Enzyme- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges

Springer Science & Business Media
2
Free sample

The goal of this book is to provide a comprehensive view of the scientific bases on issues surrounding the importance of drug-enzyme and drug-transporter interactions and the quantitative predictions of clinically relevant transporter and enzyme based interactions. Although much progress has been made in predicting in vivo metabolic drug interactions based on in vitro studies, the quantitative prediction of clinically relevant transporter-and enzyme based drug interactions remains to be a challenge. The more complex metabolic drug interactions such as inductive, mechanism-based and allosteric drug interactions render difficulty for prediction in vivo. This book will further assess the progress made in quantitatively predicting metabolic and transporter-based drug interactions as well as highlight areas where such predictions are poor or not possible.
Read more

About the author

K. Sandy Pang Ph.D. is Professor of Pharmacy and Pharmacology, Faculties of Pharmacy and Medicine at the University of Toronto. She received her B.S. (Pharmacy) from the University of Toronto, Ph.D. (Pharmaceutical Chemistry) from UCSF and post-doctoral training with Dr. James R. Gillette as a Fogarty International Fellow at the National Institutes of Health. Dr. Pang’s work spans the fields of pharmacokinetics, drug metabolism and transporters and their regulation. Her research programs are aimed towards a mechanistic-based understanding of the handling of drugs and their metabolites within the liver, the intestine, and kidney via integration of relevant processes into physiologically-based models, encompassing state-of-the-art experimentation and theory. Her work emphasizes the presence of immediate removal of formed metabolites in situ the eliminating organ that reveals differences in the fates of formed vs. preformed metabolites because of transmembrane barriers, enzyme heterogeneity, enzymatic coupling, and kinetics of successive formation of metabolites. Recent studies focused on the continuation of metabolite PBPK modeling, siRNA disposition, and the role of 1a,25-dihydroxyvitamin D3-liganded vitamin D receptor on the regulation of transporters and enzymes. Dr. Pang has published over 200 original articles and chapters. She has served on various committees for NIH ASPET, AAPS, ISSX, and AAAS. She is the editor-in-chief of Biopharmaceutics and Drug Disposition, and is a member of the editorial review boards of the American Journal of Physiology, Journal of Pharmacology and Experimental Therapeutics, Drug Metabolism and Disposition, and AAPS Journal. She was the recipient of the NIH Research Career Development Award, Faculty Development award from the Medical Research Council of Canada, the McNeil Award from the Faculties of Pharmacies in Canada, and the Research Achievement Award in Pharmacokinetics, Pharmacodynamics and Drug Metabolism from the American Association of Pharmaceutical Scientists (AAPS).

A. David Rodrigues is Executive Director of the Metabolism & Pharmacokinetics Department, Pharmaceutical Candidate Optimization, at Bristol-Myers Squibb, Princeton, New Jersey. The author and co-author of over ninety peer-reviewed journal articles and book chapters, Dr. Rodrigues sits of the Editorial Board of three journals (Drug Metabolism and Disposition, Current Drug Metabolism, and Drug Metabolism Letters) and is member of the International Society for the Study of Xenobiotics (ISSX) and the American Association of Pharmaceutical Scientists (AAPS). He received the B.Sc. degree (1984) in applied science from Kingston-upon-Thames Polytechnic, Surrey, England, and the Ph.D. degree (1988) in biochemistry from the University of Surrey, Guildford, England.

Raimund M. Peter is Associate Director of the Drug Metabolism & Pharmacokinetics Section, Cardiovascular & Gastrointestinal Research Department, at AstraZeneca, Alderley Park, United Kingdom. The author and co-author of twenty peer-reviewed journal articles, Dr. Peter is the current Chairman of the Drug Metabolism Focus Group of AAPS and is member of the International Society for the Study of Xenobiotics (ISSX), the American Association of Pharmaceutical Scientists (AAPS), and the American Chemical Society. He received the Dipl.-Chem. degree (1986) in chemistry, and the Ph.D. degree (1992) in chemistry & biochemical pharmacology from the University of Erlangen-Nuernberg, Germany.

Read more
4.0
2 total
Loading...

Additional Information

Publisher
Springer Science & Business Media
Read more
Published on
Dec 17, 2009
Read more
Pages
746
Read more
ISBN
9781441908407
Read more
Language
English
Read more
Genres
Medical / Pharmacology
Medical / Pharmacy
Science / Chemistry / Analytic
Science / Chemistry / Clinical
Science / Life Sciences / Biochemistry
Read more
Content Protection
This content is DRM protected.
Read more

Reading information

Smartphones and Tablets

Install the Google Play Books app for Android and iPad/iPhone. It syncs automatically with your account and allows you to read online or offline wherever you are.

