Determined to shield humanity from the harmful effects of Exotic Matter (XM), Devra Bogdanovich unleashes a Portal Virus designed to shut down the XM flow in Portals worldwide. The interruption of XM flow drives Roland Jarvis, who is deeply dependent on it, to the brink of death. ADA is also negatively affected. Agents around the globe respond with efforts to eliminate the virus and protect the Portals. Unbeknownst to them, efforts to resuscitate the Portals using a set of ancient objects known as the ‘Helios Artifacts’ send out a surge of XM to the far corners of the Universe, awakening a long dormant force. Hank Johnson re-emerges from the ‘nest’ in Afghanistan where his body has been entombed to warn of an ancient entity that has acted as a rival to the Shapers throughout history. His search for answers leads him to India and an encounter that will forever alter his future.