of the organic chemistry of drug degradation is essential to maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events would be the identification of drug degradants and understanding of drug degradation mechanisms and pathways. This book is written by a veteran of the pharmaceutical industry who has first-hand experience in drug design and development, drug degradation mechanism studies, analytical development, and manufacturing process troubleshooting and improvement. The author discusses various degradation pathways with an emphasis on the mechanisms of the underlying organic chemistry, which should aid greatly in the efforts of degradant identification, formulation development, analytical development, and manufacturing process improvement. Organic reactions that are significant in drug degradation will first be reviewed and then illustrated by examples of drug degradation reported in the literature. The author brings the book to a close with a final chapter dedicated to the strategy for rapid elucidation of drug degradants with regard to the current regulatory requirements and guidelines. One chapter that should be given special attention is Chapter 3, Oxidative Degradation. Oxidative degradation is one of the most common degradation pathways but perhaps the most complex one. This chapter employs more than sixty drug degradation case studies with in-depth discussion in regard to their unique degradation pathways. With the increasing regulatory requirements on the quality and safety of pharmaceutical products, in particular with regard to drug impurities and degradants, the book will be an invaluable resource for pharmaceutical and analytical scientists who engage in formulation development, analytical development, stability studies, degradant identification, and support of manufacturing process improvement. In addition, it will also be helpful to scientists engaged in drug discovery and development as well as in drug metabolism studies.
Covering everything you need to study for and pass the Pharmacy Technician Certification Board (PTCB) and ExCPT exams, Mosby's Review for the Pharmacy Technician Certification Examination, 3rd Edition makes exam preparation easy. Review the content you'll see on the exam with handy outlines, test-taking tips and strategies, and electronic flash cards. Written by noted pharmacy technician educator James J. Mizner, this complete review tests your knowledge and simulates the actual PTCB exam with 17 different, 100-question practice exams in the book and online. This edition is modeled after the updated Pharmacy Technician Certification Exam Blueprint.A total of 1,700 review questions are included in 17 practice exams in the book and online.100-question format of each practice exam simulates the PTCB and ExCPT exams, with multiple-choice questions and the same balance of content, for a realistic test taking experience.700 electronic flash cards help you learn and remember facts by covering the top 200 most prescribed pharmaceuticals, top 50 herbals, abbreviations, and sound-alike drugs.Review content reflects the new percentages covered on the PTCB exam.A convenient outline format helps you to quickly review important information you'll see on the exam.Tips and suggestions prepare you for test-taking success by providing an insider’s perspective on what to expect and how to prepare for your exam when you have limited time. Seven practice exams in the book feature the same format and content emphasis as the national exam. Ten practice exams on the Evolve companion website in both timed and untimed modes help you identify any areas of weakness, and include instant feedback and remediation. UPDATED content includes current drug information and pharmacy practice procedures based on the new Pharmacy Technician Certification Exam Blueprint.NEW! Chapter objectives provide a clear breakdown of content and goals for review.
Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation.

In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group.

Key features include:
• Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups.
• How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism.
• Numerous examples and expanded discussions for complex concepts.
• Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice.
• An overview of structure activity relationships (SARs) and concepts that govern drug design.
• Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix.

Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry.

About the Authors

Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS"  (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy.

Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.

Concise Review for the PTCB Exam is a comprehensive approach to preparing for the pharmacy technician certification exam. It does not try to cover every aspect about the field of pharmacy. Rather, it targets the information that is relevant to the certification exam. The text includes drug information, test-taking strategies, examples and practice questions that will prepare a student to pass the test the first time. . Instruction in all test areas: math, law, hospital, drug information. . Contains strategies you MUST know to ace the exam. . Over 750 practice questions that will familiarize you with the PTCB format and help you master the techniques taught. . Detailed answer explanations that will help you avoid making the same mistake twice. . Pharmacy calculations are completely worked out so that all math problems on the exam can be easily understood and solved. . Gives unique ways to learn many of the drugs that will be on the exam. . Includes three practice PTCB tests. All of these questions are similar to those that you will see on the actual PTCB exam. . Covers pharmacy law and hospital information in a way that will make it easy to recall the information. .Contains a list of the top 200 drugs with brand, generic, indication and class. About the Authors Brian Tuschl, Pharm. D., is the president of Tech Prep Solutions. He is an Adjunct Clinical Assistant Professor in the Department of Clinical Sciences and Administration in the College of Pharmacy at the University of Houston and was presented with the Roche Preceptor of the Year Award in 2006. Dr. Tuschl currently serves as a member of the advisory boards of two local technical schools with pharmacy technician programs and also practices retail pharmacy in Houston, Texas. Christopher Ardoin, BSPharm, is the co-founder of Tech Prep Solutions. He is a preceptor with the University of Houston College of Pharmacy. He is a licensed pharmacist in both Texas and Louisiana. Mr. Ardoin has over ten years of pharmacy experience in areas including hospital, compounding, and retail pharmacy.
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