A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Edition 4

Elsevier
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A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition features the latest ideas and research about the application of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery, biased signaling, structure-based drug design, drug activity screening, drug development (including pharmacokinetics and safety Pharmacology), and much more. With more color illustrations, examples, and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research.
  • Highlights changes surrounding the strategy of drug discovery to provide you with a comprehensive reference featuring advances in the methods involved in lead optimization and more effective drug discovery
  • Includes a new chapter on data-driven drug discovery in terms of the optimal design of pharmacological experiments to identify mechanism of action of new molecules
  • Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data
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About the author

Terry P. Kenakin is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society. Having been involved in drug discovery for over 30 years, his interests include the optimal design of drug activity assays systems and quantitative drug receptor theory. He is a member of numerous editorial boards as well as Editor-in-Chief of the Journal of Receptors and Signal Transduction and Current Opinion in Pharmacology. In addition, Dr. Kenakin has authored numerous articles and has also written a number of books on pharmacology.

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Additional Information

Publisher
Elsevier
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Published on
Mar 26, 2014
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Pages
450
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ISBN
9780124076891
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Language
English
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Genres
Medical / Pharmacology
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Content Protection
This content is DRM protected.
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Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book allow for the application of more predictive pharmacological procedures aimed at increasing therapeutic efficacy that will lead to more successful drug development.

Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization.

This edition has been fully revised to address the latest advances and research related to real time kinetic assays, pluridimensional efficacy, signaling bias, irreversible and chemical antagonism, allosterically-induced bias, pharmacokinetics and safety, target and pathway validation, and much more. With numerous valuable chapter summaries, detailed references, practical examples and case studies throughout, Dr. Kenakin successfully navigates a highly complex subject, making it accessible for students, professors, and new researchers working in pharmacology and drug discovery.

Includes example-based cases that illustrate how the pharmacological concepts discussed in this book lead to practical outcomes for further researchProvides vignettes on those researchers and scientists who have contributed significantly to the fields of pharmacology and drug discovery throughout historyOffers sample questions throughout the book and an appendix containing answers for self-testing and retention
Buprenorphine, often better known by the brand name Suboxone®, is currently the preferred drug for helping people recover from opiate addiction. But how is the drug best used? Is it something that should be used on a short-term or long-term basis? Can patients really taper off the drug, and if so, how do they go about it with a minimal amount of problems? And what other things should Suboxone patients be doing to ensure they have a positive experience with the drug? In this compelling book, Sebastian Enfield lays it all on the line, and explains how doctors and patients should approach buprenorphine therapy to maximize the chances of successful treatment and recovery.

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And so, he set out to investigate all of this, and to write a book that explained his findings in clear and simple terms. Sebastian spoke with various doctors, Suboxone patients and therapists, and synthesized their views and opinions, along with his own experiences, into a book of tips and suggestions that would help doctors and patients best approach buprenorphine treatment.

Sebastian begins with his own compelling story, where he details the life journey that ultimately led to drug addiction. He then presents several suggestions and tips that cover a wide range of questions he knew Suboxone patients had. The book covers a variety of topics, such as how to best select a doctor, how to approach counseling (and whether you really need counseling), how to taper off the medication with minimal discomfort (and whether you even should taper off the medication), resources that may help with paying for treatment, and a variety of “lifestyle hacks” Sebastian found to be useful while being treated. Sebastian lays all of this out clearly, and provides a positive and motivating read that will help patients understand that treatment with buprenorphine need not be a scary and uncertain thing. On the contrary, it can be a constructive part of recovery from opiate addiction. As he put it, “This is the book I wish I had when I began buprenorphine treatment.”

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