Laptops and Computers

You can read books purchased on Google Play using your computer's web browser.

eReaders and other devices

To read on e-ink devices like the Sony eReader or Barnes & Noble Nook, you'll need to download a file and transfer it to your device. Please follow the detailed Help center instructions to transfer the files to supported eReaders.
REA's PTCE (Pharmacy Technician Certification Exam) Flashcard Book
Updated Second Edition

500 Questions & Answers You Need to Know

This latest addition to our Health Sciences series of flashcards is designed to help PTCE candidates check their test-readiness before taking the Pharmacy Technician Certification Exam. Unlike most flashcards that come in a box, our cards are bound in an easy-to-use, organized book that makes it convenient to study anywhere.

Written by a seasoned pharmacy technician instructor and based on the most recent exam, our study supplement covers everything you need to know for the PTCE: assisting the pharmacist in serving patients, maintaining medication and inventory control systems, and participating in the management of pharmacy practice.

The flashcards are broken down by PTCE test topics and include multiple-choice questions with detailed answer explanations. The questions are similar to what you may encounter on the PTCE. The 500 flashcards are divided as follows:

* 200 flashcards focused on the top 200 brand/generic drug names including their respective drug classes, indications, side effects, and special considerations

* 50 flashcards focused on pharmaceutical terms and abbreviations

* 250 flashcards focused on PTCE review material:

- 165 flashcards on Assisting the Pharmacist in Serving Patients

- 55 flashcards on Maintaining Medication and Inventory Control Systems

- 30 flashcards on Participating in the Administration and Management of Pharmacy Practice

After studying with the book, go online and review what you have learned at REA's Study Center. Our customizable e-flashcards and 3 practice quizzes give you the freedom to create your own PTCE study plan and study anywhere, anytime. You can also create your own unique flashcards for any sections of the test that give you difficulty.

This flashcard book and the online tools that come with it, will help you personalize your PTCE prep by testing your understanding, pinpointing your weaknesses, and delivering flashcard study materials unique to you.

If you're a pharmacy tech student and want extra practice and review before the exam, REA's PTCE Flashcard Book is the right Rx for your study needs.
Certification Review for Pharmacy Technicians has been recognized as the best review text for the PTCB's National Certification Exam by pharmacy technicians nationwide. But don't take our word for it...here's what just a few pharmacy technicians and educators have to say... "I am a certified pharmacy technician and an instructor at the central Arizona College, Pharmacy Technician Program. I have prepared all of our technicians for the national certification exam with the text Certification Review for Pharmacy Technicians by Noah Reifman. It is by far the best study guide available to prepare for the PTCB exam.” -Myela Fox, CphT Banner Home Care “I am a Pharmacy Technician Instructor at Stark State College and Wayne College in Ohio. Certification Review for Pharmacy Technicians written by Noah Reifman, RPH, MS., changed fear into confidence for the PTCB exam. The text is written in a ‘reader friendly’ fashion yet very ‘detail oriented’. It made the difference for my students.” - Janice Norcia-Sprankle Pharmacy Technician Instructor “I found the review text Certification Review for Pharmacy Technicians to cover all topics needed to pass the national certification exam. I passed the exam with this review book and have personally recommended it to many technicians taking the exam. Written by a pharmacist who really cares about technicians and their future.” Kelly Fash, CphT With over 100,000 texts sold, Certification Review for Pharmacy Technicians has an overall greater than 96% pass rate.
This book covers in detail the mechanisms for how energy is managed in the human body. The basic principles that elucidate the reactivity and physical interactions of matter are addressed and quantified with simple approaches. Three-dimensional representations of molecules are presented throughout the book so molecules can be viewed as unique entities in their shape and function.

The book is focused on the molecular mechanisms of cellular processes in the context of human physiological situations such as fasting, feeding and physical exercise, in which metabolic regulation is highlighted. Furthermore the book uses key historical experiments that opened up new concepts in Biochemistry to further illustrate how the human body functions at molecular level, helping students to appreciate how scientific knowledge emerges.

This book also:

Elucidates the foundations of the molecular events of life


Uses key historical experiments that opened up new concepts in Biochemistry to further illustrate how the human body functions at molecular level, helping students to appreciate how scientific knowledge emerges

Provides realistic representations of molecules throughout the book

Advance Praise for Integrative Human Biochemistry

“This textbook provides a modern and integrative perspective of human biochemistry and will be a faithful companion to health science students following curricula in which this discipline is addressed. This textbook will be a most useful tool for the teaching community.”

–Joan Guinovart

Director of the Institute for Research in Biomedicine, Barcelona, Spain

President-elect of the International Union of Biochemistry and Molecular Biology, IUBMB


Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.
©2018 GoogleSite Terms of ServicePrivacyDevelopersArtistsAbout Google|Location: United StatesLanguage: English (United States)
By purchasing this item, you are transacting with Google Payments and agreeing to the Google Payments Terms of Service and Privacy Notice.