Genomics and Personalized Medicine: What Everyone Needs to Know®

Oxford University Press
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In 2001 the Human Genome Project succeeded in mapping the DNA of humans. This landmark accomplishment launched the field of genomics, the integrated study of all the genes in the human body and the related biomedical interventions that can be tailored to benefit a person's health. Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. By cross-referencing an individual's genetic sequence -- their genome -- against known elements of "Big Data," elements of genomics are already being incorporated on a widespread basis, including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution is limitless. This entry in the What Everyone Needs to Know series offers an authoritative resource on the prospects and realities of genomics and personalized medicine. As this science continues to alter traditional medical paradigms, consumers are faced with additional options and more complicated decisions regarding their health care. This book provides the essential information everyone needs.
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About the author

Michael Snyder, PhD, is the Stanford Ascherman Professor, Chair of the Department of Genetics, and Director of the Center of Genomics and Personalized Medicine at Stanford University. His laboratory has produced many fundamental technologies for characterizing the human genome and other "-omes," including many pivotal discoveries about our DNA. In 2012 he used his own genome sequence to predict and help diagnose his own metabolic disorder, a story that received international news attention and shined a light on the promise of genomics. Snyder a co-founder of several successful biotechnology companies, including Personalis, Protometrix (now part of Life Technologies), Affomix (now part of Illumina), and Exelixis. He is regarded as a pioneer in bringing Big Data into medicine.
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Additional Information

Publisher
Oxford University Press
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Published on
Feb 9, 2016
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Pages
240
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ISBN
9780190234799
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Language
English
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Genres
Health & Fitness / Health Care Issues
Medical / Genetics
Science / Life Sciences / Genetics & Genomics
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Content Protection
This content is DRM protected.
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Read Aloud
Available on Android devices
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Eligible for Family Library

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NEW YORK TIMES BESTSELLER

The New York Times bestselling author of The Hormone Cure and The Hormone Reset Diet shows every woman how to create a lifestyle that will help her look great, feel energized, and slow down the effects of aging.

Feel destined for cellulite, saddle bags, and belly fat? Does your family come from a long line of Alzheimer's, cancer, or heart disease? Will nothing help your aging skin or declining libido or flagging energy? This book is for you.

The body is magnificent but it doesn't come with a lifetime warranty, or an operating manual. You're the result of millions of years of evolution, but many of the adaptations that helped your ancestors survive are now working overtime to accelerate the aging process. The assumption here is that we are our genes and therefore trapped by the past. The good news is that your genetic code—the DNA sequence that is the biochemical basis of heredity—can play a minor role in the way you age.

The scientific reality is that 90 percent of the signs of aging and disease are caused by lifestyle choices, not your genes. In other words, you have the capability to overcome and transform your genetic history and tendencies. Harvard/MIT—trained physician Sara Gottfried, M.D. has created a revolutionary 7-week program that empowers us to make the critical choices necessary to not just look young, but also feel young.

Dr. Gottfried identifies and builds this book around the five-key factors that lead to accelerated aging -the muscle factor, the brain factor, the hormone factor, the gut factor, and the toxic fat factor. The 7-week program addresses these factors and treats them in an accessible and highly practical protocol and is as follows:

Feed—Week 1Sleep—Week 2Move—Week 3Release—Week 4Expose—Week 5Soothe—Week 6Think—Week 7

Younger increases not only your lifespan, but also your healthspan. Dr. Gottfried's program makes it possible to change the way you age, stay younger longer, and remain healthy and vibrant for all of your days.


John Joseph Mathews (1894–1979) is one of Oklahoma’s most revered twentieth-century authors. An Osage Indian, he was also one of the first Indigenous authors to gain national renown. Yet fame did not come easily to Mathews, and his personality was full of contradictions. In this captivating biography, Michael Snyder provides the first book-length account of this fascinating figure.

Known as “Jo” to all his friends, Mathews had a multifaceted identity. A novelist, naturalist, biographer, historian, and tribal preservationist, he was a true “man of letters.” Snyder draws on a wealth of sources, many of them previously untapped, to narrate Mathews’s story. Much of the writer’s family life—especially his two marriages and his relationships with his two children and two stepchildren—is explored here for the first time.

Born in the town of Pawhuska in Indian Territory, Mathews attended the University of Oklahoma before venturing abroad and earning a second degree from Oxford. He served as a flight instructor during World War I, traveled across Europe and northern Africa, and bought and sold land in California. A proud Osage who devoted himself to preserving Osage culture, Mathews also served as tribal councilman and cultural historian for the Osage Nation.

Like many gifted artists, Mathews was not without flaws. And perhaps in the eyes of some critics, he occupies a nebulous space in literary history. Through insightful analysis of his major works, especially his semiautobiographical novel Sundown and his meditative Talking to the Moon, Snyder revises this impression. The story he tells, of one remarkable individual, is also the story of the Osage Nation, the state of Oklahoma, and Native America in the twentieth century.
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Was diabetes evolution's response to the last Ice Age? Did a deadly genetic disease help our ancestors survive the bubonic plagues of Europe? Will a visit to the tanning salon help lower your cholesterol? Why do we age? Why are some people immune to HIV? Can your genes be turned on -- or off?

Joining the ranks of modern myth busters, Dr. Sharon Moalem turns our current understanding of illness on its head and challenges us to fundamentally change the way we think about our bodies, our health, and our relationship to just about every other living thing on earth, from plants and animals to insects and bacteria.

Through a fresh and engaging examination of our evolutionary history, Dr. Moalem reveals how many of the conditions that are diseases today actually gave our ancestors a leg up in the survival sweepstakes. When the option is a long life with a disease or a short one without it, evolution opts for disease almost every time.

Everything from the climate our ancestors lived in to the crops they planted and ate to their beverage of choice can be seen in our genetic inheritance. But Survival of the Sickest doesn't stop there. It goes on to demonstrate just how little modern medicine really understands about human health, and offers a new way of thinking that can help all of us live longer, healthier lives.

Survival of the Sickest is filled with fascinating insights and cutting-edge research, presented in a way that is both accessible and utterly absorbing. This is a book about the interconnectedness of all life on earth -- and, especially, what that means for us.

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