Bay Area scientists, university administrators, and government officials were fascinated by and increasingly engaged in the economic and political opportunities associated with the privatization of academic research. Yi uncovers how the attempts made by Stanford scientists and administrators to demonstrate the relevance of academic research were increasingly mediated by capitalistic conceptions of knowledge, medical innovation, and the public interest. Their interventions resulted in legal shifts and moral realignments that encouraged the privatization of academic research for public benefit. The Recombinant University brings to life the hybrid origin story of biotechnology and the ways the academic culture of science has changed in tandem with the early commercialization of recombinant DNA technology.
Drawing on corporate documents obtained from patent litigation, as well as interviews with the ambitious biologists who called themselves gene jockeys, historian Nicolas Rasmussen chronicles the remarkable, and often secretive, work of the scientists who built a new domain between academia and the drug industry in the pursuit of intellectual rewards and big payouts. In contrast to some who critique the rise of biotechnology, Rasmussen contends that biotech was not a swindle, even if the public did pay a very high price for the development of what began as public scientific resources. Within the biotech enterprise, the work of corporate scientists went well beyond what biologists had already accomplished within universities, and it accelerated the medical use of the new drugs by several years.
In his technically detailed and readable narrative, Rasmussen focuses on the visible and often heavy hands that construct and maintain the markets in public goods like science. He looks closely at how science follows money, and vice versa, as researchers respond to the pressures and potential rewards of commercially viable innovations. In biotechnology, many of those engaged in crafting markets for genetically engineered drugs were biologists themselves who were in fact trying to do science.
This book captures that heady, fleeting moment when a biologist could expect to do great science through the private sector and be rewarded with both wealth and scientific acclaim.-- Sir Richard Roberts, New England Biolabs
Americans have a long tradition of making heroes out of their inventors. But before the 1960s and '70s neither policymakers nor economists paid much attention to the critical economic role played by innovation. However, during the late 1970s, a confluence of events--industry concern with the perceived deterioration of innovation in the United States, a growing body of economic research on innovation's importance, and the stagnation of the larger economy--led to a broad political interest in fostering invention. The policy decisions shaped by this change were diverse, influencing arenas from patents and taxes to pensions and science policy, and encouraged practices that would focus specifically on the economic value of academic science. By the early 1980s, universities were nurturing the rapid growth of areas such as biotech entrepreneurship, patenting, and university-industry research centers.
Contributing to debates about the relationship between universities, government, and industry, Creating the Market University sheds light on how knowledge and politics intersect to structure the economy.
The development of antilock braking systems (ABS) provides an ideal case study for examining the process of engineering design because it presented an array of common difficulties faced by engineers in research and development. ABS did not develop predictably. Research and development took place in both the public and private sectors and involved individuals working in different disciplines, languages, institutions, and corporations. Johnson traces ABS development from its first patents in the 1930s to the successful 1978 market introduction of integrated ABS by Daimler and Bosch. She examines how a knowledge community first formed around understanding the phenomenon of skidding, before it turned its attention to building instruments to measure, model, and prevent cars’ wheels from locking up. While corporations’ accounts of ABS development often present a simple linear story, Hitting the Brakes describes the full social and cognitive complexity and context of engineering design.
Rescuing Prometheus is an eye-opening and marvelously informative look at some of the technological projects that helped shape the modern world. Thomas P. Hughes focuses on four postwar projects whose vastness and complexity inspired new technology, new organizations, and new management styles. The first use of computers to run systems was developed for the SAGE air defense project. The Atlas missile project was so complicated it required the development of systems engineering in order to complete it. The Boston Central Artery/Tunnel Project tested systems engineering in the complex crucible of a large scale civilian roadway. And finally, the origins of the Internet fostered the collegial management style that later would take over Silicon Valley and define the modern computer industry. With keen insight, Hughes tells these fascinating stories while providing a riveting history of modern technology and the management systems that made it possible.
From the Trade Paperback edition.
Packed with key facts and analysis, "Genetic Engineering: A Reference Handbook, Second Edition" provides an expert guide to the very latest discoveries in genetic engineering and genetic modification and the technology's complex ethical, scientific, and economic implications.
For the nonscientist, the claims and counterclaims are dizzying—what does it really mean to understand the genome? Barry Barnes and John Dupré offer an answer to that question and much more in Genomes and What to Make of Them, a clear and lively account of the genomic revolution and its promise. The book opens with a brief history of the science of genetics and genomics, from Mendel to Watson and Crick and all the way up to Craig Venter; from there the authors delve into the use of genomics in determining evolutionary paths—and what it can tell us, for example, about how far we really have come from our ape ancestors. Barnes and Dupré then consider both the power and risks of genetics, from the economic potential of plant genomes to overblown claims that certain human genes can be directly tied to such traits as intelligence or homosexuality. Ultimately, the authors argue, we are now living with a new knowledge as powerful in its way as nuclear physics, and the stark choices that face us—between biological warfare and gene therapy, a new eugenics or a new agricultural revolution—will demand the full engagement of both scientists and citizens.
Written in straightforward language but without denying the complexity of the issues, Genomes and What to Make of Them is both an up-to-date primer and a blueprint for the future.