Selective permeability of biological membranes also known as semipermeability, partial permeability or differential permeability allows molecules to diffuse, pass by passive and active or by other types of transport processes mediated by proteins.
The first chapter of the book deals with the composition of biological membranes, characterizes cellular membranes of prokaryotic, eukaryotic cells, membranes of cellular organelles and the function of biological membranes. The second chapter provides an overview of bilayer permeability, selectivity of permeabilization and cellular transport processes. Chapter 3 overviews different cell manipulations that aim to make cells permeable while maintaining not only the structural but also the functional integrity of cells. The last chapter deals with applications, particularly with reversible permeabilization to study macromolecular (DNA, RNA, poly-ADP ribose) biosynthetic processes, replication, gene expression, visualization of replicons, intermediates of chromosome condensation, genotoxic chromatin changes, upon treatment with heavy metals and different types of irradiation.
The interdisciplinary aspects of the book contribute to the understanding of the structure of nucleic acids, replicative intermediates, Okazaki fragments, RNA primer mechanism, subphases of replication and repair synthesis, replicons, gene expression, chromosome condensation generated a wealth of information that will attract a wide readership. The natural audience engaged in DNA research, including genetics, cell and molecular biology, chemistry, biochemistry, medicine, pharmacy will find essential material in the book.
MasteringBiology should only be purchased when required by an instructor.
For courses in cell biology.
Widely praised for its strong biochemistry coverage, Becker’s World of the Cell, Eighth Edition, provides a clear, up-to-date introduction to cell biology concepts, processes, and applications. Informed by many years of teaching the introductory cell biology course, the authors have added new emphasis on modern genetic/genomic/proteomic approaches to cell biology while using clear language to ensure that students comprehend the material. Becker’s World of the Cell provides accessible and authoritative descriptions of all major principles, as well as unique scientific insights into visualization and applications of cell biology. Media icons within the text and figures call attention to an enhanced media selection–350 up-to-date animations, videos, and activities–that helps students visualize concepts.
The Becker World of the Cell 8e Technology Update brings the power of MasteringBiology to Cell Biology for the first time. MasteringBiology is an online homework, tutorial and assessment system that delivers self-paced tutorials that provide individualized coaching, focus on your course objectives, and are responsive to each student's progress. The Mastering system helps instructors maximize class time with customizable, easy-to-assign, and automatically graded assessments that motivate students to learn outside of class and arrive prepared for lecture.
The first edition of the present book was published in 2005 when lipidomics was still very much an emerging science and lipids about to be recognized as being as important for life as proteins, sugars, and genes. This significantly expanded and revised edition takes into account the tremendous amount of knowledge gained over the past decade. In addition, the book now includes more tutorial material on the biochemistry of lipids and the principles of lipid self-assembly.
The book is aimed at undergraduate students and young research workers within physics, chemistry, biochemistry, molecular biology, nutrition, as well as pharmaceutical and biomedical sciences.
From the reviews of the first edition:
"This is a highly interesting book and a pleasure to read. It represents a new and excellent pedagogical introduction to the field of lipids and the biophysics of biological membranes. I reckon that physicists and chemists as well as biologists will benefit from this approach to the field and Mouritsen shows a deep insight into the physical chemistry of lipids." (Göran Lindblom, Chemistryand Physics of Lipids 2005, vol. 135, page 105-106)
"The book takes the reader on an exciting journey through the lipid world, and Mouritsen attracts the attention with a lively style of writing ... . a comprehensive view of the ‘lipid sea’ can be easily achieved, gaining the right perspectives for envisaging future developments in the nascent field of lipidomics." (Carla Ferreri, ChemBioChem, Vol. 6 (8), 2005)