Atlas of Clinical Neurology: Edition 2

Springer Science & Business Media
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'---~~~~-~~---------------. . . . . . . . . -. . . . . . . . . . . . . . . . . . . -. . . . . . . . . . . . . . . . . . . . . . . . . 41 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ••••••• he year 2001 marks the beginning of a new millenium, and (chromosome 1) result in dominantly inherited AD. A major risk T the second edition of the Atlas of Clinical Neurology high factor for AD is the presence of the E4 allele of apolipoprotein E lights and underscores the enormous strides being made in (chromosome 19). Additional detailed images related to the the biologic understanding of neurologic disease. Neurology is a dementias are included in the second edition of the Atlas. These highly visual specialty. The neurologic examination, magnetic reso clinical-molecular correlations are all very recent and attest to the nance imaging, electroencephalography, positron-emission tomo scientific vigor of current neuroscientific research. It is my view that graphic (PET) and functional magnetic resonance (fMRI) scan these new data will lead in the near future to effective new therapy ning, and light- and electron-microscopy are examples of visual for AD that will slow its rate of progress and reduce significantly images that define neurologic disease and normal brain functions. the incidence of this major, debilitating disease. Positron-emission This Atlas of Clinical Neurology has been designed to provide a pic tomographic and fMRI brain scanning have effectively defined torial comprehensive visual exposition and integration of all aspects regional brain areas for behaviors.
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Publisher
Springer Science & Business Media
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Published on
Jun 29, 2013
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Pages
565
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ISBN
9781475745528
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Best For
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Language
English
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Genres
Medical / Clinical Medicine
Medical / Neurology
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This content is DRM protected.
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Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format.

Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases.

Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric diseaseDetailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brainDetailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations
“My book … details the living hell that was my experience with concussions. The majority of this story was kept from even my closest relationships. It wasn’t easy, but it’s time to tell it.” – Dale Jr.

It was a seemingly minor crash at Michigan International Speedway in June 2016 that ended the day early for Dale Earnhardt Jr. What he didn’t know was that it would also end his driving for the year. He’d dealt with concussions before, but concussions are like snowflakes—no two are the same. And recovery can be brutal—and lengthy.

As a third-generation driver in a family forever connected to the sport of stock-car racing, how could Dale Earnhardt Jr. sit on the sidelines and watch everyone else take their laps? It was one of the toughest seasons of his life—one that changed him forever.

In this gripping narrative from one of professional sports’ most beloved figures, Dale Jr. shares stories from his journey: how his career and his injury have transformed him, how he made the decision to retire at the end of the 2017 season after eighteen years behind the wheel, and what lies ahead for him in the next chapter of his life. There’s no second-guessing and no regrets from Driver #88. He simply wants to go out on his own terms and make the rest of his life off the racetrack count. Junior says, “I don’t want these last races to be just about me but rather the people who made my success possible: my fans, the folks who pack the grandstands rain or shine, my teammates and crew members through the years, industry colleagues, track volunteers, friends, family, sponsors. They’ve all played a role. I couldn’t have done it without them.”

The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions.
This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987.
This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.
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