Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

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Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications critically evaluates the basic concepts and methodologies of conventional biomarkers as well as current state-of-the-art assays for measuring antioxidant activity/oxidative stress and their practical applications. . Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications will be of a great interest to scientists who are involved in basic research on oxidation, applied scientists evaluating the effects of nutraceuticals or pharmaceutical compounds on antioxidant activity/oxidative stress, and physicians who want to understand the degree of oxidative damage in patients with certain chronic diseases.

Discovering sensitive and specific biomarkers for systemic oxidative damage is essential to understand the role of oxidative stress in human disease. Once these roles are clearly understood, we are able to identify novel drug and nutraceutical targets. This volume goes beyond conventional analytical methods of measuring overall antioxidant activity and provides insight to the discovery of biomarkers that reveal information on specific areas of oxidative stress. Contributed by an international list of experts, Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications describes both conventional biomarkers and recent developments in this area.

Special Features:

  • Discusses conventional biomarkers as well as recent advances for measuring antioxidants and oxidative stress
  • Biomarkers for lipid peroxidation: isoprostane, hydroxyloctadecaenoic acid, oxysterols, and reactive carbonyl species from lipid peroxidation
  • Biomarkers for protein oxidation: carbonylation, tyrosine oxidation, ubiquitin-conjugation
  • Biomarkers for DNA oxidative damage: comet assay, hydroxylated nucleotides, and exocylcic DNA adducts
  • Recently developed biomarkers from cutting-edge technology
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About the author

Giancarlo Aldini, Ph.D., Department of Pharmaceutical

Sciences "Pietro Pratesi", Università degli Studi di Milano, Milan, Italy

Kyung-Jin Yeum, Ph.D., Jean Mayer USDA-Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.

Etsuo Niki, Ph.D., , Health Research Institute, National Institute of Advanced Industrial Science & Technology, Osaka, Japan.

Robert M. Russell, M.D., Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Bethesda, MD 20892-7517, USA

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Additional Information

Publisher
John Wiley & Sons
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Published on
Jun 9, 2011
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Pages
380
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ISBN
9780470961759
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Language
English
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Genres
Medical / General
Medical / Nutrition
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Content Protection
This content is DRM protected.
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Available on Android devices
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Providing clear examples of the use of state-of-the-art computer programs for analyses of bioassay data, Bioassays with Arthropods, Second Edition explains the statistical basis and analysis for each kind of quantal response bioassay. The first edition was a must-have reference for designing, conducting, and interpreting bioassays: this completely revised and updated second edition is positioned to be the same.

New in the Second Edition:

· Includes new chapters on Natural Variation, Quarantine Statistics, Statistical Analysis of Data from Bioassays with Microbial Insecticides, and Pesticide Resistance

· Emphasizes estimation of natural variation in response as the necessary precursor for claims of pesticide resistance, varietal differences, and differences in microbial potency

· Expands the coverage of binary Quantal Response: Dose Number, Dose Selection, and Sample Size

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Building on the foundation set by the much-cited first edition, the authors clearly delineate applications and ideas that are exceptionally challenging for those not already familiar with their use. They lead you through the methods with such ease and organization, that you suddenly find yourself readily able to apply concepts that you never thought you would understand.

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