Arteriovenous and Cavernous Malformations

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Arteriovenous and Cavernous Malformations, Volume 143, is the latest addition in the ongoing HCN series, an evidence-based compendium which addresses both the scientific and clinical aspects of this unique disease process. The volume covers didactic aspects, such as the epidemiology, etiology, and diagnosis of AVMs, while also providing expert clinical information on the management and treatment of these lesions.

In addition, it provides coverage of modern-day advances in the genetics of cavernous malformations, as well as discussion regarding future open research questions. Readers from the laboratory bench to the bedside can expect a broad, yet objective, review of this pathology, with updates from the latest scientific literature and data supporting current practices.

  • Offers an evidence-based focus with coverage of both the scientific and clinical aspects of cavernous malformations
  • Addresses epidemiology, etiology, diagnosis, and genetics
  • Contains clinical insights regarding indications for surgery, surgical techniques, outcomes, and prognostic factors drawn from the authors' extensive experiences
  • Edited work with chapters authored by leaders in the field from around the globe – the broadest, most expert coverage available
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About the author

Dr. Spetzler is President and Chief Executive Officer of Barrow Neurological Institute in Phoenix, Arizona, where he has been Director since 1986 and has held the J. N. Harber Chair of Neurological Surgery since first joining the staff in 1983. Under his guidance and focus on education, research, and patient care, Barrow Neurological Institute has become one of the top neuroscience centers and the largest neurosurgical center in the United States, with the largest neurosurgical residency training program in the country.

His neurosurgical work focuses on vascular neurosurgery and skull base surgery to treat aneurysms, arteriovenous malformations (AVMs), and cavernous malformations. He has developed more effective and safer neurosurgical approaches to deep areas of the brain. During his extensive surgical practice, he has clipped more than 6,400 aneurysms, and he has developed theories on normal perfusion pressure breakthrough and how AVM size reveals the potential for rupture. He codeveloped a heuristic grading system (the Spetzler-Martin grading scale) for estimating the risk of open neurosurgery for AVMs.

Dr. Spetzler is a sought-after presenter at national and international neurosurgical conferences. He has edited or coedited more than 20 books and neurosurgical atlases, has published more than 700 articles in peer-reviewed academic medical journals, and has coauthored more than 270 book chapters. He frequently serves as a peer reviewer of scholarly manuscripts on vascular topics. He has been editor-in-chief of the journals Operative Techniques in Neurosurgery and Skull Base: An Interdisciplinary Approach, and he has been an editorial board member, a section editor, and an advisory board member for numerous journals.

He holds chairs in Neurosurgical Education and in Neurosurgical Research at Barrow Neurological Institute, and serves as a professor and executive chair of the Department of Neurosurgery at the University of Arizona College of Medicine, Phoenix. He also is a past president of the American Academy of Neurological Surgery and the North American Skull Base Society, and a past honorary president of the World Federation of Neurosurgical Societies Foundation.

Dr. Karam Moon is a fellowship-trained cerebrovascular neurosurgeon in Phoenix, Arizona. He received his Bachelor of Science from the University of Washington in Seattle, Washington and attended medical school at Case Western Reserve University in Cleveland, Ohio. He completed his neurosurgical residency training under Dr. Robert Spetzler at the venerable Barrow Neurological Institute in Phoenix, Arizona, where he also completed his fellowship training in endovascular neurosurgery under Drs. Cameron G. McDougall and Felipe C. Albuquerque. He is a prolific academic neurosurgeon, regularly publishing clinical outcomes studies in leading neurosurgery journals and speaking at national conferences throughout the year. He was also the recipient of two consecutive Synthes Cerebrovascular Awards in the 2014-2015 academic year. He also served as a sideline concussion consultant for Arizona State University Football during the 2014 season. In his spare time, he enjoys a variety of sports, mountain biking, and traveling.

Rami Almefty is a chief resident in neurological surgery at Barlow Neurological Institute. He received his medical degree from the University of Arkansas, and he completed a skull base fellowship at Harvard Medical School. His neurosurgical interests are skull base and cerebrovascular surgery.

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Published on
May 25, 2017
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Medical / Neurology
Medical / Pathology
Science / Life Sciences / Neuroscience
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This book will cover recent advances in genetics and molecular biology of cerebrovascular diseases, including ischemic stroke, brain arteriovenous malformation, brain aneurysms, and cavernous malformation. Developments in diagnostics, imaging and treatment will also be discussed.

Much progress has been made in recent years in these fields, but not been summarized in one comprehensive text. This volume fills the gap in the literature by compiling them in one convenient, handy volume for neuroscience researchers and medical professionals.

