California Cures!: How The California Stem Cell Program Is Fighting Your Incurable Disease!

World Scientific
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Thirteen years ago, America faced an epidemic of chronic disease: cancer, paralysis, blindness, arthritis, Alzheimer's disease, diabetes and more.

But California voters said "YES!" to a $3 billion stem cell research program: the awkwardly-named California Institute for Regenerative Medicine (CIRM). Born into battle, the scrappy little state agency was immediately blocked by three years of anti-science lawsuits -- but it defeated them all. And then?

A quiet triumph. With a focused intensity like the Manhattan Project (but for peaceful purposes, not to build a bomb), scientists funded by CIRM took on the challenges: disease and disability called chronic: incurable.

In a series of connected stories, accurate though written to entertain, "California Cures" relates a war: science against disease, with lives on the line. Think what it means for a paralyzed young man to recover the use of his hands, or for a formerly-blind mother to see her teenaged children -- for the first time!

Do you know the "bubble-baby" syndrome? Infants without a proper immune system typically die young; a common cold can kill. But for eighteen babies in a stem cell clinical trial, a different future: they were cured of their disease.

No one can predict the pace of science, nor say when cures will come; but California is bringing the fight. The reader will meet the scientists involved, the women and men behind the microscope, and share their struggle.

Above all, "California Cures" is a call for action. Washington may argue about the expense of health care (and who will get it), but California works to bring down the mountain of medical debt: stem cell therapies to ease suffering, and save lives.

Will California build on success -- and invest $5 billion more in stem cell research?

"We have the momentum," says author Don C Reed, "We dare not stop short. Chronic disease threatens everyone -- we are fighting for your family, and mine!"

Contents: Introduction: Evangelina and the Golden StateThe Absolute Minimum You Need to Know FirstTo Breathe, or Not to BreatheThe Strongest Man in the WorldWhen the Dolphin Broke My EarThe Boy with Butterfly SkinThe Great Baldness "Comb-Over" Replacement?"He Sees! He Sees!"Cop at the Window"Go West, Young (Wo)Man" -- To a Biomed Career?And How Will You be Paying for that New Heart?The Answer to Cancer?A Political Obstacle to Heart Disease Cure?Your Friend, the Liver!"Bring 'em Back Alive"The Color of FatRevenge for My SisterA Story with No Happy Ending?Aging and Stem CellsThe "Impending Alzheimer's Healthcare Disaster"President Trump's Great Stem Cell OpportunityLeiningen's Ants and Parkinson's DiseaseOn the Morality of Fetal Cell ResearchDemocracy and Gloria's KneesThree Children, and the Eternal FlameAutism, Mini-Brains, and the Zika VirusWhy "The Big Bang Theory" Matters to MeMusashi and the Two-Sword Solution"The Magnificent Seven"The Connecticut CommitmentIn Memory of BeauTo Relocate Alligators, or Turn a Country on to Biomed?Whale Sharks and Outer SpaceMr Science Goes to Washington?When Oklahoma is Not OkJames Bond and MelanomaNeurological Diseases vs. CaliforniaDriving to the StormDoor into TomorrowStem Cell Battles -- On Times Square?Annette, Richard Pryor, and Multiple SclerosisMike Pence, and Reproductive ServitudeMotorcycle Wrecks and Complex FracturesEven Dracula Gets ArthritisTugboat for CureWheelchair Warriors, Take Back Your Rights!Sickle Cell Dis
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Additional Information

Publisher
World Scientific
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Published on
Mar 16, 2018
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Pages
352
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ISBN
9789813231382
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Best For
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Language
English
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Genres
Science / Life Sciences / Cell Biology
Science / Life Sciences / Neuroscience
Technology & Engineering / Biomedical
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Content Protection
This content is DRM protected.
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Eligible for Family Library

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Tissue engineering integrates knowledge and tools from biological sciences and engineering for tissue regeneration. A challenge for tissue engineering is to identify appropriate cell sources. The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering. The impact of stem cell technology on tissue engineering will be revolutionary.

This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs, including cardiovascular, musculoskeletal, neurological and skin tissues. The technology platforms for studying and engineering stem cells, such as hydrogel and biomaterials development, microfluidics system and microscale patterning, are also illustrated. Regulatory challenges and quality control for clinical translation are also detailed. This book provides an comprehensive update on the advancement in the field of stem cells and regenerative medicine, and serves as a valuable resource for both researchers and students.


