Pandora's DNA: Tracing the Breast Cancer Genes Through History, Science, and One Family Tree

Chicago Review Press
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2015 ALA Notable Book Would you cut out your healthy breasts and ovaries if you thought it might save your life? That's not a theoretical question for journalist Lizzie Stark's relatives, who grapple with the horrific legacy of cancer built into the family DNA, a BRCA mutation that has robbed most of her female relatives of breasts, ovaries, peace of mind, or life itself. In Pandora's DNA, Stark uses her family's experience to frame a larger story about the so-called breast cancer genes, exploring the morass of legal quandaries, scientific developments, medical breakthroughs, and ethical concerns that surround the BRCA mutations, from the troubling history of prophylactic surgery and the storied origins of the boob job to the landmark lawsuit against Myriad Genetics, which held patents on the BRCA genes every human carries in their body until the Supreme Court overturned them in 2013. Although a genetic test for cancer risk may sound like the height of scientific development, the treatment remains crude and barbaric. Through her own experience, Stark shows what it's like to live in a brave new world where gazing into a crystal ball of genetics has many unintended consequences.
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About the author

Lizzie Stark is the author of Leaving Mundania and a freelance journalist who has written for io9.com, The Today Show website, Psychology Today, the Daily Beast, and the Philadelphia Inquirer. She holds an MS in New Media Journalism from the Columbia University Graduate School of Journalism. 
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Additional Information

Publisher
Chicago Review Press
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Published on
Oct 1, 2014
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Pages
336
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ISBN
9781613748633
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Language
English
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Genres
Biography & Autobiography / Medical
Medical / History
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Content Protection
This content is DRM protected.
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Winner of the Pulitzer Prize, and now a documentary from Ken Burns on PBS, The Emperor of All Maladies is a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence.

Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years.

The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist.

From the Persian Queen Atossa, whose Greek slave may have cut off her diseased breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease.

Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
This guide introduces gamers, actors, and other imaginative folks to this emerging form. American freeform games share a common format—they are rules-light one-shot productions, a bit like improv theater games performed without an audience, requiring only a few people, and lasting for several hours. With few setting or scenography requirements, these games are easy to run, and are especially friendly to new players and organizers. 

Leaving Mundania author Lizzie Stark takes the reader through the history and development of the style, which counts US chamber larp, indie games and Nordic larp and freeform among its influences. The guide provides easy-to-understand instruction on how to play, run, and write these short scenarios, as well as advanced tips for those who want a deep dive.

Calling all theater educators, improv actors, and larpers: come join the American freeform revolution.

“If you are new to freeform roleplaying, the Pocket Guide to American Freeform is really useful. If you are a grizzled veteran who knows everything, it is a necessity.” 

-Jason Morningstar, creator of Fiasco, Bully Pulpit Games

“Lizzie Stark is a uniquely important figure in the LARP community, bringing Nordic design know-how to the American gaming experience. In this book, she shares her key findings from the experimental side of the American larp scene as well as the critical components to designing these kinds of games. If you’re a roleplayer looking to make the leap into less linear, more potent, and more original work, the Pocket Guide to American Freeform is the first book you should read.”

–Nick Fortugno, Playmatics

THE #1 NEW YORK TIMES BESTSELLER
A New York Times Notable Book
A Washington Post and Seattle Times Best Book of the Year

From the Pulitzer Prize-winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle).

“Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.

“Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome.

“A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).
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