Early chapters provide valuable diagnostic information, and review the course, outcome, and genetics of this highly heritable condition, allowing clinicians to distinguish between the various mood disorders. The book offers a thorough and unique overview of the neurobiology of the disorder, including what is known from recent neuroimaging work. Several chapters delineate the treatment of bipolar depression in special populations such as children and pregnant women, and another chapter addresses the particular issues of suicide, focusing on the need for assessment during both acute and maintenance treatment with interventions appropriate to a patient's symptoms and history. Finally, the book covers acute and long-term treatment strategies for bipolar depression, including both traditional and novel therapeutics for the disorder, as well as non-pharmacological treatments.
This book has assembled a widely respected group of preclinical and clinical researchers who bring their expertise to bear upon this illness. It offers researchers, clinicians, and postgraduate students key insights into this devastating disorder.
This second edition reflects significant advances, including an improved understanding of the altered neurobiology of patients suffering from bipolar depression, new information on pathophysiology and genetic findings drawn from diverse studies, and a discussion of the significant strides made towards improved treatment with already available and novel agents.
Five Current Topics are discussed in this volume: Neurobiological mechanisms of alcoholism, Genetics, Clinical phenotypes and their preclinical models, Brain imaging, and Translational approaches for treatment development, both pharmacological and non-pharmacological. These areas have in our opinion brought alcohol research substantially forward and influenced our thinking about how to reach our common paramount goal, namely to offer effective treatment solutions for an extensive group of patients with largely unmet medical needs.