PET Chemistry

Ernst Schering Foundation Symposium Proceedings

Book 62
Springer Science & Business Media
4
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Personalized medicine employing patient-based tailor-made therapeutic drugs is taking over treatment paradigms in a variety of ?elds in oncology and the central nervous system. The success of such therapies is mainly dependent on ef?cacious therapeutic drugs and a selective imaging probe for identi?cation of potential responders as well as therapy monitoring for an early bene?t assessment. Molecular imaging (MI) is based on the selective and speci?c interaction of a molecular probe with a biological target which is visualized through nuclear, magnetic resonance, near infrared or other methods. Therefore it is the method of choice for patient selection and therapy monitoring as well as for speci?c e- point monitoring in modern drug development. PET (positron emitting tomography), a nuclear medical imaging modality, is ideally suited to produce three-dimensional images of various targets or processes. The rapidly increasing demand for highly selective probes for MI strongly pushes the development of new PET tracers and PET chemistry. ‘PET chemistry’ can be de?ned as the study of positron-emitting compounds regarding their synthesis, structure, composition, reactivity, nuclear properties and processes and their properties in natural and - natural environments. In practice PET chemistry is strongly in?uenced by the unique properties of the radioisotopes used (e. g. , half-life, che- cal reactivity, etc. ) and integrates scienti?c aspects of nuclear-, organic-, inorganic- and biochemistry.
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Additional Information

Publisher
Springer Science & Business Media
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Published on
Jan 19, 2007
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Pages
345
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ISBN
9783540495277
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Language
English
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Genres
Medical / Radiology, Radiotherapy & Nuclear Medicine
Science / Chemistry / General
Science / Chemistry / Industrial & Technical
Science / Chemistry / Inorganic
Science / Chemistry / Organic
Science / Chemistry / Physical & Theoretical
Science / Life Sciences / Biochemistry
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The European Workshops on Molecular and Cellular Endocrinology of the Testis have become by now a well-established tradition. Thanks to their special format, the quality of the main lectures and miniposters, and the vivid discussions, they enjoy the ever-increasing interest and active participation of all European scientists working in the field. Moreover, since the very beginning they have attracted investigators from all over the world. The most recent "Testis Workshop" was held in De Panne, Belgium, from 27-3\ March, 1994. As always, the frame work of the workshop was provided by a series of lectures delivered by a panel of internationally recognized authorities. These lectures are ga thered in the present volume of the Ernst Schering Foundation Work shop series. Together with the Miniposter book they constitute an excel lent written account of the Proceedings of the 8th European Testis Workshop. The testis undoubtedly represents one of the most complex and in triguing tissues in the body. Both its endocrine function, the secretion of male sex hormones, and its exocrine role, the production of mature spermatozoa, continue to raise startling questions to clinicians, physi ologists, endocrinologists, and scientists involved in fundamental re search. Few organs maintain and support a differentiation process as complicated as spermatogenesis; few tissues continually display both mitotic and meiotic cell cyles in such a stringently controlled fashion or a comparable need for coordinated endocrine and local control.
The European Workshops on Molecular and Cellular Endocrinology of the Testis have become by now a well-established tradition. Thanks to their special format, the quality of the main lectures and miniposters, and the vivid discussions, they enjoy the ever-increasing interest and active participation of all European scientists working in the field. Moreover, since the very beginning they have attracted investigators from all over the world. The most recent "Testis Workshop" was held in De Panne, Belgium, from 27-3\ March, 1994. As always, the frame work of the workshop was provided by a series of lectures delivered by a panel of internationally recognized authorities. These lectures are ga thered in the present volume of the Ernst Schering Foundation Work shop series. Together with the Miniposter book they constitute an excel lent written account of the Proceedings of the 8th European Testis Workshop. The testis undoubtedly represents one of the most complex and in triguing tissues in the body. Both its endocrine function, the secretion of male sex hormones, and its exocrine role, the production of mature spermatozoa, continue to raise startling questions to clinicians, physi ologists, endocrinologists, and scientists involved in fundamental re search. Few organs maintain and support a differentiation process as complicated as spermatogenesis; few tissues continually display both mitotic and meiotic cell cyles in such a stringently controlled fashion or a comparable need for coordinated endocrine and local control.
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