In addition, it provides coverage of modern-day advances in the genetics of cavernous malformations, as well as discussion regarding future open research questions. Readers from the laboratory bench to the bedside can expect a broad, yet objective, review of this pathology, with updates from the latest scientific literature and data supporting current practices.
Dr. Spetzler is President and Chief Executive Officer of Barrow Neurological Institute in Phoenix, Arizona, where he has been Director since 1986 and has held the J. N. Harber Chair of Neurological Surgery since first joining the staff in 1983. Under his guidance and focus on education, research, and patient care, Barrow Neurological Institute has become one of the top neuroscience centers and the largest neurosurgical center in the United States, with the largest neurosurgical residency training program in the country.
His neurosurgical work focuses on vascular neurosurgery and skull base surgery to treat aneurysms, arteriovenous malformations (AVMs), and cavernous malformations. He has developed more effective and safer neurosurgical approaches to deep areas of the brain. During his extensive surgical practice, he has clipped more than 6,400 aneurysms, and he has developed theories on normal perfusion pressure breakthrough and how AVM size reveals the potential for rupture. He codeveloped a heuristic grading system (the Spetzler-Martin grading scale) for estimating the risk of open neurosurgery for AVMs.
Dr. Spetzler is a sought-after presenter at national and international neurosurgical conferences. He has edited or coedited more than 20 books and neurosurgical atlases, has published more than 700 articles in peer-reviewed academic medical journals, and has coauthored more than 270 book chapters. He frequently serves as a peer reviewer of scholarly manuscripts on vascular topics. He has been editor-in-chief of the journals Operative Techniques in Neurosurgery and Skull Base: An Interdisciplinary Approach, and he has been an editorial board member, a section editor, and an advisory board member for numerous journals.
He holds chairs in Neurosurgical Education and in Neurosurgical Research at Barrow Neurological Institute, and serves as a professor and executive chair of the Department of Neurosurgery at the University of Arizona College of Medicine, Phoenix. He also is a past president of the American Academy of Neurological Surgery and the North American Skull Base Society, and a past honorary president of the World Federation of Neurosurgical Societies Foundation.
Dr. Karam Moon is a fellowship-trained cerebrovascular neurosurgeon in Phoenix, Arizona. He received his Bachelor of Science from the University of Washington in Seattle, Washington and attended medical school at Case Western Reserve University in Cleveland, Ohio. He completed his neurosurgical residency training under Dr. Robert Spetzler at the venerable Barrow Neurological Institute in Phoenix, Arizona, where he also completed his fellowship training in endovascular neurosurgery under Drs. Cameron G. McDougall and Felipe C. Albuquerque. He is a prolific academic neurosurgeon, regularly publishing clinical outcomes studies in leading neurosurgery journals and speaking at national conferences throughout the year. He was also the recipient of two consecutive Synthes Cerebrovascular Awards in the 2014-2015 academic year. He also served as a sideline concussion consultant for Arizona State University Football during the 2014 season. In his spare time, he enjoys a variety of sports, mountain biking, and traveling.
Rami Almefty is a chief resident in neurological surgery at Barlow Neurological Institute. He received his medical degree from the University of Arkansas, and he completed a skull base fellowship at Harvard Medical School. His neurosurgical interests are skull base and cerebrovascular surgery.
Much progress has been made in recent years in these fields, but not been summarized in one comprehensive text. This volume fills the gap in the literature by compiling them in one convenient, handy volume for neuroscience researchers and medical professionals.
This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington’s disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource.Includes coverage of both basic science and clinical aspects of the disease, as well as treatment, experimental therapeutics, and biomarkersProvides an essential resource for the non-neurologist, including necessary background for understanding the disease before making a more detailed study proposalProvides an interdisciplinary approach that can be applied in everyday clinic and research effortsFeatures chapters edited by leaders in the field around the globe—the broadest expert coverage available