Contents: Imaging in Cerebrovascular Disease (Christopher P Hess)Cell Mechanisms and Clinical Targets in Stroke (Jing Lan, Elga Esposito, MingMing Ning, Xunming Ji, and Eng H Lo)Neural Repair for Cerebrovascular Diseases (Steven C Cramer)Brain AVM: Current Treatments and Challenges (W Caleb Rutledge and Michael T Lawton)Animal Models and Prospective Therapeutic Targets for Brain Arteriovenous Malformation (Wan Zhu, Rui Zhang, Li Ma, and Hua Su)Biology of Brain Aneurysms (W Caleb Rutledge and Tomoki Hashimoto)Intracranial Aneurysms: Imaging, Hemodynamics, and Remodeling (David Saloner)Recent Advances in CADASIL Research (Suning Ping and Li-Ru Zhao)Dural Fistula (Daniel L Cooke, Matthew R Amans, and Van V Halbach)Interventional Therapies for Cerebrovascular Diseases (Fabio Settecase and Steven W Hetts)Stem Cell-mediated Biobridge: Crossing the Great Divide Between Bench and Clinic in Translating Cell Therapy for Stroke (Trenton Lippert, Marci Crowley, M Grant Liska, and Cesar V Borlongan)
Readership: Neurologists, neurobiologists, neuroscientists.
Keywords: Ischemic Stroke;Brain Arteriovenous Malformation;Brain Aneurism;Cerebral Cavernous Malformation;Dural Fistula;Brain ImageReview:0
This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery.

Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to undersnd the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential.

Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA. Dr. Lapchak is an internationally recognized expert conducting translational drug development research for ischemic and hemorrhagic stroke.

Dr. John H. Zhang is Professor of Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr. Zhang is an internationally recognized expert working on drug development for hemorrhagic stroke.
The topic "Cerebrovascular Transport Mechanisms" was chosen by the General Couneil of the International Society of Neuropathology as one of the four main symposia at the IX International Congress of Neuropathology, September 1982 in Vienna. The chairmen of the symposium were asked to structure a program which would cover the reeent devel opments in this field and which could serve as a background for free communications, relevant to this topic, submitted by the participants of the Congress. Cerebrovascular transport mechanisms refleet the main function of the blood-brain barrier in providing optimaI, homeostatically regulated, biochemical environment for the brain. It is obvious that disturbanees of this function may play a significant role in patho physiology of various brain disorders. Since the elucidation of the complex blood-brain barrier phenomenon, consisting of various "barrier systems", necessarily requires applica tion of multidisciplinary approaches, the program of this symposium was structured by evaluation of ultrastructural, cytochemical, physiological, biochemical, pathophysiological and therapeutic aspects of the blood-brain barrier by invited, recognized experts in respec tive areas. As aresult, this volume of the proceedings of the symposium attempts to summarize much of today's knowledge on cerebrovascular transport mechanisms in health and disease, and is supplemented by the abstracts of free communications dealing with the most reeent research in this field. We hope that this volume wil1 serve both as an introduction and a reference book, and that it wil1 stimulate further research.
Huntington Disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinical/research specialists looking to expand their knowledge base of Huntington disease information, as well as solid groundwork for advanced students from various backgrounds (neurology, psychiatry, neuropsychology, genetics). The volume includes all major areas of Huntington disease clinical care and research, whereas many other HD texts focus solely on neurological symptoms.

This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington’s disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource.

Includes coverage of both basic science and clinical aspects of the disease, as well as treatment, experimental therapeutics, and biomarkersProvides an essential resource for the non-neurologist, including necessary background for understanding the disease before making a more detailed study proposalProvides an interdisciplinary approach that can be applied in everyday clinic and research effortsFeatures chapters edited by leaders in the field around the globe—the broadest expert coverage available
Praise for this book:Instructive and...high quality...[an] excellent fully meets its objective to highlight a very important part of both paediatric and vascular neurosurgery.--Neurosurgical ReviewBridging the gap between the pediatric specialist unaccustomed to handling neurovascular pathologies and the neurovascular specialist unaccustomed to treating pediatric patients, this text covers the cutting-edge, multi-modal techniques for managing pediatric neurovascular disease, disorders, and malformations. It contains full descriptions and insightful perspectives on the most advanced surgical, endovascular, and medical treatments for cerebral aneurysms, arteriovenous fistulas, arteriovenous malformations, Galen's vein malformations, moyamoya disease, spinal vascular malformations, pediatric stroke, and more. Highlights: Easy-to-follow organization of disease topics according to endovascular, surgical, or medical treatment method Discussion of endovascular techniques and tools for angioplasty and stents in children, as well as how to manage possible complications such as stroke and hemorrhage More than 200 illustrations highlighting principles of disease pathology Review of the existing literature helps the clinician gain a full understanding of the fundamentals in neurovascular disease management With contributions from world-renowned experts, this is an exceptional clinical reference for neurosurgeons, neuroradiologists, neurointerventionalists, neurologists, and pediatricians seeking to gain expertise in a multi-pronged approach to pediatric neurovascular disease.
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