Environmental Radiation Effects on Mammals: A Dynamical Modeling Approach, Edition 2

Springer
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Dr. Smirnova's updated text is devoted to the theoretical studies of radiation effects on mammals. It summarizes 35 years of results the author obtained from analyzing dose rate equivalents for the Galactic Cosmic Rays (GCR) and for Solar Particles Events (SPE). This edition also includes two new chapters on skin epidermal epithelium and risk assessment for myeloid leukemia, as well as extended revisions addressing the radiation effects on the blood-forming system. Mathematical models are used to explain the effects of both acute and chronic irradiation on the dynamics of vital body systems, like the hematopoietic system, the development of autoimmune diseases, and the mortality dynamics in homogeneous and nonhomogeneous mammalian populations. The proposed methodology of these studies, the models themselves, and the obtained results are of a great theoretical significance and can find wide practical use.
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About the author

Dr. Olga A. Smirnova is a physicist and researcher at the Federal State Unitary Enterprise Research and Technical Center of Radiation-Chemical Safety and Hygiene, Moscow, Russia. She uses the framework of developed deterministic mathematical models to investigate the effects of both acute and chronic irradiation in a wide range of doses and dose rates on vital body systems, including hematopoiesis, small intestine and humoral immunity, as well as on the development of autoimmune diseases. Dr. Smirnova's fields of study and expertise include modeling the dynamics of various biological systems in mammals exposed to acute/chronic radiation.
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Additional Information

Publisher
Springer
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Published on
Oct 14, 2016
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Pages
359
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ISBN
9783319457611
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Language
English
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Genres
Mathematics / Applied
Medical / Allied Health Services / Imaging Technologies
Medical / Biochemistry
Medical / Occupational & Industrial Medicine
Science / Life Sciences / Biophysics
Science / Life Sciences / Zoology / General
Technology & Engineering / Aeronautics & Astronautics
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Content Protection
This content is DRM protected.
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U Satyanarayana
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Olga A. Smirnova
Themonographisdevotedtothetheoreticalstudiesofradiationeffectsonmammals. It summarizes the results obtained by the author over the past 30 years, most of them being of high priority. In the course of these studies, a single approach to the modeling of radiation effects on mammals has been elaborated. Speci?cally, in the framework of the developed deterministic mathematical models, the effects of both acute and chronic irradiation in a wide range of doses and dose rates on vital body systems (hematopoiesis, small intestine, and humoral immunity), as well as on the development of autoimmune diseases, are investigated. The radiation effects on the mortality dynamics in homogeneous and nonhomogeneous(in radiosensitivity) mammalian populations are also studied by making use of the developed stochastic models. The most appealing feature of these mortality models consists of the fact that they account for the intrinsic properties of the exposed organism. Namely, within these models the stochastic biometrical functions are calculated proceeding from statistical characteristics and dynamics of the respective critical body system (hematopoiesis or small intestine). The performed theoretical investigations contribute to the development of the system and quantitative approaches in radiation biology and ecology. These studies elucidate the major regulatory mechanisms of the damage and recovery processes running in the vital body systems of exposed mammals and reveal the key par- eters characterizing the processes.
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