The text begins with key fundamentals including anatomy and physiology, pathophysiology, imaging and biomechanics to delineate healthy versus diseased spine. Subsequent sections discuss treatment strategies, research findings, and future developments. Throughout each chapter, renowned spine surgeons and scientists share clinical pearls gleaned from hands-on experience.
Key HighlightsThe current state of the art in biological and tissue engineering procedures for spinal disordersTreatment methodologies including nucleus replacement and repair, annulus fibrosus repair, total disc transplantation, and mechanical total disc replacementInnovative treatment strategies for disc regeneration, such as genes and proteinsGrowth factors including platelet-rich plasma (PRP), which has shown promise for the stimulation and acceleration of bone and soft tissue healingCell-based therapy for spinal disc regeneration and repair including the use of stem cells and chondrocytesIn-depth discussion of research including animal versus human model, in-vitro, and a summary of biologic clinical trials
This is a must-have resource for trainee and practicing orthopaedic surgeons and neurosurgeons who treat patients for spine-related conditions. It is essential reading for all clinicians who have an interest in cutting-edge tissue engineering and biological treatment interventions.
Written by leading scientists and clinicians, the first part of the book provides a review of the basic biology of the disc in health and disease. The second part considers strategies to mitigate the effects of disc degeneration and discusses the possibility of engineering replacement tissues. The final section is devoted to approaches to model normal development and elucidate the pathogenesis of degenerative disc disease using animal, organ and cell culture techniques.
The book bridges the gap between the basic and clinical sciences; the target audience includes basic scientists, orthopaedists and neurologists, while at the same time appealing to the needs of graduate students, medical students, interns and fellows.
Readership: Student and professional.
Keywords:Native Polymer;3D Substitutes;Zein;Collagen;Chitosan;Alginate;Hyaluronic AcidKey Features:A unique volume and the first of its kind to bring together recent research of native macromolecule-based biomaterials in the field of tissue engineeringWith the increasing popularity of tissue engineering, one of the major thrusts in substitutes is to develop 3D biomaterials that can be molded into the shape of a tissue defect and degrade after tissue repair. Advantages of native macromolecule-based biomaterials in biocompatibility and biodegradability aspects have gained more attention, and considerable advances have already been made
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