Contents: Tissue Engineering: From Basic Biology to Cell-Based Applications (R M Nerem)Recent Advances and Future Perspectives on Somatic Cell Reprogramming (K-Y Kim & I-H Park)Hematopoietic Stem Cells (J J Trowbridge)Mesenchymal Stem Cells for Tissue Regeneration (N F Huang & S Li)Delivery Vehicles for Deploying Mesenchymal Stem Cells in Tissue Repair (M S Friedman & J K Leach)Stem Cells for Cardiac Tissue Engineering (J L Young et al.)Cardiovascular System: Stem Cells in Tissue-Engineered Blood Vessels (R Sawh-Martinez et al.)Stem Cells for Vascular Regeneration: An Engineering Approach (L E Dickinson & S Gerecht)Stem Cells and Wound Repair (S H Ko et al.)Engineering Cartilage: From Materials to Small Molecules (J M Coburn & J H Elisseeff)Adult Stem Cells for Articular Cartilage Tissue Engineering (S Saha et al.)Stem Cells for Disc Repair (A A Allon et al.)Skeletal Tissue Engineering: Progress and Prospects (N J Panetta et al.)Clinical Applications of a Stem Cell Based Therapy for Oral Bone Reconstruction (B McAllister & K Haghighat)Therapeutic Strategies for Repairing the Injured Spinal Cord Using Stem Cells (M S Beattie & J C Bresnahan)Potential of Tissue Engineering and Neural Stem Cells in the Understanding and Treatment of Neurodegenerative Diseases (C Auclair-Daigle & F Berthod)High-Throughput Systems for Stem Cell Engineering (D A Brafman et al.)Microscale Technologies for Tissue Engineering and Stem Cell Differentiation (J W Nichol et al.)Quality Control of Autologous Cell- and Tissue-Based Therapies (N Dusserre et al.)Regulatory Challenges for Cell-Based Therapeutics (T McAllister et al.)
Readership: Life science scientists; biomedical researchers; cell biologists; academics, postgraduate students and advanced undergraduate students in cell biology, biochemistry and genetics; surgeons; clinicians; biotechnology and pharmaceutical industry professionals.
Keywords: Stem Cells;Tissue Engineering;Regenerative Medicine;Biotechnology;Cell EngineeringReview:0
In the last 3 decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures.

This book will present the main findings to date and the important factors to be considered when considering resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin, and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate.

Highlights basic research in tissue specific stem cells, experiments with animal models and clinical trials that are transforming the field of regenerationProvides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future researchReports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications
This is a one-of-a-kind book: combining easy-to-understand science, in-the-trenches political warfare, and inspirational stories. It aims to give hope to individuals and families who suffer from chronic disease or disability; to point out how ordinary people can make an extraordinary difference in the battle to ease suffering and save lives through supporting medical research; to share in “people talk” some of the amazing progress already achieved in the new field of stem cell research; to show how even such a magnificent success as the California stem cell program is under constant attack from ideological groups; to offer medical research as a force for international cooperation; to suggest how cure research lessens the need for the mountainous costs of endless care.Unparalleled background: the author has been involved in virtually every important stem cell battle (state, national, and international) since embryonic stem cell research began. The author works closely with Robert N. Klein, sponsor of the California stem cell program, the largest source of such stem cell research funding in the world. In addition, the author is an award-winning teacher as well as writer, and seeks to entertain as well as educate. His book is not only substantive, but also fun.The book would be a treasured gift: for anyone suffering an “incurable” illness or who is a caregiver for a loved one; for a college student considering a rewarding career in biomedicine; for scientists who want to protect and enhance their research funding; and for anyone who wants to see government respond to the needs of its citizenry. Chronic disease and disability are a prison: cure is the triumphant escape — wheelchairs should be for temporary occupancy only.
MUST WE AGE?
A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging.
Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach.

In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.

The entire scope of the BioMEMS field—at your fingertips
Helping to educate the new generation of engineers and biologists, Introduction to BioMEMS explains how certain problems in biology and medicine benefit from and often require the miniaturization of devices. The book covers the whole breadth of this dynamic field, including classical microfabrication, microfluidics, tissue engineering, cell-based and noncell-based devices, and implantable systems. It focuses on high-impact, creative work encompassing all the scales of life—from biomolecules to cells, tissues, and organisms.

Brilliant color presentation
Avoiding the overwhelming details found in many engineering and physics texts, this groundbreaking book—in color throughout—includes only the most essential formulas as well as many noncalculation-based exercises. Important terms are highlighted in bold and defined in a glossary. The text contains more than 400 color figures, most of which are from the original researchers.

Coverage of both historical perspectives and the latest developments
Developed from the author’s long-running course, this classroom-tested text gives readers a vivid picture of how the field has grown by presenting historical perspectives and a timeline of seminal discoveries. It also describes numerous state-of-the-art biomedical applications that benefit from "going small," including devices that record the electrical activity of brain cells, measure the diffusion of molecules in microfluidic channels, and allow for high-throughput studies of gene expression.

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