Andrew Chen is a PhD candidate in Computer Systems Engineering at the Univeristy of Auckland.
Francis Collins is a senior lecturer in Geography and Rutherford Discovery Fellow at the University of Auckland.
David Hall is a Senior Researcher at The Policy Observatory AUT.
Nina Hall is a lecturer at the Hertie School of Governance in Berlin.
Hautahi Kingi is an economist based in Washington, DC.
Tahu Kukutai is Professor of Demography at the National Institute of Demographic and Economic Analysis.
Evelyn Marsters is deputy editor at Impolitikal.
Kate McMillan is a senior lecturer in Politics at Victoria Univeristy of Wellington.
Arama Rata is a Research Officer at the National Institute of Demographic and Economic Analysis.
Murdoch Stephens is a lecturer at Massey Univeristy in Wellington.
This collection of reviews and laboratory protocols gives the reader an introduction to the causes of antibiotic resistance, the bacterial strains that pose the largest danger to humans (i.e., streptococci, pneumococci and enterococci) and the antimicrobial agents used to combat infections with these organisms. Some new avenues that are being investigated for antibiotic development are also discussed. Such developments include the discovery of agents that inhibit bacterial RNA degradation, the bacterial ribosome, and structure-based approaches to antibiotic drug discovery.
Two laboratory protocols are provided to illustrate different strategies for discovering new antibiotics. One is a bacterial growth inhibition assay to identify inhibitors of bacterial growth that specifically target conditionally essential enzymes in the pathway of interest. The other protocol is used to identify inhibitors of bacterial cell-to-cell signaling.
This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the field of antibiotics and antibiotic resistance for students or interdisciplinary collaborators.
Table of Contents:
Antibiotics and the Evolution of Antibiotic Resistance
Jose L Martinez, Fernando Baquero
Antimicrobials Against Streptococci, Pneumococci and Enterococci
Susan Donabedian, Adenike Shoyinka
Techniques & Applications
RNA decay: a novel therapeutic target in bacteria
Tess M. Eidem, Christelle M. Roux, Paul M. Dunman
Antibiotics that target protein synthesis
Lisa S. McCoy, Yun Xie, Yitzhak Tor
High-Throughput Assessment of Bacterial Growth Inhibition by Optical Density Measurements
Current Protocols Chemical Biology
Structure-Based Approaches to Antibiotic Drug Discovery
Current Protocols Microbiology
George Nicola, Ruben Abagyan
Novel Approaches to Bacterial Infection Therapy by Interfering with Cell-to-Cell Signaling
Current Protocols Microbiology
David A. Rasko, Vanessa Sperandio
The use of nanotechnology is currently the most promising strategy to overcome microbial drug resistance. This book shows how, due to their small size, nanoparticles can surmount existing drug resistance mechanisms, including decreased uptake and increased efflux of the drug from the microbial cell, biofilm formation, and intracellular bacteria. In particular, chapters cover the use of nanoparticles to raise intracellular antimicrobial levels, thus directly targeting sites of infection and packaging multiple antimicrobial agents onto a single nanoparticle.Provides the information users need to integrate antibacterial nanoparticles into future treatmentsGives readers with backgrounds in nanotechnology, chemistry, and materials science an understanding of the main issues concerning microbial drug resistance and its challenges Includes real-life case studies that illustrates how functionalized nanomaterials are used to manage microbial infection
Antimicrobial Resistance in Wastewater Treatment Processes assembles detailed discussions written by many of the world's best-known experts in microbiology, civil engineering, chemistry, environmental science, public health and related fields. The book presents a collection of subjects that includes:Current knowledge of the role of the environment in development and spread of antimicrobial resistance Chemical analysis of antibiotics in environmental samples Molecular methods for analysis of antimicrobial resistance genes Advanced wastewater treatment processes and antimicrobial resistance effects Public perception of risk related to health consequences of antimicrobial resistance Public health implications of antimicrobial resistance with focus on wastewater treatment processes
Antimicrobial resistance has gained a foothold in the global consciousness as a serious public health threat. There is a much greater appreciation for the role of the environment in the dissemination of antimicrobial resistance and the effects of pollutants that can potentially promote development of resistance in bacteria. Contaminants released from wastewater treatment plants are a concern. In Antimicrobial Resistance in Wastewater Treatment Processes, readers will be guided through examinations of the current science related to this important health issue.
Foodborne Pathogens and Antibiotic Resistance bridges technological gaps, focusing on critical aspects of foodborne pathogen detection and mechanisms regulating antibiotic resistance that are relevant to human health and foodborne illnesses
This groundbreaking guide:
• Introduces the microbial presence on variety of food items for human and animal consumption.
• Provides the detection strategies to screen and identify the variety of food pathogens in addition to reviews the literature.
• Provides microbial molecular mechanism of food spoilage along with molecular mechanism of microorganisms acquiring antibiotic resistance in food.
• Discusses systems biology of food borne pathogens in terms of detection and food spoilage.
• Discusses FDA’s regulations and Hazard Analysis and Critical Control Point (HACCP) towards challenges and possibilities of developing global food safety.
Foodborne Pathogens and Antibiotic Resistance is an immensely useful resource for graduate students and researchers in the food science, food microbiology, microbiology, and industrial biotechnology.
The next big human pandemic—the next disease cataclysm, perhaps on the scale of AIDS or the 1918 influenza—is likely to be caused by a new virus coming to humans from wildlife. Experts call such an event “spillover” and they warn us to brace ourselves. David Quammen has tracked this subject from the jungles of Central Africa, the rooftops of Bangladesh, and the caves of southern China to the laboratories where researchers work in space suits to study lethal viruses. He illuminates the dynamics of Ebola, SARS, bird flu, Lyme disease, and other emerging threats and tells the story of AIDS and its origins as it has never before been told. Spillover reads like a mystery tale, full of mayhem and clues and questions. When the Next Big One arrives, what will it look like? From which innocent host animal will it emerge? Will we be ready?