Advances in Linear Free Energy Relationships

Springer Science & Business Media
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Louis P. Hammett Mitchill Professor Emeritus of Chemistry, Columbia University My interest in linear free energy relationships began when, just out of graduate school, I read in 1924 the article by Bmnsted and Pedersen which for the first time reported the existence of such a relationship. That interest continues to be an active one and, to judge merely by the extensive biblio graphies contained in the present volume, it is widely shared. To my mind a particularly happy aspect of the existence of linear free energy relationships has been the proof it supplies that one need not suppose that the behavior of nature is hopelessly complicated merely because one cannot find a theoretical reason for supposing it to be otherwise. The effect of a substituent in an organic molecule on rate or equilibrium of reaction involves a fourfold difference between relatively large quantities, a situation which always makes for difficult theory. Yet systematic organic chemistry could hardly have existed were it not true that like changes in structure lead to like changes in reactivity. Linear free energy relationships constitute the quantitative specialisation of this fundamental principle, and they stand indeed more in the office of teacher to theory than in that of learner from it.
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Publisher
Springer Science & Business Media
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Published on
Dec 6, 2012
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Pages
486
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ISBN
9781461586609
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Language
English
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Genres
Science / Chemistry / Organic
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This content is DRM protected.
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New methods for the construction of condensed five-membered ring systems continue to be developed at an accelerated pace. The challenges underlying this tremendous current upsurge of interest arise from several directions. One stems from the desire to elucidate and resolve those special problems associated with the incorporation of added strain not present when six-membered rings are mutually fused. The many structurally interesting polyquinane natural products isolated and characterized in recent years have provided a particularly delightful forum for application of various new synthetic protocols, many of which must equally well accommodate the particular stereochemical demands of each indi vidual target. Synthetic elaboration of a marvellous array of new unnatural molecules also holds continued fascination. In the past, we have attempted to keep others abreast of developments in this rapidly burgeoning area by authoring a pair of comprehensive reviews in Topics in Current Chemistry that appeared in 1979 [1] and 1984 [2]. During this period, others have also surveyed the developments in cyclopentannulation [3] and the cyclopentanoid field in general [4]. In the last couple of years, the pace at which new synthetic facets have been reported has become more frenetic than ever before. Accordingly, a suitable updating of the exciting newer findings was deemed appropriate and the present overview, which extends approximately to mid - 1986, was written. Once again, our hope is that compilations of this type will serve to stimulate imaginative new scientific ventures that will propel the field forward to still greater maturity.
The second edition of the book continues to offer a range of pedagogical features maintaining the balanced approach of the text. The attempts have been made to further strengthen the conceptual understanding by introducing more ideas and a number of solved problems.

Comprehensive in approach, this text presents a rigorous treatment of organic chemistry to enable undergraduate students to learn the subject in a clear, direct, easily understandable and logical manner. Presented in a new and exciting way, the goal of this book is to make the study of organic chemistry as stimulating, interesting, and relevant as possible.

Beginning with the structures and properties of molecules, IUPAC nomenclature, stereochemistry, and mechanisms of organic reactions, proceeding next to detailed treatment of chemistry of hydrocarbons and functional groups, then to organometallic compounds and oxidation–reduction reactions, and ending with a study of selected topics (such as heterocyclic compounds, carbohydrates, amino acids, peptides and proteins, drugs and pesticides, dyes, synthetic polymers and spectroscopy), the book narrates a cohesive story about organic chemistry. Transitions between topics are smooth, explanations are lucid, and tie-ins to earlier material are frequent to maintain continuity.

The book contains over 500 solved problems from simple to really challenging ones with suitable explanations. In addition, over 275 examples and solved problems on IUPAC nomenclature, with varying levels of difficulty, are included.

About Some Key Features of the Book

• EXPLORE MORE: Four sets of solved problems provide in-depth knowledge and enhanced understanding of some important aspects of organic chemistry.
• MINI ESSAYS: Three small essays present interesting write-ups to provide students with introductory knowledge of chemistry of natural products such as lipids, terpenes, alkaloids, steroids along with nucleic acids and enzymes.
• NOTABILIA: Twenty-two ‘notabilia boxes’ interspersed throughout the text highlight the key aspects of related topics, varying from concepts of chemistry to the chemistry related to day-to-day life.
• STRUCTURES AND MECHANISMS NOT IN ORDER: Cites examples of common errors made by students while drawing structural formulae and displaying arrows in reaction mechanisms and helps them to improve on language of organic chemistry by teaching appropriate drawings and their significance.
• GLOSSARY: Includes ‘Name reactions’, ‘Reagents’, and some important terms for quick revision by students.
Clearly written and logically organized, the authors have endeavoured to make this complex and important branch of science as easy as possible for students to learn from and for teachers to teach from.
Class-tested and thoughtfully designed for student engagement, Principles of Organic Chemistry provides the tools and foundations needed by students in a short course or one-semester class on the subject. This book does not dilute the material or rely on rote memorization. Rather, it focuses on the underlying principles in order to make accessible the science that underpins so much of our day-to-day lives, as well as present further study and practice in medical and scientific fields. This book provides context and structure for learning the fundamental principles of organic chemistry, enabling the reader to proceed from simple to complex examples in a systematic and logical way.

Utilizing clear and consistently colored figures, Principles of Organic Chemistry begins by exploring the step-by-step processes (or mechanisms) by which reactions occur to create molecular structures. It then describes some of the many ways these reactions make new compounds, examined by functional groups and corresponding common reaction mechanisms. Throughout, this book includes biochemical and pharmaceutical examples with varying degrees of difficulty, with worked answers and without, as well as advanced topics in later chapters for optional coverage.

Incorporates valuable and engaging applications of the content to biological and industrial usesIncludes a wealth of useful figures and problems to support reader comprehension and studyProvides a high quality chapter on stereochemistry as well as advanced topics such as synthetic polymers and spectroscopy for class customization
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