Drug Efficacy, Safety, and Biologics Discovery

Wiley Series on Technologies for the Pharmaceutical Industry

Book 4
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Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.
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About the author

Sean Ekins, MSc, PHD, DSc, is the Principal at Collaborations in Chemistry; and Adjunct Associate Professor in the Department of Pharmaceutical Sciences at the University of Maryland, School of Pharmacy. Dr. Ekins has published widely on ADME/Tox, systems biology, computational, and in vitro drug discovery approaches. He has previously edited two Wiley books: Computer Applications in Pharmaceutical Research and Development (2006) and Computational Toxicology: Risk Assessment for Pharmaceutical and Environmental Chemicals (2007).

Jinghai J. Xu, PHD, is Director of Automated Biotechnology at Merck. Previously he headed predictive toxicology at Pfizer, where he led research activities in drug-induced liver injury, genetic toxicology, drug transporters, assay development, high content screening, in vitro in vivo correlations, systems biology, and systems toxicology. Dr. Xu has served on steering committees of academic-industry and industry-industry collaborations, and as a guest lecturer at the Massachusetts Institute of Technology.

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Additional Information

Publisher
John Wiley & Sons
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Published on
Jan 28, 2009
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Pages
336
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ISBN
9780470431801
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Best For
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Language
English
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Genres
Medical / Pharmacology
Science / Chemistry / General
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Content Protection
This content is DRM protected.
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Book 5
A unique, integrative look at information-based medicine

The convergence of medical science, biology, pharmacology, biomedical engineering, healthcare, and information technology is revolutionizing medical and scientific practice, and has broader social implications still being understood. The Engines of Hippocrates provides a unique, integrative, and holistic look at the new paradigm of information-based medicine, covering a broad range of topics for a wide readership.

The authors take a comprehensive approach, examining the prehistory, history, and future of medicine and medical technology and its relation to information; how history led to such present-day discoveries as the structure of DNA, the human genome, and the discipline of bioinformatics; and what the future results of these discoveries may hold. Their far-ranging views are their own and not necessarily those of the IBM Corporation or other employers.

The Engines of Hippocrates helps readers understand:

Forces shaping the pharmaceutical and biomedical industries today, including personalized medicine, genomics, data mining, and bionanotechnology

The relationship between pharmaceutical science today and other disciplines such as philosophy of health, history, economics, mathematics, and computer science

The integrated role alternative and non-Western medicines could play in a new, information-based medicine

Practical, ethical, organizational, technological, and social problems of information-based medicine, along with a novel data-centric computing model and a self-adaptive software engineering model, and corresponding information technology architectures, including perspectives on sharing remote data efficiently and securely for the common good

An unmatched, cross-disciplinary perspective on the big picture of today and tomorrow's medicine, The Engines of Hippocrates provides a reference to interested readers both inside and outside the pharmaceutical and medical communities, as well as a peerless classroom supplement to students in a wide variety of disciplines.

Book 2
A unique, holistic approach covering all functions and phases of pharmaceutical research and development


While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process.

Chapters are organized into the following sections:
* Computers in pharmaceutical research and development: a general overview
* Understanding diseases: mining complex systems for knowledge
* Scientific information handling and enhancing productivity
* Computers in drug discovery
* Computers in preclinical development
* Computers in development decision making, economics, and market analysis
* Computers in clinical development
* Future applications and future development

Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent structure and approach throughout the book. Figures are used extensively to illustrate complex concepts and multifaceted processes. References are provided in each chapter to enable readers to continue investigating a particular topic in depth. Finally, tables of software resources are provided in many of the chapters.

This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics and ADMET, drug discovery, and technology development. The book's cross-functional, all-phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics.
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