This second edition covers all the latest developments in the field of hemophilia, with new chapters on:
Drawing on the vast experience of the authors, the aim of this textbook remains the same - to improve the care of patients suffering from hemophilia. The book is full of detailed guidance and advice on everyday clinical questions making it invaluable to all trainee and practicing hematologists.
Erik E. Berntorp MD, PhD
Professor of Haemophilia, Lund University, Malmö Centre for Thrombosis and Haemostasis, Skåne University Hospital, Malmö, Sweden
W. Keith Hoots MD
Director, Division of Blood Diseases and Resources, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD;
Professor of Pediatrics and Internal Medicine, University of Texas Medical School at Houston,
Houston, TX, USA
This valuable book describes the important and complex role of von Willebrand factor in hemostasis and thrombosis. In addition to the current understanding of its molecular biology, this book gives particular focus to the association between genetic variants of von Willebrand factor and different von Willebrand disease phenotypes. It also reviews the important area of the obstetric and gynecological manifestations of von Willebrand disease, as well as the treatment of acute bleeding.
Written by an international team of contributors it describes the progress in, and difficulties of diagnosing phenotypes and genotypes. Molecular diagnosis of type 1, type 2 and its subgroups, and type 3 von Willebrand disease are presented as well as discussion of the potential future role of gene therapy.
Von Willebrand Disease: Basic and Clinical Aspects is a valuable resource for hematologists in practice and in training, and specialists in thrombosis and hemostasis.
Beginning with a general summary of thermodynamics, fluid mechanics and heat transfer, this book goes on to discuss practical applications with chapters that include TES systems, environmental impact, energy savings, energy and exergy analyses, numerical modeling and simulation, case studies and new techniques and performance assessment methods.
This book is intended to provide a comprehensive technical overview and survey of advanced internet protocols, first providing a solid introduction and going on to discuss internetworking technologies, architectures and protocols. The book also shows application of the concepts in next generation networks and discusses protection and restoration, as well as various tunnelling protocols and applications. The book ends with a thorough discussion of emerging topics.